CN100457088C - 含有包含极性和非极性部分的类脂的药物组合物 - Google Patents

含有包含极性和非极性部分的类脂的药物组合物 Download PDF

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CN100457088C
CN100457088C CNB028192850A CN02819285A CN100457088C CN 100457088 C CN100457088 C CN 100457088C CN B028192850 A CNB028192850 A CN B028192850A CN 02819285 A CN02819285 A CN 02819285A CN 100457088 C CN100457088 C CN 100457088C
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group
compositions
liposome
transfection
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CN1561199A (zh
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S·费勒特彻
M·R·乔根森
A·D·米勒
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Mitsubishi Chemical Corp
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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CNB028192850A 2001-07-30 2002-07-29 含有包含极性和非极性部分的类脂的药物组合物 Expired - Fee Related CN100457088C (zh)

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GB0118517.2 2001-07-30
GBGB0118517.2A GB0118517D0 (en) 2001-07-30 2001-07-30 Compound

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CN1561199A CN1561199A (zh) 2005-01-05
CN100457088C true CN100457088C (zh) 2009-02-04

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US (1) US20040219202A1 (enExample)
EP (1) EP1411898A1 (enExample)
JP (1) JP2005505521A (enExample)
CN (1) CN100457088C (enExample)
AU (1) AU2002317402B2 (enExample)
CA (1) CA2451868A1 (enExample)
GB (1) GB0118517D0 (enExample)
RU (1) RU2294738C2 (enExample)
WO (1) WO2003011252A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO328803B1 (no) * 2000-03-03 2010-05-18 Thia Medica Nye fettsyreanaloger
CA2490121C (en) * 2002-06-20 2013-01-08 Ic Vec Limited Modified phospholipids
DE10236146A1 (de) * 2002-07-31 2004-02-19 Basf Coatings Ag Beschichtungsstoff, Verfahren zu seiner Herstellung und seine Verwendung
US20090220583A1 (en) * 2005-06-09 2009-09-03 Lena Pereswetoff-Morath Method and composition for treating inflammatory disorders
CA2927045A1 (en) * 2006-10-03 2008-04-10 Muthiah Manoharan Lipid containing formulations
EP2086508A2 (en) * 2006-11-03 2009-08-12 MediGene Aktiengesellschaft Cationic colloidal carriers for delivery of active agents to the blood-brain barrier in the course of neuroinflammatory diseases
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
EP2105145A1 (en) * 2008-03-27 2009-09-30 ETH Zürich Method for muscle-specific delivery lipid-conjugated oligonucleotides
WO2009129227A1 (en) 2008-04-17 2009-10-22 Pds Biotechnology Corporation Stimulation of an immune response by enantiomers of cationic lipids
CN105152939A (zh) 2008-11-10 2015-12-16 阿尔尼拉姆医药品有限公司 用于递送治疗剂的脂质和组合物
RU2394834C1 (ru) * 2009-06-29 2010-07-20 Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) Углеводсодержащие катионные амфифилы, обладающие способностью доставлять нуклеиновые кислоты в клетки млекопитающих
WO2013126803A1 (en) * 2012-02-24 2013-08-29 Protiva Biotherapeutics Inc. Trialkyl cationic lipids and methods of use thereof
CN105163753B (zh) 2012-06-15 2018-12-21 Pds生物科技公司 阳离子脂质疫苗组合物和使用方法
KR102176971B1 (ko) 2012-07-05 2020-11-11 타이완 리포좀 캄파니 리미티드 관절염의 치료 방법
EP2897639A4 (en) 2012-09-21 2016-05-04 Frank Bedu-Addo IMPROVED VACCINATE COMPOSITIONS AND METHODS OF USE
ES2782360T3 (es) 2013-08-30 2020-09-14 Univ Dalhousie Composiciones y procedimientos para la eliminación de tatuajes
CA3005251A1 (en) 2015-11-13 2017-05-18 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
WO2017087685A1 (en) * 2015-11-20 2017-05-26 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348329A (en) * 1979-12-20 1982-09-07 Dennis Chapman Biocompatible surfaces
CN1294625A (zh) * 1997-12-31 2001-05-09 奥拉索梅尔技术公司 新的可聚合脂肪酸、磷脂和由此制备的聚合脂质体
WO2001048233A1 (en) * 1999-12-23 2001-07-05 Mitsubishi Pharma Corporation Viral core protein-cationic lipid-nucleic acid-delivery complexes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE912535A1 (en) * 1990-07-27 1992-01-29 Res Dev Foundation Liposomes that Provide Thymic Dependent Help to Weak Vaccine¹Antigens
HUT72326A (en) * 1993-10-06 1996-04-29 Amgen Inc Stable protein phospholipid compositions and methods
NZ506051A (en) * 1998-02-09 2003-08-29 Bracco Res S Targeted delivery of biologically active media

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348329A (en) * 1979-12-20 1982-09-07 Dennis Chapman Biocompatible surfaces
CN1294625A (zh) * 1997-12-31 2001-05-09 奥拉索梅尔技术公司 新的可聚合脂肪酸、磷脂和由此制备的聚合脂质体
WO2001048233A1 (en) * 1999-12-23 2001-07-05 Mitsubishi Pharma Corporation Viral core protein-cationic lipid-nucleic acid-delivery complexes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Highly stable vesicles composed of a new chain-terminusacetylenic photopolymeric phospholipid. Chemistry andPhysics of Lipids, 112(2), 99-108 ，2001. Stanish, I.CHEMICAL ABSTRACTS,No.138:81663. 2001 *

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EP1411898A1 (en) 2004-04-28
AU2002317402B2 (en) 2008-08-28
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