EA010261B1 - Производные имидазопиридина как ингибиторы индуцируемой no - синтазы - Google Patents
Производные имидазопиридина как ингибиторы индуцируемой no - синтазы Download PDFInfo
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- EA010261B1 EA010261B1 EA200600608A EA200600608A EA010261B1 EA 010261 B1 EA010261 B1 EA 010261B1 EA 200600608 A EA200600608 A EA 200600608A EA 200600608 A EA200600608 A EA 200600608A EA 010261 B1 EA010261 B1 EA 010261B1
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- Prior art keywords
- compounds
- hydrogen
- methyl
- salts
- oxides
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- 239000010936 titanium Substances 0.000 description 1
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- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03022053 | 2003-10-01 | ||
| PCT/EP2004/052378 WO2005030771A1 (en) | 2003-10-01 | 2004-09-30 | Imidazopyridine-derivatives as inductible no-synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200600608A1 EA200600608A1 (ru) | 2006-10-27 |
| EA010261B1 true EA010261B1 (ru) | 2008-06-30 |
Family
ID=34384571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200600608A EA010261B1 (ru) | 2003-10-01 | 2004-09-30 | Производные имидазопиридина как ингибиторы индуцируемой no - синтазы |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7468377B2 (enExample) |
| EP (1) | EP1675854B1 (enExample) |
| JP (1) | JP2007507467A (enExample) |
| KR (1) | KR20060092220A (enExample) |
| CN (1) | CN100415745C (enExample) |
| AT (1) | ATE399169T1 (enExample) |
| AU (1) | AU2004276015A1 (enExample) |
| BR (1) | BRPI0414972A (enExample) |
| CA (1) | CA2540083A1 (enExample) |
| DE (1) | DE602004014630D1 (enExample) |
| EA (1) | EA010261B1 (enExample) |
| ES (1) | ES2309567T3 (enExample) |
| IL (1) | IL173895A0 (enExample) |
| MX (1) | MXPA06003349A (enExample) |
| NO (1) | NO20061344L (enExample) |
| NZ (1) | NZ546437A (enExample) |
| RS (1) | RS20060196A (enExample) |
| WO (1) | WO2005030771A1 (enExample) |
| ZA (1) | ZA200601642B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2635662C2 (ru) * | 2010-09-10 | 2017-11-15 | Сионоги Энд Ко., Лтд. | Конденсированное с гетерокольцом имидазольное производное, обладающее активирующим амрк действием |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007507463A (ja) | 2003-10-01 | 2007-03-29 | アルタナ ファルマ アクチエンゲゼルシャフト | 誘導性ＮＯシンターゼ阻害剤としてのイミダゾ［４，５−ｂ］ピリジン誘導体 |
| NZ546437A (en) * | 2003-10-01 | 2009-09-25 | Altana Pharma Ag | Imidazopyridine-derivatives as inducible NO-synthase inhibitors |
| EP1670798A1 (en) | 2003-10-01 | 2006-06-21 | Altana Pharma AG | Aminopyridine-derivatives as inductible no-synthase inhibitors |
| ATE399168T1 (de) * | 2003-10-01 | 2008-07-15 | Nycomed Gmbh | Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren |
| UY29825A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones |
| AR057525A1 (es) * | 2005-10-03 | 2007-12-05 | Astrazeneca Ab | Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion |
| GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2504252A1 (de) * | 1974-02-18 | 1975-08-21 | Haessle Ab | Heterocyclische verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel |
| EP0125756A2 (en) * | 1983-03-22 | 1984-11-21 | Fujisawa Pharmaceutical Co., Ltd. | Fused imidazole compounds, processes for the preparation thereof and pharmaceutical compositions containing them |
| WO2000049015A1 (en) * | 1999-02-17 | 2000-08-24 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine compounds and their pharmaceutical use |
| WO2003080607A1 (en) * | 2002-03-27 | 2003-10-02 | Altana Pharma Ag | Novel alkoxypyridine-derivatives |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4045564A (en) * | 1974-02-18 | 1977-08-30 | Ab Hassle | Benzimidazole derivatives useful as gastric acid secretion inhibitors |
| SE512835C2 (sv) | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
| AU2003280578A1 (en) * | 2002-10-30 | 2004-05-25 | Ajinomoto Co., Inc. | Heterocyclic compounds |
| EP1673371B1 (en) | 2003-10-01 | 2008-08-06 | Nycomed GmbH | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
| JP2007507463A (ja) | 2003-10-01 | 2007-03-29 | アルタナ ファルマ アクチエンゲゼルシャフト | 誘導性ＮＯシンターゼ阻害剤としてのイミダゾ［４，５−ｂ］ピリジン誘導体 |
| NZ546437A (en) * | 2003-10-01 | 2009-09-25 | Altana Pharma Ag | Imidazopyridine-derivatives as inducible NO-synthase inhibitors |
| EP1670798A1 (en) | 2003-10-01 | 2006-06-21 | Altana Pharma AG | Aminopyridine-derivatives as inductible no-synthase inhibitors |
| ATE399168T1 (de) * | 2003-10-01 | 2008-07-15 | Nycomed Gmbh | Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren |
-
2004
- 2004-09-30 NZ NZ546437A patent/NZ546437A/en unknown
- 2004-09-30 MX MXPA06003349A patent/MXPA06003349A/es not_active Application Discontinuation
- 2004-09-30 CN CNB2004800275920A patent/CN100415745C/zh not_active Expired - Fee Related
- 2004-09-30 BR BRPI0414972-6A patent/BRPI0414972A/pt not_active IP Right Cessation
- 2004-09-30 RS YUP-2006/0196A patent/RS20060196A/sr unknown
- 2004-09-30 AT AT04787263T patent/ATE399169T1/de not_active IP Right Cessation
- 2004-09-30 CA CA002540083A patent/CA2540083A1/en not_active Abandoned
- 2004-09-30 DE DE602004014630T patent/DE602004014630D1/de not_active Expired - Lifetime
- 2004-09-30 US US10/573,484 patent/US7468377B2/en not_active Expired - Fee Related
- 2004-09-30 JP JP2006530264A patent/JP2007507467A/ja not_active Withdrawn
- 2004-09-30 EA EA200600608A patent/EA010261B1/ru not_active IP Right Cessation
- 2004-09-30 AU AU2004276015A patent/AU2004276015A1/en not_active Abandoned
- 2004-09-30 WO PCT/EP2004/052378 patent/WO2005030771A1/en not_active Ceased
- 2004-09-30 KR KR1020067005873A patent/KR20060092220A/ko not_active Withdrawn
- 2004-09-30 EP EP04787263A patent/EP1675854B1/en not_active Expired - Lifetime
- 2004-09-30 ES ES04787263T patent/ES2309567T3/es not_active Expired - Lifetime
-
2006
- 2006-02-23 IL IL173895A patent/IL173895A0/en unknown
- 2006-02-24 ZA ZA200601642A patent/ZA200601642B/en unknown
- 2006-03-24 NO NO20061344A patent/NO20061344L/no not_active Application Discontinuation
-
2008
- 2008-09-26 US US12/232,973 patent/US20090036482A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2504252A1 (de) * | 1974-02-18 | 1975-08-21 | Haessle Ab | Heterocyclische verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel |
| EP0125756A2 (en) * | 1983-03-22 | 1984-11-21 | Fujisawa Pharmaceutical Co., Ltd. | Fused imidazole compounds, processes for the preparation thereof and pharmaceutical compositions containing them |
| WO2000049015A1 (en) * | 1999-02-17 | 2000-08-24 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine compounds and their pharmaceutical use |
| WO2003080607A1 (en) * | 2002-03-27 | 2003-10-02 | Altana Pharma Ag | Novel alkoxypyridine-derivatives |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2635662C2 (ru) * | 2010-09-10 | 2017-11-15 | Сионоги Энд Ко., Лтд. | Конденсированное с гетерокольцом имидазольное производное, обладающее активирующим амрк действием |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060092220A (ko) | 2006-08-22 |
| JP2007507467A (ja) | 2007-03-29 |
| CA2540083A1 (en) | 2005-04-07 |
| MXPA06003349A (es) | 2006-06-08 |
| CN100415745C (zh) | 2008-09-03 |
| ES2309567T3 (es) | 2008-12-16 |
| NZ546437A (en) | 2009-09-25 |
| EA200600608A1 (ru) | 2006-10-27 |
| US20070043073A1 (en) | 2007-02-22 |
| AU2004276015A1 (en) | 2005-04-07 |
| WO2005030771A1 (en) | 2005-04-07 |
| HK1096548A1 (zh) | 2007-06-01 |
| US7468377B2 (en) | 2008-12-23 |
| US20090036482A1 (en) | 2009-02-05 |
| RS20060196A (sr) | 2008-08-07 |
| NO20061344L (no) | 2006-03-24 |
| ZA200601642B (en) | 2007-05-30 |
| EP1675854B1 (en) | 2008-06-25 |
| CN1856491A (zh) | 2006-11-01 |
| IL173895A0 (en) | 2006-07-05 |
| EP1675854A1 (en) | 2006-07-05 |
| ATE399169T1 (de) | 2008-07-15 |
| DE602004014630D1 (de) | 2008-08-07 |
| BRPI0414972A (pt) | 2006-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |