JP2006003167A - 生体試料分析用質量分析装置 - Google Patents

生体試料分析用質量分析装置 Download PDF

Info

Publication number
JP2006003167A
JP2006003167A JP2004178686A JP2004178686A JP2006003167A JP 2006003167 A JP2006003167 A JP 2006003167A JP 2004178686 A JP2004178686 A JP 2004178686A JP 2004178686 A JP2004178686 A JP 2004178686A JP 2006003167 A JP2006003167 A JP 2006003167A
Authority
JP
Japan
Prior art keywords
light
light source
mass
ultrashort
wavelength
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004178686A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006003167A5 (https=
Inventor
Kunihiko Okubo
邦彦 大久保
Kiichi Fukui
希一 福井
Kazuyoshi Ito
一良 伊東
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Original Assignee
Shimadzu Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corp filed Critical Shimadzu Corp
Priority to JP2004178686A priority Critical patent/JP2006003167A/ja
Priority to EP05012676A priority patent/EP1608001A3/en
Priority to US11/151,466 priority patent/US7342223B2/en
Priority to CNB2005100764872A priority patent/CN100339710C/zh
Publication of JP2006003167A publication Critical patent/JP2006003167A/ja
Publication of JP2006003167A5 publication Critical patent/JP2006003167A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/16Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/162Direct photo-ionisation, e.g. single photon or multi-photon ionisation
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463Desorption by laser or particle beam, followed by ionisation as a separate step

Landscapes

  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
JP2004178686A 2004-06-16 2004-06-16 生体試料分析用質量分析装置 Pending JP2006003167A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2004178686A JP2006003167A (ja) 2004-06-16 2004-06-16 生体試料分析用質量分析装置
EP05012676A EP1608001A3 (en) 2004-06-16 2005-06-13 Mass spectrometer for biological samples
US11/151,466 US7342223B2 (en) 2004-06-16 2005-06-14 Mass spectrometer for biological samples
CNB2005100764872A CN100339710C (zh) 2004-06-16 2005-06-16 用于生物样本的质谱仪

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004178686A JP2006003167A (ja) 2004-06-16 2004-06-16 生体試料分析用質量分析装置

Publications (2)

Publication Number Publication Date
JP2006003167A true JP2006003167A (ja) 2006-01-05
JP2006003167A5 JP2006003167A5 (https=) 2006-11-09

Family

ID=34982207

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004178686A Pending JP2006003167A (ja) 2004-06-16 2004-06-16 生体試料分析用質量分析装置

Country Status (4)

Country Link
US (1) US7342223B2 (https=)
EP (1) EP1608001A3 (https=)
JP (1) JP2006003167A (https=)
CN (1) CN100339710C (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006120770A1 (ja) * 2005-05-06 2006-11-16 Osaka Industrial Promotion Organization 生体細胞制御装置及び生体細胞制御方法
JP2008215863A (ja) * 2007-02-28 2008-09-18 Taiyo Nippon Sanso Corp 安定同位体濃度の分析方法
JP2013190251A (ja) * 2012-03-13 2013-09-26 Shimadzu Corp S−ニトロソ物質の質量分析法
WO2022064819A1 (ja) * 2020-09-28 2022-03-31 国立大学法人大阪大学 毛髪に含まれる成分の情報を得る方法

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7567596B2 (en) * 2001-01-30 2009-07-28 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
US7450618B2 (en) * 2001-01-30 2008-11-11 Board Of Trustees Operating Michigan State University Laser system using ultrashort laser pulses
US7583710B2 (en) * 2001-01-30 2009-09-01 Board Of Trustees Operating Michigan State University Laser and environmental monitoring system
US7973936B2 (en) * 2001-01-30 2011-07-05 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
US8208505B2 (en) * 2001-01-30 2012-06-26 Board Of Trustees Of Michigan State University Laser system employing harmonic generation
EP1851532A1 (en) 2005-02-14 2007-11-07 Board of Trustees of Michigan State University Ultra-fast laser system
US8618470B2 (en) 2005-11-30 2013-12-31 Board Of Trustees Of Michigan State University Laser based identification of molecular characteristics
JP4825028B2 (ja) * 2006-03-17 2011-11-30 浜松ホトニクス株式会社 イオン化装置
US9018562B2 (en) * 2006-04-10 2015-04-28 Board Of Trustees Of Michigan State University Laser material processing system
US8497992B2 (en) * 2006-07-25 2013-07-30 The Regents Of The University Of Michigan Analytical system with photonic crystal sensor
US8311069B2 (en) 2007-12-21 2012-11-13 Board Of Trustees Of Michigan State University Direct ultrashort laser system
CN101520432B (zh) * 2008-02-28 2013-04-24 岛津分析技术研发(上海)有限公司 用于质谱仪的解吸电离装置
US9202678B2 (en) * 2008-11-14 2015-12-01 Board Of Trustees Of Michigan State University Ultrafast laser system for biological mass spectrometry
EP2211430A3 (en) * 2009-01-23 2015-05-27 Board of Trustees of Michigan State University Laser autocorrelation system
US8861075B2 (en) 2009-03-05 2014-10-14 Board Of Trustees Of Michigan State University Laser amplification system
US8630322B2 (en) * 2010-03-01 2014-01-14 Board Of Trustees Of Michigan State University Laser system for output manipulation
JP5914164B2 (ja) * 2012-05-23 2016-05-11 株式会社日立製作所 微粒子検出装置及びセキュリティゲート
CN105652761B (zh) * 2016-04-08 2018-07-31 核工业理化工程研究院 激光光谱试验的实时联动控制与数据同步采集装置
FR3063929B1 (fr) * 2017-03-15 2019-03-22 Poietis Equipement pour le transfert de bio-encre
CN109300769B (zh) * 2018-08-09 2023-06-20 金华职业技术学院 一种研究大分子电荷量的方法
CN110487686B (zh) * 2019-09-03 2022-09-02 中国工程物理研究院流体物理研究所 一种空气气溶胶单粒子多模态光谱诊断装置及诊断方法
CN113921372B (zh) * 2021-12-02 2025-07-11 国开启科量子技术(北京)有限公司 一种激光溅射原子发生装置
CN116943426A (zh) * 2023-07-27 2023-10-27 兰州大学 一种小角散射磁铁表面分离锂同位素的装置及分离方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382793A (en) * 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
CN1206493A (zh) 1996-08-29 1999-01-27 日本钢管株式会社 激光离子化质量分析装置及质量分析方法
US5977541A (en) 1996-08-29 1999-11-02 Nkk Corporation Laser ionization mass spectroscope and mass spectrometric analysis method
JPH1074479A (ja) * 1996-08-30 1998-03-17 Nkk Corp レーザーイオン化質量分析装置及び質量分析方法
US6707031B1 (en) * 1999-05-13 2004-03-16 Ciphergen Biosystems, Inc. Laser optical bench for laser desorption ion sources and method of use thereof
US6326615B1 (en) * 1999-08-30 2001-12-04 Syagen Technology Rapid response mass spectrometer system
AU2002245345A1 (en) * 2001-01-30 2002-08-12 Board Of Trustees Operating Michigan State University Control system and apparatus for use with laser excitation or ionization
US6995841B2 (en) * 2001-08-28 2006-02-07 Rice University Pulsed-multiline excitation for color-blind fluorescence detection
JP3757854B2 (ja) 2001-12-06 2006-03-22 株式会社島津製作所 複数の蛍光物質を含む試料の分析方法及び装置
JP3829749B2 (ja) 2002-03-29 2006-10-04 株式会社島津製作所 多光子励起を用いた蛍光試料観測方法及び装置
JP2004037128A (ja) 2002-06-28 2004-02-05 Canon Inc マトリクス援助レーザー脱着/イオン化飛行時間型質量分析法による基板上の物質の解析方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006120770A1 (ja) * 2005-05-06 2006-11-16 Osaka Industrial Promotion Organization 生体細胞制御装置及び生体細胞制御方法
JP2008215863A (ja) * 2007-02-28 2008-09-18 Taiyo Nippon Sanso Corp 安定同位体濃度の分析方法
JP2013190251A (ja) * 2012-03-13 2013-09-26 Shimadzu Corp S−ニトロソ物質の質量分析法
WO2022064819A1 (ja) * 2020-09-28 2022-03-31 国立大学法人大阪大学 毛髪に含まれる成分の情報を得る方法

Also Published As

Publication number Publication date
CN1712954A (zh) 2005-12-28
US7342223B2 (en) 2008-03-11
EP1608001A3 (en) 2006-11-02
EP1608001A2 (en) 2005-12-21
CN100339710C (zh) 2007-09-26
US20050279928A1 (en) 2005-12-22

Similar Documents

Publication Publication Date Title
JP2006003167A (ja) 生体試料分析用質量分析装置
Dreisewerd Recent methodological advances in MALDI mass spectrometry
CN108206126B (zh) 具有用于产生不同能量的光子的激光系统的质谱仪
US20020076824A1 (en) System and method of infrared matrix-assisted laser desorption/ionization mass spectrometry in polyacrylamide gels
US20090039282A1 (en) Matrix-assisted laser desorption with high ionization yield
Steven et al. Construction and testing of an atmospheric-pressure transmission-mode matrix assisted laser desorption ionisation mass spectrometry imaging ion source with plasma ionisation enhancement
DE102004025841A1 (de) Verfahren und Vorrichtung zur massenspektroskopischen Untersuchung von Analyten
US5955731A (en) Mass spectrometric analysis of surfaces
Lawal et al. Deep‐ultraviolet laser ablation electrospray ionization mass spectrometry
JP4645197B2 (ja) 質量分析方法
Parise et al. Pulse duration effects on solution-phase protein desorption in laser electrospray mass spectrometry
US11923182B2 (en) Substantially simultaneous resonance-enhanced multiphoton and laser desorption ionization for single particle mass spectroscopy
JP2009168673A (ja) イオン化方法および装置
Asami et al. Gas‐phase hydration of the lysozyme ion produced by infrared‐laser ablation of a droplet beam studied by photodissociation and fluorescence spectroscopy
Maul et al. A laser desorption/resonance enhanced photoionisation TOF-system for the spatially resolved trace analysis of elements
WO2017210560A1 (en) Devices, systems, and methods for dissociation of ions using light emitting diodes
Laiko et al. On the mechanism of ion formation from the aqueous solutions irradiated with 3 µm IR laser pulses under atmospheric pressure
HK1085050A (en) Mass spectrometer for biological samples
Zhong et al. Dissociation pathways of sulfur dioxide clusters and mixed sulfur dioxide-water clusters
Rohlfing Resonantly enhanced multiphoton ionization for the trace detection of chlorinated aromatics
GB2453407A (en) Matrix-assisted laser desorption with high ionization yield
Kriegleder MASTERARBEIT/MASTER’S THESIS
Neidel et al. Femtosecond laser-induced dissociation (fs-LID) as an activation method in mass spectrometry
BALL Electron-Based Dissociation Techniques in Mass Spectrometry for the Structural Characterisation of Small Molecules and Synthetic and Natural Peptides
Lu Laser-assisted Spectrometry and Spectroscopy for Open-air and in Situ Analyses

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060927

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060927

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20090618

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090630

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20091027