JPH1025246A - Oral hypnotic agent, hypnotic beverage and food, and hypnotic feed - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hypnotic agent, hypnotic beverage and food products, and hypnotic feeds which contain a specific essential oil as an active ingredient and brings sleep introduction and/or sound sleep on people and animals of sleeplessness and sleepless tendency. SOLUTION: This hypnotic agent contains lavender essential oil as an active ingredient. The lavender essential oil is obtained, for example, by subjecting the flower spikes of lavender belonging to the family Labiatae. This essential oil contains linalyl acetate (about 25-55wt.%), linalol, pinene, limonene, geraniol and the like. The dose of the lavender oil every administration is preferably 0.1-640mg/kg body weight. This hypnotic agent does not cause side-effect, for example, excitation at the initial stage after administration, irritation on the stomach and giddy feeling on the next day of the treatment, and its action is mild with wide safety range and low resistance and low addiction. In addition, the lavender oil may be added to cookies, biscuits, jelly as well as to animal feeds.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a hypnotic, a hypnotic food and drink, and a hypnotic diet. Specifically, the present invention is characterized by containing lavender essential oil as an active ingredient, and has a hypnotic agent, a food and a drink, and a feed that have an effect of promoting sleep and deep sleep for humans and animals having insomnia or insomnia. About.

[0002]

2. Description of the Related Art Conventionally, sleep-inducing drugs such as tranquilizers have been used for the treatment of insomnia, but these drugs are dramatic and have many side effects such as tolerance due to continuous use and rebound insomnia. Even benzodiazepine-based drugs, which are said to have relatively few side effects, have been reported to have side effects such as anterograde amnesia and a tendency to develop a depressive state after taking the drug.Development of sleeping pills that can be taken safely without such side effects Is required.

[0003] By the way, according to aromatherapy which has been known for a long time mainly in the European region, pharmacological and psychological treatments using various essential oil scents have been widely reported ("Practical aromatherapy" by Charlie Price). (Aromatherapy: Robert Tisland, translated by Takayama Rintaro, 1985), many reports have been published on the effects of scents on physiological and psychological conditions in various research fields. [Chemical Technology Magazine, August 1990
Month: Fragrance Journal, No. 86, 1987; Fragrance Journal, No. 77, 16, 1986; Japanese Neuropsychological Pharmacology Journal, Vol. 15, 39-42, 1995; FOOD & FOOD I
NGREDIENTS JOURNAL No.156, 1993 etc.). In addition, there are reports in Japanese Patent Application Laid-Open Nos. 4-128234 and 4-149136 regarding the sleep effect of the essential oil used in aromatherapy.

In such aromatherapy (aroma therapy), lavender essential oil is often used because of its high safety and the like, in addition to its sedative, bactericidal, anti-inflammatory, antitussive and relaxing effects. Have been. If a hypnotic-promoting action is found in such highly safe vegetable essential oil, it will be possible to provide a safer hypnotic with less adverse effects compared to the tranquilizer described above.

[0005] However, Japanese Patent Application Laid-Open No. 4-149136 (Patent Publication, page 13, Example 2) discloses that lavender essential oil has almost no sleep promoting effect.
There is no report that lavender essential oil has a hypnotic effect.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a hypnotic containing lavender essential oil as an active ingredient, which has excellent effects of promoting sleep onset and maintaining sleep, and is also refreshing to wake up.

[0007] Another object of the present invention is to provide a hypnotic food and drink characterized by containing lavender essential oil.

[0008] It is another object of the present invention to provide a hypnotic food especially for animals such as pets.

[0009]

Means for Solving the Problems The present inventors have investigated the hypnotic effect of various essential oils in order to solve the conventional problems. Lavender essential oil, which was thought to be non-existent, has an excellent hypnotic effect. Further studies have found a novel fact that its hypnotic effect is exerted by absorption of lavender essential oil orally into the body through the digestive tract. The present invention has been completed based on these findings.

That is, the present invention is a hypnotic, preferably an orally administered hypnotic, comprising lavender essential oil as an active ingredient.

The present invention is also a hypnotic food and drink, preferably a diet food and drink, characterized by containing lavender essential oil.

Further, the present invention is a hypnotic feed containing lavender essential oil.

[0013]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hypnotic The hypnotic of the present invention is characterized by containing lavender essential oil as an active ingredient.

The lavender essential oil used in the present invention includes, for example, lavender belonging to the Labiatae family.
La vera Candole) includes essential oils that can be obtained by steam distillation of spikes, or equivalents thereof. Usually, such essential oils include linalyl acetate (about 25 to 55%), linalool, pinene, limonene, geraniol, cineole, and the like. It is included. There are no particular restrictions on the origin and production area of the lavender, and various production areas such as France, Italy, the United Kingdom, Russia, Australia, North America, and Hokkaido can be used.

The hypnotic of the present invention only needs to contain such lavender essential oil as an active ingredient, and the purity of the essential oil contained therein is not particularly limited.

Lavender essential oil, which is an active ingredient of the hypnotic of the present invention, preferably exhibits a hypnotic effect by absorption from the digestive tract such as the stomach and the small intestine. Therefore, the hypnotic of the present invention is preferably formulated in a form containing lavender essential oil in a form that is absorbed from the digestive tract such as the stomach and the small intestine.

As shown in the experimental examples described below, lavender essential oil, which is an active ingredient of the hypnotic of the present invention, has a significant hypnotic effect even when administered to a subject in a capsule so that the fragrance of the essential oil does not leak. Demonstrate. In general, flavor components such as lavender essential oils have a wide range of tastes, and some people may rather feel mental stress such as disgust.
Therefore, also from such a viewpoint, the hypnotic of the present invention is formulated into a dosage form that can be expected to have a stable hypnotic effect without being affected by human preference, that is, a form that can be taken orally. Is preferred. Therefore, the present invention is an oral hypnotic preferably containing lavender essential oil as a gastrointestinal absorption component.

The form of the hypnotic of the present invention is not particularly limited, and those known per se are widely used, but as described above, they are preferably those generally used as oral preparations. Specifically, tablets, pills, granules, powders, capsules, microcapsules, suspensions, liquids, syrups,
Jelly-like or the like is exemplified, and can be appropriately selected from these depending on the purpose of use, the object of use, and the like. Among them, preferred are capsules, microcapsules, granules, liquids, syrups and jellies.

The composition, preparation method and the like of the hypnotic of the present invention are not particularly limited, and can be appropriately prepared according to the purpose according to a conventional method. For example, the composition of the hypnotic of the present invention may be lavender essential oil itself, or other excipients, disintegrants, binders, lubricants, odorants, flavoring agents, sweeteners, stabilizers, vitamins. It may contain various pharmaceutically or food-sanitary acceptable oral additives such as agents and preservatives.

The hypnotic of the present invention has no side effects such as stimulating action at the early stage of administration, stomach irritation, and a feeling of lightness the next day, as compared with conventional hypnotics such as barbituric acid and chloral hydrate. It is characterized by mild action, a wide safety range, and low tolerance and habit.

Therefore, the hypnotic of the present invention can be widely used as a pharmaceutical agent, a pharmaceutical auxiliary agent, a food additive, a food auxiliary agent, a feed / feed additive and the like as well as a pharmaceutical product. That is, the hypnotics of the present invention are not limited to those for medicinal uses such as hypnotics and hypnotic aids, and include a wide range of hypnotic food additives, hypnotic food aids, hypnotic feed (feed) additives, and the like. It is inclusive.

The content of the lavender essential oil in the hypnotic of the present invention is not particularly limited, and is appropriately selected from the range of 0.0001 to 100 (w / w)% in consideration of the dose per one dose described below. Is done.

The hypnotic of the present invention may be administered to humans or animals, or may be added to or blended with pharmaceuticals, foods or drinks, or feeds.

The amount of lavender essential oil contained in the hypnotic of the present invention is not fixed depending on the condition of the subject to which the lavender is applied or on its dosage form, but it is about 3 to 15000 mg per oral unit per dosage unit. It is desirable to do. The hypnotic of the present invention is preferably taken once or twice a day, usually 1 hour to 30 minutes before going to bed. The dose of the hypnotic of the present invention per dose varies depending on the subject to be applied, the age, sex, symptoms, etc. of the human or animal, but is usually 0.1 to 64 as the amount of lavender essential oil.
It can be appropriately selected from the range of 0 mg / kg, preferably 5 to 320 mg / kg, more preferably 45 to 160 mg / kg.

The hypnotic of the present invention can be widely applied to sleep disorders except for insomnia caused by organic disorders. Above all, mental causes such as anxiety, overwork, depression,
It is effective for insomnia when excitement is a factor. In addition, the hypnotic of the present invention has an effect of inducing physiological sleep (promoting sleep onset) and an effect of continuously prolonging sleep time (continuous hypnotic effect). Therefore, the hypnotic of the present invention broadly includes a hypnotic and a continuous hypnotic.

The hypnotic of the present invention can be widely applied to animals as well as humans. Particularly in recent years, pets such as cats, dogs, birds, or hamsters, which are warm-blooded animals kept indoors, have become a problem, and they can be effectively used for improving stress insomnia of such pets. it can. In this case, the hypnotic of the present invention may be administered as it is as a capsule or a syrup, or the hypnotic of the present invention may be mixed with water, food, or the like and administered to a pet.

Hypnotic food and drink As shown in the experimental examples described below, the hypnotic effect of lavender essential oil is significantly recognized when taken orally and absorbed in the digestive tract. In addition, lavender essential oil is safe with less adverse effects such as side effects and habits, and can be easily and routinely used as compared with hypnotics conventionally used as pharmaceuticals. Eating, on the other hand, is one way to relieve mental stress, and everyone is going to experience not being able to sleep due to hunger or waking up.

In view of the above, the present invention provides a hypnotic food and drink which exerts an effect of alleviating mental stress by "eating" and satisfying a feeling of hunger and exhibiting a hypnotic effect by lavender essential oil. .

As the lavender essential oil to be used, those described above can be exemplified.

The food and drink of the present invention may be in any form in which lavender essential oil is absorbed from the gastrointestinal tract, that is, it is blended and prepared as a gastrointestinal absorption component. Is not particularly limited.

For example, the kind of food and drink to which the present invention is applied is not particularly limited as long as the hypnotic action of lavender essential oil is not impaired, and cookies, biscuits, jellies,
Sweets such as candy and marshmallows, foods such as yogurt and noodles, refreshing and carbonated drinks, milk, cocoa, tea, coffee,
A wide range of beverages or luxury items such as alcohols can be targeted.

[0032] Preference is given to diet foods and drinks.
Here, food and drink for diet refers to food and drink in consideration of nutrition and calories for weight control, specifically, the calorie per meal is usually 0 to 100 kcal, preferably 0 to 40 kcal, more preferably Is 0-3
It is in the kilocalorie range, and more specifically, cookies, biscuits, jellies, marshmallows, soft drinks or cocoa, etc. in this calorie range.

The diet or food for hypnosis of the present invention can be eaten without fear of obesity or guilt when insomnia is caused by mental depression or hunger caused by the diet. It is useful in that it can also exert the stress relieving effect of eating.

According to the food and drink of the present invention, unlike a drug, even elderly people who suffer from insomnia (mild sleep disorder) can take it without resistance due to the decrease in sleep time with aging.

The method of preparing the food and drink of the present invention is not limited either, and lavender essential oil may be blended into a commonly used food or beverage composition to prepare confectionery such as cookies and soft drinks. Alternatively, it may be prepared by adding and blending lavender essential oil itself or the above-mentioned oral hypnotic as a food additive or the like to ready-made foods and drinks such as milk and alcohols.

The form of the lavender essential oil contained is not particularly limited as long as it is absorbed in the digestive tract.
It can be appropriately selected depending on the type of food and drink. For example, the essential oil may be used as it is, or may be prepared in various forms such as powder, granule, microcapsule, and syrup. However, when lavender essential oil is contained in the food or drink in an amount of 0.5% by weight or more, the lavender essential oil is contained in a microcapsule form so as to reduce the odor and unpleasant taste of the lavender essential oil and not impair the taste of the food and drink itself. Preferably. Note that any form other than the microcapsules may be used as long as the odor and taste of the lavender essential oil are reduced.

The fragrance of food and drink is not particularly limited as long as the lavender essential oil is absorbed from the digestive tract, and it depends on the type of food and drink, its flavor and taste, and the taste of the subject. Can be selected as appropriate. Therefore, the food and drink of the present invention may or may not have an aroma derived from lavender essential oil.

The amount of lavender essential oil contained in the hypnotic food of the present invention varies depending on the type of food and the like, but is usually 0.005 to 20% by weight, preferably 0.01 to 15% by weight, and more preferably 0.1 to 5% by weight.

The amount of intake varies depending on the age, sex, and insomnia symptoms of the food and drink, but is usually 0.1 to 40 mg / kg body weight per serving as essential oil, preferably 1 to 2 mg.
The range is 0 mg / kg.

The lavender essential oil, which is a hypnotic component of the hypnotic food of the present invention, is absorbed from the digestive tract and gradually exerts its effect, and the hypnotic food of the present invention usually takes 2 hours before going to bed. It is preferably taken 30 minutes before.

Hypnotic Diet In addition, lavender essential oil can be applied to animal diets, expecting a hypnotic effect by oral administration.

That is, the present invention provides a hypnotic feed containing lavender essential oil.

The term "feed" generally refers to foods and drinks for growing and breeding animals, but the present invention is not limited to such purposes and broadly includes foods and drinks given to animals. Used for the purpose.

The animal to which the feed of the present invention is directed is
It is not limited by the type of animal, and includes warm-blooded animals, particularly mammals. Specific examples include pets and livestock such as dogs, cats, monkeys, birds, rats, and hamsters.

The feed of the present invention may be in a form in which lavender essential oil is absorbed from the gastrointestinal tract, in other words, as long as it contains a gastrointestinal absorption component.
The preparation method and the like are not particularly limited.

In general, it can be prepared by appropriately mixing with a commonly used feed / feed or feed / feed composition (regardless of whether it is a natural feed / feed or an artificial feed / feed). The content of lavender essential oil varies depending on the type, age, body weight, and the like of the animal, and can be appropriately selected and changed. Usually per serving, as a lavender essential oil,
40 to 650 mg / kg, preferably 160 to 320 m
g / kg, 0.5 to 30% by weight of lavender essential oil, preferably 1 to 20% by weight per feed
Is selected in the range.

Examples of the present invention and reference examples are shown below.
These examples are merely for illustrating the present invention, and the present invention is not limited thereto.

[0048]

EXAMPLES Example 1 (Capsule) 5 g of gelatin heated to 40 to 60 ° C. is gradually added with stirring and mixed and dissolved. After defoaming the mixed solution under reduced pressure, appropriate amounts of titanium oxide and a dye are added and further mixed. Then, after filling into a capsule type bottle and molding, the water content is 15 ~
After drying to 18%, the body part of the capsule was filled with 200 mg of lavender essential oil, and the cap part was bound to prepare a capsule containing lavender essential oil.

Example 2 (microcapsules) 5 g of gelatin was added to 100 g of purified water heated to 40 ° C.
Is added slowly with stirring, and mixed and dissolved. afterwards,
Lavender essential oil 200mg, titanium oxide, glycerin,
An appropriate amount of dye is added and mixed to obtain a capsule. The capsules were then cooled and dehydrated to 15-18% and further dried to 8.2-16% moisture. Thereafter, filtration was performed to prepare microcapsules containing lavender essential oil.

Example 3 (Cookie) A cookie containing lavender essential oil was prepared in the following manner using the following amounts.
Light flour 200 g Unsalted butter 70 g Sugar (granulated sugar) 80 g 1 egg Lavender essential oil 2 g First, butter is stirred, and sugar is gradually added with stirring. After adding the broken eggs, lavender essential oil is added, and the speed is reduced to further stir. At the stage of sufficient mixing, add the lightly sifted flour to this, stir at low speed, and combine into one. This is about 3
After lying in a low-temperature room for 0 minutes, spread uniformly about 1 cm in thickness and pull out with a 5 cm diameter circular mold. Next, the cut out cookie dough is arranged on a top plate, and to prevent volatilization of essential oil, olive oil is applied to the dough surface and heated in an oven preheated at 170 ° C for 12 to 15 minutes.

Example 4 (Soft drink) Soft drink was prepared according to the following formulation.

Fructose-glucose liquid sugar 6.0 parts by weight Sodium citrate 0.6 L-ascorbic acid 3.0 Lavender essential oil 0.5 water Suitable amount total amount 100 parts by weight Example 5 (tea) Black tea leaves 1.2 mg Is put in 100 ml of hot water (80 ° C.), sufficiently immersed, and then decanted to obtain a leachate. 5 g of sugar and 0.5 lavender essential oil were added to this leachate.
g was added to make a total of 100 ml.

Example 6 (Jelly) After heating 50 ml of water to about 60 ° C., gelatin was added and stirred. After the gelatin was dissolved, the other ingredients were added with stirring, and after everything was dissolved, the mixture was poured into a container, cooled and solidified in a low-temperature room, and a jelly containing 0.5% by weight of lavender essential oil was prepared.

Sugar 22.0 parts by weight L-tartaric acid 0.1 Sodium citrate 0.1 Gelatin 1.1 Citric acid 0.1 Lavender essential oil 0.5 Water Suitable amount Total amount 100 parts by weight Example 7 (alcohols) Neutral spirits 30.0 parts by weight Stepiosite 0.1 Fragrance 5.0 Lavender essential oil 0.3 Water Suitable amount Total amount 100 parts by weight Example 8 (pet food) Lavender essential oil is 60 parts by weight in the same manner as in Example 2. % Microcapsules were prepared. Next, the microcapsules were blended at the following ratio to prepare a feed (pet food) containing 5.4% by weight of lavender essential oil.

[0055] Beef (20 × 20 × 20 mm soybean shaped cut) 80.0 parts by weight of coagulant (carrageenan) 2.0 saline 0.1 lavender filled microcapsules 9.0 water appropriate amount Total 100.0 parts by weight

[0056]

[Experimental example]

Experimental Example 1: Barbital sleep prolongation test-Experimental example A-Lavender, marjoram as test essential oils
(Marjorum), Chamomile (Chamomile), Rose (Rose),
Using clary sage (Clary Sage), velbena (Velbena), and linalyl acetate (Lynaryl Acetate) (each manufactured by Nagaoka Perfume Co., Ltd.), each of these was orally administered to ddy male mice at a dose of 600 mg / kg. The sleep prolonging effect of essential oil was compared.

The ddy male mouse animal (Japan SLC) to be used has a temperature of 21 to 25 ° C. and a humidity of 48 to
Solid sample F-2 (Funabashi Farm) in a breeding room set under the conditions of 65%, lighting time 12 hours (7:00 to 19:00)
And tap water (conforming to tap water quality standards) was freely taken and bred. The mice were housed only with no abnormalities by observing their health condition with the naked eye, and preliminarily reared for 3 days or more from the time of arrival, and then used in more general condition.

The experiment was conducted at the age of 6 weeks (weight 27-32).
The mice in g) were used as 10 mice per group.

The experiment was conducted using a solvent (olive oil: control).
Alternatively, 30 minutes after oral administration of a test solution (test essential oil such as lavender essential oil), 45 mg / kg of pentobarbital (Nembutal: manufactured by Dainippon Pharmaceutical Co., Ltd.) was intraperitoneally administered, and before returning spontaneously from the lateral posture to the abdominal position. The time was measured as the anesthesia time.

Table 1 shows the results.

[0061]

[Table 1]

When the hypnotic effects of the essential oils were compared, a remarkable sleep-prolonging effect was observed in the lavender essential oil, and there was almost no difference in the effect due to individual differences. On the other hand, marjoram, chamomile, rose, and clary sage showed large individual differences, some of which exhibited prolonging action and those of which did not, so that the sleep prolonging action of essential oil could not be confirmed.

-Experimental Example B- Among the essential oils used in Experimental Example A, lavender essential oil having a remarkable hypnotic effect was 2.5 to 640 mg / k.
The same experiment as in Experimental Example A was performed except that the dose was changed within the range of g body weight.

Table 2 shows the results.

[0065]

[Table 2]

The sleep prolonging effect was remarkably recognized from the administration of lavender essential oil at a dose of 40 mg / kg or more.

Experimental Example 2 Insomnia-Promoting Activity Using the same system as in Experimental Example 1, mice were treated with test solution (lavender essential oil, 2.5 m / kg of body weight).
g, 10 mg, 40 mg, 160 mg, and 640 mg) or as a control, 30 minutes after oral administration of a solvent (olive oil), and 45 mg / kg of pentobarbital (Nembutal: manufactured by Dainippon Pharmaceutical) intraperitoneally, followed by righting reflex. The time until disappearance was measured and evaluated as sleep onset time.

FIG. 1 shows the results.

From this experiment, it was confirmed that the administration of lavender essential oil significantly reduced the time to sleep.

Experimental Example 3 Three adults were randomly selected from adults who were uncomfortable with falling asleep or complaining of insomnia, and these were used as subjects to take capsules containing lavender essential oil prepared with the following formulation and sleep. The effect on was examined.

The hypnotic effect was evaluated on the following evaluation items in five stages as compared with the state before the experiment.

Evaluation items: (i) falling asleep, (ii) depth of sleep, (iii) awakening during sleep, (i)
v) Awake state ・ Evaluation: Compared to usual A: Good, B: Somewhat good, C: No change, D: Somewhat bad, E: Bad In addition, taking time is 30 minutes to 1 before bedtime They were instructed to avoid taking alcohol and other psychiatric drugs when taking the drug.

Capsules: Oral preparations containing lavender essential oil were prepared by encapsulating 200 mg of lavender essential oil in hard capsules so that the fragrance did not leak.

Table 3 shows the results.

[0075]

[Table 3 ] Evaluation ABCDE (i) Sleeping 300 000 (number of people) (ii) Depth of sleep 300 000 (iii) Awakening during sleep 300 000 (iv) Awake state As is clear from the 300.000 table, the hypnotic effect of the lavender essential oil-containing agent was observed in all of the subjects. In addition,
One of the three patients took lavender essential oil three times every two days to check their sleep status. As a result, all items were evaluated as A.

At the same time, a questionnaire was taken about whether or not the following symptoms appeared when the subject took the drug or on the next day.

・ Palpitations / vertigo / rash /
Fatigue / Headache / Nausea / Vomiting /
Diarrhea / Mouth thirst / The next day, I felt drowsy during the day /
The next day, fatigue remained.

As a result, none of the subjects corresponded to any of the items.

From the above, it can be said that the hypnotic agent of the present invention is not only exerting a hypnotic effect (promoting sleep onset, maintaining hypnosis, sleeping well), but also showing no side effects including post-effects.

In addition, as a comparative experiment, a capsule containing rose essential oil (rose essential oil 200 mg / capsule) prepared with the same formulation as lavender essential oil was similarly taken from 30 minutes to 1 hour before bedtime to examine the effect on sleep. . As a result, it was found that the state of falling asleep, the depth of sleep, and the state of awakening were not changed as usual, and that the awakening during sleep was slightly worse than usual.

Reference Example The mental stability effect by inhalation of lavender aroma was examined by the tests of 1 and 2 below.

1. Kraepelin test By having the subject perform the calculation work continuously,
The mental stability effect can be evaluated from changes in work efficiency and correct answer rate. Therefore, two groups consisting of 15 healthy adults aged 24 to 32 were formed, and a room in which lavender fragrance was volatilized at room temperature from odor paper prepared by impregnating lavender essential oil, and no fragrance was presented. They were divided into rooms and the following work was performed in each room. The former is group A and the latter is group B.

<Work content> In the work, after adding the numbers printed on the paper next to each other, the last one digit of the answer is written in the “line spacing / added character space” with a pencil. is there. In accordance with the examiner's command, change the line every minute, and perform 15 minutes on the front and back of the entry form (numbers are printed on both sides). One minute was defined as one work, and 15 sets were continuously performed as one set (first half 15 minutes → break 10 minutes →
15 minutes in the latter half). In order to see the difference in work efficiency between morning and afternoon, we carried out twice a day in the morning and in the afternoon. The results are shown in FIG. 2. In the group B who performed the work in the room where the scent was not presented, the correct answer rate in the latter half of the work was lower than that in the first half of the work (99.6%
In contrast, the correct answer rate for the second half of the work in the group A working in the room where the aroma evaporates is higher than that of the first half (99.63% → 99.83%). Was.
From this, it was recognized that mental stability was obtained by inhalation of the fragrance component of the lavender essential oil.

2. Brain wave measurement Brain wave is the one that electrically captures the activity of nerve cells in the brain. Among them, α wave is one of the components of brain wave.
It is known that the amount of α-waves increases in a resting state when a human subjectively feels “calm down” (“Effect of fragrance on brain function”, Fragrance Journal, 1989) No. 9, Years 20-26
page). Therefore, the rest effect can be evaluated by measuring the amount of appearance of α waves of brain waves.

<Experimental method>
A method in which 0.02 to 0.06 ml of lavender essential oil was dropped in liter of hot water (about 40 ° C.) was placed in front of the subject, and the lavender essential oil volatilized therefrom was inhaled.

Two electrodes on the subject's forehead were attached, and
After measuring the EEG at the point and performing fast Fourier transform, 6-12
The α-wave appearance amount of Hz was extracted and compared with the case where the scent was not inhaled. The experiment was performed by inhalation for 5 minutes, α
The amount of wave appearance is calculated using the Brain-Machine Interf
ace (manufactured by Ability Development Laboratory Co., Ltd.).

FIG. 3 shows the results. As is evident from the results, the inhalation of the lavender aroma significantly increased the appearance of the α-wave, and a tranquilizing effect of the aroma component of the lavender essential oil was recognized.

Incidentally, Japanese Patent Laid-Open No. 4-149136, No. 1
From the bottom left column of the third page, the fifth line to the bottom right column of the same page, the 15th line, there is the following description.

Example 2 A total of 68 adults (17 groups × 4 people) aged 24 to 45 who tend to be insomnia, such as having difficulty falling asleep or not having a feeling of deep sleep
Inhaled essential oil for aroma therapy, and examined the effect on sleep. ... (on the way, omitted) ... 1 ml of essential oil for aroma therapy was placed in a glass bottle with a lid. Each one
The subjects of the seven groups (four in each group) inhaled the aroma that volatilizes at room temperature from the odor paper prepared by impregnating the essential oil in the glass bottle for about 15 to 25 seconds before going to bed every night. This aroma therapy was performed for a maximum of three consecutive days (three inhalations in total) (if subjective symptoms were improved on the way, it was stopped at that point). The promotion of a good night's sleep was evaluated in the following three stages as compared with before the aroma therapy.

I: no change (no effect); II: some sleep was achieved; III: considerable sleep was obtained. The results are shown in Table 3 below. The numerical values in Table 3 are the number of subjects who have been evaluated.

Table 3 Evaluation I II III (Omitted) Group 4 (Lavender oil alone) 310 Group 5 (Rose oil alone) 310 (Omitted) From the results shown in the above-mentioned Reference Examples and the description of the cited patent publication, lavender essential oil No relationship was found between the tranquilizer effect and the sleep-promoting effect of inhalation of fragrance components.

[Brief description of the drawings]

FIG. 1 is a diagram showing the results of an experimental study on the effect of lavender essential oil on falling asleep.

FIG. 2 is a diagram comparing the results of the Kraepelin test shown in Reference Example in the presence and absence of a lavender aroma.

FIG. 3 is a diagram comparing the appearance amounts of α-waves due to inhalation of lavender aroma shown in Reference Example.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code Agency reference number FI Technical display location A23L 1/30 A23L 1/30 B 1/307 1/307 2/00 C11B 9/00 A C11B 9 / 00 A23L 2/00 Z

Claims (8)

[Claims] 1. A hypnotic containing lavender essential oil as an active ingredient. 2. The hypnotic according to claim 1, which is administered orally. 3. The lavender essential oil is used in a dose of 0.1% per dose.
The hypnotic according to claim 1, wherein the hypnotic is contained in the range of ６640 mg / kg body weight. 4. A hypnotic food or drink comprising lavender essential oil. 5. A lavender essential oil content of 0.005 to 0.005.
The hypnotic food or drink according to claim 4, which is in a range of 20% by weight. 6. The hypnotic food or drink according to claim 4, wherein the food or drink is a diet food or drink. 7. The hypnotic food or drink according to claim 4, wherein the food or drink is selected from cookies, biscuits, jellies, marshmallows, soft drinks and cocoa. 8. A hypnotic feed containing lavender essential oil.