CL2020002954A1 - Célula modificada por ingeniería genética, que expresa un receptor exógeno que se une a un antígeno diana y a ccl21 exógena, y que es capaz de expresar una proteína de unión a il-7r o a il-7 exógena; y usos relacionados - Google Patents

Célula modificada por ingeniería genética, que expresa un receptor exógeno que se une a un antígeno diana y a ccl21 exógena, y que es capaz de expresar una proteína de unión a il-7r o a il-7 exógena; y usos relacionados

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Publication number
CL2020002954A1
CL2020002954A1 CL2020002954A CL2020002954A CL2020002954A1 CL 2020002954 A1 CL2020002954 A1 CL 2020002954A1 CL 2020002954 A CL2020002954 A CL 2020002954A CL 2020002954 A CL2020002954 A CL 2020002954A CL 2020002954 A1 CL2020002954 A1 CL 2020002954A1
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CL
Chile
Prior art keywords
span
exogenous
dir
ltr
ccl21
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CL2020002954A
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English (en)
Inventor
Huamao Wang
Zonghai Li
Hong Luo
Hua Jiang
Original Assignee
Carsgen Therapeutics Co Ltd
Shanghai Cancer Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Carsgen Therapeutics Co Ltd, Shanghai Cancer Inst filed Critical Carsgen Therapeutics Co Ltd
Publication of CL2020002954A1 publication Critical patent/CL2020002954A1/es

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Abstract

<span dir="ltr">La presente invención divulga una célula modificada por ingeniería genética, la cual expresa un receptor exógeno que </span><span dir="ltr">se une específicamente a un antígeno diana y a CCL21 exógena, y</span><span dir="ltr">que además es capaz de expresar una proteína de </span><span dir="ltr">unión a IL</span><span dir="ltr">-</span><span dir="ltr">7R o a IL</span><span dir="ltr">-</span><span dir="ltr">7 exógena que promueve la proliferación celular. También se da a conocer un constructo de </span><span dir="ltr">expresión que comprende un casete de expresión de CCL21 exógena, y un vector que lo contiene, un</span><span dir="ltr">virus, y una </span><span dir="ltr">composición farmacéutica que comprende dicha célula. También se divulga una aplicación para la célula, el constructo </span><span dir="ltr">de expresión, el vector, y el virus en la preparación de fármacos para inhibir tumores o inhibir patógenos.</span>
CL2020002954A 2018-05-15 2020-11-13 Célula modificada por ingeniería genética, que expresa un receptor exógeno que se une a un antígeno diana y a ccl21 exógena, y que es capaz de expresar una proteína de unión a il-7r o a il-7 exógena; y usos relacionados CL2020002954A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201810463564 2018-05-15
CN201811088090 2018-09-18
CN201811552806 2018-12-19
CN201910151930 2019-02-28

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CL2020002954A1 true CL2020002954A1 (es) 2021-06-04

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