ZA200601642B - Imidazopyridine-derivatives as inductible no-synthase inhibitors - Google Patents
Imidazopyridine-derivatives as inductible no-synthase inhibitors Download PDFInfo
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- ZA200601642B ZA200601642B ZA200601642A ZA200601642A ZA200601642B ZA 200601642 B ZA200601642 B ZA 200601642B ZA 200601642 A ZA200601642 A ZA 200601642A ZA 200601642 A ZA200601642 A ZA 200601642A ZA 200601642 B ZA200601642 B ZA 200601642B
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- South Africa
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- compounds
- hydrogen
- salts
- methyl
- oxides
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 230000008707 rearrangement Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
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- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000012552 review Methods 0.000 description 1
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- 229960004617 sapropterin Drugs 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 206010040400 serum sickness Diseases 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 229910021515 thallium hydroxide Inorganic materials 0.000 description 1
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- 230000009529 traumatic brain injury Effects 0.000 description 1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03022053 | 2003-10-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200601642B true ZA200601642B (en) | 2007-05-30 |
Family
ID=34384571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200601642A ZA200601642B (en) | 2003-10-01 | 2006-02-24 | Imidazopyridine-derivatives as inductible no-synthase inhibitors |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7468377B2 (enExample) |
| EP (1) | EP1675854B1 (enExample) |
| JP (1) | JP2007507467A (enExample) |
| KR (1) | KR20060092220A (enExample) |
| CN (1) | CN100415745C (enExample) |
| AT (1) | ATE399169T1 (enExample) |
| AU (1) | AU2004276015A1 (enExample) |
| BR (1) | BRPI0414972A (enExample) |
| CA (1) | CA2540083A1 (enExample) |
| DE (1) | DE602004014630D1 (enExample) |
| EA (1) | EA010261B1 (enExample) |
| ES (1) | ES2309567T3 (enExample) |
| IL (1) | IL173895A0 (enExample) |
| MX (1) | MXPA06003349A (enExample) |
| NO (1) | NO20061344L (enExample) |
| NZ (1) | NZ546437A (enExample) |
| RS (1) | RS20060196A (enExample) |
| WO (1) | WO2005030771A1 (enExample) |
| ZA (1) | ZA200601642B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE398617T1 (de) | 2003-10-01 | 2008-07-15 | Nycomed Gmbh | Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase |
| EA010261B1 (ru) * | 2003-10-01 | 2008-06-30 | Алтана Фарма Аг | Производные имидазопиридина как ингибиторы индуцируемой no - синтазы |
| AU2004276014A1 (en) * | 2003-10-01 | 2005-04-07 | Altana Pharma Ag | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
| BRPI0415034A (pt) | 2003-10-01 | 2006-12-12 | Altana Pharma Ag | derivados de aminopiridina como inibidores de não-sintase induzìveis |
| UY29825A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones |
| AR057525A1 (es) * | 2005-10-03 | 2007-12-05 | Astrazeneca Ab | Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion |
| CA2811025C (en) * | 2010-09-10 | 2018-07-17 | Shionogi & Co., Ltd. | Hetero ring-fused imidazole derivative having ampk activating effect |
| GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4045564A (en) * | 1974-02-18 | 1977-08-30 | Ab Hassle | Benzimidazole derivatives useful as gastric acid secretion inhibitors |
| SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
| GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| SE512835C2 (sv) | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
| AUPP873799A0 (en) * | 1999-02-17 | 1999-03-11 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine compounds |
| DE60318826T2 (de) * | 2002-03-27 | 2009-01-22 | Nycomed Gmbh | Alkoxypyridinderivate |
| JP4552651B2 (ja) * | 2002-10-30 | 2010-09-29 | 味の素株式会社 | 複素環化合物 |
| ATE398617T1 (de) | 2003-10-01 | 2008-07-15 | Nycomed Gmbh | Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase |
| EA010261B1 (ru) * | 2003-10-01 | 2008-06-30 | Алтана Фарма Аг | Производные имидазопиридина как ингибиторы индуцируемой no - синтазы |
| CA2540242A1 (en) | 2003-10-01 | 2005-04-07 | Altana Pharma Ag | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
| AU2004276014A1 (en) * | 2003-10-01 | 2005-04-07 | Altana Pharma Ag | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
| BRPI0415034A (pt) | 2003-10-01 | 2006-12-12 | Altana Pharma Ag | derivados de aminopiridina como inibidores de não-sintase induzìveis |
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2004
- 2004-09-30 EA EA200600608A patent/EA010261B1/ru not_active IP Right Cessation
- 2004-09-30 AU AU2004276015A patent/AU2004276015A1/en not_active Abandoned
- 2004-09-30 CA CA002540083A patent/CA2540083A1/en not_active Abandoned
- 2004-09-30 KR KR1020067005873A patent/KR20060092220A/ko not_active Withdrawn
- 2004-09-30 EP EP04787263A patent/EP1675854B1/en not_active Expired - Lifetime
- 2004-09-30 WO PCT/EP2004/052378 patent/WO2005030771A1/en not_active Ceased
- 2004-09-30 NZ NZ546437A patent/NZ546437A/en unknown
- 2004-09-30 JP JP2006530264A patent/JP2007507467A/ja not_active Withdrawn
- 2004-09-30 CN CNB2004800275920A patent/CN100415745C/zh not_active Expired - Fee Related
- 2004-09-30 MX MXPA06003349A patent/MXPA06003349A/es not_active Application Discontinuation
- 2004-09-30 RS YUP-2006/0196A patent/RS20060196A/sr unknown
- 2004-09-30 BR BRPI0414972-6A patent/BRPI0414972A/pt not_active IP Right Cessation
- 2004-09-30 DE DE602004014630T patent/DE602004014630D1/de not_active Expired - Lifetime
- 2004-09-30 ES ES04787263T patent/ES2309567T3/es not_active Expired - Lifetime
- 2004-09-30 US US10/573,484 patent/US7468377B2/en not_active Expired - Fee Related
- 2004-09-30 AT AT04787263T patent/ATE399169T1/de not_active IP Right Cessation
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2006
- 2006-02-23 IL IL173895A patent/IL173895A0/en unknown
- 2006-02-24 ZA ZA200601642A patent/ZA200601642B/en unknown
- 2006-03-24 NO NO20061344A patent/NO20061344L/no not_active Application Discontinuation
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2008
- 2008-09-26 US US12/232,973 patent/US20090036482A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2309567T3 (es) | 2008-12-16 |
| EP1675854A1 (en) | 2006-07-05 |
| US7468377B2 (en) | 2008-12-23 |
| NO20061344L (no) | 2006-03-24 |
| ATE399169T1 (de) | 2008-07-15 |
| NZ546437A (en) | 2009-09-25 |
| CA2540083A1 (en) | 2005-04-07 |
| CN1856491A (zh) | 2006-11-01 |
| EA010261B1 (ru) | 2008-06-30 |
| DE602004014630D1 (de) | 2008-08-07 |
| BRPI0414972A (pt) | 2006-11-07 |
| HK1096548A1 (zh) | 2007-06-01 |
| WO2005030771A1 (en) | 2005-04-07 |
| JP2007507467A (ja) | 2007-03-29 |
| IL173895A0 (en) | 2006-07-05 |
| RS20060196A (sr) | 2008-08-07 |
| CN100415745C (zh) | 2008-09-03 |
| AU2004276015A1 (en) | 2005-04-07 |
| EA200600608A1 (ru) | 2006-10-27 |
| EP1675854B1 (en) | 2008-06-25 |
| MXPA06003349A (es) | 2006-06-08 |
| US20070043073A1 (en) | 2007-02-22 |
| KR20060092220A (ko) | 2006-08-22 |
| US20090036482A1 (en) | 2009-02-05 |
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