PE20011043A1 - Derivados de aminometil-fenil-ciclohexanona, procedimiento para su preparacion y medicamentos que los contienen - Google Patents

Derivados de aminometil-fenil-ciclohexanona, procedimiento para su preparacion y medicamentos que los contienen

Info

Publication number
PE20011043A1
PE20011043A1 PE2001000012A PE2001000012A PE20011043A1 PE 20011043 A1 PE20011043 A1 PE 20011043A1 PE 2001000012 A PE2001000012 A PE 2001000012A PE 2001000012 A PE2001000012 A PE 2001000012A PE 20011043 A1 PE20011043 A1 PE 20011043A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
cyclohexanone
aminometil
procedure
Prior art date
Application number
PE2001000012A
Other languages
English (en)
Inventor
Helmut Buschmann
Babette-Yvonne Koegel
Claudia Puetz
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20011043A1 publication Critical patent/PE20011043A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C225/18—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings the carbon skeleton containing also rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

SE REFIERE A DERIVADOS DE AMINOMETIL-FENIL-CICLOHEXANONA DE FORMULA I, Ia DONDE R1 YH R2 SON R5, YR5; DONDE Y ES ALQUILO C1-C10, ALQUENILO C2-C10, ALQUINILO C2-10, ENTRE OTROS; R5 ES H, HALO, CH, NO2, ALQUILO C1-C8, ENTRE OTROS; R6 ES H, ALQUILO C1-C10, ALQUENILO, C2-C18, ALQUINILO C2-C18, ENTRE OTROS; R1 Y R2 JUNTOS FORMAN -CH=CH-CH=CH-; X ES H, HALO, CR3, ENTRE OTROS; R3 Y R4 JUNTOS SON H, ALQUILO C1-*C10, ALQUENILO C2-C10, ENTRE OTROS; R3 Y R4 JUNTOS FORMAN CICLOALQUILO C3-C7,O UN HETEROCICLO CON, S, O. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y COMPUESTOS INTERMEDIOS. UN COMPUESTO PREFERIDO ES RAC-CIS-[4-DIMETILAMINO-3-HIDROXI-3-(3-METOXI-FENIL)-CICLOHEXANONA] ENTRE OTROS. LOS COMPUESTOS DE FORMULA I, Ia TIENEN EFECTO ANALGESICO
PE2001000012A 2000-01-05 2001-01-04 Derivados de aminometil-fenil-ciclohexanona, procedimiento para su preparacion y medicamentos que los contienen PE20011043A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10000311A DE10000311A1 (de) 2000-01-05 2000-01-05 Aminomethyl-Phonyl-Cyclohexanonderivate

Publications (1)

Publication Number Publication Date
PE20011043A1 true PE20011043A1 (es) 2001-11-24

Family

ID=7626852

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000012A PE20011043A1 (es) 2000-01-05 2001-01-04 Derivados de aminometil-fenil-ciclohexanona, procedimiento para su preparacion y medicamentos que los contienen

Country Status (29)

Country Link
US (1) US6890959B2 (es)
EP (1) EP1246791B1 (es)
JP (1) JP2003519209A (es)
KR (1) KR100748378B1 (es)
CN (1) CN100467441C (es)
AR (1) AR030683A1 (es)
AT (1) ATE280752T1 (es)
AU (1) AU782862B2 (es)
BR (1) BR0016941A (es)
CA (1) CA2396310A1 (es)
CO (1) CO5261627A1 (es)
CZ (1) CZ20022338A3 (es)
DE (2) DE10000311A1 (es)
DK (1) DK1246791T3 (es)
ES (1) ES2231304T3 (es)
HK (1) HK1050890A1 (es)
HU (1) HUP0203859A3 (es)
IL (2) IL150558A0 (es)
MX (1) MXPA02006697A (es)
NO (1) NO20022983L (es)
NZ (1) NZ520468A (es)
PE (1) PE20011043A1 (es)
PL (1) PL356642A1 (es)
PT (1) PT1246791E (es)
RU (1) RU2002120897A (es)
SI (1) SI1246791T1 (es)
SK (1) SK286799B6 (es)
WO (1) WO2001049651A2 (es)
ZA (1) ZA200206150B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7457762B2 (en) * 2001-09-04 2008-11-25 Accenture Global Services Gmbh Optimization of management of maintenance, repair and overhaul of equipment in a specified time window
DE10326097A1 (de) * 2003-06-06 2005-01-05 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
DE10328316A1 (de) 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
US7260408B2 (en) * 2004-02-20 2007-08-21 Airespace, Inc. Wireless node location mechanism using antenna pattern diversity to enhance accuracy of location estimates
US20050236892A1 (en) * 2004-04-27 2005-10-27 Akihito Kusano Hydraulic braking pressure generating apparatus for vehicles
DE102005052588A1 (de) 2005-11-02 2007-05-10 Grünenthal GmbH Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse
TWI496762B (zh) 2006-07-24 2015-08-21 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
JP5009736B2 (ja) * 2007-10-15 2012-08-22 日本曹達株式会社 環状アミノエーテルを用いたマンニッヒ反応
EP2262759A1 (de) 2008-02-29 2010-12-22 Grünenthal GmbH Verfahren zur herstellung von (1rs,3rs,6rs)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexan-1,3-diol

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518663A1 (de) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3974157A (en) * 1974-03-04 1976-08-10 Pennwalt Corporation 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters
JPS51143650A (en) * 1975-06-06 1976-12-10 Takeda Chem Ind Ltd A process for preparing cyclohexanol derivatives
IL93610A0 (en) 1989-03-08 1990-12-23 Merck Sharp & Dohme Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them
IL112569A (en) * 1994-02-10 1999-12-22 Wyeth John & Brother Ltd Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19547766A1 (de) 1995-12-20 1997-06-26 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
MY125037A (en) 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
DE19830105C1 (de) * 1998-07-06 2000-02-17 Gruenenthal Gmbh Acridinderivate

Also Published As

Publication number Publication date
AU782862B2 (en) 2005-09-01
KR100748378B1 (ko) 2007-08-10
IL150558A0 (en) 2003-02-12
CN100467441C (zh) 2009-03-11
NO20022983D0 (no) 2002-06-20
CA2396310A1 (en) 2001-07-12
EP1246791A2 (de) 2002-10-09
ATE280752T1 (de) 2004-11-15
WO2001049651A2 (de) 2001-07-12
PT1246791E (pt) 2005-03-31
AR030683A1 (es) 2003-09-03
US20030096811A1 (en) 2003-05-22
KR20020063296A (ko) 2002-08-01
RU2002120897A (ru) 2004-01-10
SK286799B6 (sk) 2009-05-07
ES2231304T3 (es) 2005-05-16
PL356642A1 (en) 2004-06-28
MXPA02006697A (es) 2002-09-30
SK9802002A3 (en) 2003-03-04
EP1246791B1 (de) 2004-10-27
HUP0203859A3 (en) 2008-01-28
AU3016901A (en) 2001-07-16
NO20022983L (no) 2002-08-28
WO2001049651A3 (de) 2002-05-23
CN1437575A (zh) 2003-08-20
ZA200206150B (en) 2003-11-03
DE50008447D1 (en) 2004-12-02
BR0016941A (pt) 2003-02-25
JP2003519209A (ja) 2003-06-17
SI1246791T1 (en) 2005-06-30
NZ520468A (en) 2003-11-28
DK1246791T3 (da) 2005-02-14
HK1050890A1 (en) 2003-07-11
US6890959B2 (en) 2005-05-10
HUP0203859A2 (hu) 2003-03-28
CO5261627A1 (es) 2003-03-31
DE10000311A1 (de) 2001-07-12
CZ20022338A3 (cs) 2002-11-13
IL150558A (en) 2007-03-08

Similar Documents

Publication Publication Date Title
BRPI0511504A (pt) composto ou um sal farmaceuticamente aceitável do mesmo, e, agente preventivo ou terapêutico para uma doença resultante de beta-amilóides
BR0311806A (pt) Derivados heteroaril benzocondensado-amida de tienopiridinas úteis como agentes terapêuticos, composições farmacêuticas que os incluem e métodos para o seu uso
DOP2001000170A (es) Derivados de tiofeno utiles como agentes anticancesoros
RS53627B1 (en) N- (3-Amino-quinoxalin-2-yl) -sulfonamide derivatives and their use as phosphatidylinositol 3-kinase inhibitors
AR037682A1 (es) Derivados de acetileno que tienen actividad antagonista para receptores glutamato metabotropico humanos, composicion farmaceutica, una combinacion y el uso de dichos derivados para la fabricacion de composiciones farmaceuticas
AR120680A1 (es) Tetrahidrofuranos sustituidos como moduladores de canales de sodio
ATE297910T1 (de) Retinoid x rezeptormodulatoren
UY30440A1 (es) Nuevos compuestos
EA200000391A1 (ru) Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
EA200300172A1 (ru) Метод обезболивания
DK1885187T3 (da) Fremgangsmåde til behandling af lægemiddelresistent cancer
AR049577A1 (es) Derivados de hidantoina, procesos para su preparacion, composiciones y su uso
ATE307810T1 (de) Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
PE20011043A1 (es) Derivados de aminometil-fenil-ciclohexanona, procedimiento para su preparacion y medicamentos que los contienen
RU2007118727A (ru) Ингибиторы mif
AR059501A1 (es) Uso de derivados de benzo-heteroaril sulfamida para el tratamiento del dolor
PE20011134A1 (es) 4-fluoralquil-2h-benzopiranos con efecto antiestrogenico, metodo para su obtencion, preparados farmaceuticos que los contienen y su utilizacion para obtener medicamentos
AR033957A1 (es) Nuevos compuestos
BR0308162A (pt) Derivados de indolil-uréia de tienopiridinas úteis como agentes antiangiogênicos e métodos para o seu uso
AR069749A1 (es) Proceso de dehidrohalogenacion para la preparacion de intermediarios utiles en el suministro de compuestos 6,6- dimetil-3-azabiciclo -(3.1.0)- hexano
UY30356A1 (es) Derivados de 3-halo-n-(2.(4-fluorofenil)-4-oxobutil)-n-metil-5-(trifluorometil)benzamida y composiciones de los mismos.
UY27651A1 (es) Nuevas composiciones de medicamentos que, junto a agentes colinérgicos, contienen compuestos heterocíclicos
PT1412332E (pt) Derivados de quinolina e sua utilizacao como agentes antitumorais
PE20011044A1 (es) Derivados de aminometil-fenil-ciclohexano sustituidos, procedimiento para su preparacion y medicamentos que contienen estos compuestos
AR043186A1 (es) Indozolamidas dotadas de actividad analgesica, metodo de preparacion de las mismas y compuesto farmaceutico que las comprende

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed