CN102343085B - Oil in water (O/W) emulsion for treating skin trauma and preparation method of oil in water emulsion - Google Patents
Oil in water (O/W) emulsion for treating skin trauma and preparation method of oil in water emulsion Download PDFInfo
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- CN102343085B CN102343085B CN201010500291.2A CN201010500291A CN102343085B CN 102343085 B CN102343085 B CN 102343085B CN 201010500291 A CN201010500291 A CN 201010500291A CN 102343085 B CN102343085 B CN 102343085B
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Abstract
The invention relates to an oil in water (O/W) emulsion for treating skin trauma and preparation method of the oil in water emulsion, more particularly, the emulsion in the invention is also suitable for treating burn, scald and gunshot wounds. The O/W emulsion comprises a water phase material, a fat phase material, a widely-sterilized nano silver oxide particle, an epidermis cell repairing material, a moisture-remaining and crease-resisting material, a PH buffering agent, a penetrant, an antioxidant and fibronectin.
Description
Technical field
The present invention relates to a kind of a kind of oil-in-water O/W emulsion and manufacture method thereof for the treatment of skin trauma, the emulsion more particularly the present invention relates to is also suitable for treating burn, scald and gunshot wound.
Background technology
Skin trauma, particularly burn, scald and gunshot wound, the skin epidermis even more tissue of deep layer is subject to serious wound, general dry method treatment is unfavorable for the histiocytic treatment of skin trauma, reparation, regeneration and healing, the sterilizing effectively of the medicine of general Soaking therapy, antiinflammatory, pain relieving, antiseepage, and can not make as early as possible the cell tissue that is subject to wound obtain repairing, regenerate and healing.
Have a large amount of bacterial reproductions at site of injury, also have a large amount of free radicals, the especially ultra-oxygen anion free radical that stress produce simultaneously, the existence of free radical, will be unfavorable for the healing of reparation, regeneration and wound face of damaged cell.
Object of the present invention be exactly to provide a kind of have sterilizing, remove skin surface free radical, repair impaired epidermis cell, keep skin moisture, prevent pigmentation and melanic formation, make skin there is better permeability, healing of wound as early as possible, the local environment of the suitable Growth of Cells that forming is isolated from the outside seals.
Summary of the invention
O/w emulsion of the present invention comprises aqueous phase substance; Fat phase material; The extensively nano phase ag_2 o granule of sterilizing; Epidermal cell repairing material; Keep moisture content and crease-resistant material; PH buffer agent; Penetrating agent; Antioxidant; Fibronectin (FN, Fibronection have multiple biological activity and biological function).
Various compositions and shared percentage by weight below will be described, taking overall emulsion as 1000 milliliters.
Aqueous phase substance of the present invention is distilled water, and shared percentage by weight is 70 % by weight-80 % by weight;
10 grams, sodium chloride;
Lidocaine hydrochloride or lidocaine carbonate 0.1-2 gram;
The present invention uses nano phase ag_2 o granule, and silver oxide Bactericidal Mechanism is Ag
2o forms AgOH, AG in water environment
+by be replaced as-SAg of the sulfydryl-SH in the enzyme of depending on for existence in thalline, make enzyme loss of activity, cause pathogenic bacteria death.The antibacterial kind more than 40 of this nano phase ag_2 o granule, comprises bacillus pyocyaneus, Staphyloccocus aureus, escherichia coli, Candida albicans etc.Nano phase ag_2 o granular size size 10 to 200nm (nanometer), because specific surface area is large, so consumption seldom just can reach effect of sterilizing, its weight is 0.001 % by weight-0.01 % by weight, use polar substances to make the dispersant of nano phase ag_2 o granule, for example long-pending bisphosphate, consumption is few, is 0.0005 % by weight-0.01 % by weight;
Fatty phase material of the present invention accounts for 5-30 % by weight, glycerol and vitamin E oil, and vitamin E oil 0.01 % by weight wherein;
Epidermal cell repairing material of the present invention is superoxide dismutase (SOD) and glutathion (GSH), and these two kinds of materials all can be removed the harmful free radical of human body.SOD comprises Cu, and Zn-SOD, Mn-SOD, Fe-SOD, EC-SOD and gene recombinaton HR-SOD in use can use wherein any one or a few;
It is Hyaluronic Acid that skin of the present invention keeps moisture content and crease-resistant material, i.e. hyaluronic acid, and this material can prevent cicatrix in the time of wound healing.Its percentage by weight is 0.001 % by weight-0.01 % by weight;
PH buffer agent of the present invention is vitamin C;
Penetrating agent of the present invention is propylene glycol, dipropylene glycol or propylene glycol dipelargonate; If use the propylene glycol should 5 % by weight-25 % by weight;
Antioxidant of the present invention is ascorbic acid, bata-carotene (with oil mediation, because it is fat-soluble) resveratrol etc., can select wherein one or more, and consumption is 0.01 % by weight;
0.1 milligram-1 milligram of fibronectin, this material contributes to the healing of wound, due to very expensive, also can not add or add less;
Final emulsion pH value is adjusted between 4.5-6.0, to adapt to people's the needs of skin environment.
Detailed description of the invention
Embodiment 1
Various compositions and shared percentage by weight below will be described, taking overall emulsion as 1000 milliliters.
Aqueous phase substance of the present invention is distilled water, and shared percentage by weight is 70 % by weight-80 % by weight;
10 grams, sodium chloride;
Lidocaine hydrochloride or lidocaine carbonate 0.1-2 gram;
Nano phase ag_2 o granule of the present invention, granular size size 10 to 200nm (nanometer), because specific surface area is large, so consumption seldom just can reach effect of sterilizing, its weight is 0.001 % by weight-0.01 % by weight, uses polar substances to make the dispersant of nano phase ag_2 o granule, for example long-pending bisphosphate, consumption is few, is 0.0005 % by weight-0.01 % by weight;
Fatty phase material of the present invention accounts for 5-30 % by weight, glycerol and vitamin E oil, and vitamin E oil 0.01 % by weight wherein;
Epidermal cell repairing material of the present invention is superoxide dismutase (SOD) and glutathion, SOD comprises Cu, Zn-SOD, Mn-SOD, Fe-SOD, EC-SOD and gene recombinaton HR-SOD, in use can use wherein any one or a few, add SOD, the enzyme that produces family and different lot numbers due to difference is alive all different, guarantees that every ml emulsion has 40-500u (enzyme is alive)/ml so institute adds SOD amount; Glutathion 0.5-2 gram;
It is Hyaluronic Acid that skin of the present invention keeps moisture content and crease-resistant material, i.e. hyaluronic acid, and percentage by weight is 0.001 % by weight-0.01 % by weight;
PH buffer agent of the present invention is vitamin C;
Penetrating agent of the present invention is propylene glycol, dipropylene glycol or propylene glycol dipelargonate; If use the propylene glycol should 5 % by weight-25 % by weight;
Antioxidant of the present invention is ascorbic acid, bata-carotene (with oil mediation, because it is fat-soluble) etc., can select wherein one or more, and consumption is 0.01 % by weight;
0.1 milligram-1 milligram of fibronectin;
Final emulsion pH value is adjusted between 4.5-6.0, to adapt to people's the need of skin environment
Manufacture method: first use 700-800 ml distilled water by 10 grams, sodium chloride and lidocaine hydrochloride or lidocaine carbonate 0.1-2 gram dissolving, filter out impurities and non-dissolved matter matter, then remaining composition is added in solution and fully stir.Ambient temperature remains on 15 DEG C-25 DEG C.Emulsion pH value is adjusted between 4.5-6.0 with PH buffer agent vitamin C.
Embodiment 2
Various compositions and shared percentage by weight below will be described, taking overall emulsion as 1000 milliliters.
Aqueous phase substance of the present invention is distilled water, and shared percentage by weight is 70 % by weight-80 % by weight;
10 grams, sodium chloride;
Lidocaine hydrochloride or lidocaine carbonate 0.1-2 gram;
Nano phase ag_2 o granule of the present invention, granular size size 10 to 200nm (nanometer), because specific surface area is large, so consumption seldom just can reach effect of sterilizing, its weight is 0.001 % by weight-0.01 % by weight, uses polar substances to make the dispersant of nano phase ag_2 o granule, for example long-pending bisphosphate, consumption is few, is 0.0005 % by weight-0.01 % by weight;
Fatty phase material of the present invention accounts for 5-30 % by weight, glycerol and vitamin E oil, and vitamin E oil 0.01 % by weight wherein;
Epidermal cell repairing material of the present invention is superoxide dismutase (SOD) and glutathion, SOD comprises Cu, Zn-SOD, Mn-SOD, Fe-SOD, EC-SOD and gene recombinaton HR-SOD, in use can use wherein any one or a few, add SOD, the enzyme that produces family and different lot numbers due to difference is alive all different, guarantees that every ml emulsion has 40u (enzyme is alive)/ml-500u (enzyme is lived)/ml so institute adds SOD amount; Glutathion 0.5-2 gram;
It is Hyaluronic Acid that skin of the present invention keeps moisture content and crease-resistant material, i.e. hyaluronic acid, and percentage by weight is 0.001 % by weight-0.01 % by weight;
PH buffer agent of the present invention is vitamin C;
Penetrating agent of the present invention is propylene glycol, dipropylene glycol or propylene glycol dipelargonate; If use the propylene glycol should 10 % by weight;
Antioxidant of the present invention is ascorbic acid, bata-carotene (with oil mediation, because it is fat-soluble) etc., can select wherein one or more, and consumption is 0.01 % by weight; Final emulsion pH value is adjusted between 4.5-6.0, to adapt to people's the need of skin environment
Manufacture method: first use 700-800 ml distilled water by 10 grams, sodium chloride and lidocaine hydrochloride or lidocaine carbonate 0.1-2 gram dissolving, filter out impurities and non-dissolved matter matter, then remaining composition is added in solution and fully stir.Ambient temperature remains on 15 DEG C-25 DEG C.Emulsion pH value is adjusted between 4.5-6.0 with PH buffer agent vitamin C.
Claims (2)
1. an oil-in-water O/W emulsion for the treatment of skin trauma, is characterized in that: comprise aqueous phase substance; Sodium chloride; Lidocaine hydrochloride or lidocaine carbonate; Nano phase ag_2 o granule; Nano phase ag_2 o particle dispersants; Fat phase material; Epidermal cell repairing material; Skin keeps moisture content and crease-resistant material; PH buffer agent; Penetrating agent; Antioxidant; Fibronectin; Entirety emulsion is 1000 milliliters, using overall emulsion as 100 % by weight:
Described aqueous phase substance is distilled water, 70 % by weight-80 % by weight;
Described sodium chloride is 10 grams;
Described lidocaine hydrochloride or lidocaine carbonate 0.1-2 gram;
Described nano phase ag_2 o granule, granular size size 10 to 200nm (nanometer), because specific surface area is large, so consumption seldom just can reach effect of sterilizing, its consumption is 0.001 % by weight-0.01 % by weight;
Described nano phase ag_2 o particle dispersants, diphosphonate ester, consumption is 0.0005 % by weight-0.01 % by weight;
Described fatty phase material is glycerol and vitamin E oil, and fatty phase material accounts for 5-30 % by weight, and vitamin E oil consumption is wherein 0.01 % by weight;
Described epidermal cell repairing material, epidermal cell repairing material is superoxide dismutase (SOD) and glutathion, SOD comprises Cu, Zn-SOD, Mn-SOD, Fe-SOD, EC-SOD and gene recombinaton HR-SOD, use wherein any one or a few, add SOD, the enzyme that produces family and different lot numbers due to difference is alive all different, and SOD amount guarantees that every ml emulsion has 40-500u; Glutathion 0.5-2 gram;
It is hyaluronic acid that described skin keeps moisture content and crease-resistant material, and consumption is 0.001 % by weight-0.01 % by weight;
Described pH buffer agent is vitamin C;
Described penetrating agent is propylene glycol, dipropylene glycol or propylene glycol dipelargonate, and using the consumption of propylene glycol is 5 % by weight-25 % by weight;
Described antioxidant is ascorbic acid, bata-carotene, selects wherein a kind of or two kinds, and consumption is 0.01 % by weight;
Described fibronectin is 0.1 milligram-1 milligram;
Final ph value of emulsion is adjusted between 4.5-6.0, to adapt to people's the demand of skin environment.
2. according to the manufacture method of a kind of oil-in-water O/W emulsion for the treatment of skin trauma of claim 1, it is characterized in that: first use 700-800 ml distilled water by 10 grams, sodium chloride and lidocaine hydrochloride or lidocaine carbonate 0.1-2 gram dissolving, filter out impurities and dissolved substance not, then remaining composition is added in solution and fully stir, ambient temperature remains on 15 DEG C-25 DEG C, ph value of emulsion is adjusted between 4.5-6.0 with pH buffer agent vitamin C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010500291.2A CN102343085B (en) | 2010-08-02 | 2010-10-09 | Oil in water (O/W) emulsion for treating skin trauma and preparation method of oil in water emulsion |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010241490.6 | 2010-08-02 | ||
| CN201010241490 | 2010-08-02 | ||
| CN201010500291.2A CN102343085B (en) | 2010-08-02 | 2010-10-09 | Oil in water (O/W) emulsion for treating skin trauma and preparation method of oil in water emulsion |
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| CN102343085A CN102343085A (en) | 2012-02-08 |
| CN102343085B true CN102343085B (en) | 2014-08-27 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107812179A (en) * | 2017-12-01 | 2018-03-20 | 成都卓阳生物科技有限公司 | A kind of application of reduced glutathione in preparing treatment wound and smearing medicament |
| CN107951865A (en) * | 2017-12-04 | 2018-04-24 | 长沙英芙机电科技有限公司 | A kind of nanometer agent patch for being used to treat skin and mucosa damage |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1506071A (en) * | 2002-12-12 | 2004-06-23 | 季海平 | High-permeability burn treating prepn |
| CN1850291A (en) * | 2006-06-09 | 2006-10-25 | 山东省医疗器械研究所 | Liquid wound-dressing with functions of promoting heal of wound and bacterial-resisting |
| CN1911238A (en) * | 2005-08-08 | 2007-02-14 | 美时化学制药股份有限公司 | Composite used for skin, and its application method |
| CN101658470A (en) * | 2009-09-18 | 2010-03-03 | 北京欧凯纳斯科技有限公司 | Moisturizer and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007044582A1 (en) * | 2007-09-19 | 2009-04-09 | Deckner, Peter G., Dr. med. | Composition for wound treatment in the human area |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1506071A (en) * | 2002-12-12 | 2004-06-23 | 季海平 | High-permeability burn treating prepn |
| CN1911238A (en) * | 2005-08-08 | 2007-02-14 | 美时化学制药股份有限公司 | Composite used for skin, and its application method |
| CN1850291A (en) * | 2006-06-09 | 2006-10-25 | 山东省医疗器械研究所 | Liquid wound-dressing with functions of promoting heal of wound and bacterial-resisting |
| CN101658470A (en) * | 2009-09-18 | 2010-03-03 | 北京欧凯纳斯科技有限公司 | Moisturizer and preparation method thereof |
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Address after: 100023 1307, 402 / F, cuichengxinyuan, Longtou, Chaoyang District, Beijing Patentee after: Gong Senmiao Address before: 100011 room 402, door 2, 11th floor, 47 ande Road, Dongcheng District, Beijing Patentee before: Gong Senmiao |