CN114190544A - Nutritional preparation for improving bone mineral density and supplementing calcium for astronauts - Google Patents

Nutritional preparation for improving bone mineral density and supplementing calcium for astronauts Download PDF

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Publication number
CN114190544A
CN114190544A CN202010909240.9A CN202010909240A CN114190544A CN 114190544 A CN114190544 A CN 114190544A CN 202010909240 A CN202010909240 A CN 202010909240A CN 114190544 A CN114190544 A CN 114190544A
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China
Prior art keywords
calcium
parts
astronauts
nutritional preparation
supplementing
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CN202010909240.9A
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Chinese (zh)
Inventor
白飞
张大旗
郭骁才
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Sichuan Saien Dekun Biotechnology Co ltd
Tianjin Xingyu Space Biotechnology Co ltd
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Sichuan Saien Dekun Biotechnology Co ltd
Tianjin Xingyu Space Biotechnology Co ltd
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Priority to CN202010909240.9A priority Critical patent/CN114190544A/en
Publication of CN114190544A publication Critical patent/CN114190544A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
    • A23L33/165Complexes or chelates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21Addition of substantially indigestible substances, e.g. dietary fibres
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention belongs to the technical field of food and health food, and particularly relates to a nutritional preparation for improving bone mineral density and supplementing calcium for astronauts. The main raw materials comprise calcium aspartate (chelated calcium), ossein protein peptide, milk mineral salt, eucommia male flower, and stachyose. The human metabolic theory is used as guidance, the absorption of calcium and other nutrients in the body is promoted, the utilization of tissue cells to the nutrients is improved, the conversion of blood calcium and bone calcium is enhanced, and the effects of increasing bone density and supplementing calcium are achieved. Easy absorption, obvious effect and short acting period, and is especially suitable for special workers such as astronauts.

Description

Nutritional preparation for improving bone mineral density and supplementing calcium for astronauts
Technical Field
The invention relates to the technical field of food and health food, in particular to a nutritional preparation for improving bone density of astronauts and supplementing calcium.
Background
Bone density (BMD) is called bone mineral density, is an index of human bone strength, is an important mark of bone quality, reflects osteoporosis degree and predicts important basis of fracture risk. Calcium is the support of the skeleton, and more than 99% of the human body's calcium is present in the skeleton and teeth. After the age of 35, the bone density is gradually reduced, and after the middle-aged, the calcium loss is accelerated, which is a big cause of osteoporosis. Calcium supplementation is a process aimed at increasing calcium intake, but in many osteoporosis, rather than simply lacking calcium, it is the result of supplementing bone density, which is also intended to increase bone density, and in the event of calcium deficiency, calcium is supplemented by calcium supplements. Supplementing magnesium, phosphorus, potassium, vitamin K, vitamin B and the like can form bones and promote the key of bone density.
Calcium cannot be synthesized in the human body and can only be taken from food, but 800 mg of calcium required by the human body per day cannot be met from the ordinary diet at all, and the human body is additionally charged. Calcium deficiency is one of the main causes of senile osteoporosis, however, many aging symptoms of the elderly are caused by osteoporosis, such as systemic osteodynia, particularly senile lumbocrural pain, early hunchback, body movement disorder and the like. Osteoporosis can cause fracture of the elderly, such as lumbar vertebral compression fracture and limb fracture.
In various people in China, the intake of calcium only accounts for 33.9-53.7% of the recommended amount standard of the Chinese society of Nutrition. According to the standard of Chinese resident dietary nutrient reference intakes (Chinese DIRs) passed by the eighth national nutrition conference, the recommended daily calcium intake is 800 mg, and the recommended calcium intake of teenagers and pregnant women is 1200-1500 mg. On the basis of normal diet, each person needs to supplement 400-600 mg of calcium every day, and especially teenagers, pregnant and lying-in women and middle-aged and old people need to supplement proper amount of calcium. Due to the dietary habits of Chinese people, the calcium intake of most people is less than half of the standard amount, and scientific calcium supplement is very important for ensuring the health of Chinese people and preventing various diseases caused by calcium deficiency. China is wide in regions, and the calcium deficiency conditions of different regions are different. The calcium intake of the crowd in the animal husbandry area and the crowd in the area with high soybean product intake is sufficient, the calcium deficiency condition of the urban crowd with more egg and milk intake and the crowd with more edible fishes in the coastal area is not serious, the calcium intake of the crowd in the inland part of areas, particularly the northern rural areas taking the rice and flour vegetables as daily staple food is low, and the daily calcium intake is only about 400 mg. In contrast, oral calcium supplement is an effective calcium supplement method because of insufficient calcium supplement of Chinese food due to dietary habits.
The biological agent of Johnson space center, Paget wittson, in the United states, carried the research group to conduct the "astronauts' risk of developing kidney stones" investigation, selected astronauts who worked continuously in the "peace and number" space station for more than 100 days in 1995-. The results show that under the condition of space weightlessness, the astronaut can form kidney stones very quickly in long-term space life. The investigators confined 12 healthy volunteers to bed for 30 days to induce bone loss in the volunteer's bones. Surprisingly, the method judges the early stage of osteoporosis in one week after the experiment is started, and the result is more excellent than the previous traditional medical scanning result, and the research result is published in the journal of the national academy of sciences of the United states.
Based on the current situation, people working at special posts are more concerned about, especially for astronauts struggling with the Chinese aerospace industry. Space flight is a special professional activity, and has the characteristics of special working environment, highly complex professional skills, difficult flight task and the like. Such occupations require astronauts to have not only a healthy physical constitution and good psychological quality, but also high resistance and pressure resistance to the aerospace environment, as well as profound knowledge and high skills. Therefore, a nutritional preparation for improving bone density and supplementing calcium for astronauts, alleviating adverse effects caused by aerospace environmental factors and maintaining physical and mental health of astronauts is needed.
Disclosure of Invention
The invention provides a nutritional preparation for improving bone mineral density and supplementing calcium for astronauts.
In order to achieve the above object, the embodiment of the present invention provides a nutritional preparation for increasing bone density and supplementing calcium for astronauts, which is characterized in that: comprises main components of calcium aspartate (chelated calcium), milk mineral salt, collagen peptide, stachyose and eucommia male flower.
Further, the nutritional preparation for improving the bone density of astronauts and supplementing calcium is characterized by being prepared from the following main components in parts by weight: 6-9 parts of calcium aspartate (chelated calcium), 4-6 parts of milk mineral salt, 18-21 parts of collagen peptide, 13-16 parts of stachyose and 6-9 parts of eucommia male flower.
Further, the nutritional preparation for improving the bone density of astronauts and supplementing calcium is characterized by being prepared from the following main components in parts by weight: 6 parts of calcium aspartate (chelated calcium), 5 parts of milk mineral salt, 18 parts of collagen peptide, 13 parts of stachyose and 6 parts of eucommia male flower.
Further, the nutritional preparation for improving the bone density of astronauts and supplementing calcium is characterized by being prepared from the following main components in parts by weight: 8 parts of calcium aspartate (chelated calcium), 6 parts of milk mineral salt, 20 parts of collagen peptide, 15 parts of stachyose and 9 parts of eucommia male flower.
The nutritional preparation for improving the bone mineral density and supplementing calcium of astronauts is characterized in that L-aspartic acid and calcium hydroxide are used as main raw materials of the main component, and the main component is a food-grade additive prepared through chelation reaction, so that the nutritional preparation has the characteristics of easiness in absorption, strong penetrability, high bioavailability, no irritation, good stability, no need of reinforcement, stable blood calcium level, good tolerance, increase in bone mineral density and the like.
Further, the nutritional preparation for improving the bone density of astronauts and supplementing calcium is characterized in that milk mineral salt in the main component is a new food raw material approved by national ministry of health 2009, No. 18, and meets the quality requirements of national regulations.
Further, the nutritional preparation for improving the bone density and supplementing calcium of astronauts is characterized in that the main component of the collagen peptide is fresh high-quality animal collagen essence, micromolecule collagen polypeptide which is easy to digest and absorb by human bodies is prepared by a scientific high-temperature and high-pressure boiling method and a modern bio-enzyme engineering technology, and collagen polypeptide essence liquid which is separated, purified and concentrated is refined into collagen powder which is convenient to transport and eat.
Further, the nutritional preparation for improving the bone density of astronauts and supplementing calcium is characterized in that the main component eucommia male flower is purchased from Jiang grass Biotechnology GmbH in Shaanxi, and is produced by water extraction and then concentration at a ratio of 30: 1.
Furthermore, the nutritional preparation for improving the bone density of astronauts and supplementing calcium is characterized in that other auxiliary materials are added according to the proportion of the main components to prepare tablets, powder, liquid preparations and other dosage forms.
The invention is used as a nutritional preparation for increasing bone mineral density and supplementing calcium, and has the advantages that: according to the specific embodiment of the invention, the calcium aspartate and the milk mineral salt are organically combined to meet the requirements of different people on calcium, and simultaneously the stachyose is combined to promote the absorption of calcium and other minerals, and then the collagen peptide with the hands is carried to enhance the bone mineral density, so that the eucommia male flowers can enhance the absorption, utilization and excretion, and the effects of increasing the bone mineral density and supplementing calcium are achieved.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment of the invention provides a nutritional preparation for improving bone mineral density and supplementing calcium for astronauts, which is characterized by comprising the following components in parts by weight: comprises main components of calcium aspartate (chelated calcium), milk mineral salt, collagen peptide, stachyose and eucommia male flower. The nutritional preparation for improving the bone density of astronauts and supplementing calcium is prepared from the following main components in parts by weight: 6-9 parts of calcium aspartate (chelated calcium), 4-6 parts of milk mineral salt, 18-21 parts of collagen peptide, 13-16 parts of stachyose and 6-9 parts of eucommia male flower.
Calcium aspartate (chelated calcium) is used as a calcium source and is implemented according to the relevant regulations of the food nutrition enhancer use health standard (the implementation standard GB29226-2012 made by the participation of Saibetai) in China, can stably enter the small intestine through the stomach and be absorbed by the human body, and the molecular structure of the calcium aspartate is similar to dipeptide protein calcium in natural food and is easy to be absorbed by intestinal tracts.
The milk mineral salt is prepared from whey as raw material by removing protein, lactose, etc., and is a nutritional supplement easy to be absorbed by human body. The milk mineral salt is a new resource food, contains more minerals, mainly calcium and phosphorus, is close to the composition of human skeleton teeth, has better calcium supplementing effect due to reasonable calcium-phosphorus ratio, has small irritation to intestines and stomach, can not reverse the calcium supplementing effect, can still maintain the increased bone density even after the milk mineral salt is stopped to be supplemented for three years, and can gradually disappear after the inorganic calcium is stopped to be supplemented.
The collagen peptide is a structural protein of extracellular matrix, is a main component in animal connective tissue, is formed with the tissue, matures, transfers intercellular information, promotes the generation of osteocyte, accelerates the development of bones, improves the firmness of the bones, relieves joint pain, improves the loss of proteoglycan in articular cartilage, prevents osteoporosis, increases bone density and the like, is used as a small molecular peptide, has lower molecular weight and better digestion and absorption, can be directly absorbed by intestinal tracts, enters blood and reaches various parts of the body such as skin, liver, kidney and the like.
Stachyose is functional oligosaccharide, can replace metal ions, thereby promoting the absorption of mineral substances such as calcium, magnesium and the like, has very obvious proliferation effect on beneficial flora such as bifidobacterium, lactobacillus and the like in the gastrointestinal tract of a human body, can quickly improve the environment in the digestive tract of the human body and adjust the balance of microecological flora.
The eucommia male flower contains more than 60 effective plant components, such as lignins, iridoids, phenylpropanoid active substances (such as geniposide acid, chlorogenic acid and aucubin), pinoresinol diglucoside, flavone, alkaloid, amino acid, polysaccharide, mineral elements Zn, Mn, Cu, Fe, Ca, P, B, Mg, K and the like, wherein the content of the amino acid reaches 21.47%, the content of the calcium reaches 0.92%, the content of the zinc reaches 51Mg/100g, which is 1.8 times and 5.2 times of that of eucommia leaves respectively, the effective components are most comprehensive and higher, the eucommia male flower integrates all eucommia, can be said to have all health-care effects of the plant eucommia, and has particularly obvious effects on 'liver strengthening, kidney tonifying, bowel relaxing, sleep improving and three-high'. The Shennong Ben Cao Jing records that eucommia bark is mainly used for treating lumbar pain, strengthening the middle-jiao, benefiting vital essence and strengthening bones and muscles.
The nutritional preparation for improving the bone density and supplementing calcium of the astronaut is characterized by being prepared from the following main components in parts by weight: 6 parts of calcium aspartate (chelated calcium), 5 parts of milk mineral salt, 18 parts of collagen peptide, 13 parts of stachyose and 6 parts of eucommia male flower.
The nutritional preparation for improving the bone density and supplementing calcium of the astronaut is characterized by being prepared from the following main components in parts by weight: 8 parts of calcium aspartate (chelated calcium), 6 parts of milk mineral salt, 20 parts of collagen peptide, 15 parts of stachyose and 9 parts of eucommia male flower.
The nutritional preparation for improving the bone density of astronauts and supplementing calcium is characterized in that other auxiliary materials are added according to the proportion of the main components to prepare tablets, powder, liquid preparations and other dosage forms.
The calcium aspartate (chelated calcium), milk mineral salt, ossein peptide, stachyose and eucommia male flower are reasonably matched and scientifically matched, and the human metabolic theory is used as guidance, so that the requirements for improving the bone density of astronauts and supplementing calcium are met.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (9)

1. A nutritional preparation for improving bone density and supplementing calcium of astronauts is characterized in that: comprises main components of calcium aspartate (chelated calcium), milk mineral salt, collagen peptide, stachyose and eucommia male flower.
2. The nutritional preparation for increasing the bone density and supplementing calcium of astronauts according to claim 1, which is prepared from the following main components in parts by weight: 6-9 parts of calcium aspartate (chelated calcium), 4-6 parts of milk mineral salt, 18-21 parts of collagen peptide, 13-16 parts of stachyose and 6-9 parts of eucommia male flower.
3. The nutritional preparation for increasing the bone density and supplementing calcium of astronauts according to claim 2, which is prepared from the following main components in parts by weight: 6 parts of calcium aspartate (chelated calcium), 5 parts of milk mineral salt, 18 parts of collagen peptide, 13 parts of stachyose and 6 parts of eucommia male flower.
4. The nutritional preparation for increasing the bone density and supplementing calcium of astronauts according to claim 2, which is prepared from the following main components in parts by weight: 8 parts of calcium aspartate (chelated calcium), 6 parts of milk mineral salt, 20 parts of collagen peptide, 15 parts of stachyose and 9 parts of eucommia male flower.
5. The nutritional preparation according to any one of claims 1 to 4, wherein aspartic acid (chelated calcium), also called amino acid chelated calcium, in the main component is a food grade additive prepared by chelating reaction with L-aspartic acid and calcium hydroxide as main raw materials, and has the characteristics of easy absorption, strong penetrability, high bioavailability, no irritation, good stability, no need of reinforcement, stable blood calcium level, good tolerance, increased bone density and the like.
6. The nutritional preparation for improving the bone density and supplementing calcium of astronauts according to any one of claims 1 to 4, wherein the milk mineral salt in the main component is a new food raw material approved by national Ministry of health 2009, No. 18, and meets the quality requirements of national regulations.
7. The nutritional preparation for increasing the bone density and supplementing calcium of astronauts according to any one of claims 1 to 4, wherein the main component of the collagen peptide is selected from fresh high-quality animal collagen essence, small molecular collagen polypeptide which is easy to be digested and absorbed by human body is prepared by scientific high-temperature and high-pressure boiling method and modern bio-enzyme engineering technology, and the collagen peptide essence is separated, purified and concentrated to be refined into collagen powder which is convenient to transport and eat.
8. The nutritional preparation for improving the bone density and supplementing calcium of astronauts according to any one of claims 1 to 4, wherein the main component eucommia male flower is purchased from Jiang He Biotechnology GmbH, Shaanxi, and is produced by extracting with water and then concentrating at a ratio of 30: 1.
9. The nutritional preparation for increasing the bone density and supplementing calcium of astronauts according to any one of claims 1 to 4, wherein other auxiliary materials are added according to the proportion of each main component to prepare tablets, powder, liquid preparations and other dosage forms.
CN202010909240.9A 2020-09-02 2020-09-02 Nutritional preparation for improving bone mineral density and supplementing calcium for astronauts Pending CN114190544A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1785427A (en) * 2005-11-21 2006-06-14 陈斌 Compound calcium preparation for astronaut
CN107625124A (en) * 2017-09-29 2018-01-26 武汉华士特工业生物技术开发有限公司 A kind of functional food for increasing bone density and preparation method thereof
CN110074250A (en) * 2019-03-29 2019-08-02 广东澳思瑞雅健康美容生物科技有限公司 A kind of formula and preparation method of supplement skeleton nutrition and improvement skeletal function
CN110269243A (en) * 2018-03-17 2019-09-24 北京神飞航天应用技术研究院 A kind of dedicated raising bone density nutritional preparation of spacefarer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1785427A (en) * 2005-11-21 2006-06-14 陈斌 Compound calcium preparation for astronaut
CN107625124A (en) * 2017-09-29 2018-01-26 武汉华士特工业生物技术开发有限公司 A kind of functional food for increasing bone density and preparation method thereof
CN110269243A (en) * 2018-03-17 2019-09-24 北京神飞航天应用技术研究院 A kind of dedicated raising bone density nutritional preparation of spacefarer
CN110074250A (en) * 2019-03-29 2019-08-02 广东澳思瑞雅健康美容生物科技有限公司 A kind of formula and preparation method of supplement skeleton nutrition and improvement skeletal function

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