CN100339710C - 用于生物样本的质谱仪 - Google Patents

用于生物样本的质谱仪 Download PDF

Info

Publication number
CN100339710C
CN100339710C CNB2005100764872A CN200510076487A CN100339710C CN 100339710 C CN100339710 C CN 100339710C CN B2005100764872 A CNB2005100764872 A CN B2005100764872A CN 200510076487 A CN200510076487 A CN 200510076487A CN 100339710 C CN100339710 C CN 100339710C
Authority
CN
China
Prior art keywords
light
wavelength
sample
ultrashort
light source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2005100764872A
Other languages
English (en)
Chinese (zh)
Other versions
CN1712954A (zh
Inventor
大久保邦彦
福井希一
伊东一良
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Original Assignee
Shimadzu Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corp filed Critical Shimadzu Corp
Publication of CN1712954A publication Critical patent/CN1712954A/zh
Application granted granted Critical
Publication of CN100339710C publication Critical patent/CN100339710C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/162—Direct photo-ionisation, e.g. single photon or multi-photon ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step

Landscapes

  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CNB2005100764872A 2004-06-16 2005-06-16 用于生物样本的质谱仪 Expired - Fee Related CN100339710C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004178686 2004-06-16
JP2004178686A JP2006003167A (ja) 2004-06-16 2004-06-16 生体試料分析用質量分析装置

Publications (2)

Publication Number Publication Date
CN1712954A CN1712954A (zh) 2005-12-28
CN100339710C true CN100339710C (zh) 2007-09-26

Family

ID=34982207

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2005100764872A Expired - Fee Related CN100339710C (zh) 2004-06-16 2005-06-16 用于生物样本的质谱仪

Country Status (4)

Country Link
US (1) US7342223B2 (https=)
EP (1) EP1608001A3 (https=)
JP (1) JP2006003167A (https=)
CN (1) CN100339710C (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7567596B2 (en) * 2001-01-30 2009-07-28 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
US7450618B2 (en) * 2001-01-30 2008-11-11 Board Of Trustees Operating Michigan State University Laser system using ultrashort laser pulses
US7583710B2 (en) * 2001-01-30 2009-09-01 Board Of Trustees Operating Michigan State University Laser and environmental monitoring system
US7973936B2 (en) * 2001-01-30 2011-07-05 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
US8208505B2 (en) * 2001-01-30 2012-06-26 Board Of Trustees Of Michigan State University Laser system employing harmonic generation
EP1851532A1 (en) 2005-02-14 2007-11-07 Board of Trustees of Michigan State University Ultra-fast laser system
JP2006311807A (ja) * 2005-05-06 2006-11-16 Osaka Industrial Promotion Organization 生体細胞制御装置及び生体細胞制御方法
US8618470B2 (en) 2005-11-30 2013-12-31 Board Of Trustees Of Michigan State University Laser based identification of molecular characteristics
JP4825028B2 (ja) * 2006-03-17 2011-11-30 浜松ホトニクス株式会社 イオン化装置
US9018562B2 (en) * 2006-04-10 2015-04-28 Board Of Trustees Of Michigan State University Laser material processing system
US8497992B2 (en) * 2006-07-25 2013-07-30 The Regents Of The University Of Michigan Analytical system with photonic crystal sensor
JP4857148B2 (ja) * 2007-02-28 2012-01-18 大陽日酸株式会社 安定同位体濃度の分析方法
US8311069B2 (en) 2007-12-21 2012-11-13 Board Of Trustees Of Michigan State University Direct ultrashort laser system
CN101520432B (zh) * 2008-02-28 2013-04-24 岛津分析技术研发（上海）有限公司 用于质谱仪的解吸电离装置
US9202678B2 (en) * 2008-11-14 2015-12-01 Board Of Trustees Of Michigan State University Ultrafast laser system for biological mass spectrometry
EP2211430A3 (en) * 2009-01-23 2015-05-27 Board of Trustees of Michigan State University Laser autocorrelation system
US8861075B2 (en) 2009-03-05 2014-10-14 Board Of Trustees Of Michigan State University Laser amplification system
US8630322B2 (en) * 2010-03-01 2014-01-14 Board Of Trustees Of Michigan State University Laser system for output manipulation
JP5864312B2 (ja) * 2012-03-13 2016-02-17 株式会社島津製作所 Ｓ−ニトロソ物質の質量分析法
JP5914164B2 (ja) * 2012-05-23 2016-05-11 株式会社日立製作所 微粒子検出装置及びセキュリティゲート
CN105652761B (zh) * 2016-04-08 2018-07-31 核工业理化工程研究院 激光光谱试验的实时联动控制与数据同步采集装置
FR3063929B1 (fr) * 2017-03-15 2019-03-22 Poietis Equipement pour le transfert de bio-encre
CN109300769B (zh) * 2018-08-09 2023-06-20 金华职业技术学院 一种研究大分子电荷量的方法
CN110487686B (zh) * 2019-09-03 2022-09-02 中国工程物理研究院流体物理研究所 一种空气气溶胶单粒子多模态光谱诊断装置及诊断方法
WO2022064819A1 (ja) * 2020-09-28 2022-03-31 国立大学法人大阪大学 毛髪に含まれる成分の情報を得る方法
CN113921372B (zh) * 2021-12-02 2025-07-11 国开启科量子技术(北京)有限公司 一种激光溅射原子发生装置
CN116943426A (zh) * 2023-07-27 2023-10-27 兰州大学 一种小角散射磁铁表面分离锂同位素的装置及分离方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1206493A (zh) * 1996-08-29 1999-01-27 日本钢管株式会社 激光离子化质量分析装置及质量分析方法
US6326615B1 (en) * 1999-08-30 2001-12-04 Syagen Technology Rapid response mass spectrometer system
CN1350697A (zh) * 1999-05-13 2002-05-22 赛弗根生物系统股份有限公司 激光解吸附/离子化质谱仪的光机
CN1424574A (zh) * 2001-12-06 2003-06-18 株式会社岛津制作所 分析包含多种荧光物质的样本的方法和系统

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382793A (en) * 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
US5977541A (en) 1996-08-29 1999-11-02 Nkk Corporation Laser ionization mass spectroscope and mass spectrometric analysis method
JPH1074479A (ja) * 1996-08-30 1998-03-17 Nkk Corp レーザーイオン化質量分析装置及び質量分析方法
AU2002245345A1 (en) * 2001-01-30 2002-08-12 Board Of Trustees Operating Michigan State University Control system and apparatus for use with laser excitation or ionization
US6995841B2 (en) * 2001-08-28 2006-02-07 Rice University Pulsed-multiline excitation for color-blind fluorescence detection
JP3829749B2 (ja) 2002-03-29 2006-10-04 株式会社島津製作所 多光子励起を用いた蛍光試料観測方法及び装置
JP2004037128A (ja) 2002-06-28 2004-02-05 Canon Inc マトリクス援助レーザー脱着／イオン化飛行時間型質量分析法による基板上の物質の解析方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1206493A (zh) * 1996-08-29 1999-01-27 日本钢管株式会社 激光离子化质量分析装置及质量分析方法
CN1350697A (zh) * 1999-05-13 2002-05-22 赛弗根生物系统股份有限公司 激光解吸附/离子化质谱仪的光机
US6326615B1 (en) * 1999-08-30 2001-12-04 Syagen Technology Rapid response mass spectrometer system
CN1424574A (zh) * 2001-12-06 2003-06-18 株式会社岛津制作所 分析包含多种荧光物质的样本的方法和系统

Also Published As

Publication number Publication date
JP2006003167A (ja) 2006-01-05
CN1712954A (zh) 2005-12-28
US7342223B2 (en) 2008-03-11
EP1608001A3 (en) 2006-11-02
EP1608001A2 (en) 2005-12-21
US20050279928A1 (en) 2005-12-22

Similar Documents

Publication Publication Date Title
CN100339710C (zh) 用于生物样本的质谱仪
Dreisewerd Recent methodological advances in MALDI mass spectrometry
Dreisewerd et al. Fundamentals of matrix-assisted laser desorption/ionization mass spectrometry with pulsed infrared lasers
US7385192B2 (en) Laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis
WO2013127262A1 (zh) 一种低压下产生分析用离子的方法和装置
US20090039282A1 (en) Matrix-assisted laser desorption with high ionization yield
GB2492664A (en) MALDI imaging and ion guide
EP1381446A4 (en) METHOD AND SYSTEM FOR MASS SPECTROSCOPY
GB2558741A (en) Mass spectrometer with laser system for producing photons of different energies
Steven et al. Construction and testing of an atmospheric-pressure transmission-mode matrix assisted laser desorption ionisation mass spectrometry imaging ion source with plasma ionisation enhancement
CN115020190A (zh) 透射几何中具有解吸后电离的解吸离子源
Moon et al. Photodissociation of singly protonated peptides at 193 nm investigated with tandem time‐of‐flight mass spectrometry
Schätti et al. Pushing the mass limit for intact launch and photoionization of large neutral biopolymers
WO2007044361A2 (en) Ldi/maldi source for enhanced spatial resolution
WO2009069816A1 (ja) イオン化方法ならびにイオン化方法を利用した質量分析方法および装置
US7351955B2 (en) Reduction of chemical noise in a MALDI mass spectrometer by in-trap photodissociation of matrix cluster ions
US8110795B2 (en) Laser system for MALDI mass spectrometry
JP2009168673A (ja) イオン化方法および装置
HK1085050A (en) Mass spectrometer for biological samples
GB2468394A (en) Pulsed laser system for MALDI mass spectrometry
Calvert et al. LIAD-fs: A novel method for studies of ultrafast processes in gas phase neutral biomolecules
Yoon et al. Influence of basic residues on dissociation kinetics and dynamics of singly protonated peptides: time‐resolved photodissociation study
Wattenberg et al. Laser desorption mass spectrometry on liquid beams
Neidel et al. Femtosecond laser-induced dissociation (fs-LID) as an activation method in mass spectrometry
US20240213012A1 (en) Ion generator, mass spectrometer and method of generating ions

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee