KR20100043010A - Composition for improving and preventing snoring - Google Patents

Abstract

PURPOSE: A composition containing tannin for relieving and preventing snoring is provided to ensure simple portability and to prevent sleep apnea syndrome. CONSTITUTION: A composition for relieving and preventing snoring comprises 0.1-10 weight% of tannin based on total composition weight. The composition also contains 0.1-10 weight% of alum. The composition also contains Schizandrae Fructus, platycodon grandiflorum, Liriopis Tuber or Cnidii Rhizoma. The dose of the tannin or alum is 1~1000mg/day. The composition is manufactured in a tablet form.

Description

Composition for improving and preventing snoring

The present invention constricts the muscles or mucous membranes of the throat around the throat, so that the mucous membrane of the neck or the study area around the throat is sagging or the tonsils are enlarged during sleep. The present invention relates to a composition for improving and preventing snoring, and more particularly, to a composition for improving and preventing snoring, comprising tannin. In addition, the composition of the present invention provides tablet and candy-like compositions for snoring improvement, including functional ingredients such as alum, Schizandra chinensis, Bellflower, Magmundong, Cheongung.

In general, snoring (snoring) is a noise phenomenon caused by the friction between the air and the upper airway mucosa when the air is not easily entered due to narrowing around the upper airway during breathing, and is a symptom mainly at bedtime. In other words, when the human body breathes, the air passes through flexible tissues such as the palate, neck, tonsils, tongue, etc. During the day, the pharyngeal main gastrocnemius maintains its position and opens the upper airway so that the snoring phenomenon rarely occurs. However, during sleep, lowering of the muscles that make up the upper airway and congestion of the upper respiratory tract mucosa increases resistance and compliance of the temporal cavity, resulting in partial narrowing of the air passages, resulting in soft mucosal tissue as the air passes around the upper airway. Vibration will cause symptoms of snoring.

On the other hand, if the air passage is completely blocked due to severe muscle relaxation during sleep or other causes such as obesity, no air flows to the lungs, which is called sleep apnea. Therefore, excessive snoring symptoms can be said to be a symptom that indicates that the sleeping person has difficulty breathing. In addition, sleep respiratory disorders have been reported to occur easily in people with chronic respiratory diseases, neuromuscular diseases, obesity, and morphological and functional abnormalities of the upper airway.

If sleep apnea persists, lower intrathoracic pressure and hypoxia progress, which causes arousal, which increases the activity of the upper airway muscles, which wakes our body and constricts muscles, opening the air passages again. At this time, the patient breathes greatly and then resumes breathing.

As such, snoring symptoms do not sleep well by the person sleeping and cause sleep respiratory disorders, as well as damage to the family or people around them due to noise. Therefore, in the past, snoring was not particularly regarded as a disease, but recently, snoring is also recognized as a disease.

In other words, snoring or sleep apnea rapidly reduces or stops the amount of oxygen supplied to the human body through breathing, resulting in an abnormally fast heart rate and rough blood flow that can damage blood vessels and cause various diseases. The main cause of hypertension is snoring, snoring is 3 times higher in the incidence of diabetes and 10 times higher in the incidence of diabetes, and snoring is 75% of obese people with severe erectile dysfunction, especially When a child snores, it is about 20 times lower than the average IQ, and 66% of male drivers who have had a traffic accident are snorers.

In order to treat such snoring and sleep apnea can be divided into five methods currently proposed.

First, changes in sleep methods and lifestyles. Sleeping sideways can prevent the structures in the throat from slipping back and block the air passages, while drugs such as alcohol, sedatives, sleeping pills and antihistamines slow and shallow the breath and relax the muscles around the throat more than usual. Reducing these drugs can also help reduce snoring and sleep apnea. You can also reduce snoring by losing weight and doing regular exercises to keep your muscles more elastic and boost your lungs.

However, this method cannot be a fundamental treatment, and even if it is treated, the snoring can be passed for a very long time, so the patient will have to take longer discomfort than other methods that can be treated in a short period of time. In case it would make sense.

Second, there is a snoring treatment through surgery, most of the surgery is performed to tighten or remove the structure of the throat to widen the airway. The most commonly used type of surgery is to cut off the surrounding tissues of the throat. That is, surgery to remove the neck, part of the furrows and tonsils from the throat. Extraction of the tissues is often enlarged, such as neck milk, unnecessary mucosal walls of the throat, hypertrophy in the soft palate, enlarged tonsils and unnecessary oral mucosa. Removal of oral pharyngeal effluents.

This surgery has the effect of preventing the snoring and sleep apnea to some extent by expanding the airway, but requires a general anesthesia and hospitalization for one to two days after the operation. In addition, a few weeks after surgery, sore throat pain should eat a soft food.

Another surgical method is to remove the entire breast and part of the palate using a laser. This surgery can be done only with local anesthesia, and in some cases, the surgery may be repeated one or more times at intervals of several weeks. However, the above surgical methods may cause serious problems that may cause complications such as food entering the nose during meals, negative changes, infections, paresthesia of the tongue, bleeding, etc., so care must be taken, and sometimes do not improve after surgery There is also.

Third, the method of using a breathing aid. Mainly used in developed countries for the treatment of respiratory disorders, it is a method of forcibly pushing air into the airways during sleep (Continuous Positive Air Pressure). This method is excellent in terms of effectiveness, but the user must be provided with expensive equipment to inflate himself, and a mask must be worn in his mouth and nose during sleep, making the user uncomfortable.

Fourth, there is a method of attaching the device in the oral cavity. While sleeping, a special device is inserted into the mouth to treat breathing disorders during sleep. There are many different types of devices, which can be broadly categorized as pushing the entire lower jaw forward, pulling the entire lower jaw forward, pulling the tongue forward, and lifting the neck. have. These instruments were developed for the purpose of securing the upper respiratory tract, and are inconvenient to use due to the characteristics of the instruments, have low therapeutic effects, and have very low effectiveness of commercialization. In addition, it is not a practical solution to snoring and airway obstruction most of the mechanically expand the upper airway to solve the snoring and sleep apnea because there is a disadvantage in discomfort and discomfort during wearing.

Fifth, it is a method of taking a recently developed therapeutic drug. Several studies have used trotriptyline, non-sedating, tricyclic antidepressants, etc., but these methods have been associated with shorter REM sleep associated with apnea, although snoring and apnea have been somewhat reduced. The decrease rose. In addition, side effects including urinary hesitation, impotence, rash and ataxia occurred. In addition, methoxyprotestone acetate was used, but the effect was not very high in the medical statistics. Similarly, tryptophan, serotonin precursor, and the like were sometimes used, but the utility was hardly found.

As described above, various methods for treating or alleviating snoring and sleep apnea have been tried in the related art, but the conventional methods are not fundamental solutions, or give patients excessive discomfort or psychological resistance, and in some cases, side effects There were problems such as this happening.

The present invention is to solve the problems described above, in view of the reality that many people are experiencing snoring symptoms, and the damage caused by snoring phenomenon is increasing, more convenient and lower cost to side effects It is an object of the present invention to provide a composition for snoring improvement and prevention that can improve and prevent snoring without concern. In addition, there is another object to provide a composition for snoring improvement and prevention that can simultaneously solve the serious problems associated with snoring, sleep apnea, erectile dysfunction, and sleep disturbance.

In order to solve the above problems, the present invention provides a composition for snoring improvement and prevention, comprising tannin (tannin). In addition, the composition of the present invention provides tablet and candy-like compositions for snoring improvement, including functional ingredients such as alum, Schizandra chinensis, Bellflower, Magmundong, Cheongung.

The composition of the present invention is a tablet and candy composition for preventing snoring containing tannin, which is taken 1 to 3 hours before bedtime, and is very simple to use, easy to carry, and has no side effects, and is used at low cost. This has a possible effect. In addition, there is also an effect that can simultaneously solve the sleep apnea and sleep disturbance accompanying snoring without side effects.

The present invention provides a snoring improvement and prevention composition comprising a tannin (tannin).

The composition may include 0.1 to 10% by weight of tannin, and preferably 0.5 to 5% by weight, based on the total weight of the composition.

In the present invention, the composition may further include alum.

The composition may include 0.1 to 10% by weight of the alum, preferably 0.5 to 5% by weight, based on the total weight of the composition.

In addition, the weight ratio of the tannin and alum in the present invention may be 1: 0.1 to 10.

In the present invention, the composition may further comprise one or more selected from Schizandra chinensis, bellflower, pulmonary dong and cheongung.

Hereinafter, the snoring improvement and prevention composition of the present invention will be described in more detail.

The composition of the present invention relates to a snoring improvement and prevention composition characterized in that it contains tannin (tannin), and further comprises a snoring symptom, including Schisandra chinensis, bellflower, pulmonary dong, cheongoung, etc. It relates to a functional composition that can alleviate the pain of people with disabilities.

Tannin, which is the main component of the composition of the present invention, is an aromatic compound having a large number of phenolic hydroxyl groups, although the constituent components are separated into the crystalline phase as a single substance, most of them are a mixture of several kinds of substances, white or It is obtained as a pale brown amorphous powder. It is a kind of polyphenol with a very bitter taste. It is synthesized by plants and precipitated by binding to protein, and the molecular weight of tannin is more than 500 to 20,000.

There are two representative classification of tannins. One is divided into hydrolyzable tannins, which are hydrolyzed upon dilution with dilute acid to produce gallic acid or eractic acid, and condensed tannins that polymerize to produce red or brown precipitates of probafen. The other method is divided into a pyrogallol system which mainly produces pyrogallol by alkali melting, a catechol system which mainly produces catechol, and an intermediate thereof. When hydrolyzed, galactanine is mainly produced, and galaxanthin is produced, called eraditannin. Many of them are composed of sugars (usually glucose) and esters of one or several phenolcarboxylic acids, and are hydrolyzed by tanases.

The pyrogallol-based tannins contain tannins, such as smarks, chestnuts, oaks, and balonia, as well as gall bladder and gluttony, and generally have strong astringent properties. It becomes blue by iron white solution and then turns black, and bromine water does not produce a precipitate but becomes blue by lime water. In contrast, the catechol system contains tannins such as mangroves, oak (bark), mimosa (wattle), kepraco, gambia, and generally has low astringent properties. In addition, it becomes green by black iron and then turns black. It precipitates by bromine water and does not develop color by lime water.

The distribution in the plant system is very wide, usually in less ripe fruits or seeds, and tends to decrease with maturity. This may indicate that tannins are metabolizable, but their physiological function is not known.

Imported tannin extract is mainly used in Korea. The production of blue black ink using blue iron by reacting with iron (III) salt in addition to skin repellent, separation or quantification of metal ions using metal ions to produce colored precipitates Tannin acid, which is used to purify gallotannin, is astringent, hemostatic agent, and albumin tannin that combines egg white and tannic acid.

Tannins can significantly improve or prevent the sound of snoring (snoring) through throat and mucosal contraction around the throat when the mucous membrane of the neck or the periphery of the study area is sagging or the tonsils are enlarged and the airway narrows. Can be.

Alum, which is another main component of the composition of the present invention, is a double salt made by aluminum sulfate and sulfate of monovalent metal. Alkali metals other than lithium, potassium, ammonium, etc. are used as monovalent metals. . Double salts refer to salts in which two or more salts combine, and the ions in the salts do not form polyatomic ions such as complex ions, but exist as independent ions. Alum is also known as alum and has the general formula of MAl (SO ₄ ) ₂ .12H ₂ O or M ₂ SO ₄ .Al ₂ (SO ₄ ) ₃ .24H ₂ O. M is a monovalent metal. It is called potassium alum (KAl (SO ₄ ) ₂ · 12H ₂ O), ammonium alum ((NH ₄ ) Al (SO ₄ ) ₂ · 12H ₂ O), etc., depending on what monovalent metal ions are contained. In addition, a case where other trivalent metal ions such as Ti, V, Cr, Mn, Fe, Co, Rn, Ir, Ga, In are substituted in place of aluminum is also referred to as alum in a broad sense. It is named after each metal ion. For example, (NH ₄ ) Fe (SO ₄ ) ₂ .12H ₂ O is called ammonium-iron alum.

Any alum crystals dissolve in water. When the crystal is heated, it is dissolved in the crystal water to form a solution. Most of the alum we talk about are potassium alum. Potassium alum is used as a coagulant or mordant, and mordant refers to a material that helps dyeing well by connecting dyes with fibers to be dyed. This is why the use of alum is used to paint balsam nails. Sodium alum, dehydrated by heating potassium alum, is used as an astringent (收斂 劑) that has the effect of inhibiting hemostasis or diarrhea. Alum also improves and prevents snoring by contracting muscles that are severely relaxed during sleep, and combines with tannins to show excellent effects in improving and preventing snoring symptoms.

Tannins or alums, which are compositions of the present invention, can be administered in known pharmaceutical dosage forms. The dosage of tannin or alum can vary depending on a number of factors, including the age of the patient, the severity of the pathology and the patient's past history and are always within the discretion of the attending physician, but generally the full dosage range of tannin or alum Is 1 to 1000 mg / day, preferably 5 to 200 mg / day, more preferably 20 mg / day, which may be administered in two or more divided doses, but administered about 1 to 3 hours before bedtime improves snoring during sleep. And a prophylactic effect. At this time, when tannin and alum are administered at the same time, the weight ratio of tannin and alum is set to 1: 0.1 to 10 to improve synergistic effects due to mutual coupling.

If only tannin is administered, less than 1 mg / day may not have the effect of relaxed muscle contraction during sleep, and over 1000 mg / day may cause heartburn or stomach upset, and tannin may excessively interfere with iron absorption. . However, there is no side effect if administered within this range. In addition, even when only alum is administered less than 1mg / day snoring is not effective in improving, if more than 1000mg / day aluminum contained in the alum may adversely affect the cerebrum.

Oral dosage forms are preferred compositions for use in the present invention, which are known pharmaceutical forms for such administration, such as tablets, capsules, granules, syrups and aqueous or oily suspensions. Excipients used in the preparation of such compositions are excipients known in the pharmaceutical and food arts. Tablets may contain active compounds and fillers (e.g. calcium phosphate), disintegrants (e.g. corn starch), lubricants (e.g. magnesium stearate), binders (e.g. microcrystalline cellulose or polyvinylpyrrolidone), and mixtures thereof. It can be prepared from mixtures with any other ingredients known in the art that can be purified by known methods. Tablets may be formulated in a manner known to those skilled in the art for sustained release of the tannins and / or alum of the invention.

In addition, in the present invention, conventional additives that may be added in the production of other foods (candy, etc.) may be added. More specifically, by adding the tannin 0.01 to 5% by weight and the alum 0.01 to 5% by weight relative to the total weight of the candy can be prepared candy containing tannin and alum.

Schisandra chinensis, an additional composition component of the present invention, protects lung function, attenuates chronic bronchitis and pharyngitis sputum, promotes spermatogenic bile branches, and schizolic acid of Schisandra chinensis removes the mucous membranes that block the passage of the airways. Let's do it.

In addition, the bellflower, an additional composition component of the present invention, is a perennial herb belonging to the family Campanula, the main pharmacological component is triterenoids (triteroenoid) -based saponins, which subsides the swollen tonsil with strong antioxidant activity, acute bronchitis, pneumonia, And diseases such as asthma.

In addition, Macmundong, an additional composition component of the present invention, is a perennial herb of the Liliaceae lily family, enhances pulmonary function of tuberculosis, replenishes the pulmonary fluid and is used for respiratory diseases and chronic sore throat. In addition, Macmundong has various medicinal effects and almost no side effects, so it is easy to use and shows excellent efficacy even in chronic marine diseases.

In addition, cheonggung, an additional composition component of the present invention, has been found to have a coercive action, a contraction action, and an antifungal action in pharmacological experiments, and the essential oil component is excitable in a small amount with respect to the central nervous system. Taste is hot and helps to keep warm celestial energy and tendons.

In the present invention, tannin and alum can be added one or more selected from Schisandra chinensis, Bellflower, Magmundong, and Cheonung, and Schisandra, Bellflower, Magmundong and Cheongung in consideration of the improvement effect of snoring and tannin and / or alum. The total amount of one or more selected from the range of 1 to 1000 mg / day, preferably 5 to 200 mg / day, more preferably 10 mg / day may be.

Hereinafter, examples and experimental examples of the present invention. However, the following examples and the like are intended to describe the present invention in more detail, and the scope of the present invention is not intended to be limited thereto.

Example 1 Preparation of a Tablet Composition Comprising Tannins and Alum

Tannin and alum purchased from a specialized chemical purchaser (Shin Won Trading Co.) was prepared, and a tablet-type snoring improvement and prevention composition was prepared by a method of preparing a conventional tablet.

20 mg of tannin, 20 mg of alum; 100 mg of calcium phosphate as filler, 700 mg of corn starch as disintegrant, 100 mg of magnesium stearate as lubricant, and 100 mg of microcrystalline cellulose as binder; Tablets were prepared by mixing 200 mg of purified water.

Example 2-8 Preparation of Tablet Composition Containing Tannins and Alum

A tablet was prepared in the same manner as in Example 1, except that only the contents of tannin and alum were used to prepare a tablet type snoring improvement and prevention composition (see Table 1 below).

TABLE 1 (unit: mg)

division Tannins alum Remarks Example 2 40 0  The content of the remaining excipients, etc. is the same as in Example 1 Example 3 35 5 Example 4 30 10 Example 5 25 15 Example 6 15 25 Example 7 10 30 Example 8 5 35

Example 9-18 Preparation of a Tablet Composition Containing Functional Ingredients More

Tablets were prepared in the same manner as in Example 1, but tablets were prepared by adding Schizandra chinensis, Bellflower, Magmundong, Cheongung, in addition to tannin and alum, which are the main components of the composition (see Table 2 below).

TABLE 2 (unit: mg)

division Schisandra Bellflower Macmundong Cheongung Remarks Example 9 10 0 0 0   The content of the remaining excipients, etc. is the same as in Example 1 Example 10 0 10 0 0 Example 11 0 0 10 0 Example 12 0 0 0 10 Example 13 10 10 0 0 Example 14 10 10 10 0 Example 15 10 10 10 10 Example 16 5 5 5 5 Example 17 20 20 20 20 Example 18 30 30 30 30

Comparative Example 1 Preparation of Tablet Composition Excluding Tannins and Alum

Tablets were prepared in the same manner as in Example 1, except that both tablets of tannin and alum were prepared.

Comparative Example 2 Preparation of Tablet-Type Composition Excluding Tannins

To prepare a tablet in the same manner as in Example 1, except for tannin to prepare a tablet containing only 40mg of alum.

<Application Example> Preparation of candy type composition containing tannin and alum

Compared to the total candy composition, tannin and alum were added by adding 0.2% by weight of tannin and 0.2% by weight of alum, and a composition for improving snoring and preventing snoring was prepared by a conventional method of preparing candy.

<Experiment 1> Selection of subjects by measuring snoring improvement and prevention effect

The subjects of the experiment were selected to test the snoring improvement and prevention effect on the participants with snoring symptoms using the tablet for snoring improvement and prevention composition prepared in the above examples. The test subjects who participated in this experiment were adult males who had no health problems except snoring symptoms.

1. Current Status of Subjects

1) The answer to the question, “Do you correspond to obesity (BMI> 30)?

[Table 3]

Total number of people Yes no 30 20 10

2) In response to the question “Have you ever heard complaints from family members or people around you due to your snoring symptoms?”

[Table 4]

Total number of people Yes no 10 29 One

3) The following question is answered in the following table, “Do you feel refreshed like you have a good night's sleep?”

TABLE 5

Total number of people Yes no 10 7 23

2. Set up test subject

The above three questions correspond to obesity, hear complaints from the surroundings, and 20 people with all the phenomena that the body is not refreshed. These were carried out to effect experiment of the composition of the present invention.

Experimental Example 2 Experiment for Measuring Snoring Improvement and Prevention Effect of the Composition of the Present Invention

The selector of Experimental Example 1 was administered to the tablet composition prepared according to the embodiments of the present invention and observed the results. All the selectors took the tablet-type composition of the present invention 3 hours before bedtime and carried out for 30 days to perform a snoring quantitative analysis.

1. How to measure the noise level of snoring

The 20 subjects were divided into five groups and tested. One group of tablets prepared by the method of Example 1, two groups of tablets prepared by the method of Example 2, and three groups of Example 15 The tablets prepared by the method, the tablets prepared by the method of Comparative Example 1 in the fourth group, and the tablets prepared in the method of Comparative Example 2 in the fifth group to examine the experimental results. Decibel (dB) at bedtime was measured as one of the well-known tests for sleep polysomnography, and the noise levels after 30 days of continuous tablets were measured. The sound level meter used TES-1350 (TES electrical electronics).

2. Noise level measurement result of snoring

Initial snoring noise levels and noise levels after 30 days of tablet use were measured for each of the five divided groups, and each subject was found not to drink alcohol or take any other medicine for 30 days. The results are summarized in Table 6 below.

[Table 6] Noise Level Measurement Results (Unit: dB)

division Subject Before taking (0 days) After taking (30 days)  1 group One 97 0 2 95 67 3 90 60 4 97 53  2 groups 5 94 36 6 96 59 7 98 0 8 100 62  3 groups 9 89 10 10 93 0 11 93 54 12 96 39  4 groups 13 97 97 14 94 95 15 99 98 16 96 96  5 groups 17 92 89 18 96 93 19 95 91 20 96 90

(The measured experimental value in Table 6 indicates that the average noise level during sleep was measured three times each, and the average (the decimal places were rounded) was obtained.)

As can be seen in Table 6, the group (1, 2, 3) taking the composition of the present invention was significantly reduced noise compared to the group (4, 5) taking the composition prepared by the method of the comparative example I could see that. There were even subjects with snoring habits (subjects 1, 7, 10).

In addition, among the groups prepared by the method of the same embodiment, the group (3 groups) ingesting tablets prepared by addition of tannins or by adding additional functional ingredients such as Schisandra chinensis showed better snoring effect. Could know.

Experimental Example 3 Experiment of Measuring Apnea Inhibition Effect of the Present Invention

The selector of Experimental Example 1 was administered to the tablet formulation composition prepared by the embodiments of the present invention and observed the degree of apnea closely related to snoring. All the selectors took the tablet-type composition of the present invention for 30 days three hours before bedtime and conducted a quantitative analysis of the degree of apnea.

1. How to measure apnea

As in Experiment 2, 20 subjects were divided into 5 groups, and experiments were performed. One group was a tablet prepared by the method of Example 1, and two groups were tablets prepared by the method of Example 2. The experimental results were examined by taking the tablets prepared by the method of Example 15, the tablets prepared by the method of Comparative Example 1, and the group 4 prepared by the method of Comparative Example 2. The number of apneas and the degree of drop of arterial blood acid saturation (SpO ₂ ) were measured by a known apnea measurement method. The measuring instrument used LT-200 (Fukuda Senshi Co., Ltd.) which is a slip tester.

2. Apnea degree measurement result

Initial snoring noise levels and apnea levels after 30 days of tablet use were measured for each of the five divided groups, and each subject was found to have no drinking or other medications for 30 days. The results are summarized in Table 7 below.

[Table 7] Apnea degree measurement result

division Subject Apnea count 30 days after taking SpO ₂ drop 30 days after taking  1 group One 27 0 50 4 2 20 6 55 8 3 18 7 54 10 4 30 4 60 18  2 groups 5 28 10 43 9 6 41 12 53 5 7 26 2 40 0 8 23 9 45 13  3 groups 9 29 2 44 6 10 34 0 51 0 11 32 4 39 7 12 33 5 47 4  4 groups 13 35 34 43 40 14 29 37 40 42 15 30 35 50 44 16 21 29 56 55  5 groups 17 17 18 43 50 18 28 27 52 51 19 33 30 55 49 20 32 36 45 46

(In Table 7, the measured experimental value is a value obtained by measuring the number of apneas during sleep and the degree of SpO ₂ drop three times each, and rounding off the average (rounding up to the decimal point).)

As can be seen in Table 7, in the degree of apnea and SpO ₂ drop closely related to snoring, it can be seen that the apnea phenomenon was significantly improved than when the composition of the present invention was taken. Therefore, it was concluded that the composition of the present invention is also helpful in preventing and treating snoring.

The composition of the present invention can be usefully used for the prevention and treatment of snoring, etc., which can be applied to functional foods or medicines, which is helpful for the profit creation of producers and ultimately contributes to the industrial development of the country. do.

Claims (4)

Snoring improvement and prevention composition comprising a tannin (tannin). The method of claim 1, Snoring improvement and prevention composition, characterized in that it further comprises alum (alum). The method of claim 2, The snoring improvement and prevention composition, characterized in that the weight ratio of the tannin and alum is 1: 0.1 to 10. The method according to any one of claims 1 to 3, Snoring improvement and prevention composition, characterized in that it comprises at least one selected from Schisandra chinensis, bellflower, pulmonary dong and cheonggung.