CN100345842C - 二聚化合物及其作为抗病毒剂的用途 - Google Patents

二聚化合物及其作为抗病毒剂的用途 Download PDF

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Publication number
CN100345842C
CN100345842C CNB02822244XA CN02822244A CN100345842C CN 100345842 C CN100345842 C CN 100345842C CN B02822244X A CNB02822244X A CN B02822244XA CN 02822244 A CN02822244 A CN 02822244A CN 100345842 C CN100345842 C CN 100345842C
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compound
phenyl
amino
formula
sucker
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Expired - Fee Related
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CNB02822244XA
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Chinese (zh)
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CN1585764A (zh
Inventor
德里克·A.·德迈纳
海登·T.·琼斯
西蒙·J.·F.·麦克唐纳
安德鲁·McM.·梅森
斯蒂芬·E.·沙纳汉
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Biota Scientific Management Pty Ltd
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Biota Scientific Management Pty Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CNB02822244XA 2001-11-09 2002-11-08 二聚化合物及其作为抗病毒剂的用途 Expired - Fee Related CN100345842C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR8797A AUPR879701A0 (en) 2001-11-09 2001-11-09 Novel chemical compounds and their use
AUPR8797 2001-11-09

Publications (2)

Publication Number Publication Date
CN1585764A CN1585764A (zh) 2005-02-23
CN100345842C true CN100345842C (zh) 2007-10-31

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CNB02822244XA Expired - Fee Related CN100345842C (zh) 2001-11-09 2002-11-08 二聚化合物及其作为抗病毒剂的用途

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US (2) US7214707B2 (enExample)
EP (1) EP1451183A4 (enExample)
JP (2) JP5183854B2 (enExample)
KR (1) KR100942494B1 (enExample)
CN (1) CN100345842C (enExample)
AU (2) AUPR879701A0 (enExample)
CA (1) CA2463835C (enExample)
TW (1) TW200303196A (enExample)
WO (1) WO2003040136A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR879701A0 (en) 2001-11-09 2001-12-06 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
CN108047153A (zh) * 2017-12-20 2018-05-18 上海朗亿功能材料有限公司 一种低挥发环状碳化二亚胺类化合物及其制备方法
JP7520816B2 (ja) * 2018-09-06 2024-07-23 シダラ セラピューティクス インコーポレーテッド ウイルス感染症の治療のための組成物及び方法
TWI861205B (zh) * 2019-09-06 2024-11-11 美商席達拉醫療有限公司 用於治療病毒感染之組合物及方法
CN110981754A (zh) * 2019-12-19 2020-04-10 山东华阳农药化工集团有限公司 一种二苯基乙烷二异氰酸酯及其制备方法
CN110981753A (zh) * 2019-12-19 2020-04-10 山东华阳农药化工集团有限公司 一种碳酸二甲酯法制备二苯基乙烷二异氰酸酯及其应用
CN110903216A (zh) * 2019-12-19 2020-03-24 山东华阳农药化工集团有限公司 一种固体光气法制备二苯基乙烷二异氰酸酯及其应用
EP4192512A1 (en) * 2020-08-06 2023-06-14 Cidara Therapeutics, Inc. Methods for the synthesis of protein-drug conjugates
WO2022032188A1 (en) * 2020-08-06 2022-02-10 Cidara Therapeutics, Inc. Methods for the synthesis of protein-drug conjugates
CA3211494A1 (en) * 2021-03-11 2022-09-15 Leslie W. Tari Protein-drug conjugates for antiviral therapy
US20250144220A1 (en) * 2021-12-30 2025-05-08 Suzhou Ark Biopharmaceutical Co., Ltd. Conjugate for preventing and treating viral infections and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000055149A1 (en) * 1999-03-12 2000-09-21 Biota Scientific Management Pty. Ltd. Dimeric compounds and as inhibitors of neuraminidase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10507624A (ja) * 1994-08-18 1998-07-28 アリアド・ジーン・セラピューティクス・インコーポレーテッド 遺伝子発現、遺伝子産物機能および工学処理された宿主細胞の調節可能な除去
GB9516276D0 (en) * 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds
KR19990087449A (ko) * 1996-03-01 1999-12-27 리차드 웨드레이 인플루엔자 바이러스의 검출방법 및 이에 이용되는 화합물
AUPR001000A0 (en) * 2000-09-08 2000-10-05 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
AUPR879701A0 (en) 2001-11-09 2001-12-06 Biota Scientific Management Pty Ltd Novel chemical compounds and their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000055149A1 (en) * 1999-03-12 2000-09-21 Biota Scientific Management Pty. Ltd. Dimeric compounds and as inhibitors of neuraminidase

Also Published As

Publication number Publication date
US7504434B2 (en) 2009-03-17
WO2003040136A1 (en) 2003-05-15
US20070225361A1 (en) 2007-09-27
KR100942494B1 (ko) 2010-02-12
US7214707B2 (en) 2007-05-08
EP1451183A4 (en) 2006-03-15
JP5183854B2 (ja) 2013-04-17
AU2002340634B2 (en) 2008-03-20
KR20050044339A (ko) 2005-05-12
TW200303196A (en) 2003-09-01
CN1585764A (zh) 2005-02-23
CA2463835C (en) 2011-09-27
JP2010285436A (ja) 2010-12-24
CA2463835A1 (en) 2003-05-15
JP2005511609A (ja) 2005-04-28
AUPR879701A0 (en) 2001-12-06
EP1451183A1 (en) 2004-09-01
US20050054718A1 (en) 2005-03-10

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Termination date: 20131108