CN100439397C - Igf-1的结晶 - Google Patents

Igf-1的结晶 Download PDF

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Publication number
CN100439397C
CN100439397C CNB028047079A CN02804707A CN100439397C CN 100439397 C CN100439397 C CN 100439397C CN B028047079 A CNB028047079 A CN B028047079A CN 02804707 A CN02804707 A CN 02804707A CN 100439397 C CN100439397 C CN 100439397C
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CN
China
Prior art keywords
igf
crystals
crystal
dimensional structure
igfbp
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Expired - Fee Related
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CNB028047079A
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English (en)
Chinese (zh)
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CN1703425A (zh
Inventor
M·谢夫勒
M·乌尔茨
F·沃伊道斯
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • AIDS & HIV (AREA)
CNB028047079A 2001-02-09 2002-02-01 Igf-1的结晶 Expired - Fee Related CN100439397C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26797701P 2001-02-09 2001-02-09
US28707201P 2001-04-27 2001-04-27
PCT/US2002/003156 WO2002064627A2 (en) 2001-02-09 2002-02-01 Crystallization of igf-1

Publications (2)

Publication Number Publication Date
CN1703425A CN1703425A (zh) 2005-11-30
CN100439397C true CN100439397C (zh) 2008-12-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028047079A Expired - Fee Related CN100439397C (zh) 2001-02-09 2002-02-01 Igf-1的结晶

Country Status (19)

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US (8) US7084240B2 (enExample)
EP (3) EP1801120A1 (enExample)
JP (2) JP4489352B2 (enExample)
KR (1) KR100872613B1 (enExample)
CN (1) CN100439397C (enExample)
AT (2) ATE439378T1 (enExample)
AU (1) AU2002255508B2 (enExample)
BR (1) BR0207422A (enExample)
CA (1) CA2431033A1 (enExample)
DE (3) DE60217066D1 (enExample)
DK (2) DK1772464T3 (enExample)
ES (2) ES2278020T3 (enExample)
HU (1) HUP0500733A3 (enExample)
IL (2) IL156435A0 (enExample)
MX (1) MXPA03007042A (enExample)
NZ (3) NZ526672A (enExample)
PL (1) PL374181A1 (enExample)
WO (1) WO2002064627A2 (enExample)
ZA (1) ZA200304900B (enExample)

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WO2009134395A2 (en) 2008-04-28 2009-11-05 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
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WO2011047204A1 (en) * 2009-10-14 2011-04-21 Mount Sinai School Of Medicine Method of treating memory disorders and enhancing memory using igf-ii compounds
US20150119394A1 (en) * 2012-03-28 2015-04-30 Merck Sharp & Dohme Corp. Insulin-Like Growth Factor-1 Receptor Inhibitors
KR101711584B1 (ko) * 2012-12-18 2017-03-02 재단법인 의약바이오컨버젼스연구단 변형된 eprs 단백질의 결정 구조 및 이의 결정화 방법
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Also Published As

Publication number Publication date
JP4489352B2 (ja) 2010-06-23
US20060287235A1 (en) 2006-12-21
WO2002064627A2 (en) 2002-08-22
US20060276397A1 (en) 2006-12-07
EP1358209B1 (en) 2006-12-27
US20060287510A1 (en) 2006-12-21
DK1772464T3 (da) 2009-12-14
BR0207422A (pt) 2005-04-19
NZ548358A (en) 2008-04-30
DE60217066T4 (de) 2010-07-01
MXPA03007042A (es) 2004-05-24
US20050215477A1 (en) 2005-09-29
US7238658B2 (en) 2007-07-03
US7084240B2 (en) 2006-08-01
US7297763B2 (en) 2007-11-20
WO2002064627A3 (en) 2003-07-31
AU2002255508B2 (en) 2008-04-03
NZ548359A (en) 2007-11-30
NZ526672A (en) 2006-10-27
IL156435A0 (en) 2004-01-04
US20060281905A1 (en) 2006-12-14
EP1801120A1 (en) 2007-06-27
DE60217066D1 (de) 2007-02-08
US20060270839A1 (en) 2006-11-30
DE60233359D1 (de) 2009-09-24
JP2009215299A (ja) 2009-09-24
ES2278020T3 (es) 2007-08-01
DK1358209T3 (da) 2007-05-07
CN1703425A (zh) 2005-11-30
EP1772464B1 (en) 2009-08-12
DE60217066T2 (de) 2007-07-12
ZA200304900B (en) 2005-07-27
ATE349469T1 (de) 2007-01-15
ATE439378T1 (de) 2009-08-15
US20060293507A1 (en) 2006-12-28
EP1772464A3 (en) 2007-10-03
IL156435A (en) 2009-09-22
JP2005503329A (ja) 2005-02-03
EP1358209A2 (en) 2003-11-05
ES2331150T3 (es) 2009-12-22
HK1060138A1 (en) 2004-07-30
US7433788B2 (en) 2008-10-07
US7596455B2 (en) 2009-09-29
PL374181A1 (en) 2005-10-03
CA2431033A1 (en) 2002-08-22
KR20040064610A (ko) 2004-07-19
HUP0500733A2 (hu) 2005-10-28
US7354769B2 (en) 2008-04-08
US20020165155A1 (en) 2002-11-07
KR100872613B1 (ko) 2008-12-09
HUP0500733A3 (en) 2010-01-28
EP1772464A2 (en) 2007-04-11

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