CN100364498C - Oral aerosol for reducing or eliminating snore and its preparation method - Google Patents

Oral aerosol for reducing or eliminating snore and its preparation method Download PDF

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Publication number
CN100364498C
CN100364498C CNB031131174A CN03113117A CN100364498C CN 100364498 C CN100364498 C CN 100364498C CN B031131174 A CNB031131174 A CN B031131174A CN 03113117 A CN03113117 A CN 03113117A CN 100364498 C CN100364498 C CN 100364498C
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China
Prior art keywords
oil
vitamin
snoring
present
alleviate
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Expired - Fee Related
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CNB031131174A
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Chinese (zh)
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CN1535708A (en
Inventor
陈依军
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Zhejiang Jing Jia Medical Technology Co., Ltd.
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陈依军
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Application granted granted Critical
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Abstract

The present invention relates to an oral cavity spraying agent for lightening or eliminating snore. The present invention is characterized in that the present invention comprises natural vegetable oil (one kind of oil in olive oil, sunflower oil, sesame oil, almond oil, peppermint oil, grape seed oil, fennel oil, thyme oil, rue oil, eucalyptus oil and chrysanthemum oil or a mixture of a plurality of kinds of the oil), vitamin, soybean lecithin and agar powder. The natural vegetable oil has the functions of lubricating surrounding soft tissue such as the throat, the tongue, etc. and promoting the microcirculation of oral cavity tissue, so the noise caused by the snore during the sleep can be effectively lightened or eliminated, the present invention has no toxic and side effect, the effect of the present invention maintains more than 8 hours, and patients obtain complete and good sleep.

Description

Be used to alleviate or eliminate oral spray of the sound of snoring and preparation method thereof
Technical field
The present invention relates to a kind of oral spray and preparation method thereof, this oral spray can alleviate or eliminate the caused noise of snoring, thereby improves sleep quality and improve quality of the life.
Background technology
Multiple statistical findings shows that the adult above 30% can snore when sleep, wherein over half is serious habitual snorer.Though, the incidence rate of snoring has significant difference on the gender, simultaneously confidential relation is arranged with age, body weight and living habit etc., but, so far still be that pathological phenomenon does not still have and clearly defines medically belonging to physiological phenomenon for snoring, and the mechanism of snoring and cause the reason of snoring still uncertain.Yet, because the noise that sends during snoring not only influences my sleep quality, more seriously this noise greatly influences spouse, children, relatives and other common habitants' the length of one's sleep and quality, therefore, alleviate effectively or eliminate snoring, can alleviate snorer's puzzlement and inconvenience, and can greatly improve sleep quality and improve quality of the life.
In order to solve the problem that snoring brings, people are just alleviating or are eliminating the articles for use of the sound of snoring by the different approaches exploitation.Common method comprises, places implant by operation, changes the dynamic response of soft palate for the air flow of process soft palate; Utilize apparatus, as so-called snore-proof device; Heal with medicine, as synthetic receptor antagonist etc.But their effectiveness and long-term safety are not estimated and statistical analysis as yet objectively, and particularly, operation can make human body suffer misery or inconvenience with apparatus, and synthetic drug has potential untoward reaction and toxic and side effects to human body.
Summary of the invention
The object of the invention provides a kind of oral spray, and it can be used for alleviating or eliminating the noise that snoring causes when sleeping, and has higher safety;
The present invention provides the preparation method of this oral spray simultaneously.
For achieving the above object, the technical solution used in the present invention is: a kind of oral spray that is used to alleviate or eliminate the sound of snoring comprises following component:
A. crude vegetal can be a kind of in olive oil, sunflower oil, Oleum sesami, almond oil, Oleum menthae, Oleum Vitis viniferae, Oleum Anisi Stellati, thyme oil, Rue oil., Eucalyptus oil, the oil of Flos Chrysanthemi, also can be several mixture wherein;
B. vitamin;
C. soybean lecithin;
D. agar powder.
In the technique scheme, usually, described each components contents is (percentage by weight), crude vegetal 10%~40%, and vitamin 0.05%~1%, soybean lecithin 1%~5%, agar powder 0.1%~0.5%, all the other are water and edible adjuvant.
According to traditional theory of Chinese medical science, volatile plant oil, have heat clearing away as Oleum menthae, Oleum Anisi Stellati, thyme oil, Rue oil., Eucalyptus oil, Flos Chrysanthemi wet goods and separate fire, ventilation effect such as have one's ideas straightened out, modern study shows, contain a certain amount of terpenoid in these volatile plant oil, can stimulate and promote the microcirculation of tissue; In addition, vegetable oil commonly used such as Oleum sesami, sunflower oil, olive oil, almond oil and Semen Vitis viniferae wet goods can lubricate soft tissue on every side such as larynx, tongue, thereby improve the function of soft tissue when sleep in the oral cavity.The present invention utilizes vegetable oil to play soft tissue on every side such as lubricated larynx, tongue, and promotes the microcirculation of oral cavity tissue, thereby can alleviate or eliminate the noise that snoring is caused when sleeping effectively.
The crude vegetal mixing energy of suitable kind is played better effect, and the mode that can adopt is that described crude vegetal is the mixture of olive oil, sunflower oil, Oleum sesami, almond oil and Oleum menthae; Wherein, comprise the olive oil of total amount 2%~10%, 1%~5% sunflower oil, 0.5%~3% Oleum sesami, 0.5%~3% almond oil and 0.5%~3% Oleum menthae.
In order to keep action time, described oral spray is a kind of liposome or emulsion solution.Soybean lecithin has hydrophilic and lipophilic double characteristic, through specific preparation technology, formed by the stabilized liposome of lecithin as substrate, and its vegetable oil functional component in being wrapped in can slowly discharge and keep and prolong action time, by the agar powder that extracts in the natural plants such as Thallus Laminariae (Thallus Eckloniae) is another kind of extensively edible polysaccharide food, it can form microsphere in conjunction with the vegetable oil molecule, thereby helps vegetable oil to rest on the soft tissue around the mouthpiece and keep action time.
In the technique scheme, for prolonging life of product and more helping health, added a spot of vitamin, described vitamin is vitamin E and vitamin B6, usually the content of vitamin E is 0.05%~0.3%, and the content of vitamin B6 is 0.05%~0.4%.Because of vitamin E and vitamin B6 are the materials of needed by human and have functions such as antioxidation, defying age and prophylaxis of cancer that their adding can improve the overall efficacy of oral spray of the present invention.
Putting before this, we obtain a kind of effect component prescription (percentage by weight) preferably:
Vitamin E 0.05%~0.3%
Vitamin B6 0.05%~0.4%
Olive oil 2.0%~10.0%
Sunflower oil 1.0%~5.0%
Oleum menthae 0.5%~3.0%
Almond oil 0.5%~3.0%
Oleum sesami 0.5%~3.0%
Glycerol 5.0%~15.0%
Soybean lecithin 1.0%~5.0%
Agar powder 0.1%~0.5%
Pure water 54.8%~89.3%
The preparation method of oral spray of the present invention is, above-mentioned each component is divided into two groups according to character, is mixed with respectively to obtain oil phase and aqueous phase solution, oil-phase solution poured slowly into mix homogeneously promptly obtains described oral spray in the aqueous phase solution.
Usually, vegetable oil, vitamin E, agar powder and soybean lecithin heating are mixed and dissolving, simultaneously, vitamin B6, G ﹠ W are mixed and heating, oil solution is slowly poured in the aqueous solution, then, after powerful vibration of ultrasound wave or the processing of other method, be prepared into liposome solutions.
Because the technique scheme utilization, the present invention compared with prior art has following advantage:
1. because the present invention utilizes crude vegetal to play soft tissue on every side such as lubricated larynx, tongue, reach the microcirculation that promotes oral cavity tissue, thereby can alleviate or eliminate the noise that snoring is caused when sleeping effectively;
2. because all components of the present invention all is a wholefood, life-time service can not cause any harm or produces any toxic and side effects health and histoorgan;
3. the present invention prepares through liposome technology, only needs spraying into just before going to bed on a small quantity in the oral cavity, and liposome can be controlled the rate of release of functional component, obtains the good sleep of complete sum thereby its effect can be kept more than 8 hours.
The specific embodiment
Below in conjunction with embodiment the present invention is further described, but the preparation method of oral spray of the present invention is not limited to the described method of embodiment:
Embodiment:
Component A: vitamin E 1 gram
32.5 milliliters in olive oil
19 milliliters of sunflower oils
9.5 milliliters of Oleum menthae
4.5 milliliters of almond oil
4.5 milliliters of Oleum sesami
Agar powder 1 gram
Soybean lecithin 10 grams
B component: 50 milliliters of glycerol
Vitamin B6 0.5 gram
367.5 milliliters of pure water
Component A and B component are heated with stirring to 60 degree respectively.In 1000 ml beakers, A pours in the B component with component.Use ultrasonic generator (model W140D, 20 kilo hertzs) vibration to mix 15 fens kinds then.Treat that solution cools off the back packing fully.

Claims (6)

1. an oral spray that is used to alleviate or eliminate the sound of snoring is characterized in that, comprises following component:
A. crude vegetal is the mixture of olive oil, sunflower oil, Oleum sesami, almond oil, Oleum menthae;
B. vitamin is selected from vitamin E, vitamin B6;
C. soybean lecithin;
D. agar powder.
2. the oral spray that is used to alleviate or eliminate the sound of snoring as claimed in claim 1 is characterized in that: described each components contents is crude vegetal 10%~40%, vitamin 0.05%~1%, soybean lecithin 1%~5%, agar powder 0.1%~0.5%, all the other are water and edible adjuvant.
3. the oral spray that is used to alleviate or eliminate the sound of snoring as claimed in claim 1 or 2 is characterized in that: comprise 2%~10% olive oil, 1%~5% sunflower oil, 0.5%~3% Oleum sesami, 0.5%~3% almond oil and 0.5%~3% Oleum menthae.
4. the oral spray that is used to alleviate or eliminate the sound of snoring as claimed in claim 1 or 2 is characterized in that: the content of vitamin E is 0.05%~0.3%, and the content of vitamin B6 is 0.05%~0.4%.
5. the oral spray that is used to alleviate or eliminate the sound of snoring as claimed in claim 1 is characterized in that: it is a kind of liposome or emulsion solution.
6. the described preparation method that is used to alleviate or eliminate the oral spray of the sound of snoring of claim 1, it is characterized in that: described each component is divided into two groups according to character, be mixed with respectively and obtain oil phase and aqueous phase solution, biphase mix homogeneously is promptly obtained described oral spray.
CNB031131174A 2003-04-03 2003-04-03 Oral aerosol for reducing or eliminating snore and its preparation method Expired - Fee Related CN100364498C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CNB031131174A CN100364498C (en) 2003-04-03 2003-04-03 Oral aerosol for reducing or eliminating snore and its preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB031131174A CN100364498C (en) 2003-04-03 2003-04-03 Oral aerosol for reducing or eliminating snore and its preparation method

Publications (2)

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CN1535708A CN1535708A (en) 2004-10-13
CN100364498C true CN100364498C (en) 2008-01-30

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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100852745B1 (en) 2007-04-06 2008-08-18 김교연 Lubricious herbal composition for improving snoring and sleep apnea
JP5998351B2 (en) * 2011-12-09 2016-09-28 日東薬品工業株式会社 Composition for preventing or improving snoring
US20140363528A1 (en) * 2013-06-06 2014-12-11 Pharmacure Health Care Ab Composition for preventing or ameliorating snoring
JP6860917B2 (en) * 2015-08-04 2021-04-21 日東薬品工業株式会社 Emulsified composition for preventing or improving snoring
CN105343331A (en) * 2015-11-12 2016-02-24 无锡瑞盈生命科学有限公司 Almond oil compound healthcare spray and preparation method thereof
CN106176313A (en) * 2016-08-24 2016-12-07 杭州美库生物技术有限公司 A kind of Derma-Guard repaired for barrier function

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR940003987B1 (en) * 1991-10-08 1994-05-10 주식회사 청록천 Foods for good health contains of albumin in capsule
JPH07171377A (en) * 1993-12-20 1995-07-11 Sanei Gen F F I Inc Manufacture of emulsified composition
JPH08154597A (en) * 1994-11-30 1996-06-18 Honen Corp Additive to food
JPH08198777A (en) * 1995-01-25 1996-08-06 Taisho Pharmaceut Co Ltd Lipid emulsion for injection
JPH09157159A (en) * 1995-12-11 1997-06-17 Lion Corp Composition containing carotinoid

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR940003987B1 (en) * 1991-10-08 1994-05-10 주식회사 청록천 Foods for good health contains of albumin in capsule
JPH07171377A (en) * 1993-12-20 1995-07-11 Sanei Gen F F I Inc Manufacture of emulsified composition
JPH08154597A (en) * 1994-11-30 1996-06-18 Honen Corp Additive to food
JPH08198777A (en) * 1995-01-25 1996-08-06 Taisho Pharmaceut Co Ltd Lipid emulsion for injection
JPH09157159A (en) * 1995-12-11 1997-06-17 Lion Corp Composition containing carotinoid

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Assignee: Hangzhou Gallop Biological products Co., Ltd.

Assignor: Chen Yijun

Contract fulfillment period: 2008.8.6 to 2013.7.31

Contract record no.: 2008330001897

Denomination of invention: Oral aerosol for reducing or eliminating snore and its preparation method

Granted publication date: 20080130

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Record date: 20081111

LIC Patent licence contract for exploitation submitted for record

Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.8.6 TO 2013.7.31; CHANGE OF CONTRACT

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Owner name: HANGZHOU GALLOP BIOLOGICAL PRODUCTS CO., LTD.

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Address after: Hangzhou City, Zhejiang province 310030 Xihu District Xiyuan eight road No. 2

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Address before: 215002, 4, building 104, Lane 42, Lotus Lane, Suzhou, Jiangsu

Patentee before: Chen Yijun

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Address after: Hangzhou City, Zhejiang province 310030 Xihu District three Town Road No. 206 building 3 three isolation layer and a layer of room 105

Patentee after: Zhejiang Jing Jia Medical Technology Co., Ltd.

Address before: Hangzhou City, Zhejiang province 310030 Xihu District Xiyuan eight road No. 2

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CF01 Termination of patent right due to non-payment of annual fee