CN102342890A - Oil-in-water (O/W) skin protecting emulsion and preparation method thereof - Google Patents
Oil-in-water (O/W) skin protecting emulsion and preparation method thereof Download PDFInfo
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- CN102342890A CN102342890A CN2010105003027A CN201010500302A CN102342890A CN 102342890 A CN102342890 A CN 102342890A CN 2010105003027 A CN2010105003027 A CN 2010105003027A CN 201010500302 A CN201010500302 A CN 201010500302A CN 102342890 A CN102342890 A CN 102342890A
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Abstract
The invention relates to an oil-in-water (O/W) skin protecting emulsion, and more specifically, the emulsion provided by the invention comprises nano silver oxide particles with broad sterilization capability, superoxide dismutase (SOD) and glutathione capable of scavenging harmful free radicals from a human body, anti-oxidation substances and other multiple effective ingredients.
Description
Technical field
The present invention relates to a kind of oil-in-water O/W facial treatment milk and manufacturing approach thereof, the superoxide dismutase (Superoxide dismutase) that the emulsion that more particularly the present invention relates to comprises nano phase ag_2 o granule with extensive sterilization ability, remove human body harmful's free radical (SOD) and multiple active ingredients such as glutathion (Glutathione), antioxidant.
Background technology
Along with the quickening of people's rhythm of life, from the increase of the pressure of various aspects, the continuous deterioration of ecological environment because people's skin, outside especially face is directly exposed to, need stand cold and heat is wrecked, and also has various rays and ultraviolet radiation.Make facial epidermis cell receive great damage.Make people occur wrinkle, dark class, various dermatitis macule and acne prematurely.
To the problems referred to above; Popular a lot of skin care item in the society; Much be to control table not effect a permanent cure; Have plenty of too greasy; Make skin can't bear the heavy load, skin is the metabolic pith of human body, need excrete the harmful substance that produces in many metabolic processes through skin; Also to resist the invasion of various outside harmful substances and antibacterial through skin simultaneously through the perspiration regulate body temperature.The skin of keeping fit is everyone pursuit and yearning.
Abominable ecological environment comes to harm human face's Skin Cell, and there is a large amount of free radicals in the cell peripheral that comes to harm, comprises ultra-oxygen anion free radical and hydroxy radical.Free radical further injures damaged cells, and has influence on the reparation and the regeneration of cell.If on skin, smear skin care item inferior,, injure skin all the more with causing the more gathering of polyradical.
The object of the invention is exactly that a kind of free radical that has sterilization, removes skin surface, impaired epidermis cell, the maintenance skin moisture of reparation will be provided, and prevents pigmentation and melanic formation.Make that skin is bright and clean, moist, high resilience and have better permeability.
Summary of the invention
O/w emulsion of the present invention comprises aqueous phase substance; Fat phase material; The nano phase ag_2 o granule of extensive sterilization; The epidermal cell repairing material; Keep moisture content and crease-resistant material; Non-ionic surface active agent; Thickening agent; The PH buffer agent; Penetrating agent; Antioxidant with make the people feel fresh and clean spice.
This emulsion has the advantage of ointment and the advantage of emulsion at continuous aqueous phase, and existing property contained and emollient have the characteristics that are prone to smear with noresidue again.
Various compositions and shared percentage by weight below will be described, with whole emulsion as 100 weight %.
Aqueous phase substance of the present invention is a pure water, and shared percentage by weight is 50 weight %-80 weight %;
The present invention uses the nano phase ag_2 o granule, and silver oxide sterilization mechanism is Ag
2O forms AgOH, AG in water environment
+Sulfydryl-SH in the enzyme of depending on for existence in the thalline is replaced as-SAg, makes the enzyme loss of activity, cause pathogenic bacteria dead.The antibiotic kind more than 40 of this nano phase ag_2 o granule comprises bacillus pyocyaneus, Staphyloccocus aureus, escherichia coli, Candida albicans etc.Because granular size size 10 to 200nm (nanometer); Because specific surface area is big; So consumption seldom just can reach the effect of sterilization; Its weight is 0.001 weight %-0.01 weight %; Use polar substances to make the particulate dispersant of nano phase ag_2 o; For example long-pending bisphosphate, consumption is few, is 0.0005 weight %;
Fatty phase material of the present invention accounts for 5-30 weight %; Can comprise: vegetable oil; For example olive oil, sunflower oil, almond oil, Petiolus Trachycarpi oil, triglyceride, quintessence oil, vitamin E oil and lycopene oil (vitamin E and lycopene all are fat-soluble, need it be dissolved with oils and fats);
Epidermal cell repairing material of the present invention is superoxide dismutase (SOD) and glutathion (GSH), and these two kinds of materials all can be removed human body harmful's free radical.SOD comprises Cu; Zn-SOD, Mn-SOD, Fe-SOD, EC-SOD and gene recombinaton HR-SOD; In use can use wherein any one or a few; Add SOD; Because it is all different that the different enzymes that produce family and different lot numbers are lived,, institute guarantees that every ml emulsion has 40-500u (enzyme is lived)/ml so adding the SOD amount; Glutathion 0.5-2 gram.
It is glass acid that skin of the present invention keeps moisture content and crease-resistant material, i.e. hyaluronic acid, and percentage by weight is 0.001 weight %-0.01 weight %;
Non-ionic surface active agent of the present invention adopts sorbitan ester class with hydrophile-lipophile balance value (HLB) 10-18 to be lower than 10 sorbitan class and to be used with having, and consumption is 3 weight %-15 weight %;
Thickening agent 0.1% weight-3% weight of the present invention specifically can be selected materials such as polyacrylamide homopolymer or cellulose ether;
PH buffer agent of the present invention is citric acid or sodium citrate, perhaps is vitamin C;
Penetrating agent of the present invention is propylene glycol, dipropylene glycol or propylene glycol dipelargonate; If use the propylene glycol should 5 weight %-25 weight %;
Antioxidant of the present invention is ascorbic acid, bata-carotene (being in harmonious proportion with oil, because of it is fat-soluble), tea polyphenols, anthocyanidin etc., can select wherein one or more, and consumption is 0.01 weight %-1 weight %;
The present invention can be selected spice flavors such as jasmine, clove oil, lemon oil, peppermint oil and bees flower oil, etc., the amount is minimal, 0.0001 to 0.001 wt%, reaching people feel natural, fresh;
Final emulsion pH value is adjusted between the 4.5-6.0, with the needs of the skin environment that adapts to the people.
Antioxidant and superoxide dismutase and glutathion combined effect can be removed the unnecessary free radical of skin surface better, are of value to the elimination of inflammation and the regeneration and the reparation of cell.
The specific embodiment
Embodiment 1
With whole emulsion as 100 weight %.
Aqueous phase substance of the present invention is a pure water, and shared percentage by weight is 50 weight %-80 weight %;
Nano phase ag_2 o granule of the present invention is because specific surface area is big, so consumption seldom just can reach the effect of sterilization, its weight is 0.001 weight %-0.01 weight %, and dispersant is long-pending bisphosphate, 0.0005 weight %-0.01 weight %;
Fatty phase material of the present invention accounts for 5-40 weight %; Can comprise: vegetable oil; For example olive oil, sunflower oil, almond oil, Petiolus Trachycarpi oil, triglyceride, quintessence oil, vitamin E oil and lycopene oil (vitamin E and lycopene all are fat-soluble, need it be dissolved with oils and fats);
Epidermal cell repairing material of the present invention is superoxide dismutase (SOD) and glutathion; SOD comprises Cu; Zn-SOD, Mn-SOD, Fe-SOD, EC-SOD and gene recombinaton HR-SOD; In use can use wherein any one or a few; Add SOD; Because it is all different that the different enzymes that produce family and different lot numbers are lived,, institute guarantees that every ml emulsion has 40-500u (enzyme is lived)/ml so adding the SOD amount; Glutathion 0.5-2 gram.
It is glass acid that skin of the present invention keeps moisture content and crease-resistant material, i.e. hyaluronic acid, and percentage by weight is 0.001 weight %-0.01 weight %;
Non-ionic surface active agent of the present invention adopts sorbitan ester class with hydrophile-lipophile balance value (HLB) 10-18 to be lower than 10 sorbitan class and to be used with having, and consumption is 3 weight %-15 weight %;
Thickening agent 0.1% weight-3% weight of the present invention specifically can be selected materials such as polyacrylamide homopolymer or cellulose ether;
PH buffer agent of the present invention is citric acid or sodium citrate, perhaps is vitamin C;
Penetrating agent of the present invention is propylene glycol, dipropylene glycol or propylene glycol dipelargonate; If use the propylene glycol should 5 weight %-25 weight %;
Antioxidant of the present invention is ascorbic acid, bata-carotene (being in harmonious proportion with oil, because of it is fat-soluble), tea polyphenols, anthocyanidin etc., can select wherein one or more, and consumption is 0.01 weight %-1 weight %;
The present invention can be selected spice flavors such as jasmine, clove oil, lemon oil, peppermint oil and bees flower oil, etc., the amount is minimal, 0.0001 to 0.001 wt%, reaching people feel natural, fresh;
Final emulsion pH value is adjusted between the 4.5-6.0, with the needs of the skin environment that adapts to the people.
The concrete operations step:
1. under 40 ℃-60 ℃, non-ionic surface active agent, water soluble antioxidant, PH buffer agent, penetrating agent are distributed in the pure water, the limit heating, stir on the limit, and mixing speed is 1000-1500r/mim, stops heating then, naturally cooling;
2. under agitation, the aqueous phase substance that step 1 is obtained be added to fat mutually in, preheating is cooled off under 15 ℃-30 ℃ under 40 ℃-60 ℃ then;
3. under agitation, with the polar substances dispersant, for example long-pending two acid esters, nano phase ag_2 o granule, SOD and glutathion, spice join in the emulsion that step 2 obtains.Mixing speed is 1000-1500r/mim.Obtain the oil-in-water O/W facial treatment milk of wanting required for the present invention at last.
Embodiment 2
With whole emulsion as 100 weight %.
Aqueous phase substance of the present invention is a pure water, and shared percentage by weight is 60 weight %-70 weight %;
Nano phase ag_2 o granule of the present invention is because specific surface area is big, so consumption seldom just can reach the effect of sterilization, its weight is 0.001 weight %-0.01 weight %, and dispersant is long-pending bisphosphate, 0.0005 weight %-0.01 weight %;
Fatty phase material of the present invention accounts for 20-30 weight %, can comprise: vegetable oil, for example olive oil, almond oil, triglyceride, quintessence oil, vitamin E oil or lycopene oil (vitamin E and lycopene all are fat-soluble, need it be dissolved with oils and fats);
Epidermal cell repairing material of the present invention is superoxide dismutase (SOD) and glutathion; SOD comprises Cu; Zn-SOD, Mn-SOD, Fe-SOD, EC-SOD and gene recombinaton HR-SOD; In use can use wherein any one or a few; Add SOD; Because it is all different that the different enzymes that produce family and different lot numbers are lived,, institute guarantees that every ml emulsion has 40-500u (enzyme is lived)/ml so adding the SOD amount; Glutathion 0.5-2 gram.
It is glass acid that skin of the present invention keeps moisture content and crease-resistant material, i.e. hyaluronic acid, and percentage by weight is 0.001 weight %-0.01 weight %;
Non-ionic surface active agent of the present invention adopts sorbitan ester class with hydrophile-lipophile balance value (HLB) 10-18 to be lower than 10 sorbitan class and to be used with having, and consumption is 5 weight %-8 weight %;
Thickening agent 0.5% weight-1% weight of the present invention specifically can be selected materials such as polyacrylamide homopolymer or cellulose ether;
PH buffer agent of the present invention is citric acid or sodium citrate, perhaps is vitamin C;
Penetrating agent of the present invention is a propylene glycol, 8 weight %-10 weight %;
Antioxidant of the present invention is ascorbic acid, bata-carotene (being in harmonious proportion with oil, because of it is fat-soluble), tea polyphenols, anthocyanidin etc., can select wherein one or more, and consumption is 0.1 weight %-0.5 weight %;
The present invention can be selected spice flavors such as jasmine, clove oil, lemon oil, peppermint oil and bees flower oil, etc., the amount is minimal, 0.0001 to 0.001 wt%, reaching people feel natural, fresh;
Final emulsion pH value is adjusted between the 4.5-6.0, with the needs of the skin environment that adapts to the people.
The concrete operations step:
1. under 40 ℃-60 ℃, non-ionic surface active agent, water soluble antioxidant, PH buffer agent, penetrating agent are distributed in the pure water, the limit heating, stir on the limit, and mixing speed is 1000-1500r/mim, stops heating then, naturally cooling;
2. under agitation, the aqueous phase substance that step 1 is obtained be added to fat mutually in, preheating is cooled off under 15 ℃-30 ℃ under 40 ℃-60 ℃ then;
3. under agitation, with the polar substances dispersant, for example long-pending two acid esters, nano phase ag_2 o granule, SOD and glutathion, spice join in the emulsion that step 2 obtains.Mixing speed is 1000-1500r/mim.Obtain the oil-in-water O/W facial treatment milk of wanting required for the present invention at last.
Embodiment 3
With whole emulsion as 100 weight %.
Aqueous phase substance of the present invention is a pure water, and shared percentage by weight is 65 weight %;
Nano phase ag_2 o granule of the present invention is because specific surface area is big, so consumption seldom just can reach the effect of sterilization, its weight is 0.005 weight %, and dispersant is long-pending bisphosphate, 0.0005 weight %-0.01 weight %;
Fatty phase material of the present invention accounts for 25 weight %, can comprise: vegetable oil, for example olive oil, almond oil, triglyceride, quintessence oil, vitamin E oil or lycopene oil (vitamin E and lycopene all are fat-soluble, need it be dissolved with oils and fats);
Epidermal cell repairing material of the present invention is superoxide dismutase (SOD) and glutathion; SOD comprises Cu; Zn-SOD, Mn-SOD, Fe-SOD, EC-SOD and gene recombinaton HR-SOD; In use can use wherein any one or a few; Add SOD; Because it is all different that the different enzymes that produce family and different lot numbers are lived,, institute guarantees that every ml emulsion has 40-500u (enzyme is lived)/ml so adding the SOD amount; Glutathion 0.5-2 gram.
It is glass acid that skin of the present invention keeps moisture content and crease-resistant material, i.e. hyaluronic acid, and percentage by weight is 0.005 weight %;
Non-ionic surface active agent of the present invention adopts sorbitan ester class with hydrophile-lipophile balance value (HLB) 10-18 to be lower than 10 sorbitan class and to be used with having, and consumption is 6 weight %;
Thickening agent of the present invention occupies 0.75% weight, specifically can select materials such as polyacrylamide homopolymer or cellulose ether;
PH buffer agent of the present invention is citric acid or sodium citrate, perhaps is vitamin C;
Penetrating agent of the present invention is a propylene glycol, 9 weight %;
Antioxidant of the present invention is ascorbic acid, bata-carotene (being in harmonious proportion with oil, because of it is fat-soluble), tea polyphenols, anthocyanidin etc., can select wherein one or more, and consumption is 0.75 weight %;
The present invention can be selected spice flavors such as jasmine, clove oil, lemon oil, peppermint oil and bees flower oil, etc., the amount is minimal, 0.0001 to 0.001 wt%, reaching people feel natural, fresh;
Final emulsion pH value is perhaps adjusted between the 4.5-6.0 for vitamin C with citric acid or sodium citrate, with the needs of the skin environment that adapts to the people.
The concrete operations step:
1. under 40 ℃-60 ℃, non-ionic surface active agent, water soluble antioxidant, PH buffer agent, penetrating agent are distributed in the pure water, the limit heating, stir on the limit, and mixing speed is 1000-1500r/mim, stops heating then, naturally cooling;
2. under 1000-1500r/mim stirs, the aqueous phase substance that step 1 is obtained be added to fat mutually in, preheating is cooled off under 15 ℃-30 ℃ under 40 ℃-60 ℃ then;
3. under agitation, with the polar substances dispersant, for example long-pending two acid esters, nano phase ag_2 o granule, SOD and glutathion, spice join in the emulsion that step 2 obtains.Mixing speed is 1000-1500r/mim.Obtain the oil-in-water O/W facial treatment milk of wanting required for the present invention at last.
Claims (5)
1. an oil-in-water O/W facial treatment milk comprises aqueous phase substance; Fat phase material; The nano phase ag_2 o granule of extensive sterilization; The epidermal cell repairing material; Keep moisture content and crease-resistant material; Non-ionic surface active agent; Thickening agent; The PH buffer agent; Penetrating agent; Antioxidant with make the people feel fresh and clean spice.
2. according to a kind of oil-in-water O/W facial treatment milk of claim 1, with whole emulsion as 100 weight %,
Aqueous phase substance of the present invention is a pure water, and shared percentage by weight is 50 weight %-80 weight %;
Nano phase ag_2 o granule of the present invention is because specific surface area is big, so consumption seldom just can reach the effect of sterilization, its percentage by weight is 0.001 weight %-0.01 weight %, and dispersant is long-pending bisphosphate, 0.0005 weight %-0.01 weight %;
Fatty phase material 5 weight %-40 weight % of the present invention; Can comprise: vegetable oil; For example (vitamin E and lycopene all are fat-soluble for olive oil, sunflower oil, almond oil, Petiolus Trachycarpi oil, triglyceride, quintessence oil, vitamin E oil and lycopene oil; Need it be dissolved with oils and fats), can use wherein a kind of or use wherein several simultaneously;
Epidermal cell repairing material of the present invention is superoxide dismutase (SOD) and glutathion; SOD comprises Cu; Zn-SOD, Mn-SOD, Fe-SOD, EC-SOD and gene recombinaton HR-SOD; In use can use wherein any one or a few; Add SOD; Because it is all different that the different enzymes that produce family and different lot numbers are lived,, institute guarantees that every ml emulsion has 40-500u (enzyme is lived)/ml so adding the SOD amount; Glutathion 0.5-2 gram;
It is glass acid that skin of the present invention keeps moisture content and crease-resistant material, i.e. hyaluronic acid, and percentage by weight is 0.001 weight %-0.01 weight %;
Non-ionic surface active agent of the present invention adopts sorbitan ester class with hydrophile-lipophile balance value (HLB) 10-18 to be lower than 10 sorbitan class and to be used with having; Consumption is 3 weight %-15 weight %, can certainly use disclosed other material in the prior art;
Thickening agent 0.1% weight-3% weight of the present invention specifically can be selected materials such as polyacrylamide homopolymer or cellulose ether;
PH buffer agent of the present invention is citric acid or sodium citrate, perhaps is vitamin C;
Penetrating agent of the present invention is propylene glycol, dipropylene glycol or propylene glycol dipelargonate, if use the propylene glycol should 5 weight %-25 weight %;
Antioxidant of the present invention is ascorbic acid, bata-carotene (being in harmonious proportion with oil, because of it is fat-soluble), tea polyphenols, anthocyanidin etc., can select wherein one or more, and consumption is 0.01 weight %-1 weight %;
The present invention can be selected spice flavors such as jasmine, clove oil, lemon oil, peppermint oil and bees flower oil, etc., the amount is minimal, 0.0001 to 0.001 wt%, reaching people feel natural, fresh;
Final emulsion pH value is adjusted between the 4.5-6.0, with the needs of the skin environment that adapts to the people.
3. according to a kind of oil-in-water O/W facial treatment milk of claim 1, with whole emulsion as 100 weight %,
Aqueous phase substance of the present invention is a pure water, and shared percentage by weight is 60 weight %-70 weight %;
Nano phase ag_2 o granule of the present invention is because specific surface area is big, so consumption seldom just can reach the effect of sterilization, its weight is 0.001 weight %-0.01 weight %, and dispersant is long-pending bisphosphate, 0.0005 weight %-0.01 weight %;
Fatty phase material of the present invention accounts for 20-30 weight %, can comprise: vegetable oil, for example olive oil, almond oil, triglyceride, quintessence oil, vitamin E oil or lycopene oil (vitamin E and lycopene all are fat-soluble, need it be dissolved with oils and fats);
Epidermal cell repairing material of the present invention is superoxide dismutase (SOD) and glutathion; SOD comprises Cu; Zn-SOD, Mn-SOD, Fe-SOD, EC-SOD and gene recombinaton HR-SOD; In use can use wherein any one or a few; Add SOD; Because it is all different that the different enzymes that produce family and different lot numbers are lived,, institute guarantees that every ml emulsion has 40-500u (enzyme is lived)/ml so adding the SOD amount; Glutathion 0.5-2 gram;
It is glass acid that skin of the present invention keeps moisture content and crease-resistant material, i.e. hyaluronic acid, and percentage by weight is 0.001 weight %-0.01 weight %;
Non-ionic surface active agent of the present invention adopts sorbitan ester class with hydrophile-lipophile balance value (HLB) 10-18 to be lower than 10 sorbitan class and to be used with having, and consumption is 5 weight %-8 weight %;
Thickening agent 0.5% weight-1% weight of the present invention specifically can be selected materials such as polyacrylamide homopolymer or cellulose ether;
PH buffer agent of the present invention is citric acid or sodium citrate, perhaps is vitamin C;
Penetrating agent of the present invention is a propylene glycol, 8 weight %-10 weight %;
Antioxidant of the present invention is ascorbic acid, bata-carotene (being in harmonious proportion with oil, because of it is fat-soluble), tea polyphenols, anthocyanidin etc., can select wherein one or more, and consumption is 0.1 weight %-0.5 weight %;
The present invention can be selected spice flavors such as jasmine, clove oil, lemon oil, peppermint oil and bees flower oil, etc., the amount is minimal, 0.0001 to 0.001 wt%, reaching people feel natural, fresh;
Final emulsion pH value is adjusted between the 4.5-6.0, with the needs of the skin environment that adapts to the people.
4. according to a kind of oil-in-water O/W facial treatment milk of claim 1, with whole emulsion as 100 weight %,
Aqueous phase substance of the present invention is a pure water, and shared percentage by weight is 65 weight %;
Nano phase ag_2 o granule of the present invention is because specific surface area is big, so consumption seldom just can reach the effect of sterilization, its weight is 0.005 weight %, and dispersant is long-pending bisphosphate, 0.0005 weight %-0.01 weight %;
Fatty phase material of the present invention accounts for 25 weight %, can comprise: vegetable oil, for example olive oil, almond oil, triglyceride, quintessence oil, vitamin E oil or lycopene oil (vitamin E and lycopene all are fat-soluble, need it be dissolved with oils and fats);
Epidermal cell repairing material of the present invention is superoxide dismutase (SOD) and glutathion; SOD comprises Cu; Zn-SOD, Mn-SOD; And Fe-SOD; In use can use wherein any one or a few; Addition restrains by the SOD 0.5-2 that 1000 milliliters of emulsions addings have 5000u (enzyme is lived)/mg, glutathion 0.5-2 gram;
It is glass acid that skin of the present invention keeps moisture content and crease-resistant material, i.e. hyaluronic acid, and percentage by weight is 0.005 weight %;
Non-ionic surface active agent of the present invention adopts sorbitan ester class with hydrophile-lipophile balance value (HLB) 10-18 to be lower than 10 sorbitan class and to be used with having, and consumption is 6 weight %;
Thickening agent 0.75% weight of the present invention specifically can be selected materials such as polyacrylamide homopolymer or cellulose ether;
PH buffer agent of the present invention is citric acid or sodium citrate, perhaps is vitamin C;
Penetrating agent of the present invention is a propylene glycol, 9 weight %;
Antioxidant of the present invention is ascorbic acid, bata-carotene (being in harmonious proportion with oil, because of it is fat-soluble), tea polyphenols, anthocyanidin etc., can select wherein one or more, and consumption is 0.01 weight %-1 weight %;
The present invention can be selected spice flavors such as jasmine, clove oil, lemon oil, peppermint oil and bees flower oil, etc., the amount is minimal, 0.0001 to 0.001 wt%, reaching people feel natural, fresh;
Final emulsion pH value is perhaps adjusted between the 4.5-6.0 for vitamin C with citric acid or sodium citrate, with the needs of the skin environment that adapts to the people.
5. according to the manufacturing approach of a kind of oil-in-water O/W facial treatment milk of claim 1-4, it is characterized in that:
A. under 40 ℃-60 ℃, non-ionic surface active agent, water soluble antioxidant, PH buffer agent, penetrating agent are distributed in the pure water, the limit heating, stir on the limit, and mixing speed is 1000-1500r/mim, stops heating then, naturally cooling;
B. under 1000-1500r/mim stirs, the aqueous phase substance that step 1 is obtained be added to fat mutually in, preheating is cooled off under 15 ℃-30 ℃ under 40 ℃-60 ℃ then;
C. under agitation; With the polar substances dispersant, long-pending bisphosphate, nano phase ag_2 o granule, SOD and glutathion, spice join in the emulsion that step 2 obtains; Mixing speed is 1000-1500r/mim, obtains the oil-in-water O/W facial treatment milk of wanting required for the present invention at last.
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CN104661739A (en) * | 2012-09-28 | 2015-05-27 | 富士胶片株式会社 | Lycopene-containing oil-in-water emulsion composition and production method therefor |
CN105250203A (en) * | 2015-11-08 | 2016-01-20 | 广州市花安堂生物科技有限公司 | Moistening aqua-mask free of preservative and preparing method thereof |
CN105943417A (en) * | 2016-04-29 | 2016-09-21 | 佛山市芊茹化妆品有限公司 | Skin care composition and skin care cream having function of preventing and treating rhagadia manus et pedis |
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CN106344452A (en) * | 2016-09-19 | 2017-01-25 | 拉芳家化股份有限公司 | Skin-care emulsion containing chitosan PCA salt |
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CN104661739A (en) * | 2012-09-28 | 2015-05-27 | 富士胶片株式会社 | Lycopene-containing oil-in-water emulsion composition and production method therefor |
CN104661739B (en) * | 2012-09-28 | 2018-02-16 | 富士胶片株式会社 | Emulsion oil-in-water composition and its manufacture method containing lycopene |
CN105250203A (en) * | 2015-11-08 | 2016-01-20 | 广州市花安堂生物科技有限公司 | Moistening aqua-mask free of preservative and preparing method thereof |
CN105943417A (en) * | 2016-04-29 | 2016-09-21 | 佛山市芊茹化妆品有限公司 | Skin care composition and skin care cream having function of preventing and treating rhagadia manus et pedis |
CN106176313A (en) * | 2016-08-24 | 2016-12-07 | 杭州美库生物技术有限公司 | A kind of Derma-Guard repaired for barrier function |
CN106344452A (en) * | 2016-09-19 | 2017-01-25 | 拉芳家化股份有限公司 | Skin-care emulsion containing chitosan PCA salt |
CN106344452B (en) * | 2016-09-19 | 2020-03-24 | 拉芳家化股份有限公司 | Skin care emulsion containing chitosan PCA salt |
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