CN101926982A - Medicament or health-care food for increasing bone mineral density - Google Patents
Medicament or health-care food for increasing bone mineral density Download PDFInfo
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- CN101926982A CN101926982A CN2010102659566A CN201010265956A CN101926982A CN 101926982 A CN101926982 A CN 101926982A CN 2010102659566 A CN2010102659566 A CN 2010102659566A CN 201010265956 A CN201010265956 A CN 201010265956A CN 101926982 A CN101926982 A CN 101926982A
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- vitamin
- bone density
- medicine
- collagen protein
- radix achyranthis
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Abstract
The invention discloses a medicament or health-care food for increasing bone mineral density. The formula of the medicament comprises the following active ingredients: calcium salts, vitamin D, collagen and twotooth achyranthes root, optimally 2.5*10<6> weight parts of L-calcium lactate, 34 weight parts of vitamin D, 1*10<6> weight parts of collagen and 4.5*10<6> weight parts of achyranthes root. Pharmacological tests prove that the formula, indeed, has an obvious bone mineral density increasing effect, is very safe and causes no adverse reactions.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of medicine or health food that strengthens the bone density effect that have.
Background technology
Osteoporosis be with the bone amount reduce, the microstructure degeneration of bone is feature, a kind of general skeleton disease that causes bone fragility to increase is the commonly encountered diseases and the frequently-occurring disease of middle-aged and elderly people.Because the serious harm people's is healthy, has become one of social problem of world today's extensive concern.
China has the maximum country of patients with osteoporosis in the world at present, pointed out on October 20th, 2008 " osteoporosis is prevented and treated Chinese white paper " of Beijing issue, China has at least 6,944 ten thousand people to suffer from osteoporosis, annual probability because of the concurrent fracture of osteoporosis surpasses 9%, other has 2.1 hundred million people to hang down the bone amount, exists osteoporotic hidden danger takes place.And along with the aggravation of China's aged tendency of population, this situation is also increasing the weight of year by year.
Bone density is an important symbol weighing bone mass, and it reflects degree of osteoporosis, is to be used for diagnosis of osteoporosis and most important, the most objective detection index of risk of fractures degree evaluation at present.
Therefore, develop a kind of effective bone density improving, prevent and treat osteoporosis, have the medicine or the health food of higher-security again, will have important society and economic implications.
Summary of the invention
Problem to be solved by this invention is: a kind of effective bone density improving is provided, prevents and treats osteoporosis, have the medicine or the health food of higher-security again.
Medicine or health food with the effect of enhancing bone density of the present invention contains following functional component: calcium salt, vitamin D, collagen protein and Radix Achyranthis Bidentatae.Its best effective ingredient and optimum weight proportioning thereof are: L-calcium lactate 2.5 * 10
6Part; Vitamin D
34 parts; Collagen protein 1 * 10
6Part; Radix Achyranthis Bidentatae 4.5 * 10
6Part.
Best preparation technology of the present invention:
Get 4.5 kilograms of Radix Achyranthis Bidentataes, add 8 times of water gagings and decocted 2 hours, filter, filtering residue adds 6 times of water gagings and decocted 1.5 hours, and merging filtrate is condensed into thick paste.Add 2.5 kilograms of L-calcium lactate, 1 kilogram of collagen protein, 4 milligrams of vitamin D3,10.5 kilograms in dextrin, 0.08 kilogram of stevioside, make granule.
Consumption: the granule that need the above-mentioned technology of oral one thousandth weight portion to make the every day of generally being grown up.
Beneficial effect: medicine of the present invention has the bone density of enhancing, prevents and treats osteoporotic effect; And safety is good, is fit to take for a long time.
Below example illustrates beneficial effect of the present invention by experiment:
1, strengthens the bone density experiment
Take out 50 of the ablactation female rats (about 60～75 grams of body weight) of giving birth to about 4 weeks, be divided into 5 groups at random, dosage as shown in table 1 is gastric infusion respectively, the low calcium feedstuff of feeding simultaneously.Weigh weekly once, continue to observe 3 months.With sacrifice of animal, peel off the right side femur afterwards, 105 ℃ of oven for drying are to constant weight, and record bone this moment is heavy.Single photon bone density machine is measured the bone density of femur center and distal end.Experimental result sees Table 1.
Table 1 experiment medicine is to the influence of rat femur bone density
* compare P＜0.05 with low calcium matched group
Analyze experimental result, high, middle dosage group distal end bone density, center bone density all are significantly higher than low calcium matched group (P＜0.05), and the illustrative experiment medicine can obviously increase rat bone density.
2, long term toxicity test
20 of healthy SD rats, male and female half and half, body weight 180～220 grams are divided into 2 groups at random.Matched group is irritated stomach equivalent distilled water, and experimental group is pressed 16g/kg and irritated stomach medicine of the present invention, every day 3 times, successive administration 3 months.Carrying out the general situation observation of rat (comprising: indexs such as outward appearance sign, behavioral activity, glandular secretion, breathing, feces character, appetite, body weight, local response), carry out inspections such as hematological indices, biochemical indexes, body temperature, ophthalmology, urine, electrocardiogram simultaneously.When finishing, experiment carries out that system becomes celestial and histopathological examination.
As a result, with matched group relatively: the experimental group rat generally in order; Every inspection such as hematological indices is no abnormal; System becomes celestial all no abnormal with histopathological examination.
Experimental result shows that medicine drug safety of the present invention is good, is fit to take for a long time.
The specific embodiment
Embodiment 1:
Get 1 kilogram of Radix Achyranthis Bidentatae, add 6 times of water gagings and decocted 1 hour, filter, filtrate is condensed into thick paste, adds 1 kilogram of calcium hydrogen phosphate, vitamin D
30.1 kilogram of 1 milligram, collagen protein incapsulate shell, capsule.
Embodiment 2:
Get 1 kilogram of Radix Cyathulae, add 6 times of water gagings and decocted 1 hour, filter, filtrate is condensed into thick paste, adds 1 kilogram of calcium gluconate, vitamin D
20.1 kilogram of 1 milligram, collagen protein add 0.2 kilogram of starch, 0.02 kilogram of magnesium stearate, and mixing is granulated, and tabletting is made tablet.
Embodiment 3:
Get 20 kilograms of Radix Achyranthis Bidentataes, add 10 times of water gagings and decocted 3 hours, filter, filtering residue adds 8 times of water gagings and decocted 2 hours, and merging filtrate is condensed into thick paste, adds 10 kilograms in calcium chloride, vitamin D
310 kilograms of 10 milligrams, collagen protein incapsulate shell, capsule.
Embodiment 4:
Get 4.5 kilograms of Radix Achyranthis Bidentataes, add 8 times of water gagings and decocted 2 hours, filter, filtering residue adds 6 times of water gagings and decocted 1.5 hours, and merging filtrate is condensed into thick paste.Add 2.5 kilograms of calcium lactate, 1 kilogram of collagen protein, vitamin D
34 milligrams, add 10.5 kilograms in dextrin, 0.08 kilogram of stevioside, make granule.
Embodiment 5:
Get 4.5 kilograms of Radix Achyranthis Bidentataes, add 8 times of water gagings and decocted 2 hours, filter, filtering residue adds 6 times of water gagings and decocted 1.5 hours, and merging filtrate is condensed into thick paste.Add 2.5 kilograms of L-calcium lactate, 1 kilogram of collagen protein, vitamin D
34 milligrams, add 10.5 kilograms in dextrin, 0.08 kilogram of stevioside, make granule.
Embodiment 6:
Get 1 kilogram of Radix Achyranthis Bidentatae, add 8 times of water gagings and decocted 2 hours, filter, filtering residue adds 6 times of water gagings and decocted 1.5 hours, and merging filtrate is condensed into thick paste.Add 1 kilogram of L-calcium lactate, 0.1 kilogram of collagen protein, vitamin D
31 milligram, incapsulate shell, get capsule.
Embodiment 7:
Get 20 kilograms of Radix Achyranthis Bidentataes, add 8 times of water gagings and decocted 2 hours, filter, filtering residue adds 6 times of water gagings and decocted 1.5 hours, and merging filtrate is condensed into thick paste.Add 10 kilograms of L-calcium lactate, 10 kilograms of collagen protein, vitamin D
310 milligrams, incapsulate shell, get capsule.
Claims (5)
1. one kind has medicine or the health food that strengthens the bone density effect, it is characterized in that containing active ingredient: calcium salt, vitamin D, collagen protein, Radix Achyranthis Bidentatae.
2. medicine or the health food with the effect of enhancing bone density according to claim 1 is characterized in that its weight proportion that contains each composition is: calcium salt 1 * 10
6～1 * 10
7Part, vitamin D1～10 part, collagen protein 1 * 10
5～1 * 10
7Part, Radix Achyranthis Bidentatae 1 * 10
6～2 * 10
7Part.
3. medicine or the health food with the effect of enhancing bone density according to claim 1 is characterized in that its contained best active ingredient is: L-calcium lactate, vitamin D
3, collagen protein, Radix Achyranthis Bidentatae.
4. medicine or the health food with the effect of enhancing bone density according to claim 3 is characterized in that its weight proportion that contains each composition is: L-calcium lactate 1 * 10
6～1 * 10
7Part, vitamin D
31～10 part, collagen protein 1 * 10
5～1 * 10
7Part, Radix Achyranthis Bidentatae 1 * 10
6～2 * 10
7Part.
5. medicine or the health food with the effect of enhancing bone density according to claim 4 is characterized in that its optimum weight proportioning that contains each composition is: L-calcium lactate 2.5 * 10
6Part, vitamin D
34 parts, collagen protein 1 * 10
6Part, Radix Achyranthis Bidentatae 4.5 * 10
6Part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102659566A CN101926982A (en) | 2010-08-26 | 2010-08-26 | Medicament or health-care food for increasing bone mineral density |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102659566A CN101926982A (en) | 2010-08-26 | 2010-08-26 | Medicament or health-care food for increasing bone mineral density |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101926982A true CN101926982A (en) | 2010-12-29 |
Family
ID=43366583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102659566A Pending CN101926982A (en) | 2010-08-26 | 2010-08-26 | Medicament or health-care food for increasing bone mineral density |
Country Status (1)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099842A (en) * | 2011-11-14 | 2013-05-15 | 甘肃创兴生物工程有限责任公司 | Soft capsule helpful for increasing bone density and preparation method thereof |
| CN103405755A (en) * | 2013-08-29 | 2013-11-27 | 赵全成 | Pharmaceutical composition for treating primary osteoporosis |
| CN105749255A (en) * | 2014-12-19 | 2016-07-13 | 烟台宝备生物技术有限公司 | Drug or health food with bone mineral density enhancing effect |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368375A (en) * | 2001-02-06 | 2002-09-11 | 四川省中药研究所 | Composite medicine for treating osteoporosis |
| CN1543857A (en) * | 2003-11-13 | 2004-11-10 | 上海奥医高科技实业有限公司 | Health food having functions of postponing senescence and increasing bone mineral density |
| CN1785427A (en) * | 2005-11-21 | 2006-06-14 | 陈斌 | Compound calcium preparation for astronaut |
| CN101181631A (en) * | 2007-11-29 | 2008-05-21 | 北京中科雍和医药技术有限公司 | Compound prescription for preventing and improving osteosporosis as well as preparation method thereof |
| CN101508720A (en) * | 2003-06-27 | 2009-08-19 | 南京大学 | Triterpene extracts of achyranthes bidentata and uses in osteosporosis resistant medicament |
-
2010
- 2010-08-26 CN CN2010102659566A patent/CN101926982A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368375A (en) * | 2001-02-06 | 2002-09-11 | 四川省中药研究所 | Composite medicine for treating osteoporosis |
| CN101508720A (en) * | 2003-06-27 | 2009-08-19 | 南京大学 | Triterpene extracts of achyranthes bidentata and uses in osteosporosis resistant medicament |
| CN1543857A (en) * | 2003-11-13 | 2004-11-10 | 上海奥医高科技实业有限公司 | Health food having functions of postponing senescence and increasing bone mineral density |
| CN1785427A (en) * | 2005-11-21 | 2006-06-14 | 陈斌 | Compound calcium preparation for astronaut |
| CN101181631A (en) * | 2007-11-29 | 2008-05-21 | 北京中科雍和医药技术有限公司 | Compound prescription for preventing and improving osteosporosis as well as preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《基层中药杂志》 20011231 高昌琨 怀牛膝对维甲酸所致大鼠骨质疏松防治作用的实验研究 , * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099842A (en) * | 2011-11-14 | 2013-05-15 | 甘肃创兴生物工程有限责任公司 | Soft capsule helpful for increasing bone density and preparation method thereof |
| CN103405755A (en) * | 2013-08-29 | 2013-11-27 | 赵全成 | Pharmaceutical composition for treating primary osteoporosis |
| CN105749255A (en) * | 2014-12-19 | 2016-07-13 | 烟台宝备生物技术有限公司 | Drug or health food with bone mineral density enhancing effect |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20101229 |