CN104056081A - Traditional Chinese medicine preparation for treating epilepsy - Google Patents

Traditional Chinese medicine preparation for treating epilepsy Download PDF

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Publication number
CN104056081A
CN104056081A CN201410333430.5A CN201410333430A CN104056081A CN 104056081 A CN104056081 A CN 104056081A CN 201410333430 A CN201410333430 A CN 201410333430A CN 104056081 A CN104056081 A CN 104056081A
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grams
rhizoma
radix
chinese medicine
medicine preparation
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王星芹
孟云霞
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Ma Haiyan
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Abstract

The invention discloses a traditional Chinese medicine preparation for treating epilepsy. The traditional Chinese medicine preparation comprises the following selected raw material medicines by weight: 10-20g of pericarpium citri reticulatae, 10-20g of elecampane, 20-30g of rhizoma cyperi, 8-12g of defatted croton seed powder, 8-12g of amber, 8-12g of gastrodia elata, 8-15g of polygala tenuifolia, 10-20g of vermillion, 8-12g of rhizoma typhonii, 5-10g of Chinese trumpet creeper, 10-20g of rhizoma nardostachyos and 5-10g of black false hellebore. The selected medicinal materials have the effects of promoting blood circulation to remove blood stasis, restoring consciousness and nourishing marrow, eliminating phlegm and dispelling the wind, guiding qi downward and treating epilepsy and regulating vital energy and dispelling melancholy. The clinical application proves that the traditional Chinese medicine preparation has the advantages of obvious effect, complete treatment, no reoccurrence and zero toxic or side effect and is worthy of popularization and application.

Description

A kind of Chinese medicine preparation for the treatment of epilepsy
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation that can treat epilepsy.
Background technology
Epilepsy is commonly called as " sheep is insane crazy ", and " epilepsy " or " epilepsy " is that many reasons causes the paroxysmal movement due to brain neuroblastoma unit group paroxysmal paradoxical discharge, sensation, consciousness, spirit, a kind of disease that vegetative nerve function is abnormal.In Huangdi's Internal Classics before in two thousand 2 hundred, just record to some extent.People can't be very strange to this disease mostly, usually by popular being called of people " convulsion ".This disease belongs to a kind of chronic disease, when having patient to fall ill, clinical cardinal symptom faints suddenly, and foam at the mouth, eyes upwards turn over, and extremity knot, pale complexion or black, gnathospasma, head is to the cry that has pig, sheep or other animal in layback or when morbidity mouth, and after waking up, as ordinary person, nothing is peculiar especially.
The pathologic basis of epilepsy is because disappearance, necrosis or textural anomaly have occurred brain nervous cell, or blood supply obstacle etc., making brain cell maintain the stable ability of current potential declines, in a kind of unsure state, once inside and outside environment changes, the neurocyte that just may cause this position discharges suddenly, and from the close-by examples to those far off causes more polyneural cells Synchronous electric discharge.A lot of reasons can cause epilepsy, and particularly corticocerebral pathological changes be it is generally acknowledged relevant with four factors such as inherited genetic factors, cerebral lesion and brain injury, cranium brain Other diseases, environmental factorss.
Epileptics is a kind of generally acknowledged difficult and complicated illness, and conventional western medicine method exists a lot of drawbacks and toxic and side effects, and the impact of the various internal organs on human body is very large.As informal dress Western medicine easily causes cerebellar syndrome, dystropy is drowsiness, affects work and life, particularly Western medicine has infringement in various degree to liver, shows as that nauseating, vomiting, appetite decline, unable, lethargy etc., and toxic and side effects is large, cure the symptoms, not the disease, medication relies on strong.The existing traditional Chinese medical science is that onset is slow, the course for the treatment of long mostly, is difficult to the defects such as radical cure.
Summary of the invention
The invention solves at present in the defect and the deficiency that exist aspect treatment epilepsy, provide a kind of effect significantly, thorough treatment, without the Chinese medicine preparation of recurrence, the treatment epilepsy that has no side effect.
The technical solution adopted in the present invention is: a kind of Chinese medicine preparation for the treatment of epilepsy, it is characterized in that, and described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
Pericarpium Citri Reticulatae 10-20 gram, Radix Aucklandiae 10-20 gram, Rhizoma Cyperi 20-30 gram, Semen Crotonis Pulveratum 8-12 gram, succinum 8-12 gram, Rhizoma Gastrodiae 8-12 gram, Radix Polygalae 8-15 gram, cinnabar 10-20 gram, Rhizoma Typhonii 8-12 gram, Flos Campsis 5-10 gram, Radix Et Rhizoma Nardostachyos 10-20 gram, Rhizoma et radix veratri (Radix Rhizoma Veratri) 5-10 gram.
As this kind of prioritization scheme:
Described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
10 grams of Pericarpium Citri Reticulataes, 10 grams of the Radix Aucklandiae, 20 grams of Rhizoma Cyperis, 8 grams of Semen Crotonis Pulveratums, 8 grams of succinums, 8 grams, Rhizoma Gastrodiae, 8 grams of Radix Polygalaes, 10 grams of cinnabars, 8 grams of Rhizoma Typhoniis, 5 grams of Flos Campsiss, 10 grams of Radix Et Rhizoma Nardostachyos, 5 grams of Rhizoma et radix veratri (Radix Rhizoma Veratri)s.
As this kind of prioritization scheme:
Described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
15 grams of Pericarpium Citri Reticulataes, 15 grams of the Radix Aucklandiae, 25 grams of Rhizoma Cyperis, 10 grams of Semen Crotonis Pulveratums, 10 grams of succinums, 10 grams, Rhizoma Gastrodiae, 12 grams of Radix Polygalaes, 15 grams of cinnabars, 10 grams of Rhizoma Typhoniis, 8 grams of Flos Campsiss, 15 grams of Radix Et Rhizoma Nardostachyos, 8 grams of Rhizoma et radix veratri (Radix Rhizoma Veratri)s.
As this kind of prioritization scheme:
Described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
20 grams of Pericarpium Citri Reticulataes, 20 grams of the Radix Aucklandiae, 30 grams of Rhizoma Cyperis, 12 grams of Semen Crotonis Pulveratums, 12 grams of succinums, 12 grams, Rhizoma Gastrodiae, 15 grams of Radix Polygalaes, 20 grams of cinnabars, 12 grams of Rhizoma Typhoniis, 10 grams of Flos Campsiss, 20 grams of Radix Et Rhizoma Nardostachyos, 10 grams of Rhizoma et radix veratri (Radix Rhizoma Veratri)s.
The instructions of taking of above-mentioned Chinese medicine preparation is: after the Chinese herb of above-mentioned weight proportion is mixed, get its medicine juice according to the method for the fried Chinese medicine of tradition, 1 dose of every day, point 2 clothes, ten days are a course for the treatment of.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Pericarpium Citri Reticulatae, acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.There is regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm, effect of diuretic relieving constipation.
Radix Aucklandiae acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.There are promoting the circulation of QI to relieve pain, effect of intestinal stasis relieving in tune.
Rhizoma Cyperi, acrid in the mouth, micro-hardship, sweet, property is flat; Enter liver spleen tri-jiao channel.There is dispersing the stagnated live-QI to relieve the stagnation of QI, menstruction regulating and pain relieving, the effect of regulating the flow of vital energy in adjusting.
Semen Crotonis Pulveratum, acrid in the mouth, heat; Return stomach, large intestine channel.There is drastic purgation to treat cold constipation, the detumescence of relieving oedema or abdominal distension through diuresis or purgation, effect of phagedenoma putrefaction removing
Succinum, sweet in the mouth, property are put down; GUIXIN, liver, small intestinal, bladder, lung, spleen channel.There is tranquillizing the mind by relieving convulsion, dissipating blood stasis hemostasis, relieving stranguria by diuresis, effect of removing nebula improving eyesight.
Rhizoma Gastrodiae, nature and flavor are sweet, flat; Enter Liver Channel.Have suppressing the hyperactive liver to relieve the wind syndrome, wind-expelling pain-stopping, reduces blood pressure, and improving eyesight increases effect of intelligence.
Radix Polygalae, property is pungent, hardship, temperature; GUIXIN, kidney, lung meridian.There is waking up the patient from unconsciousness by clearing away phlegm, effect of the Fructus Alpiniae Oxyphyllae of calming the nerves.
Cinnabar, sweet in the mouth, cold; GUIXIN warp.There is tranquilizing mind, effect of heat-clearing and toxic substances removing.
Rhizoma Typhonii, property is pungent, temperature; Return stomach, Liver Channel.There is the arresting convulsion of eliminating the phlegm, effect of detoxicating and resolving stagnation of pathogens pain relieving.Be used for middle wind-phlegm and stop up, facial hemiparalysis, the disease such as language is puckery stuttering, syncope due to accumulation of phlegm headache.
Flos Campsis, acrid in the mouth, is slightly cold; Return liver, pericardium channel.There is dissipating blood stasis to promote menstruationg, effect of cooling blood, expelling wind.
Radix Et Rhizoma Nardostachyos, taste acrid, sweet, warm; Return spleen, stomach warp.There are promoting the circulation of QI to relieve pain, effect of relieving stagnation and activating the spleen.
Rhizoma et radix veratri (Radix Rhizoma Veratri), acrid in the mouth, hardship, cold; Return lung, stomach, Liver Channel.There is vomiting wind-phlegm by emesis, effect of parasite killing furuncle.
Chinese medicine has saying of " the many stasis of bloods of prolonged illness ", for epileptics, has blood stasis symptom, and application activating blood and removing stasis Method is advisable.But for part epilepsy syndrome, sometimes stasis blocking resemble not obviously, but sick difficult for a long time,, also can be used in conjunction with promoting blood circulation to remove obstruction in the collateral and treat significantly time by other method for the treatment of effects, often can receive curative effect.Therefore in treatment when epileptics, with blood circulation promoting and blood stasis dispelling, regulating menstruation dredging collateral, nourishing YIN for attracting YANG, determines epilepsy and relieves dizziness, high fever, infantile convulsions, epilepsy, etc. and be as the criterion.
Chinese medicine preparation of the present invention, Pericarpium Citri Reticulatae, Rhizoma Cyperi, the Radix Aucklandiae are joined altogether can regulating the flow of Qi and the middle Jiao, menstruction regulating and pain relieving; The Semen Crotonis Pulveratum detumescence of can relieving oedema or abdominal distension through diuresis or purgation, phagedenoma putrefaction removing; Succinum, Radix Polygalae are associated with and can be determined epilepsy and relieve dizziness, high fever, infantile convulsions, epilepsy, etc., dissipating blood stasis hemostasis; Cinnabar, Rhizoma Typhonii, Rhizoma et radix veratri (Radix Rhizoma Veratri) three medicines mutual 5 can heat-clearing and toxic substances removing, tranquilizing mind, waking up the patient from unconsciousness by clearing away phlegm; Rhizoma Gastrodiae can suppressing the hyperactive liver to relieve the wind syndrome, nourishing YIN for attracting YANG; Flos Campsis can dissipating blood stasis to promote menstruationg, cooling blood, expelling wind; Radix Et Rhizoma Nardostachyos can promoting the circulation of QI to relieve pain, invigorating the spleen and benefiting QI; All medicines gather waking up the patient from unconsciousness by clearing away phlegm altogether, dredging collateral is only jerked, and relieves dizziness, high fever, infantile convulsions, epilepsy, etc. and determines epilepsy, effect of the resolving depression of regulating the flow of vital energy, can promote the metabolism of patient's neuron to accelerate, infiltration activates injured neurons cell, until functional rehabilitation, balance paradoxical discharge, make pericaryon cell transmembrane potential difference recover normal, ion channel on dredging cell space film, recovers body various functions in brain, reaches the object of clinical cure epilepsy.
For further investigating the clinical efficacy of medicine of the present invention, we have selected 82 routine patients to carry out clinical trial, male's 45 examples, and women's 37 examples, the course of disease 3 months-16 years, between 16~43 years old age.Outbreak inducement all belongs to repeatedly risk factor, by statistics, fatigue is brought out 12, is seen a film, TV brings out 3 examples, 10 examples are brought out in menstruation, fever is brought out, drink and bring out that 8 examples, scaring are brought out, anger is brought out 23 examples, 3 examples are brought out in examination, other inducement 23 examples, patients approximately more than half have two or more inducements concurrently, and all the other case inducements are not clear.Be divided at random treatment group and matched group, every group of 41 examples.In seizure frequency, send out author's 18 examples every day, monthly send out author's 48 examples, the several months is sent out author's 16 examples.When patient shows effect, mostly have suddenly and faint, foam at the mouth, eyes upwards turn over, and extremity knot, pale complexion or black, gnathospasma, head is to the cry that has pig, sheep or other animal in layback or when morbidity mouth, the symptoms such as nothing is peculiar especially as ordinary person after waking up.
Criterion of therapeutical effect:
To start the seizure frequency before drug administration is treated, basis as a comparison.The degree reducing by outbreak, is divided into three grades of Estimating curative effects.
Effective: outbreak reduces more than 90%.
Effective: outbreak reduces more than 50%.
Invalid: outbreak reduces less than 50%.
Therapeutic Method:
Treatment group is taken the Chinese medicine preparation of embodiment 2, gets its medicine juice according to the method for the fried Chinese medicine of tradition, and 1 dose of every day, point 2 clothes, ten days are a course for the treatment of, take the circumstances into consideration to increase and decrease Chinese medicine weight ratio according to disease serious degree.Matched group is according to disease serious, and 1. grand mal is selected phenobarbital 90-300mg/d.Sodium valproate 0.6-1.2/d, carbamazepine 600-1200mg/d etc.2. complex partial seizures: phenytoin Sodium 0.2-0.6/d, carbamazepine 0.2-1.2/d.3. petit mal: clonazepam 5-25mg/d, stable 7.5-40mg/d.4. status epilepticus: first-selected stable 10-20mg/ quiet note.
Medication is noted:
Drug dose, from usual amounts lower bound, increases to gradually the serious toxic and side effects of outbreak control ideal and nothing and is advisable.
Female patient sends out author in menstrual phase, at suitable increment premenstruum, after menstrual period, recovers commercial weight.Outbreak frequently, needs by the state of an illness, can increase dosage.
That adds up patient's drug administration the results are shown in Table one.In treatment group, epileptic cures 26 examples, cure rate 63.4%, effective 13 examples, total effective rate 95.1%; Matched group is cured 16 examples, cure rate 39.0%, effective 16 examples, total effective rate 78.0%; Add up each group of patient, treatment group have no occur feeling sick, the symptom such as vomiting, appetite decline, unable, lethargy, matched group has 23 routine patients to occur erythra in various degree, dizzy, drowsiness, disequilibrium and gastrointestinal reaction, all take treatment measure in time.
Table one: the curative effect comparision result after two groups of case treatments
Group Number of cases Cure n (%) Effectively n (%) Invalid n (%) Total effective rate (%)
Treatment group 41 26(63.4) 13(31.7) 2(4.9) 95.1
Matched group 41 16(39.0) 16(39.0) 9(22.0) 78.0
Result shows, Chinese medicine preparation of the present invention has good efficacy to epilepsy, and Chinese medicine preparation instant effect of the present invention, evident in efficacy, with low cost, be difficult for recurrence, and without any side effects.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine preparation for the treatment of epilepsy, choose 10 grams of Pericarpium Citri Reticulataes, 10 grams of the Radix Aucklandiae, 20 grams of Rhizoma Cyperis, 8 grams of Semen Crotonis Pulveratums, 8 grams of succinums, 8 grams, Rhizoma Gastrodiae, 8 grams of Radix Polygalaes, 10 grams of cinnabars, 8 grams of Rhizoma Typhoniis, 5 grams of Flos Campsiss, 10 grams of Radix Et Rhizoma Nardostachyos, 5 grams of Rhizoma et radix veratri (Radix Rhizoma Veratri)s.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of epilepsy, choose 15 grams of Pericarpium Citri Reticulataes, 15 grams of the Radix Aucklandiae, 25 grams of Rhizoma Cyperis, 10 grams of Semen Crotonis Pulveratums, 10 grams of succinums, 10 grams, Rhizoma Gastrodiae, 12 grams of Radix Polygalaes, 15 grams of cinnabars, 10 grams of Rhizoma Typhoniis, 8 grams of Flos Campsiss, 15 grams of Radix Et Rhizoma Nardostachyos, 8 grams of Rhizoma et radix veratri (Radix Rhizoma Veratri)s.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of epilepsy, choose 20 grams of Pericarpium Citri Reticulataes, 20 grams of the Radix Aucklandiae, 30 grams of Rhizoma Cyperis, 12 grams of Semen Crotonis Pulveratums, 12 grams of succinums, 12 grams, Rhizoma Gastrodiae, 15 grams of Radix Polygalaes, 20 grams of cinnabars, 12 grams of Rhizoma Typhoniis, 10 grams of Flos Campsiss, 20 grams of Radix Et Rhizoma Nardostachyos, 10 grams of Rhizoma et radix veratri (Radix Rhizoma Veratri)s.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is further verified:
Case 1
Wang, man, 24 years old.Patient's course of disease 7 years, shakes all over when outbreak, grinds one's teeth in sleep, and lisps, unconscious.Approximately monthly outbreak once, is carried out medical treatment in Duo Jia hospital before this, but does not do other treatment except taking medicine, but poor effect, doctor checks as a child head injuries of prompting, congestion is made.Upon somebody's introduction, take Chinese medicine preparation of the present invention and treat, after one month, the health mental status takes a turn for the better, and appetite increases, sleep improvement, and spirit is good, continues to take after second month, during this time always without outbreak.Follow up a case by regular visits to half a year without recurrence.
Case 2
Jiang, man, 32 years old.The time that patient falls ill is for the first time 12 years old, and disease symptom was not obvious at that time, and the obvious number of times of sequela symptom is frequent, and convulsive seizure is frequent, not occurrences in human life, and binocular stravismus, mouthful bend neck is strong, gnathospasma, slobbering, cyanotic lips.Duration of seizure is more than 5 minutes.After be diagnosed as epilepsy.After alleviating with Western medicine, still frequent recurrence, January 2-3 time.Visit too much therapeutic effect not good.Take Chinese medicine preparation of the present invention and treat, after one month, the state of an illness is clearly better, and only occur once during this time, and time remaining is shorter, and symptom alleviates.Continue to take after three courses for the treatment of of Chinese medicine preparation of the present invention, occur without rebound phenomenon, the health mental status also greatly takes a turn for the better.Follow up a case by regular visits to 1 year without recurrence.
Case 3
Feng, female, 20 years old.When patient 9 years old, faint from fear because once high delivery in hot weather is raw, then outbreak often, each outbreak all can fall down to the ground suddenly, extremity are stiff, unconsciousness, spit out white foams, and duration of seizure continues 2-3 minute, and monthly outbreak several, through examining as epileptics.Give oral sodium valproate routinely consumption take.After one month, still can not get controlling, attack times obviously increases on the contrary, arrives again the treatment of Shuo Jia epilepsy section hospital in then several years, and Chinese medicine, Western medicine were all eaten, and effect neither be very desirable.Take upon somebody's introduction Chinese medicine preparation of the present invention and treat, after taking medicine one month, monthly attack times reduces, never outbreak after taking medicine three months.Take the circumstances into consideration to increase and decrease drug ratio according to health afterwards, continue to take and consolidate two months, successfully break away from epileptics, cure.Follow up a case by regular visits to 2 years without recurrence.
Case 4
Lin, female, 35 years old, patient because scaring is suffered from epilepsy, fell down to the ground suddenly when outbreak before 4 years, spat out white foams, tic of the limbs, after within 2-3 minute, alleviating, made a scene, dances for joy, ran everywhere, continued lethargy in about 15 minutes, and after waking up, the thing of generation is entirely ignorant of.Be epileptics after diagnosing.Repeatedly take western medicine, but effect is bad, still again and again occurs recurrence, patient's stress is huge, has affected normal work and life.Upon somebody's introduction, take Chinese medicine preparation of the present invention after one month, sb.'s illness took a favorable turn, and condition feels obvious improvement, takes after three month, and disease attack rate obviously reduces, and continues to take and carry out after treatment in 3 months, and the state of an illness greatly takes a turn for the better.Normal through clinical examination electroencephalogram, epilepsy is not reaccessed.Follow up a case by regular visits to not recurrence so far.

Claims (4)

1. a Chinese medicine preparation for the treatment of epilepsy, is characterized in that, described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
Pericarpium Citri Reticulatae 10-20 gram, Radix Aucklandiae 10-20 gram, Rhizoma Cyperi 20-30 gram, Semen Crotonis Pulveratum 8-12 gram, succinum 8-12 gram, Rhizoma Gastrodiae 8-12 gram, Radix Polygalae 8-15 gram, cinnabar 10-20 gram, Rhizoma Typhonii 8-12 gram, Flos Campsis 5-10 gram, Radix Et Rhizoma Nardostachyos 10-20 gram, Rhizoma et radix veratri (Radix Rhizoma Veratri) 5-10 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
10 grams of Pericarpium Citri Reticulataes, 10 grams of the Radix Aucklandiae, 20 grams of Rhizoma Cyperis, 8 grams of Semen Crotonis Pulveratums, 8 grams of succinums, 8 grams, Rhizoma Gastrodiae, 8 grams of Radix Polygalaes, 10 grams of cinnabars, 8 grams of Rhizoma Typhoniis, 5 grams of Flos Campsiss, 10 grams of Radix Et Rhizoma Nardostachyos, 5 grams of Rhizoma et radix veratri (Radix Rhizoma Veratri)s.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
15 grams of Pericarpium Citri Reticulataes, 15 grams of the Radix Aucklandiae, 25 grams of Rhizoma Cyperis, 10 grams of Semen Crotonis Pulveratums, 10 grams of succinums, 10 grams, Rhizoma Gastrodiae, 12 grams of Radix Polygalaes, 15 grams of cinnabars, 10 grams of Rhizoma Typhoniis, 8 grams of Flos Campsiss, 15 grams of Radix Et Rhizoma Nardostachyos, 8 grams of Rhizoma et radix veratri (Radix Rhizoma Veratri)s.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation comprises the Chinese herb of following weight in grams:
20 grams of Pericarpium Citri Reticulataes, 20 grams of the Radix Aucklandiae, 30 grams of Rhizoma Cyperis, 12 grams of Semen Crotonis Pulveratums, 12 grams of succinums, 12 grams, Rhizoma Gastrodiae, 15 grams of Radix Polygalaes, 20 grams of cinnabars, 12 grams of Rhizoma Typhoniis, 10 grams of Flos Campsiss, 20 grams of Radix Et Rhizoma Nardostachyos, 10 grams of Rhizoma et radix veratri (Radix Rhizoma Veratri)s.
CN201410333430.5A 2014-07-08 2014-07-08 Traditional Chinese medicine preparation for treating epilepsy Pending CN104056081A (en)

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Application publication date: 20140924