KR100852745B1 - Lubricious herbal composition for improving snoring and sleep apnea - Google Patents

Abstract

A composition for improving snoring and sleep apnea is provided to be convenient for use by applying the same to the nasal mucous membrane before going to bed, reduce manufacturing cost due to being made of vegetable oils and herb medicinal ingredients, alleviate the snoring, promote sleeping and treat bronchial inflammation without side effects. A composition for improving snoring and sleep apnea comprises: 5-50 wt.% of at least one vegetable oil selected from the group consisting of soybean oil, corn oil, olive oil, grapeseed oil, palm oil, sesame oil, perilla oil, and apricot kernel oil; and 50-95 wt.% of a herb medicine extract obtained by extracting 20-60 parts by weight of Ulmi cortex, 20-40 parts by weight of Thujae semen and 20-80 parts by weight of Zizyphi spinosi Semen with 500-2,000 parts by weight of water. The composition further comprises at least one selected from the group consisting of 5-20 parts by weight of an extract of soybean, 5-20 parts by weight of an extract of apricot stone, 5-20 parts by weight of an extract of Angelicae Gigantis Radix, 5-20 parts by weight of an extract of sesame, and 5-20 parts by weight of an extract of perilla.

Description

Lubricious herbal composition for improving snoring and sleep apnea}

The present invention relates to a lubricating herbal composition for snoring and sleep apnea relief, and more specifically, a vegetable oil component and a vegetable oil component to smoothly coat the upper airway mucosa before going to bed to reduce friction with air. The present invention relates to a lubricating herbal composition for relieving snoring and sleep apnea, which is made of a herbal ingredient that prevents snoring and takes a good night's sleep while being uniformly applied to the mucous membrane until morning.

In general, snoring (snoring) is a noise phenomenon caused by the friction between the air and the upper airway mucosa when the air is not easily entered due to narrowing around the upper airway during breathing, and is a symptom mainly at bedtime. In other words, when the human body breathes air passes through a flexible tissue such as the palate, neck, tonsils, tongue, etc. During the day, the snoring phenomenon is hardly seen because the muscles around the pharynx maintain their positions and open the upper airway. However, during sleep, lowering of the muscles that make up the upper airway and congestion of the upper respiratory tract mucosa increases resistance and compliance of the temporal cavity, resulting in partial narrowing of the air passages, resulting in soft mucosal tissue as the air passes around the upper airway. Vibration will cause symptoms of snoring.

On the other hand, if the air passage is completely blocked due to severe muscle relaxation during sleep or other causes such as severe obesity, no air flows to the lungs, which is called sleep apnea. Therefore, excessive snoring symptoms can be said to be a symptom that indicates that the sleeping person has difficulty breathing. In addition, sleep respiratory disorders have been reported to occur easily in people with chronic respiratory diseases, neuromuscular diseases, obesity, upper respiratory morphology, and functional abnormalities.

If sleep apnea persists, lower intrathoracic pressure and hypoxia progress, which causes arousal, which increases the activity of the upper airway muscles, which wakes our body and constricts muscles, opening the air passages again. At this point, the patient takes a deep breath and resumes breathing.

As such, snoring symptoms do not sleep well by the person sleeping and cause sleep respiratory disorders, as well as damage to the family or people around them due to noise. Therefore, in the past, snoring was not particularly regarded as a disease, but in recent years, snoring is also recognized as a disease, and in order to treat or alleviate the symptoms, a lot of efforts and costs have been invested.

Here, look at the methods that are conventionally used to treat or alleviate snoring and sleep apnea.

First, change your sleeping posture or lifestyle. In other words, sleeping in the lateral position (sleeping sideways) posture can prevent the structure of the throat to slide down to block the air passage. However, when going to bed for a long time in the side and side position, there is a high risk of causing various side effects to the human body, such as back pain. In addition, drugs such as alcohol, alcohol, sedatives, sleeping pills, antihistamines, etc. slow and shallow the breathing to relax the muscles around the throat than usual to block the air passages. Therefore, reducing the intake of these medications may help prevent snoring or sleep apnea. You can also reduce snoring symptoms by losing weight, doing regular exercises to keep your muscles more elastic, and increasing lung activity. However, this method is temporary and does not provide a fundamental solution.

Second, there is treatment through surgery. Surgical methods are performed with the aim of expanding the airways by dissecting the structures of the throat. The most commonly used surgery is laser surgery to cut tissue around the throat. In other words, the operation of incision of the neck, part of the study canal and tonsils, and the extraction of the tissue is performed by the enlarged oral pharyngeal effusions such as the milk, unnecessary mucosa of the throat wall, hypertrophy in the soft palate, enlarged tonsil and unnecessary oral mucosa. Includes removal. This surgery has the effect of preventing snoring and sleep apnea to some extent by expanding the airways, but requires general anesthesia and hospitalization for one to two days after surgery. In addition, a few weeks after surgery, sore throat pain should eat a soft food.

Another surgical method is to remove the entire breast and part of the palate using a laser. This surgery can be done only with local anesthesia, and in some cases, the surgery may be repeated one or more times at intervals of several weeks. However, the surgical methods have to be cautious because food may enter the nose during meals or cause serious complications such as negative changes, infections, numbness of the tongue, and bleeding. There is also.

Third, the method of using a breathing aid. Mainly used in developed countries for the treatment of respiratory disorders, it is a method of forcibly pushing air into the airways during sleep (Continuous Positive Air Pressure). This method is excellent in terms of effectiveness, but the user must be provided with expensive equipment to inflate himself, and a mask must be worn in the mouth and nose during sleep, which makes the user uncomfortable.

Fourth, there is a method of attaching the device in the oral cavity. While sleeping, a special device is inserted into the mouth to treat breathing disorders during sleep. There are many different types of devices, which can be broadly categorized as pushing the entire lower jaw forward, pulling the entire lower jaw forward, pulling the tongue forward, and lifting the neck. have. These instruments were developed for the purpose of securing the upper respiratory tract, and are inconvenient to use, have low therapeutic effects, and have very low effectiveness of commercialization. In addition, it is not a practical solution to snoring and airway obstruction most of the mechanically expand the upper airway to solve the snoring and sleep apnea, so there is a disadvantage in discomfort and discomfort during wearing.

Fifth, it is a method of taking a recently developed therapeutic drug. Drugs used for this purpose include acetazoramid (carbonate dehydrogenase inhibitors), progesterone preparations (female hormones), tricyclics, cardiocyclic antidepressants (protriptyrin, clomipramine, imiprabin), Xanthine preparations are used. However, although the drug administration method may improve snoring and apnea symptoms to some extent, REM sleep associated with apnea is shortened and various side effects including urinary hesitation, impotence, rash and ataxia occur. Reported. In addition, methoxy protesterone acetate, tryptophan, serotonin precursor, and the like have also been used, but the medical efficacy is not so high.

Finally, there is a method of reducing friction between mucosal tissue and air by administering a local lubricant around the upper airway. For example, US Pat. No. 6,187,318 introduces a snoring improvement lubricating composition in which the oil component is stabilized by adding a carrageenan stabilizer to various edible oils. However, according to a research paper published by Dr. Joanne K. Tobacman of the University of Iowa, the carrageenan is a food additive that causes intestinal ulcers and develops malignant tumors. Have been reported {see US “Environmental Health Perspectives” October 2001}.

As described above, various methods for treating or alleviating snoring and sleep apnea have been attempted. However, the conventional methods are not fundamental solutions or provide excessive discomfort or psychological resistance to the patient, and in some cases, side effects occur. There were problems such as doing.

Therefore, in view of the fact that many people are experiencing snoring symptoms and snoring symptoms are increasing, snoring and sleep apnea can be alleviated more easily and at low cost without worrying about side effects. There is an urgent need for the development of new technologies.

An object of the present invention is to lubricate the nasal mucosa before bedtime to alleviate snoring and sleep apnea, the method of use is simple and low manufacturing costs, because it consists of herbal ingredients, there are no side effects, snoring In addition to alleviating this symptom, the present invention provides a new lubricious herbal composition that also has an effect of treating sleep promotion and bronchial inflammation.

Lubricant herbal composition for snoring and sleep apnea relief according to the present invention for achieving the above object is any one selected from soybean oil, corn oil, olive oil, almond oil, grapeseed oil, palm oil, sesame oil, perilla oil, almond oil or 5-50% by weight of two or more vegetable oils; 50 to 95% by weight of the herbal extract extracted from 20 to 60 parts by weight of 20-60 parts by weight of yellow root skin (elm bark) and 20 to 40 parts by weight of white porcelain and 20 to 80 parts by weight of acidic acid with 500 to 2000 parts by weight of water; Characterized in that it comprises a.
In addition, lubricating herbal composition for snoring and sleep apnea relief according to the present invention is any one or two or more vegetable oils selected from soybean oil, corn oil, olive oil, almond oil, grapeseed oil, palm oil, sesame oil, perilla oil, almond oil 27.0% by weight Wow; 68.7% by weight of the herbal extract extracted with 20-60 parts by weight of Yu-Geun skin (elm bark), 20-40 parts by weight of white porcelain and 20-80 parts by weight of acidic acid with 500-2000 parts by weight of water; 3.0 wt% of one or two or more coolants selected from spearmint oil, peppermint oil, xylitol; 1.3% by weight of any one or more antioxidants selected from vitamin C, vitamin E, grapefruit seed extract; Characterized in that consists of.

Hereinafter, the present invention will be described in more detail. The present invention consists of 5 to 50% by weight of vegetable oil and 50 to 95% by weight of herbal extract.

First, the vegetable oil is a lubricating material that smoothly applies the mucous membrane around the upper airway to reduce the friction between the mucosa tissue and the air as the air passes through the breath, thereby reducing the noise caused by snoring. do. The vegetable oil may be any one or two or more selected from soybean oil, corn oil, olive oil, almond oil, grape seed oil, palm oil, sesame oil, perilla oil and almond oil.

However, if only the vegetable oil is used, the vegetable oil is not uniformly applied to the intranasal mucosal tissue due to the lack of dispersibility and the incompatibility with moisture in vivo, and the vegetable oil is applied to the nasal mucosa for a long time. It is also difficult to remain. So, in the present invention, the herbal extract is used with the vegetable oil.

The herbal extract according to the present invention is extracted from 20 to 60 parts by weight and 20 to 40 parts by weight of white porcelain and 20 to 80 parts by weight of sanjoin with 500 to 2000 parts by weight of water. The herbal extract functions as a stabilizer for uniformly dispersing and emulsifying the vegetable oil in an aqueous solution, and at the same time, increases the viscosity of the vegetable oil to extend the time remaining in the nasal mucosa. In addition, the herbal extracts have an effect of improving snoring symptoms due to the inherent pharmacological effects of each herbal ingredient, and snoring patients can take a good night's sleep with psychological stability.

In the present invention, the desired effect can be obtained to some extent even if only one of the root skin, white porcelain, and sanjoin is used, but the most preferable effect is obtained when these three components are used simultaneously. In addition, if the content of the water used as the extraction solvent is 500 parts by weight or less, the extraction effect on the herbal ingredients is inferior, on the contrary, if it is 2000 parts by weight or more, the concentration of the herbal extracts is too thin, resulting in sufficient functions as stabilizers and thickeners. There is a fear that it can not be exercised.

In the present invention, the root component of the root extract of the herbal extract (elm bark) serves as a stabilizer and thickener, and at the same time serves to cure or alleviate insomnia and snoring symptoms. For reference, Pharmacokinetics says that "Yu-Geun-Yeop" mainly deals with Orim (五淋), controls insomnia, and cures snoring. " In addition, according to the New Nongbyeon Manuscript, "Yu-Geun-Pi is the dominant man who manages fecal discomfort, eases the capital, and removes fraud." 사) to control the four swelling (가), to reduce swelling and to treat children's head (頭 瘡), "also in the" herbaceous tree "" to make urine outsing well and infiltrate moist heat (濕熱 邪) It turns the essence and extinguishes the swelling. "

In addition, white porcelain acts as a stabilizer, antioxidant and thickener, and at the same time, snoring has the effect of stabilizing the mind and body of the patient. For reference, Baekjain is a representative ophthalmic medicine, and in <Nong-Nongbyeon>, it treats the boundary (驚悸: palpitation), stabilizes the five intestines comfortably, ripens (益氣), and moist (,: numbness). ), And in <Annex>, it treats ecstasy, shortness of breath, regurgitation (back pain), lower back pain, blood loss and late cold. "Ilja Jagyebon Herb" describes "treating winds and moisturizing the skin." In addition, the Chinese Herbal Dictionary has the effect of relieving the mind, stabilizing the mind, clarifying the intestines, and faeces, and having vigilance, insomnia, oil well, dohan, To treat constipation ”.

Lastly, Sanjoin is effective for snoring to stabilize the mind and body of patients, and acts as a stabilizer and thickener by working with other herbal ingredients. For reference, Sanjoin is said to cure heart pain, abdominal pain, extremity pain, and customary ache. Heal fever (虛熱), multi-sided (多 眠: excessive sleep), mental fatigue heal. " In addition, heals the essence and heals (혈: anemia), blows (번: chest tight, fever, thirsty), and cold (虛汗: weak body sweat) heals " In <Main Herb Life>, "When it comes to herbal medicine, it is mainly hepatobiliary, and the premature is sex ratio, scapula, and muscle and bone. , The first (지), jigal (止渴), and the effect of the () "is described.

In the present invention, if the content of the vegetable oil is 5% by weight or less or the content of the herbal extracts of 95% by weight or more, there is a fear that the snoring effect is not sufficiently exhibited by the lubrication function as a whole, and the content of the vegetable oil is 50% by weight. If it is abnormal or the content of the herbal extract is 50% by weight or less, the function of the stabilizer and the thickener is weakened, there is a fear that the vegetable oil is not uniformly applied to the nasal mucosa, or the time for showing the lubricating function is shortened.

On the other hand, the herbal extract according to the present invention may include 5 to 20 parts by weight of any one or more of soybean or algae, Angelica, sesame seeds, perilla extract in addition to the roots and white porcelain and sanjoin.

Soybean (大豆) works with other herbal ingredients to enhance the function of stabilizers, thickeners. According to <Primary herb,> soybean is said to have a sweet taste, flat or cold nature, and acts on the spleen and stomach. In addition, it helps to circulate the scalp well, urinates well, removes the wind and detoxifies it. It is introduced to release the poison.

Apricot (apricot seed) has a snoring effect such as asthma, a common disease in patients, and acts as an emulsifier and thickener by working with other drugs. For reference, according to <Agreement Bom>, apricot seeds are thick and act as expectoration when breathing is difficult or when the breath is short and the sputum is boiled.

Angelica moisturizes the nasal tissues. "Original gangnok" "Danggui has the effect of drainage pain and blood donation blood (和 血 補血) is effective for the treatment of headaches, all pains in the abdomen (heart 腹部), tumors, stomach, (,) It moisturizes and smoothes the musculature and skin of the musculature. " Also, in Chinese Medicinal Dictionary, "Donggui makes blood flow well, makes menstruation even, and stops pain. It also has the effect of stool and stops bleeding. Headache, hyeonhun, bruises, uterine fibroids, constipation, dyspareunia (), uterine dysplasia, nervous breakdown, uterine bleeding, "he said.

Sesame seeds are rarely used as food ingredients. Water-soluble liglan oil is present in trace amounts, and it has a function of controlling bio functions, thus enhancing immune function, preventing hangover, relieving stress, inhibiting cancer cell proliferation, enhancing liver function, and increasing blood pressure. Tryptophan and vitamin B6 are converted to serotonin to induce sleep.

Perilla also works with other herbal ingredients to enhance the function of stabilizers and thickeners. Especially, it contains fatty acid linoleic acid to prevent atherosclerosis, breast cancer and colon cancer, and contains a lot of vitamins E and F. It is known to help beauty.

On the other hand, the lubricious herbal composition according to the present invention may further comprise 0.5 to 5% by weight of any one or more cold agent selected from spearmint oil, peppermint oil, xylitol. The cold sensitizer makes the patient feel a refreshing feeling, and the function of securing the airway by shrinking the mucosal tissue in the upper airway, and at the same time serves to prevent caries. Since the lubricious herbal composition of the present invention is used in the oral cavity during bedtime, there is a risk of damaging the teeth. If the content of the cooling agent in the present invention is less than 0.5% by weight, the effect is too small meaningless, on the contrary 5% by weight or more is not good because there is a fear that the patient feels pain too strong.

Finally, the lubricious herbal composition according to the present invention may additionally comprise 0.2 to 4% by weight of any one or two or more antioxidants selected from vitamin C, vitamin E, grapefruit seed extract. Among the antioxidants, vitamin C prevents oxidation of water-soluble substances, vitamin E prevents oxidation of fat-soluble substances, and grapefruit seed extract functions as a natural preservative.

Hereinafter, examples of the present invention will be described.

<Example>

Next, herbal extracts and vegetable oils were prepared according to the following Tables 1 and 2, respectively, these herbal extracts and vegetable oils were mixed at the ratio of the following Table 3, and then the mixture was sufficiently stirred to prepare a lubricious herbal composition according to the present invention. It was.

Table 1 Preparation of herbal extracts

Ingredient Compounding ratio Root muscle 50 g White porcelain 30 g Mountain join 50 g Extract (water) 1,000 cc

Table 2) Preparation of Vegetable Oils

Ingredient Compounding ratio olive oil 11 wt% Sunflower oil 16 wt% Grapeseed oil 11 wt% Soybean milk 47 wt% Corn oil 11 wt% Hang In Yu 4 wt%

Table 3) Preparation of lubricious herbal composition

Composition usage Herbal extract 68.7 wt% vegetable oil 27 wt% Cold agent Xylitol 2 wt% Spearmint 0.5 wt% Peppermint 0.5 wt% Antioxidant Grapefruit Seed Extract 0.5 wt% Vitamin c 0.3 wt% Vitamin E 0.5 wt%

Experimental Example 1

The snoring alleviation effect was tested in 26 adult patients with snoring symptoms using the lubricious herbal composition prepared in the above example. The test subjects were 26 adult males with no health problems except snoring symptoms.

A. Status of test subjects

1) Have you ever used other drugs to treat or alleviate snoring symptoms before?

Total number of people Yes no 26 2 24

2) When did snoring start?

Years personnel % 1 to 10 years 13 people 50.0% 11-20 years 8 people 30.8% 21 years 5 people 19.2% system 26 people 100.0%

3) Have you ever heard complaints from your family or from people around you because of your snoring symptoms?

Total number of people Yes no 26 23 3

B. Test Method

Before bedtime, the lubricant herbal composition of the present invention was sprayed 4 to 5 times in the nasal cavity, observed for at least 2 hours after bedtime, and the degree of snoring of the test subjects was checked from the person and his / her bedtime the morning before.

C. Test Results

division Person ratio Very satisfied 12 46.2% satisfied 5 19.2% Slightly satisfied 4 15.4% dissatisfaction 5 19.2% system 26 100.0%

As can be seen from the test results, the lubricant composition of the present invention showed about 80% of the test subjects were generally satisfied.

The present invention is a method of applying the nasal mucosa before bedtime, easy to use, consisting of vegetable oil and herbal ingredients inexpensive manufacturing cost, no side effects, while snoring symptoms and at the same time sleep and bronchial inflammation It is effective to cure.

Claims (4)

5 to 50% by weight of any one or two or more vegetable oils selected from soybean oil, corn oil, olive oil, almond oil, grape seed oil, palm oil, sesame oil, perilla oil and almond oil; 50 to 95% by weight of the herbal extract extracted with 20 to 60 parts by weight of 20-60 parts by weight of Yu-Geun skin (elm bark) and 20 to 40 parts by weight of white porcelain and 20 to 80 parts by weight of acidic acid with 500 to 2000 parts by weight of water; Herbal composition for snoring and sleep apnea relief comprising a. delete The medicinal composition for snoring and sleep apnea relief according to claim 1, wherein the herbal extract further comprises 5 to 20 parts by weight of any one or more of soybean or algae, Angelica, sesame and perilla extract. 27.0 wt% of any one or two vegetable oils selected from soybean oil, corn oil, olive oil, almond oil, grape seed oil, palm oil, sesame oil, perilla oil and almond oil; 68.7% by weight of the herbal extract extracted with 20-60 parts by weight of Yu-Geun skin (elm bark), 20-40 parts by weight of white porcelain and 20-80 parts by weight of acidic acid with 500-2000 parts by weight of water; 3.0 wt% of one or two or more coolants selected from spearmint oil, peppermint oil, xylitol; 1.3% by weight of any one or more antioxidants selected from vitamin C, vitamin E, grapefruit seed extract; Lubricating herbal composition for snoring and sleep apnea relief, characterized in that consisting of.