CN100415745C - 作为可诱导的no合成酶抑制剂的咪唑并吡啶衍生物 - Google Patents

作为可诱导的no合成酶抑制剂的咪唑并吡啶衍生物 Download PDF

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Publication number
CN100415745C
CN100415745C CNB2004800275920A CN200480027592A CN100415745C CN 100415745 C CN100415745 C CN 100415745C CN B2004800275920 A CNB2004800275920 A CN B2004800275920A CN 200480027592 A CN200480027592 A CN 200480027592A CN 100415745 C CN100415745 C CN 100415745C
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CN
China
Prior art keywords
compound
hydrogen
methyl
formula
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800275920A
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English (en)
Chinese (zh)
Other versions
CN1856491A (zh
Inventor
T·福赫斯
T·马丁
R·贝尔
A·斯特拉布
M·埃尔策
M·勒纳
W·-R·乌尔里希
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Takeda GmbH
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Altana Pharma AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
CNB2004800275920A 2003-10-01 2004-09-30 作为可诱导的no合成酶抑制剂的咪唑并吡啶衍生物 Expired - Fee Related CN100415745C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03022053 2003-10-01
EP03022053.7 2003-10-01

Publications (2)

Publication Number Publication Date
CN1856491A CN1856491A (zh) 2006-11-01
CN100415745C true CN100415745C (zh) 2008-09-03

Family

ID=34384571

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800275920A Expired - Fee Related CN100415745C (zh) 2003-10-01 2004-09-30 作为可诱导的no合成酶抑制剂的咪唑并吡啶衍生物

Country Status (19)

Country Link
US (2) US7468377B2 (enExample)
EP (1) EP1675854B1 (enExample)
JP (1) JP2007507467A (enExample)
KR (1) KR20060092220A (enExample)
CN (1) CN100415745C (enExample)
AT (1) ATE399169T1 (enExample)
AU (1) AU2004276015A1 (enExample)
BR (1) BRPI0414972A (enExample)
CA (1) CA2540083A1 (enExample)
DE (1) DE602004014630D1 (enExample)
EA (1) EA010261B1 (enExample)
ES (1) ES2309567T3 (enExample)
IL (1) IL173895A0 (enExample)
MX (1) MXPA06003349A (enExample)
NO (1) NO20061344L (enExample)
NZ (1) NZ546437A (enExample)
RS (1) RS20060196A (enExample)
WO (1) WO2005030771A1 (enExample)
ZA (1) ZA200601642B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007507463A (ja) 2003-10-01 2007-03-29 アルタナ　ファルマ　アクチエンゲゼルシャフト 誘導性ＮＯシンターゼ阻害剤としてのイミダゾ［４，５−ｂ］ピリジン誘導体
NZ546437A (en) * 2003-10-01 2009-09-25 Altana Pharma Ag Imidazopyridine-derivatives as inducible NO-synthase inhibitors
EP1670798A1 (en) 2003-10-01 2006-06-21 Altana Pharma AG Aminopyridine-derivatives as inductible no-synthase inhibitors
ATE399168T1 (de) * 2003-10-01 2008-07-15 Nycomed Gmbh Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren
UY29825A1 (es) * 2005-10-03 2007-05-31 Astrazeneca Ab Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones
AR057525A1 (es) * 2005-10-03 2007-12-05 Astrazeneca Ab Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion
KR101889993B1 (ko) * 2010-09-10 2018-08-20 시오노기세야쿠 가부시키가이샤 Ａｍｐｋ 활성화 작용을 갖는 헤테로환 축합 이미다졸 유도체
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2504252A1 (de) * 1974-02-18 1975-08-21 Haessle Ab Heterocyclische verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel
EP0125756A2 (en) * 1983-03-22 1984-11-21 Fujisawa Pharmaceutical Co., Ltd. Fused imidazole compounds, processes for the preparation thereof and pharmaceutical compositions containing them
WO2000049015A1 (en) * 1999-02-17 2000-08-24 Fujisawa Pharmaceutical Co., Ltd. Pyridine compounds and their pharmaceutical use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045564A (en) * 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
SE512835C2 (sv) 1996-01-08 2000-05-22 Astrazeneca Ab Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare
BR0308785A (pt) * 2002-03-27 2005-01-11 Altana Pharma Ag Derivados de alcoxipiridina
AU2003280578A1 (en) * 2002-10-30 2004-05-25 Ajinomoto Co., Inc. Heterocyclic compounds
EP1673371B1 (en) 2003-10-01 2008-08-06 Nycomed GmbH Imidazopyridine-derivatives as inducible no-synthase inhibitors
JP2007507463A (ja) 2003-10-01 2007-03-29 アルタナ　ファルマ　アクチエンゲゼルシャフト 誘導性ＮＯシンターゼ阻害剤としてのイミダゾ［４，５−ｂ］ピリジン誘導体
NZ546437A (en) * 2003-10-01 2009-09-25 Altana Pharma Ag Imidazopyridine-derivatives as inducible NO-synthase inhibitors
EP1670798A1 (en) 2003-10-01 2006-06-21 Altana Pharma AG Aminopyridine-derivatives as inductible no-synthase inhibitors
ATE399168T1 (de) * 2003-10-01 2008-07-15 Nycomed Gmbh Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2504252A1 (de) * 1974-02-18 1975-08-21 Haessle Ab Heterocyclische verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel
EP0125756A2 (en) * 1983-03-22 1984-11-21 Fujisawa Pharmaceutical Co., Ltd. Fused imidazole compounds, processes for the preparation thereof and pharmaceutical compositions containing them
WO2000049015A1 (en) * 1999-02-17 2000-08-24 Fujisawa Pharmaceutical Co., Ltd. Pyridine compounds and their pharmaceutical use

Also Published As

Publication number Publication date
KR20060092220A (ko) 2006-08-22
JP2007507467A (ja) 2007-03-29
CA2540083A1 (en) 2005-04-07
MXPA06003349A (es) 2006-06-08
ES2309567T3 (es) 2008-12-16
NZ546437A (en) 2009-09-25
EA200600608A1 (ru) 2006-10-27
US20070043073A1 (en) 2007-02-22
AU2004276015A1 (en) 2005-04-07
WO2005030771A1 (en) 2005-04-07
HK1096548A1 (zh) 2007-06-01
US7468377B2 (en) 2008-12-23
US20090036482A1 (en) 2009-02-05
RS20060196A (sr) 2008-08-07
NO20061344L (no) 2006-03-24
EA010261B1 (ru) 2008-06-30
ZA200601642B (en) 2007-05-30
EP1675854B1 (en) 2008-06-25
CN1856491A (zh) 2006-11-01
IL173895A0 (en) 2006-07-05
EP1675854A1 (en) 2006-07-05
ATE399169T1 (de) 2008-07-15
DE602004014630D1 (de) 2008-08-07
BRPI0414972A (pt) 2006-11-07

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