CN100378106C - 噻吩并吡咯衍生物的制备方法和中间体 - Google Patents

噻吩并吡咯衍生物的制备方法和中间体 Download PDF

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Publication number
CN100378106C
CN100378106C CNB038236176A CN03823617A CN100378106C CN 100378106 C CN100378106 C CN 100378106C CN B038236176 A CNB038236176 A CN B038236176A CN 03823617 A CN03823617 A CN 03823617A CN 100378106 C CN100378106 C CN 100378106C
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CN
China
Prior art keywords
alkyl
formula
carbamoyl
amino
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB038236176A
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English (en)
Chinese (zh)
Other versions
CN1688587A (zh
Inventor
P·M·墨累
J·S·帕克
P·肖菲尔德
A·斯托克
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AstraZeneca AB
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AstraZeneca AB
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Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1688587A publication Critical patent/CN1688587A/zh
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Publication of CN100378106C publication Critical patent/CN100378106C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CNB038236176A 2002-10-03 2003-09-29 噻吩并吡咯衍生物的制备方法和中间体 Expired - Fee Related CN100378106C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0222912.8 2002-10-03
GBGB0222912.8A GB0222912D0 (en) 2002-10-03 2002-10-03 Novel process and intermediates

Publications (2)

Publication Number Publication Date
CN1688587A CN1688587A (zh) 2005-10-26
CN100378106C true CN100378106C (zh) 2008-04-02

Family

ID=9945219

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038236176A Expired - Fee Related CN100378106C (zh) 2002-10-03 2003-09-29 噻吩并吡咯衍生物的制备方法和中间体

Country Status (13)

Country Link
US (1) US7411074B2 (enExample)
EP (1) EP1549654A1 (enExample)
JP (1) JP2006505541A (enExample)
KR (1) KR20050061503A (enExample)
CN (1) CN100378106C (enExample)
AU (1) AU2003269219A1 (enExample)
BR (1) BR0314966A (enExample)
CA (1) CA2500145A1 (enExample)
GB (1) GB0222912D0 (enExample)
MX (1) MXPA05003327A (enExample)
NO (1) NO20051393L (enExample)
WO (1) WO2004031194A1 (enExample)
ZA (1) ZA200502340B (enExample)

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* Cited by examiner, † Cited by third party
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GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205166D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
CA2551952A1 (en) 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole daao inhibitors
CA2636324C (en) 2006-01-06 2012-03-20 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
WO2007081542A2 (en) 2006-01-06 2007-07-19 Sepracor Inc. Tetralone-based monoamine reuptake inhibitors
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
RU2470011C2 (ru) 2007-05-31 2012-12-20 Сепракор Инк. Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов

Citations (1)

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WO2002020530A1 (en) * 2000-09-06 2002-03-14 Astrazeneca Ab Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors

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GB9302622D0 (en) 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
DK1088824T3 (da) 1999-09-30 2004-04-13 Pfizer Prod Inc Bicykliske pyrrolylamider som glycogen phosphorylase inhibitorer
WO2001028993A2 (en) * 1999-10-19 2001-04-26 Merck & Co. Inc. Tyrosine kinase inhibitors
SE9903998D0 (sv) 1999-11-03 1999-11-03 Astra Ab New compounds
JP2001294572A (ja) 2000-02-09 2001-10-23 Dai Ichi Seiyaku Co Ltd 新規スルホニル誘導体
EP1136071A3 (en) 2000-03-22 2003-03-26 Pfizer Products Inc. Use of glycogen phosphorylase inhibitors
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
MXPA03000966A (es) 2002-02-28 2003-09-04 Pfizer Prod Inc Agentes antidiabeticos.
GB0205166D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
AU2003227360A1 (en) 2002-04-25 2003-11-10 Yamanouchi Pharmaceutical Co., Ltd. Novel amide derivatives or salts thereof
AU2003272285A1 (en) * 2002-09-06 2004-03-29 Janssen Pharmaceutica, N.V. Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
MXPA05004968A (es) 2002-11-07 2005-08-02 Pfizer Prod Inc N-(indol-z-carbonil)amidas como agentes anti-diabeticos.
US7098235B2 (en) * 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
JP2004196702A (ja) 2002-12-18 2004-07-15 Yamanouchi Pharmaceut Co Ltd 新規なアミド誘導体又はその塩
RU2333203C2 (ru) 2002-12-25 2008-09-10 Дайити Фармасьютикал Ко., Лтд. Диаминовые производные
CA2522225A1 (en) 2003-04-17 2004-10-28 Pfizer Products Inc. Carboxamide derivatives as anti-diabetic agents
MXPA05011702A (es) * 2003-04-30 2006-01-23 Pfizer Prod Inc Agentes antidiabeticos.
WO2004113345A1 (ja) 2003-06-20 2004-12-29 Japan Tobacco Inc. 縮合ピロール化合物及びその医薬用途
GB0318464D0 (en) 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0318463D0 (en) 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0319690D0 (en) 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
GB0319759D0 (en) 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
WO2005020986A1 (en) 2003-08-29 2005-03-10 Astrazeneca Ab Heterocyclic amide derivatives which posses glycogen phosphorylase inhibitory activity
WO2005020985A1 (en) 2003-08-29 2005-03-10 Astrazeneca Ab Indolamide derivatives which possess glycogen phosphorylase inhibitory activity
GB0320422D0 (en) 2003-08-30 2003-10-01 Astrazeneca Ab Chemical compounds

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2002020530A1 (en) * 2000-09-06 2002-03-14 Astrazeneca Ab Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
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Construction of heterocyclic compounds by useofalpha-diazaphosphonates: new one-pot syntheses ofindolesand isocoumarines. YOSHINORI NAKAMURA.ORGANIC LETTERS.,Vol.4 No.14. 2002 *

Also Published As

Publication number Publication date
AU2003269219A1 (en) 2004-04-23
WO2004031194A1 (en) 2004-04-15
US7411074B2 (en) 2008-08-12
EP1549654A1 (en) 2005-07-06
GB0222912D0 (en) 2002-11-13
CA2500145A1 (en) 2004-04-15
US20060035953A1 (en) 2006-02-16
BR0314966A (pt) 2005-08-02
NO20051393L (no) 2005-04-20
JP2006505541A (ja) 2006-02-16
ZA200502340B (en) 2005-09-19
MXPA05003327A (es) 2005-07-05
KR20050061503A (ko) 2005-06-22
CN1688587A (zh) 2005-10-26

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Granted publication date: 20080402

Termination date: 20091029