CN100467441C - 氨甲基-苯基-环己酮衍生物 - Google Patents

氨甲基-苯基-环己酮衍生物 Download PDF

Info

Publication number
CN100467441C
CN100467441C CNB008192669A CN00819266A CN100467441C CN 100467441 C CN100467441 C CN 100467441C CN B008192669 A CNB008192669 A CN B008192669A CN 00819266 A CN00819266 A CN 00819266A CN 100467441 C CN100467441 C CN 100467441C
Authority
CN
China
Prior art keywords
phenyl
mono
polysubstituted
unsubstituted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008192669A
Other languages
English (en)
Chinese (zh)
Other versions
CN1437575A (zh
Inventor
C·皮茨
H·布施曼
B·-Y·克格尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of CN1437575A publication Critical patent/CN1437575A/zh
Application granted granted Critical
Publication of CN100467441C publication Critical patent/CN100467441C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C225/18—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings the carbon skeleton containing also rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
CNB008192669A 2000-01-05 2000-12-27 氨甲基-苯基-环己酮衍生物 Expired - Fee Related CN100467441C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10000311.7 2000-01-05
DE10000311A DE10000311A1 (de) 2000-01-05 2000-01-05 Aminomethyl-Phonyl-Cyclohexanonderivate

Publications (2)

Publication Number Publication Date
CN1437575A CN1437575A (zh) 2003-08-20
CN100467441C true CN100467441C (zh) 2009-03-11

Family

ID=7626852

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008192669A Expired - Fee Related CN100467441C (zh) 2000-01-05 2000-12-27 氨甲基-苯基-环己酮衍生物

Country Status (28)

Country Link
US (1) US6890959B2 (enExample)
EP (1) EP1246791B1 (enExample)
JP (1) JP2003519209A (enExample)
KR (1) KR100748378B1 (enExample)
CN (1) CN100467441C (enExample)
AR (1) AR030683A1 (enExample)
AT (1) ATE280752T1 (enExample)
AU (1) AU782862B2 (enExample)
BR (1) BR0016941A (enExample)
CA (1) CA2396310A1 (enExample)
CO (1) CO5261627A1 (enExample)
CZ (1) CZ20022338A3 (enExample)
DE (2) DE10000311A1 (enExample)
DK (1) DK1246791T3 (enExample)
ES (1) ES2231304T3 (enExample)
HU (1) HUP0203859A3 (enExample)
IL (2) IL150558A0 (enExample)
MX (1) MXPA02006697A (enExample)
NO (1) NO20022983L (enExample)
NZ (1) NZ520468A (enExample)
PE (1) PE20011043A1 (enExample)
PL (1) PL356642A1 (enExample)
PT (1) PT1246791E (enExample)
RU (1) RU2002120897A (enExample)
SI (1) SI1246791T1 (enExample)
SK (1) SK286799B6 (enExample)
WO (1) WO2001049651A2 (enExample)
ZA (1) ZA200206150B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7457762B2 (en) * 2001-09-04 2008-11-25 Accenture Global Services Gmbh Optimization of management of maintenance, repair and overhaul of equipment in a specified time window
DE10326097A1 (de) * 2003-06-06 2005-01-05 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
DE10328316A1 (de) 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
US7260408B2 (en) * 2004-02-20 2007-08-21 Airespace, Inc. Wireless node location mechanism using antenna pattern diversity to enhance accuracy of location estimates
US20050236892A1 (en) * 2004-04-27 2005-10-27 Akihito Kusano Hydraulic braking pressure generating apparatus for vehicles
DE102005052588A1 (de) 2005-11-02 2007-05-10 Grünenthal GmbH Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse
TWI448447B (zh) 2006-07-24 2014-08-11 Gruenenthal Chemie 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
JP5009736B2 (ja) * 2007-10-15 2012-08-22 日本曹達株式会社 環状アミノエーテルを用いたマンニッヒ反応
EP2262759A1 (de) * 2008-02-29 2010-12-22 Grünenthal GmbH Verfahren zur herstellung von (1rs,3rs,6rs)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexan-1,3-diol

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1146987A (zh) * 1995-07-11 1997-04-09 格吕伦塔尔有限公司 作为药用活性成分的6-二甲氨基甲基-1-苯基环己烷化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518663A1 (de) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3974157A (en) * 1974-03-04 1976-08-10 Pennwalt Corporation 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters
JPS51143650A (en) * 1975-06-06 1976-12-10 Takeda Chem Ind Ltd A process for preparing cyclohexanol derivatives
ATE147732T1 (de) 1989-03-08 1997-02-15 Merck Sharp & Dohme Tetrahydroquinolin-derivate, verwendbar bei neurodegenerativen krankheiten
IL112569A (en) * 1994-02-10 1999-12-22 Wyeth John & Brother Ltd Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation
DE19547766A1 (de) * 1995-12-20 1997-06-26 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
MY125037A (en) 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
DE19830105C1 (de) * 1998-07-06 2000-02-17 Gruenenthal Gmbh Acridinderivate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1146987A (zh) * 1995-07-11 1997-04-09 格吕伦塔尔有限公司 作为药用活性成分的6-二甲氨基甲基-1-苯基环己烷化合物

Also Published As

Publication number Publication date
US6890959B2 (en) 2005-05-10
WO2001049651A2 (de) 2001-07-12
HUP0203859A3 (en) 2008-01-28
ZA200206150B (en) 2003-11-03
CA2396310A1 (en) 2001-07-12
AU3016901A (en) 2001-07-16
DK1246791T3 (da) 2005-02-14
MXPA02006697A (es) 2002-09-30
DE10000311A1 (de) 2001-07-12
RU2002120897A (ru) 2004-01-10
PT1246791E (pt) 2005-03-31
CZ20022338A3 (cs) 2002-11-13
EP1246791B1 (de) 2004-10-27
AR030683A1 (es) 2003-09-03
DE50008447D1 (en) 2004-12-02
HK1050890A1 (en) 2003-07-11
KR100748378B1 (ko) 2007-08-10
WO2001049651A3 (de) 2002-05-23
IL150558A (en) 2007-03-08
NO20022983D0 (no) 2002-06-20
SI1246791T1 (en) 2005-06-30
JP2003519209A (ja) 2003-06-17
CN1437575A (zh) 2003-08-20
ATE280752T1 (de) 2004-11-15
BR0016941A (pt) 2003-02-25
CO5261627A1 (es) 2003-03-31
NZ520468A (en) 2003-11-28
NO20022983L (no) 2002-08-28
PE20011043A1 (es) 2001-11-24
PL356642A1 (en) 2004-06-28
ES2231304T3 (es) 2005-05-16
EP1246791A2 (de) 2002-10-09
SK9802002A3 (en) 2003-03-04
US20030096811A1 (en) 2003-05-22
SK286799B6 (sk) 2009-05-07
KR20020063296A (ko) 2002-08-01
AU782862B2 (en) 2005-09-01
HUP0203859A2 (hu) 2003-03-28
IL150558A0 (en) 2003-02-12

Similar Documents

Publication Publication Date Title
JP3982853B2 (ja) 医薬有効物質としての６− ジメチルアミノメチル− １− フエニル− シクロヘキサン化合物
JP4846552B2 (ja) １−フエニル−３−ジメチルアミノ−プロパン化合物の製造方法
JP4846750B2 (ja) 医薬有効物質としてのジメチル−（３−アリール−ブト−３−エニル）−アミノ化合物
CN100467441C (zh) 氨甲基-苯基-环己酮衍生物
US6828345B2 (en) O-substituted 6-methyltramadol derivatives
US6673794B2 (en) Substituted aminomethyl-phenyl-cyclohexane derivatives
AU777873B2 (en) 3-amino-3-arylpropan-1-ol derivatives, their preparation and use

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090311

Termination date: 20100127