CN100418575C - Compound calcium preparation for astronaut - Google Patents
Compound calcium preparation for astronaut Download PDFInfo
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- CN100418575C CN100418575C CNB2005101234426A CN200510123442A CN100418575C CN 100418575 C CN100418575 C CN 100418575C CN B2005101234426 A CNB2005101234426 A CN B2005101234426A CN 200510123442 A CN200510123442 A CN 200510123442A CN 100418575 C CN100418575 C CN 100418575C
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Abstract
The present invention relates to a high-efficiency compound calcium preparation which is manufactured to resist the problem of osteal calcium lost for spacefarers who work in the outer space in a weightless environment. The calcium preparation is composed of calcium carbonate, collagen peptide, stachyose, VD3, etc. and the formulation is different, aiming at the physiological differences of men and women. The present invention is characterized in that the compound calcium preparation is dissolvable in stomachs. Because of the deadening effect of the collagen peptide, the stimulation of the calcium carbonate to the stomachs can be reduced, and the collagen peptide and the calcium ion forms complex compounds. By using the characteristic that the absorption efficiency of peptide is higher than protein, even amino acid, and the stachyose can regulate the intestine and stomach functions, the present invention improves intestinal flora so as to promote the intestine and the stomach to efficiently absorb the calcium. The present invention is a good calcium replenishing agent.
Description
Technical field
The present invention relates to a kind of health product, particularly resist high-efficiency composite calcium pharmaceutical formulation and the production technology that bone calcium is lost problem at the spacefarer who under the weightlessness of space environment, works.
Background technology
When the long-term living in space of spacefarer, weightlessness can be lost by accelerated bone calcium in a large number, has a strong impact on spacefarer's healthy and work efficiency.Body bone tissue is made of 1/3 organic matter and two kinds of compositions of 2/3 inanimate matter, and the inanimate matter of bone is mainly bone mineral, and wherein 95% is solid calcium.The organic matter of bone comprises collagen protein and noncollagen protein material, and collagen protein accounts for more than 90%, and its network structure is to keeping the complete of bone structure and the bone biomechanical characteristic is extremely important.Owing to causing that the bone calcium of different crowd is lost, multiple reason has a strong impact on health, add the change of people's dietary structure and living habit, be difficult to from food, replenish enough calcium and collagenic proteins, therefore replenish the calcium by all means and more and more be subject to people's attention, calcium preparation is of all shapes and colors on the market, general single calsium supplement, it is low and disadvantage such as calcium deposition easily takes place to exist small intestinal to absorb the efficient of calcium.Though the compound recipe calsium supplement has overcome above-mentioned shortcoming to a certain extent, when human body lacks collagen protein, then be difficult for fixing calcareously, therefore, the situation of calcium loss just can't improve, and then has influence on bone density and cause osteoporotic situation generation.
Summary of the invention
Purpose of the present invention is at the deficiency of calsium supplement in the market, provides a kind of with water-solubility collagen matter peptide, the stachyose that can improve intestinal microbial population, vitamin D
3With the high-quality calcium carbonate be efficient compound calsium supplement---the compound calcium preparation for astronaut in calcium source.
The objective of the invention is to be achieved through the following technical solutions.
Compound calcium preparation for astronaut is to be primary raw material with high-quality calcium carbonate, collagen peptide, the stachyose that can improve intestinal microbial population, is aided with vitamin D
3, pregelatinized Starch, magnesium stearate is made.The percentage by weight of described calcium preparation component raw material is as follows:
Consisting of of astronautess's type: calcium carbonate 20～60%, collagen peptide 15～50%, stachyose 5～25%, vitamin D
30.0001～0.0005%, soybean isoflavone or Radix Puerariae isoflavone 0.1～5%, pregelatinized Starch 5～25%, magnesium stearate 0.1～1.5%.
Consisting of of man's spacefarer's type: calcium carbonate 20～60%, collagen peptide 15～50%, stachyose 5～35%, vitamin D
30.0001～0.0005%, pregelatinized Starch 5～25%, magnesium stearate 0.1～1.5%.
Its production technology is as follows:
To in blender, carry out abundant mixing by a certain percentage except that the raw material pregelatinized Starch, the magnesium stearate, in mixed process, edible ethanol with 40～80% sprays pelletize with fine mist, cross 10～60 mesh sieves, 60～90 ℃ of oven dry down, add pregelatinized Starch, the abundant mixing of magnesium stearate then in proportion, be pressed into the capsule of the tablet of certain specification or the certain specification of packing into.
The specific embodiment
Embodiment 1
Calcium carbonate 40%, mean molecule quantity are the collagen peptide 33% of 3Kda, stachyose 15%, VD
30.0002%, soybean isoflavone or Radix Puerariae isoflavone 1.5%, pregelatinized Starch 10%, magnesium stearate 0.5%.
In above-mentioned prescription, with calcium carbonate and stachyose, collagen peptide, VD
3, soybean isoflavone or the abundant mixing of Radix Puerariae isoflavone, in mixed process, the edible ethanol with 60% sprays into pelletize with fine mist, cross 20 mesh sieves, 80 ℃ of oven dry down add pregelatinized Starch, the abundant mixing of magnesium stearate then, tablet forming weigh 1 the gram tablet, one day three.
This calcium preparation is applicable to that astronautess and middle aged and aged women replenish the calcium.
Carry out following animal experiment with this calcium preparation
Grouping of 1 animal and raising
With 32 of SPF (specific pathogen free bacterium) level female sd inbred rats, body weight (160～180) g, adaptability fed after 5 days, implemented oophorectomize castration model, and antibiotic therapy is divided into 4 groups (8 every group) at random by body weight after one week:
The A group: Sham-operated control group, raise the low calcium feedstuff of SPF level (calcium content is 0.3%, down together);
The B group: oophorectomize castration group, raise the low calcium feedstuff of SPF level;
The C group: castration+Radix Puerariae isoflavone group (filling stomach), raise the low calcium feedstuff of SPF level; The D group: castration+calcium tablet group (filling stomach), raise the low calcium feedstuff of SPF level.The all single cage of above-mentioned 4 groups of rats is raised ad lib and drinking pure water, experiment periods 30d.
The 2 oophorectomizes castration model that becomes
With 2% pentobarbital sodium intraperitoneal injection of anesthesia, from back spinal column escribe mouth, the fractional resection bilateral ovaries, tubal ligation and [, flushing back sew up wound, and with gentamycin intramuscular injection 2d infection.The sham operated rats rat undergos surgery but spay not, only excises the fritter fatty tissue.
3 detect index
Femoral bmd, biomechanical parameter (maximum load and elastic load) and calcium content of bone.
4 results:
This calcium tablet sees the following form to the influence of rat femur bone density, biomechanical parameter and bone calcium.
Annotate: #P＜0.05, compared significant difference with the A group; Utmost point significant difference has been compared with the A group in ##P＜0.01;
*Significant difference has been compared with the B group in P＜0.05;
*Utmost point significant difference has been compared with the B group in P＜0.01.
Can find out that from table B organizes each index and compares with A group respectively significant difference is all arranged, and illustrates that castration oophorectomize model is successful; C organizes each index and compares with B group respectively and all have significant difference, D to organize each index to compare with the B group respectively utmost point significant difference is all arranged, illustrate that this calcium preparation can alleviate the bone loss of oophorectomize castrated rats, and improve bone mass.
Embodiment 2
Calcium carbonate 40%, collagen peptide 30%, stachyose 17%, VD
30.0002%, pregelatinized Starch 12.5%, magnesium stearate 0.5%.
Production technology is the same.
This calcium preparation is applicable to that the calcium deficiency crowd except that middle aged and aged women replenishes the calcium.
Carry out following animal experiment with this calcium preparation
Grouping of 1 animal and raising
With 40 of SPF (specific pathogen free bacterium) level male SD rats, body weight (160～180) g, adaptability was fed after 5 days, was divided into 5 groups at random by body weight, 8 every group:
The A group: the normal control group, raise SPF level normal diet, calcium content is 1.1%;
The B group: normally low calcium feedstuff matched group, raise the low calcium feedstuff of SPF level, calcium content is 0.3%;
The C group: the suspention matched group, raise the low calcium feedstuff of SPF level;
The D group: suspention+low dosage calcium tablet group (filling stomach), raise the low calcium feedstuff of SPF level;
The E group: suspention+high dose calcium tablet group (irritate stomach, calcium content is 2 times of low dose group), raise the low calcium feedstuff of SPF level.
The all single cage of above-mentioned 5 groups of rats is raised ad lib and drinking pure water, experiment periods 30d.
2 suspention models (simulated weightlessness model)
The rat tails suspention, hind leg is liftoff, makes trunk become 25 °～30 ° angles with ground, and forelimb lands, can be free movable.
3 testing indexs
Femoral bmd (BMD), femur biomechanical parameter (maximum load, elastic load) and calcium content of bone
4 results
The peptide TANGGAI PIAN sees the following form to the influence of rat femur bone density, biomechanical parameter and bone calcium.
Annotate: #P＜0.05, compared significant difference with the B group; Utmost point significant difference has been compared with the B group in ##P＜0.01;
*Significant difference has been compared with the C group in P＜0.05;
*Utmost point significant difference has been compared with the C group in P＜0.01.
Can find out that from table A, C organize each index and compare with B group respectively significant difference is all arranged, it is successful the calcium deficiency model be described, suspend model in midair; D organizes each index and compares with C group respectively utmost point significant difference is all arranged, and E organizes each index and compares with the C group respectively significant difference is all arranged, and illustrate that suitably replenishing this calcium preparation can alleviate the bone loss that calcium deficiency is suspended rat in midair, and improves bone mass.
Claims (2)
1. astronautess's type compound calcium preparation for astronaut is characterized in that, the composition percentage by weight of described compounded calcium preparation is:
Calcium carbonate: 20-60%, collagen peptide: 15-50%, stachyose: 5-25%, vitamin D
3: 0.0001-0.0005%, soybean isoflavone or Radix Puerariae isoflavone: 0.1-5%, pregelatinized Starch: 5-25%, magnesium stearate: 0.1-1.5%.
2. male spacefarer's type compound calcium preparation for astronaut is characterized in that the composition percentage by weight of described compounded calcium preparation is:
Calcium carbonate: 20-60%, collagen peptide: 15-50%, stachyose: 5-25%, vitamin D
3: 0.0001-0.0005%, pregelatinized Starch: 5-25%, magnesium stearate: 0.1-1.5%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101234426A CN100418575C (en) | 2005-11-21 | 2005-11-21 | Compound calcium preparation for astronaut |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101234426A CN100418575C (en) | 2005-11-21 | 2005-11-21 | Compound calcium preparation for astronaut |
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| CN1785427A CN1785427A (en) | 2006-06-14 |
| CN100418575C true CN100418575C (en) | 2008-09-17 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101803695B (en) * | 2010-04-26 | 2012-08-22 | 北京东方红航天健康科技有限公司 | Calcium and iron supplement product being applicable to children |
| CN101926982A (en) * | 2010-08-26 | 2010-12-29 | 烟台大洋制药有限公司 | Medicament or health-care food for increasing bone mineral density |
| CN102406177B (en) * | 2011-10-10 | 2013-06-12 | 李国� | Health product used for supporting strong bones |
| CN103750310B (en) * | 2014-01-03 | 2015-05-20 | 吉林修正修元生物科技有限公司 | Plant-sourced calcium capable of supplementing calcium and promoting calcium absorption and preparation method thereof |
| CN105581331B (en) * | 2015-12-31 | 2018-08-24 | 浙江康诺邦健康产品有限公司 | A kind of nutritional composition for calcium supplement |
| CN110521850A (en) * | 2019-09-24 | 2019-12-03 | 天津正合航天科技有限公司 | A kind of PURE WHEY and preparation method supplementing spacefarer's calcium preparation and protein |
| CN114190544A (en) * | 2020-09-02 | 2022-03-18 | 天津星宇航天生物科技有限公司 | Nutritional preparation for improving bone mineral density and supplementing calcium for astronauts |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205877A (en) * | 1997-07-18 | 1999-01-27 | 成都金苹果生化制品厂 | Fruit acid calcium type compound calcium supplementing agent |
| CN1209322A (en) * | 1997-08-21 | 1999-03-03 | 中国人民解放军国防科工委后勤部军事医学研究所 | Series product of high-effective neutral calcium-supplementary preparation |
| JP2001000144A (en) * | 1999-06-17 | 2001-01-09 | Asahi Chem Ind Co Ltd | Gel-like highly nutritionally auxiliary food |
| WO2004085998A2 (en) * | 2003-03-28 | 2004-10-07 | The Children's Hospital Of Philadelphia | Biomimetic hierarchies using functionalized nanoparticles as building blocks |
| CN1548179A (en) * | 2003-05-05 | 2004-11-24 | 万金华 | Dynamic amphiastral engineering system for preventing and treating osteoporosis and other space disease |
-
2005
- 2005-11-21 CN CNB2005101234426A patent/CN100418575C/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205877A (en) * | 1997-07-18 | 1999-01-27 | 成都金苹果生化制品厂 | Fruit acid calcium type compound calcium supplementing agent |
| CN1209322A (en) * | 1997-08-21 | 1999-03-03 | 中国人民解放军国防科工委后勤部军事医学研究所 | Series product of high-effective neutral calcium-supplementary preparation |
| JP2001000144A (en) * | 1999-06-17 | 2001-01-09 | Asahi Chem Ind Co Ltd | Gel-like highly nutritionally auxiliary food |
| WO2004085998A2 (en) * | 2003-03-28 | 2004-10-07 | The Children's Hospital Of Philadelphia | Biomimetic hierarchies using functionalized nanoparticles as building blocks |
| CN1548179A (en) * | 2003-05-05 | 2004-11-24 | 万金华 | Dynamic amphiastral engineering system for preventing and treating osteoporosis and other space disease |
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| CN1785427A (en) | 2006-06-14 |
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