CL2022002813A1 - Semaglutida para el tratamiento de esteatohepatitis no alcoholica. - Google Patents
Semaglutida para el tratamiento de esteatohepatitis no alcoholica.Info
- Publication number
- CL2022002813A1 CL2022002813A1 CL2022002813A CL2022002813A CL2022002813A1 CL 2022002813 A1 CL2022002813 A1 CL 2022002813A1 CL 2022002813 A CL2022002813 A CL 2022002813A CL 2022002813 A CL2022002813 A CL 2022002813A CL 2022002813 A1 CL2022002813 A1 CL 2022002813A1
- Authority
- CL
- Chile
- Prior art keywords
- treatment
- semaglutide
- alcoholic steatohepatitis
- glp
- directed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
Abstract
La presente invención se dirige al uso del agonista del receptor de GLP-1 semaglutida en la terapia médica para el tratamiento de la esteatohepatitis no alcohólica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20171536 | 2020-04-27 | ||
EP20173341 | 2020-05-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2022002813A1 true CL2022002813A1 (es) | 2023-04-21 |
Family
ID=75660049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2022002813A CL2022002813A1 (es) | 2020-04-27 | 2022-10-12 | Semaglutida para el tratamiento de esteatohepatitis no alcoholica. |
Country Status (13)
Country | Link |
---|---|
US (3) | US11478533B2 (es) |
EP (1) | EP4142770A1 (es) |
JP (1) | JP7393563B2 (es) |
KR (1) | KR20230015884A (es) |
CN (1) | CN115461072A (es) |
AU (1) | AU2021262447A1 (es) |
BR (1) | BR112022020643A2 (es) |
CA (1) | CA3174964A1 (es) |
CL (1) | CL2022002813A1 (es) |
IL (1) | IL297273A (es) |
MX (1) | MX2022013174A (es) |
TW (1) | TW202140064A (es) |
WO (1) | WO2021219543A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4138874A1 (en) | 2020-04-24 | 2023-03-01 | Boehringer Ingelheim International GmbH | Glucagon analogues as long-acting glp-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis |
US11478533B2 (en) * | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
TW202333774A (zh) * | 2021-12-01 | 2023-09-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | Glp-1和gip受體雙重激動劑的醫藥組成物及其用途 |
CN114469877A (zh) * | 2022-01-28 | 2022-05-13 | 兰州积石药业有限公司 | 一种司美格鲁肽植入剂及其制备方法 |
WO2024017139A1 (zh) * | 2022-07-20 | 2024-01-25 | 成都海博为药业有限公司 | 一种含有glp-1受体激动剂类似物的药物组合物 |
Family Cites Families (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK39892D0 (da) | 1992-03-25 | 1992-03-25 | Bernard Thorens | Peptid |
US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
DK0944648T3 (da) | 1996-08-30 | 2007-07-02 | Novo Nordisk As | GLP-1 derivater |
ATE309197T1 (de) | 1999-02-05 | 2005-11-15 | Emisphere Tech Inc | Verfahren zur herstellung alkylierter salicylamide |
AU2001275231A1 (en) | 2000-06-02 | 2001-12-11 | Emisphere Technologies, Inc. | Method of preparing salicylamides |
ATE381542T1 (de) | 2001-08-13 | 2008-01-15 | Phenex Pharmaceuticals Ag | Nr1h4-kern-rezeptor-bindende verbindungen |
WO2003016280A1 (en) | 2001-08-13 | 2003-02-27 | Lion Bioscience Ag | Nr1h4 nuclear receptor binding compounds |
EP1423113A4 (en) | 2001-08-13 | 2007-04-18 | Phenex Pharmaceuticals Ag | NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS |
AU2004290862B2 (en) | 2003-11-20 | 2010-06-03 | Novo Nordisk A/S | Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices |
TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
WO2007121318A2 (en) | 2006-04-12 | 2007-10-25 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
CA2662080C (en) | 2006-09-07 | 2012-07-17 | F. Hoffmann-La Roche Ag | A process for the manufacture of snac (salcaprozate sodium) |
NZ619520A (en) | 2009-02-13 | 2015-06-26 | Boehringer Ingelheim Int | Antidiabetic medications comprising a dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetics |
EP2289883A1 (en) | 2009-08-19 | 2011-03-02 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
ES2935300T3 (es) | 2010-05-05 | 2023-03-03 | Boehringer Ingelheim Int | Combiterapia |
EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
JP6114297B2 (ja) | 2011-11-11 | 2017-04-12 | ギリアド アポロ, エルエルシー | Acc阻害剤およびその使用 |
EP2776405A1 (en) | 2011-11-11 | 2014-09-17 | Pfizer Inc | 2-thiopyrimidinones |
EA201400990A1 (ru) | 2012-04-06 | 2015-01-30 | Пфайзер Инк. | Ингибиторы диацилглицеринацилтрансферазы 2 |
CA2911932A1 (en) | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
CA2911926A1 (en) | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
MX2015015416A (es) | 2013-05-10 | 2016-06-21 | Nimbus Apollo Inc | Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos. |
KR20160005364A (ko) | 2013-05-10 | 2016-01-14 | 님버스 아폴로, 인코포레이티드 | Acc 억제제 및 이의 용도 |
HUE039446T2 (hu) | 2014-03-17 | 2018-12-28 | Pfizer | Diacilglicerol-aciltranszferáz-2 inhibitorok metabolikus rendellenességek és kapcsolódó rendellenességek kezelésében történõ alkalmazásra |
EP3197448B1 (en) | 2014-09-24 | 2019-04-24 | Gilead Sciences, Inc. | Methods of treating liver disease |
EP3034501A1 (en) | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Hydroxy containing FXR (NR1H4) modulating compounds |
EP3034499A1 (en) | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Novel FXR (NR1H4) modulating compounds |
JP2018501276A (ja) | 2015-01-09 | 2018-01-18 | ギリアド アポロ, エルエルシー | 非アルコール性脂肪肝疾患の処置のためのacc阻害剤併用療法 |
AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
EP3368556B1 (en) | 2015-10-28 | 2024-04-10 | Tufts University | Novel polypeptides with improved proteolytic stability, and methods of preparing and using same |
WO2017091627A1 (en) | 2015-11-25 | 2017-06-01 | Gilead Apollo, Llc | Fungicidal compositions containing derivatives of 2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine |
JP2018536661A (ja) | 2015-11-25 | 2018-12-13 | ギリアド アポロ, エルエルシー | トリアゾールacc阻害剤およびその使用 |
CA3004796C (en) | 2015-11-25 | 2023-11-14 | Gilead Apollo, Llc | Pyrazole acc inhibitors and uses thereof |
EA201890949A1 (ru) | 2015-11-25 | 2018-12-28 | Джилид Аполло, Ллс | СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ |
BR112018067408A2 (pt) | 2016-03-02 | 2018-12-26 | Gilead Apollo Llc | formas sólidas de um inibidor de acc de tienopirimidinadiona e métodos para a produção das mesmas |
CA3021140A1 (en) | 2016-04-19 | 2017-10-26 | Ureka Sarl | Peptide-oligourea foldamer compounds and methods of their use |
EP3463373A4 (en) | 2016-05-25 | 2020-04-22 | Akarna Therapeutics, Ltd. | COMBINATIONS USING FARNESOID X RECEPTOR (FXR) MODULATORS |
MX2018014743A (es) | 2016-06-03 | 2019-04-11 | Chemocentryx Inc | Metodo para tratar fibrosis hepatica. |
AR108711A1 (es) | 2016-06-13 | 2018-09-19 | Gilead Sciences Inc | Compuestos moduladores de fxr (nr1h4) |
KR102269305B1 (ko) | 2016-06-13 | 2021-06-25 | 길리애드 사이언시즈, 인코포레이티드 | Fxr (nr1h4) 조정 화합물 |
CA2968836A1 (en) | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
US10344002B2 (en) | 2016-09-26 | 2019-07-09 | Nusirt Sciences, Inc. | Compositions and methods for treating metabolic disorders |
EP3518918A4 (en) | 2016-09-28 | 2020-04-22 | Eiger Biopharmaceuticals, Inc. | METHOD AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS |
WO2018071528A1 (en) | 2016-10-11 | 2018-04-19 | University Of Georgia Research Foundation, Inc. | Proteins and method for treating obesity and associated comorbidities |
AU2017356160A1 (en) | 2016-11-11 | 2019-05-23 | Gilead Sciences, Inc. | Methods of treating liver disease |
CN110198708B (zh) | 2017-01-27 | 2022-09-20 | 基恩菲特公司 | 用于组合疗法的药物组合物 |
KR102424042B1 (ko) | 2017-03-03 | 2022-07-22 | 길리애드 사이언시즈, 인코포레이티드 | Acc 억제제 및 그의 고체 형태를 제조하는 방법 |
US20200223889A1 (en) | 2017-03-15 | 2020-07-16 | Novo Nordisk A/S | Bicyclic Compounds Capable of Binding to Melanocortin 4 Receptor |
CN110461328A (zh) | 2017-03-28 | 2019-11-15 | 吉利德科学公司 | 治疗肝疾病的治疗组合 |
WO2018183342A1 (en) | 2017-03-28 | 2018-10-04 | Gilead Sciences, Inc. | Methods of treating liver disease |
KR20190132515A (ko) | 2017-04-12 | 2019-11-27 | 길리애드 사이언시즈, 인코포레이티드 | 간 질환을 치료하는 방법 |
WO2018193007A1 (en) | 2017-04-18 | 2018-10-25 | Genfit | Combination comprising a ppar agonist such as elafibranor and an acetyl-coa carboxylase (acc) inhibitor |
TW201908483A (zh) | 2017-06-02 | 2019-03-01 | 新加坡商波濤生命科學有限公司 | 寡核苷酸組合物及其使用方法 |
US10495648B2 (en) | 2017-06-13 | 2019-12-03 | Gilead Sciences, Inc. | Methods of treating liver fibrosis |
JP7273022B2 (ja) | 2017-07-19 | 2023-05-12 | バイオ―ラッド ヨーロッパ ゲーエムベーハー | 非アルコール性脂肪性肝炎及び肝線維症ステータスを同時に評価するバイオマーカの組み合わせ |
WO2019030268A1 (en) | 2017-08-09 | 2019-02-14 | Sanofi | GLP-1 / GLUCAGON RECEPTOR AGONISTS FOR THE TREATMENT OF HEPATIC STEATOSIS AND STÉATOHÉPATITE |
CN111050750A (zh) | 2017-08-24 | 2020-04-21 | 诺沃挪第克公司 | Glp-1组合物及其用途 |
KR20220103807A (ko) | 2017-10-06 | 2022-07-22 | 길리애드 사이언시즈, 인코포레이티드 | Acc 억제제를 포함하는 조합 요법 |
CN111801140A (zh) | 2018-01-17 | 2020-10-20 | 康涅狄格大学 | 治疗糖尿病、肝炎和/或炎症性肝病的方法 |
EP3755334A4 (en) | 2018-02-21 | 2022-03-23 | Melior Pharmaceuticals I, Inc. | TREATMENT OF LIVER DISEASES |
WO2019173505A1 (en) | 2018-03-06 | 2019-09-12 | Zafgen, Inc. | Methods of treating disorders related to glycemic control |
US20210069286A1 (en) | 2018-04-09 | 2021-03-11 | 9 Meters Biopharma, Inc. | Compositions and methods for treating or preventing hyperglycemia, insulin resistance, and associated organ damage |
JP2021522247A (ja) | 2018-04-24 | 2021-08-30 | ピーエイチ・ファーマ・カンパニー・リミテッドPh Pharma Co., Ltd. | 肝疾患における好中球エラスターゼ阻害薬の使用 |
WO2019213611A1 (en) | 2018-05-04 | 2019-11-07 | Cirius Therapeutics, Inc. | Thiazolidinedione analogs for the treatment of nafld and metabolic diseases |
CA3097939A1 (en) | 2018-05-04 | 2019-11-07 | Novo Nordisk A/S | Gip derivatives and uses thereof |
US11081516B2 (en) | 2018-08-10 | 2021-08-03 | Guangdong Oppo Mobile Telecommunications Corp., Ltd. | Display screen, electronic device and method for three-dimensional feature recognition |
EP3843740A1 (en) | 2018-08-31 | 2021-07-07 | Pfizer Inc. | Combinations for treatment of nash/nafld and related diseases |
BR112021006598A2 (pt) | 2018-10-26 | 2021-07-06 | Novo Nordisk As | composição farmacêutica líquida, e, kit |
US20200155487A1 (en) | 2018-11-16 | 2020-05-21 | Cymabay Therapeutics, Inc. | Treatment of obesity and its complications |
JP2022507644A (ja) | 2018-11-16 | 2022-01-18 | サイマベイ・セラピューティクス・インコーポレイテッド | Nafldおよびnashの併用治療 |
DK3911647T3 (da) | 2019-01-15 | 2024-02-26 | Gilead Sciences Inc | Isoxazol-forbindelse som FXR-agonist og farmaceutiske sammensætninger, der omfatter en sådan |
JP2022519906A (ja) | 2019-02-19 | 2022-03-25 | ギリアード サイエンシーズ, インコーポレイテッド | Fxrアゴニストの固体形態 |
AU2020234929B2 (en) | 2019-03-11 | 2023-09-14 | Gilead Sciences, Inc. | Formulations of a compound and uses thereof |
CN115135305A (zh) | 2020-02-18 | 2022-09-30 | 诺和诺德股份有限公司 | 药物制剂 |
US11478533B2 (en) * | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
-
2020
- 2020-05-13 US US15/931,093 patent/US11478533B2/en active Active
-
2021
- 2021-04-26 IL IL297273A patent/IL297273A/en unknown
- 2021-04-26 AU AU2021262447A patent/AU2021262447A1/en active Pending
- 2021-04-26 EP EP21721092.1A patent/EP4142770A1/en active Pending
- 2021-04-26 CA CA3174964A patent/CA3174964A1/en active Pending
- 2021-04-26 JP JP2022561387A patent/JP7393563B2/ja active Active
- 2021-04-26 MX MX2022013174A patent/MX2022013174A/es unknown
- 2021-04-26 TW TW110114943A patent/TW202140064A/zh unknown
- 2021-04-26 CN CN202180031190.1A patent/CN115461072A/zh active Pending
- 2021-04-26 BR BR112022020643A patent/BR112022020643A2/pt unknown
- 2021-04-26 WO PCT/EP2021/060827 patent/WO2021219543A1/en active Application Filing
- 2021-04-26 KR KR1020227035715A patent/KR20230015884A/ko active Search and Examination
-
2022
- 2022-09-20 US US17/948,279 patent/US20230023012A1/en not_active Abandoned
- 2022-10-12 CL CL2022002813A patent/CL2022002813A1/es unknown
-
2023
- 2023-10-24 US US18/383,167 patent/US20240075106A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN115461072A (zh) | 2022-12-09 |
IL297273A (en) | 2022-12-01 |
WO2021219543A1 (en) | 2021-11-04 |
MX2022013174A (es) | 2022-11-30 |
KR20230015884A (ko) | 2023-01-31 |
JP2023516505A (ja) | 2023-04-19 |
TW202140064A (zh) | 2021-11-01 |
CA3174964A1 (en) | 2021-11-04 |
US20240075106A1 (en) | 2024-03-07 |
JP7393563B2 (ja) | 2023-12-06 |
US11478533B2 (en) | 2022-10-25 |
BR112022020643A2 (pt) | 2022-12-13 |
US20210330748A1 (en) | 2021-10-28 |
EP4142770A1 (en) | 2023-03-08 |
AU2021262447A1 (en) | 2022-11-03 |
US20230023012A1 (en) | 2023-01-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2022002813A1 (es) | Semaglutida para el tratamiento de esteatohepatitis no alcoholica. | |
DOP2019000168A (es) | Compuestos de amino-triazolopiridina y su uso en el tratamiento del cáncer | |
CL2017002526A1 (es) | Uso de agonistas de receptor de péptido formilo 2 para tratar enfermedades inflamatorias oculares (divisional de solicitud n°2485-2015) | |
MX2020004467A (es) | Metodos para el tratamiento o la prevencion del asma mediante la administracion de antagonista de il-4r. | |
GT201700056A (es) | Uso de agonista dual del receptor de glp-1/glucagón de acción prolongada para el tratamento de la enfermedad del hígado graso no alcohólico. | |
DOP2012000246A (es) | Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf) | |
CL2017000191A1 (es) | Método | |
UY35465A (es) | Nuevos compuestos como inhibidores de reorganizado durante la transfección (ret) | |
CL2022001743A1 (es) | Dosis de gamma-hidroxibutirato (ghb) | |
CL2021001722A1 (es) | Inhibidores aza-heterobicíclicos de mat2a y métodos de uso en el tratamiento de cáncer | |
CL2019001749A1 (es) | Uso de anticuerpos anti-esclerostina en el tratamiento de osteogenesis imperfecta. | |
CR20180433A (es) | Métodos para tratar la depresión con antagonistas del receptor de orexina-2 | |
PH12016502353A1 (en) | Pharmaceutical composition | |
AU2019262169B2 (en) | Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (RORy) and pharmaceutical uses thereof | |
DOP2021000198A (es) | Compuestos y su uso en el tratamiento del cáncer | |
CO2021014008A2 (es) | Compuestos farmacéuticos para el tratamiento de trastornos mediados por complemento | |
BR112017006113A8 (pt) | usos de auristatina, composições farmacêuticas, formas de dosagem para o tratamento de câncer e kits. | |
CO2020005919A2 (es) | Compuestos y composiciones farmaceuticas de los mismos para usarse en el tratamiento de enfermedades fibroticas | |
AR104068A1 (es) | Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer | |
CL2022002589A1 (es) | Tratamiento de trastornos respiratorios | |
MX2020003563A (es) | Anticuerpo anti-pacap. | |
DOP2018000197A (es) | Compuestos de cinnolin-4-amina y su uso en el tratamiento del cáncer | |
ECSP22085947A (es) | Derivados de 4-(2,6-difluorofenoxi)-6-(trifluorometil)pirimidin-2-amina como potenciadores del receptor hmrgx1 para el tratamiento del dolor | |
CL2020000270A1 (es) | Combinación terapéutica de un inhibidor tirosina quinasa del egfr de tercera generación y un inhibidor raf. | |
BR112019006174A2 (pt) | proteina terapêutica |