AU2002317402B2 - Pharmaceutical composition comprising lipids comprising a polar and a nonpolar moiety - Google Patents

Pharmaceutical composition comprising lipids comprising a polar and a nonpolar moiety Download PDF

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Publication number
AU2002317402B2
AU2002317402B2 AU2002317402A AU2002317402A AU2002317402B2 AU 2002317402 B2 AU2002317402 B2 AU 2002317402B2 AU 2002317402 A AU2002317402 A AU 2002317402A AU 2002317402 A AU2002317402 A AU 2002317402A AU 2002317402 B2 AU2002317402 B2 AU 2002317402B2
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Australia
Prior art keywords
group
yne
polar
compound
hydrocarbyl group
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Ceased
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AU2002317402A
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AU2002317402A1 (en
Inventor
Steven Fletcher
Michael R. Jorgensen
Andrew David Miller
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Imuthes Ltd
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Imuthes Ltd
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Assigned to IMUTHES LIMITED reassignment IMUTHES LIMITED Request for Assignment Assignors: MITSUBISHI CHEMICAL CORPORATION
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
AU2002317402A 2001-07-30 2002-07-29 Pharmaceutical composition comprising lipids comprising a polar and a nonpolar moiety Ceased AU2002317402B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0118517.2 2001-07-30
GBGB0118517.2A GB0118517D0 (en) 2001-07-30 2001-07-30 Compound
PCT/GB2002/003488 WO2003011252A1 (en) 2001-07-30 2002-07-29 Pharmaceutical composition comprising lipids comprising a polar and a nonpolar moiety

Publications (2)

Publication Number Publication Date
AU2002317402A1 AU2002317402A1 (en) 2003-05-29
AU2002317402B2 true AU2002317402B2 (en) 2008-08-28

Family

ID=9919439

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002317402A Ceased AU2002317402B2 (en) 2001-07-30 2002-07-29 Pharmaceutical composition comprising lipids comprising a polar and a nonpolar moiety

Country Status (9)

Country Link
US (1) US20040219202A1 (enExample)
EP (1) EP1411898A1 (enExample)
JP (1) JP2005505521A (enExample)
CN (1) CN100457088C (enExample)
AU (1) AU2002317402B2 (enExample)
CA (1) CA2451868A1 (enExample)
GB (1) GB0118517D0 (enExample)
RU (1) RU2294738C2 (enExample)
WO (1) WO2003011252A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO328803B1 (no) * 2000-03-03 2010-05-18 Thia Medica Nye fettsyreanaloger
CA2490121C (en) * 2002-06-20 2013-01-08 Ic Vec Limited Modified phospholipids
DE10236146A1 (de) * 2002-07-31 2004-02-19 Basf Coatings Ag Beschichtungsstoff, Verfahren zu seiner Herstellung und seine Verwendung
US20090220583A1 (en) * 2005-06-09 2009-09-03 Lena Pereswetoff-Morath Method and composition for treating inflammatory disorders
CA2927045A1 (en) * 2006-10-03 2008-04-10 Muthiah Manoharan Lipid containing formulations
EP2086508A2 (en) * 2006-11-03 2009-08-12 MediGene Aktiengesellschaft Cationic colloidal carriers for delivery of active agents to the blood-brain barrier in the course of neuroinflammatory diseases
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
EP2105145A1 (en) * 2008-03-27 2009-09-30 ETH Zürich Method for muscle-specific delivery lipid-conjugated oligonucleotides
WO2009129227A1 (en) 2008-04-17 2009-10-22 Pds Biotechnology Corporation Stimulation of an immune response by enantiomers of cationic lipids
CN105152939A (zh) 2008-11-10 2015-12-16 阿尔尼拉姆医药品有限公司 用于递送治疗剂的脂质和组合物
RU2394834C1 (ru) * 2009-06-29 2010-07-20 Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) Углеводсодержащие катионные амфифилы, обладающие способностью доставлять нуклеиновые кислоты в клетки млекопитающих
WO2013126803A1 (en) * 2012-02-24 2013-08-29 Protiva Biotherapeutics Inc. Trialkyl cationic lipids and methods of use thereof
CN105163753B (zh) 2012-06-15 2018-12-21 Pds生物科技公司 阳离子脂质疫苗组合物和使用方法
KR102176971B1 (ko) 2012-07-05 2020-11-11 타이완 리포좀 캄파니 리미티드 관절염의 치료 방법
EP2897639A4 (en) 2012-09-21 2016-05-04 Frank Bedu-Addo IMPROVED VACCINATE COMPOSITIONS AND METHODS OF USE
ES2782360T3 (es) 2013-08-30 2020-09-14 Univ Dalhousie Composiciones y procedimientos para la eliminación de tatuajes
CA3005251A1 (en) 2015-11-13 2017-05-18 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
WO2017087685A1 (en) * 2015-11-20 2017-05-26 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0032622B1 (en) * 1979-12-20 1985-08-14 Dennis Chapman Polymerisable phospholipids and polymers thereof, methods for their preparation, methods for their use in coating substrates and forming liposomes and the resulting coated substrates and liposome compositions
IE912535A1 (en) * 1990-07-27 1992-01-29 Res Dev Foundation Liposomes that Provide Thymic Dependent Help to Weak Vaccine¹Antigens
HUT72326A (en) * 1993-10-06 1996-04-29 Amgen Inc Stable protein phospholipid compositions and methods
US6187335B1 (en) * 1997-12-31 2001-02-13 Orasomal Technologies, Inc. Polymerizable fatty acids, phospholipids and polymerized liposomes therefrom
NZ506051A (en) * 1998-02-09 2003-08-29 Bracco Res S Targeted delivery of biologically active media
GB9930533D0 (en) * 1999-12-23 2000-02-16 Mitsubishi Tokyo Pharm Inc Nucleic acid delivery

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Pisch et al. Tetrahedron (1997) vol. 53, no. 43 pages 14627-14634 *
Rurup et al. Chemistry and Physics of Lipids (1994) vol. 70, no. 2 pages 187-198 *
Stanish et al. Chemistry and Physics of Lipids (2001) vol. 112 pages 99-108 *

Also Published As

Publication number Publication date
WO2003011252A1 (en) 2003-02-13
US20040219202A1 (en) 2004-11-04
EP1411898A1 (en) 2004-04-28
CN100457088C (zh) 2009-02-04
CN1561199A (zh) 2005-01-05
RU2004106154A (ru) 2005-05-10
RU2294738C2 (ru) 2007-03-10
JP2005505521A (ja) 2005-02-24
GB0118517D0 (en) 2001-09-19
CA2451868A1 (en) 2003-02-13

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