CN106176313A - A kind of Derma-Guard repaired for barrier function - Google Patents
A kind of Derma-Guard repaired for barrier function Download PDFInfo
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- CN106176313A CN106176313A CN201610714327.4A CN201610714327A CN106176313A CN 106176313 A CN106176313 A CN 106176313A CN 201610714327 A CN201610714327 A CN 201610714327A CN 106176313 A CN106176313 A CN 106176313A
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- oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of Derma-Guard repaired for barrier function, be made up of the component of following weight percentage: crude vegetal 10 40%, vitamin E 0.05 1%, vitamin B60.05 0.8%, soybean lecithin 0.5 7%, hyaluronic acid 0.1 1%, agar powder 0.1 0.8%, glycerol 1 20%, water surplus.The present invention uses high-efficiency water-absorbing moisturizing ingredient and crude vegetal to play the moist moisturizing of skin, and the alimentation of promotion Skin Cell, contributes to the recovery of skin self barrier function, accelerates the recovery of skin problem；All the components is natural component, and health and organ will not be caused any toxic and side effects by life-time service；For reparation time impaired of the human body skin barrier, can effectively be mitigated or eliminated skin barrier function impaired cause dermatitis, eczema, the skin problem such as acne, and there is higher safety.
Description
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of Derma-Guard repaired for barrier function.
Background technology
Multiple statistical inquiry structure shows, human body skin at every moment sustains damage, such as Exposure to Sunlight, haze pollution, excessive cleaning
Nursing, daily cosmetic etc., cause the accelerated ageing of skin, even cause the pathological changes of skin.Medically think most skin
Problem is because what the reduction of skin barrier function caused, such as: once the barrier function of skin is destroyed, and the most directly shows
It is that skin becomes dry, because moisture content is very easy to run off, in addition to two cheeks are easily dried desquamation, the most also of a lot of people
The more vigorous phenomenon of fat secretion occurs, thus cause that clogging of pores causes remain silent acne and small pox problem increases the weight of.Another
Aspect, the impaired meeting of skin barrier causes: the toleration of skin or defensive decline, shows for various physically or chemically factors
Do not tolerate, such as somebody feel wind, Exposure to Sunlight, the supercool overheated skin of ambient temperature all can rubescent, twinge；Somebody is the most right
The no problem product of use used suddenly to tingle and even played measles in the past.Skin barrier function is all pointed out in these performances
Impaired.The impaired cascade reaction that may cause of skin barrier function: barrier function damage → TEWL increase → xerosis cutis → inflammation
Disease reaction → inflammatory dermatoses.
At present, simple use Drug therapy, although the symptom of dermatitis, eczema can be alleviated in a short time, but for self
The recovery of skin barrier function thinks little of, and especially life-time service hormone medicine effect is fast, but owing to hormone is to skin barrier merit
The harmful effect of energy system, may make the state of an illness be more easy to recurrent exerbation.It addition, existing most emulsifying systems employs chemistry
, there is certain zest to skin in the emulsifying agent of synthesis.
Summary of the invention
For problems of the prior art, present invention aim at providing a kind of skin repaired for barrier function
Skin protective agent, this Derma-Guard can alleviate the skin problems such as skin barrier dry, coarse, the cracking that causes of damage, adjuvant
Improve human normal skin barrier function during thing treatment, promote the recovery of the normal function of human body skin barrier.
The present invention is realized by the following technical programs:
Described a kind of Derma-Guard repaired for barrier function, it is characterised in that by the component of following weight percentage
Composition: crude vegetal 10-40%, vitamin E 0.05-1%, vitamin B60.05-0.8%, soybean lecithin 0.5-7%, transparent
Matter acid 0.1-1%, agar powder 0.1-0.8%, glycerol 1-20%, water surplus.
Described a kind of Derma-Guard repaired for barrier function, it is characterised in that by following weight percentage
Component forms: crude vegetal 5-30%, vitamin E 0.5-1%, vitamin B60.05-0.5%, soybean lecithin 1-5%, transparent
Matter acid 0.1-0.5%, agar powder 0.1-0.5%, glycerol 5-15%, water surplus.
Described a kind of Derma-Guard repaired for barrier function, it is characterised in that by following weight percentage
Component forms: crude vegetal 20%, vitamin E 0.7%, vitamin B60.1%, soybean lecithin 3%, hyaluronic acid 0.3%, fine jade
Cosmetics 0.3%, glycerol 15%, water surplus.
Described a kind of Derma-Guard repaired for barrier function, it is characterised in that described crude vegetal is Fructus Canarii albi
Arbitrary in oil, sunflower oil, Oleum sesami, almond oil, Oleum menthae, Oleum Anisi Stellati, thyme oil, Rue oil., Eucalyptus oil, Oleum Vitis viniferae
Kind or more than one mixture.
Described a kind of Derma-Guard repaired for barrier function, it is characterised in that described crude vegetal is by Fructus Canarii albi
Oil, sunflower oil, Oleum sesami, almond oil and Oleum menthae composition, the volume ratio of each composition is: olive oil: sunflower oil: Oleum sesami: Fructus Pruni
Core oil: Oleum menthae=7.2:4.2:1:1:2.1.
Described a kind of Derma-Guard repaired for barrier function, it is characterised in that this protective agent is liposome or breast
Agent solution.
According to traditional theory of Chinese medical science, volatile plant oil, have such as Oleum Anisi Stellati, thyme oil, Rue oil., Eucalyptus oil etc.
The effects such as heat clearing away solution is fiery, ventilation is had one's ideas straightened out, modern study shows, containing a certain amount of terpenoid in these volatile plant oil
Thing, can irritate and promote the microcirculation of tissue, additionally, conventional vegetable oil such as Oleum sesami, sunflower pool, olive oil, almond oil and Portugal
Grape seed oil etc., containing abundant unsaturated fatty acid, vitamin, protein, are natural skin moisturizers, can improve skin
Dry, obscure, organization of human body and functional skin injury.The internal layer of skin and outer layer can thin down, and lose bullet
Property, the partial buffer connecting corium and epidermis reduces, and skin fibrillation occurs along with the minimizing of collagen, and skin histology is the most not
Can antagonism and reparation skin injury.External environment condition such as sunray, can produce free radical, thus accelerate skin aging.Although
Skin is congenital has a characteristic neutralizing free radical aggressive behavior, but remains a need for subtracting by can reduce the inhibitor of this risk
Few cell injury.If olive oil is exactly a kind of natural inhibitor, the oils and fats feature of olive oil and human body skin feature very class
Seemingly.Containing vitamin E in olive oil, carotenoid and phenolic compound, be all antioxidant, and they have the work of defying age
With.These materials play positive effect in terms of eliminating free radical and some old and feeble correlation molecules and extending the skin life-span.
Olive oil additionally aids treatment some skin problems, such as acne, psoriasis and seborrheic eczema etc..
For the maintenance effect time, Derma-Guard of the present invention is prepared as a kind of liposome and emulsion solution, Semen sojae atricolor ovum
Phospholipid has hydrophilic and oleophylic double characteristic, and lecithin is as the stabilized liposome of substrate, and it is wrapped in interior plant
Functional oil composition can slowly discharge and maintain and extend action time, the agar powder extracted in the natural plants such as Thallus Laminariae (Thallus Eckloniae) be another
Planting the most edible polysaccharide food, it can form microsphere in conjunction with vegetable oil molecule, thus help vegetable oil to stop skin surface
The upper maintenance effect time.
In technique scheme, for strengthening product effect and being more beneficial for human body skin health, add a small amount of dimension raw
Element and hyaluronic acid, vitamin E and vitamin B6It is the material of needed by human and there are antioxidation, defying age and prophylaxis of cancer etc.
Function, hyaluronic acid is the saturating of oligomerization hyaluronic acid and the hyaluronic acid mixtures of little molecule, oligomerization hyaluronic acid and little molecule
Bright matter acid blend energy Transdermal absorption, reaches the effect of three-dimensional water suction moisturizing, and has higher removal free radical, promotes cell
The effect that propagation, damaged cell are repaired.The addition of vitamin and hyaluronic acid can improve the entirety of Derma-Guard of the present invention
Effect.
Compared with prior art, there is following beneficial effect in the present invention:
1) use high-efficiency water-absorbing moisturizing ingredient and crude vegetal to play the moist moisturizing of skin, and promote the nutrition of Skin Cell
Absorb, contribute to the recovery of skin self barrier function, accelerate the recovery of skin problem；
2) all the components of the present invention is natural component, and health and organ will not be caused the secondary work of any poison by life-time service
With；
3) product of the present invention for human body skin barrier impaired time reparation, skin barrier function can be effectively mitigated or eliminated impaired
The skin problems such as the dermatitis that causes, eczema, acne, and there is higher safety.
Accompanying drawing explanation
Fig. 1 is matched group and tested group of skin elasticity comparison diagram；
Fig. 2 is matched group and tested group of moisture of skin comparison diagram.
Detailed description of the invention
By specific examples below, the invention will be further described.
Embodiment 1
A kind of Derma-Guard repaired for barrier function, is made up of the component of following weight percentage: crude vegetal
20%, vitamin E 0.7%, vitamin B60.1%, soybean lecithin 3%, hyaluronic acid 0.3%, agar powder 0.3%, glycerol 15%, water
Surplus.Wherein, crude vegetal is made up of olive oil, sunflower oil, Oleum sesami, almond oil and Oleum menthae, the volume ratio of each composition
For: olive oil: sunflower oil: Oleum sesami: almond oil: Oleum menthae=7.2:4.2:1:1:2.1.
Its preparation method is: by the crude vegetal of formula ratio, vitamin E, agar powder and soybean lecithin Hybrid Heating
To 60 DEG C, stir prepared component A, simultaneously by the vitamin B of formula ratio6, glycerol, water be mixed and heated to 60 DEG C, stirring is all
Even prepared B component, is then poured slowly into component A in B component, mix homogeneously, and then constant temperature 45 degree, use ultrasonic generator
(model W140D, 20 kilo hertzs) vibration mixing 15 minutes, cooling packing after solution is completely dissolved.
Embodiment 2
A kind of Derma-Guard repaired for barrier function, is made up of the component of following weight percentage: crude vegetal
10%, vitamin e1 %, vitamin B60.05%, more than soybean lecithin 7%, hyaluronic acid 0.1%, agar powder 0.8%, glycerol 1%, water
Amount.Wherein, crude vegetal is made up of olive oil, sunflower oil, Oleum sesami, almond oil and Oleum menthae, and the volume ratio of each composition is:
Olive oil: sunflower oil: Oleum sesami: almond oil: Oleum menthae=7.2:4.2:1:1:2.1.
Its preparation method is with embodiment 1.
Embodiment 3
A kind of Derma-Guard repaired for barrier function, is made up of the component of following weight percentage: crude vegetal
40%, vitamin E 0.05%, vitamin B60.8%, soybean lecithin 0.5%, hyaluronic acid 1%, agar powder 0.1%, glycerol 20%, water
Surplus.Wherein, crude vegetal is made up of olive oil, sunflower oil, Oleum sesami, almond oil and Oleum menthae, the volume ratio of each composition
For: olive oil: sunflower oil: Oleum sesami: almond oil: Oleum menthae=7.2:4.2:1:1:2.1.
Embodiment 4
A kind of Derma-Guard repaired for barrier function, is made up of the component of following weight percentage: crude vegetal
5%, vitamin e1 %, vitamin B60.05%, more than soybean lecithin 5%, hyaluronic acid 0.1%, agar powder 0.5%, glycerol 5%, water
Amount.Wherein, crude vegetal is made up of olive oil, sunflower oil, Oleum sesami, almond oil and Oleum menthae, and the volume ratio of each composition is:
Olive oil: sunflower oil: Oleum sesami: almond oil: Oleum menthae=7.2:4.2:1:1:2.1.
Embodiment 5
A kind of Derma-Guard repaired for barrier function, is made up of the component of following weight percentage: crude vegetal
30%, vitamin E 0.5%, vitamin B60.5%, soybean lecithin 1%, hyaluronic acid 0.5%, agar powder 0.1%, glycerol 15%, water
Surplus.Wherein, crude vegetal is made up of olive oil, sunflower oil, Oleum sesami, almond oil and Oleum menthae, the volume ratio of each composition
For: olive oil: sunflower oil: Oleum sesami: almond oil: Oleum menthae=7.2:4.2:1:1:2.1.
Embodiment 6
A kind of Derma-Guard repaired for barrier function, its formula is identical with embodiment 1.Difference is natural plants
The selection of oil, crude vegetal uses any one in Oleum Anisi Stellati, thyme oil, Rue oil., Eucalyptus oil, Oleum Vitis viniferae or a kind of
Above mixture.
Experimental example 1
From the most tested 20-45 name women, randomly draw 100, carry out skin care prepared by inventive formulation on probation
Agent, after respectively experimenter being tried out 7 days, to product quality and the subjective survey of comfort, after continuing 30 days on probation, is subject to
Examination person's skin quality and allergic symptom improve situation, subjects subjective feels whether effective percentage, and survey result is shown in Table 1.
Table 1: survey result
As can be seen from Table 1, product prepared by inventive formulation can be accepted by most people, and its comfort level used and product matter
Ground can be accepted by major part user, and it plays for skin quality and allergic symptom and preferably improves effect, after using 30 days, greatly
The skin quality that part user can substantially be felt is improved.Above-mentioned improvement be mainly reflected in comfort level, also relate to smoothness,
Oiliness degree, aridity, erythematous papules, twinge pruritus, elasticity etc., along with the prolongation of the time of use, all have improvement trend.
It addition, in clinical trial, grow in tender degree tender, wet, be mainly distributed on good and excellent on, to moisture of skin, oil quantity
It is respectively provided with good improvement result, moisture of skin, elastic tool after laser operation is improved significantly, it is possible to reduce laser operation
The symptoms such as rear cutaneous sensibility, pruritus, erythema.
Experimental example 2
One experimenter of random choose from the patients entered one's name voluntarily, smears commercially its left surface buccal
Certain brand emulsion as a control group, is smeared 30 days continuously, and the skin that its right flank buccal is smeared the embodiment of the present invention 1 preparation is protected
Protect agent as tested group, smear continuously 30 days, in the case of other conditions are identical, respectively when smearing 7 days, 15 days and 30 days,
Two cheek skins are carried out skin elasticity test and moisture measurement respectively, and flexibility test result is shown in that Fig. 1, moisture measurement result are shown in Fig. 2.
It can be seen that use Derma-Guard prepared by inventive formulation from the comparison diagram of Fig. 1 and Fig. 2, its performance is better than on market
Certain the brand emulsion bought.
Claims (6)
1. the Derma-Guard repaired for barrier function, it is characterised in that by the component group of following weight percentage
Become: crude vegetal 10-40%, vitamin E 0.05-1%, vitamin B60.05-0.8%, soybean lecithin 0.5-7%, hyalomitome
Acid 0.1-1%, agar powder 0.1-0.8%, glycerol 1-20%, water surplus.
A kind of Derma-Guard repaired for barrier function, it is characterised in that by following weight
The component composition of percentage composition: crude vegetal 5-30%, vitamin E 0.5-1%, vitamin B60.05-0.5%, soybean lecithin
1-5%, hyaluronic acid 0.1-0.5%, agar powder 0.1-0.5%, glycerol 5-15%, water surplus.
A kind of Derma-Guard repaired for barrier function, it is characterised in that by following weight
The component composition of percentage composition: crude vegetal 20%, vitamin E 0.7%, vitamin B60.1%, soybean lecithin 3%, hyalomitome
Acid 0.3%, agar powder 0.3%, glycerol 15%, water surplus.
4. a kind of Derma-Guard repaired for barrier function as described in as arbitrary in claim 1 or 2 or 3, it is characterised in that
Described crude vegetal is olive oil, sunflower oil, Oleum sesami, almond oil, Oleum menthae, Oleum Anisi Stellati, thyme oil, Rue oil., eucalyptus globulus
The mixture of any one or more in tree oil, Oleum Vitis viniferae.
A kind of Derma-Guard repaired for barrier function, it is characterised in that described natural plant
Thing oil is made up of olive oil, sunflower oil, Oleum sesami, almond oil and Oleum menthae, and the volume ratio of each composition is: olive oil: sunflower oil:
Oleum sesami: almond oil: Oleum menthae=7.2:4.2:1:1:2.1.
A kind of Derma-Guard repaired for barrier function, it is characterised in that this protective agent is
Liposome or emulsion solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610714327.4A CN106176313A (en) | 2016-08-24 | 2016-08-24 | A kind of Derma-Guard repaired for barrier function |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610714327.4A CN106176313A (en) | 2016-08-24 | 2016-08-24 | A kind of Derma-Guard repaired for barrier function |
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| CN106176313A true CN106176313A (en) | 2016-12-07 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2019160502A1 (en) * | 2018-02-15 | 2019-08-22 | Agency For Science, Technology And Research | Methods |
| CN111388378A (en) * | 2020-04-27 | 2020-07-10 | 渠志灿 | Skin care gel containing peony seed coat extract and preparation method thereof |
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| WO2019160502A1 (en) * | 2018-02-15 | 2019-08-22 | Agency For Science, Technology And Research | Methods |
| CN111388378A (en) * | 2020-04-27 | 2020-07-10 | 渠志灿 | Skin care gel containing peony seed coat extract and preparation method thereof |
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Application publication date: 20161207 |