CL2020002943A1 - Inhibidores macrocíclicos de mcl-1 y métodos de uso. solicitud divisional de solicitud n° 363-2020 - Google Patents
Inhibidores macrocíclicos de mcl-1 y métodos de uso. solicitud divisional de solicitud n° 363-2020Info
- Publication number
- CL2020002943A1 CL2020002943A1 CL2020002943A CL2020002943A CL2020002943A1 CL 2020002943 A1 CL2020002943 A1 CL 2020002943A1 CL 2020002943 A CL2020002943 A CL 2020002943A CL 2020002943 A CL2020002943 A CL 2020002943A CL 2020002943 A1 CL2020002943 A1 CL 2020002943A1
- Authority
- CL
- Chile
- Prior art keywords
- application
- inhibitors
- methods
- mcl
- macrocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente divulgación proporciona compuestos de la Fórmula en donde A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X e Y tienen cualquiera de los valores definidos en la memoria descriptiva, y sales aceptables desde el punto de vista farmacéutico de estos, que son útiles como agentes en el tratamiento de enfermedades y afecciones, incluido el cáncer. También se proporcionan composiciones farmacéuticas que comprenden compuestos de la Fórmula (I).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762545853P | 2017-08-15 | 2017-08-15 | |
US201762555475P | 2017-09-07 | 2017-09-07 | |
US201862692663P | 2018-06-30 | 2018-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020002943A1 true CL2020002943A1 (es) | 2021-03-12 |
Family
ID=65362347
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020000363A CL2020000363A1 (es) | 2017-08-15 | 2020-02-12 | Inhibidores macrocíclicos de mcl-1 y métodos de uso. |
CL2020002943A CL2020002943A1 (es) | 2017-08-15 | 2020-11-12 | Inhibidores macrocíclicos de mcl-1 y métodos de uso. solicitud divisional de solicitud n° 363-2020 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020000363A CL2020000363A1 (es) | 2017-08-15 | 2020-02-12 | Inhibidores macrocíclicos de mcl-1 y métodos de uso. |
Country Status (21)
Country | Link |
---|---|
US (3) | US10676485B2 (es) |
EP (2) | EP3652184A1 (es) |
JP (1) | JP2020531433A (es) |
KR (1) | KR20200041942A (es) |
CN (1) | CN111818917A (es) |
AU (1) | AU2018316620A1 (es) |
BR (1) | BR112020003180A2 (es) |
CA (1) | CA3073112A1 (es) |
CL (2) | CL2020000363A1 (es) |
CO (1) | CO2020002678A2 (es) |
CR (1) | CR20200124A (es) |
EC (1) | ECSP20018703A (es) |
IL (1) | IL272681A (es) |
MX (1) | MX2020001717A (es) |
PH (1) | PH12020500327A1 (es) |
RU (1) | RU2020110517A (es) |
SG (2) | SG11202001182QA (es) |
TW (1) | TW201920194A (es) |
UA (1) | UA126586C2 (es) |
UY (1) | UY37843A (es) |
WO (1) | WO2019035911A1 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11414390B2 (en) | 2017-09-07 | 2022-08-16 | Hutchison Medipharma Limited | Cycloolefin substituted heteroaromatic compounds and their use |
US11957673B2 (en) | 2017-09-07 | 2024-04-16 | Augusta University Research Institute, Inc. | Specific AKT3 activator and uses thereof |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL272599B (en) | 2017-08-15 | 2022-08-01 | Agios Pharmaceuticals Inc | Pyruvate kinase modulators and their use |
WO2019035911A1 (en) * | 2017-08-15 | 2019-02-21 | Abbvie Inc. | MACROCYCLIC INHIBITORS OF MCL-1 AND METHODS OF USE |
US20200239494A1 (en) * | 2017-08-15 | 2020-07-30 | Abbvie Inc. | Macrocyclic mcl-1 inhibitors and methods of use |
AU2018317836A1 (en) * | 2017-08-15 | 2020-03-19 | AbbVie Deutschland GmbH & Co. KG | Macrocyclic MCL-1 inhibitors and methods of use |
BR112021023229A2 (pt) | 2019-05-20 | 2022-05-31 | Servier Lab | Conjugados anticorpo-fármaco inibidores de mcl-1 e métodos de uso |
IL303079A (en) | 2020-11-24 | 2023-07-01 | Novartis Ag | Antibody-drug conjugates inhibiting MCL-1 and methods of using them |
WO2022261301A1 (en) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-cancer agents |
EP4351657A1 (en) | 2021-06-11 | 2024-04-17 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-body drug conjugates |
TW202408588A (zh) | 2022-05-20 | 2024-03-01 | 瑞士商諾華公司 | 抗體-藥物結合物抗腫瘤化合物及其使用方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101667822B1 (ko) | 2008-04-30 | 2016-10-19 | 내셔날 헬스 리서치 인스티튜트 | 오로라 키나아제 저해제용 접합 2고리 피리미딘 화합물 |
FR3015483B1 (fr) | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JO3474B1 (ar) * | 2014-08-29 | 2020-07-05 | Amgen Inc | مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1 |
FR3037956B1 (fr) | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3037959B1 (fr) | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3037957B1 (fr) | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3037958B1 (fr) | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3046792B1 (fr) | 2016-01-19 | 2018-02-02 | Les Laboratoires Servier | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
TWI742074B (zh) | 2016-04-22 | 2021-10-11 | 瑞典商阿斯特捷利康公司 | Mcl-1抑制劑及其使用方法 |
AU2017300738A1 (en) | 2016-07-22 | 2019-02-07 | Les Laboratoires Servier | Combination of a BCL-2 inhibitor and a MCL-1 inhibitor, uses and pharmaceutical compositions thereof |
IL266198B2 (en) | 2016-10-28 | 2023-11-01 | Servier Lab | Liposomal formulation for use in cancer treatment |
EP3567043B1 (en) | 2017-01-05 | 2023-12-06 | Henan Genuine Biotech Co., Ltd. | 2-[[5-[(4-hydroxy-3-chloro-2-methyl)-phenyl]-thieno[2,3-d]pyrimidin-4-yl]oxy]-3-(2-methoxybenzene)propanoic acid derivatives as mcl-1 and bcl-2 inhibitors for treating cancer |
UY37560A (es) | 2017-01-06 | 2018-07-31 | Servier Lab | Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta |
AU2018317836A1 (en) * | 2017-08-15 | 2020-03-19 | AbbVie Deutschland GmbH & Co. KG | Macrocyclic MCL-1 inhibitors and methods of use |
US20200239494A1 (en) * | 2017-08-15 | 2020-07-30 | Abbvie Inc. | Macrocyclic mcl-1 inhibitors and methods of use |
WO2019035911A1 (en) * | 2017-08-15 | 2019-02-21 | Abbvie Inc. | MACROCYCLIC INHIBITORS OF MCL-1 AND METHODS OF USE |
CN107573360B (zh) | 2017-10-27 | 2019-08-09 | 都创(上海)医药科技有限公司 | 一种多靶点小分子化合物s63845的制备方法 |
-
2018
- 2018-08-15 WO PCT/US2018/000180 patent/WO2019035911A1/en unknown
- 2018-08-15 CN CN201880066986.9A patent/CN111818917A/zh active Pending
- 2018-08-15 CR CR20200124A patent/CR20200124A/es unknown
- 2018-08-15 AU AU2018316620A patent/AU2018316620A1/en not_active Abandoned
- 2018-08-15 TW TW107128523A patent/TW201920194A/zh unknown
- 2018-08-15 US US15/998,789 patent/US10676485B2/en active Active
- 2018-08-15 CA CA3073112A patent/CA3073112A1/en active Pending
- 2018-08-15 RU RU2020110517A patent/RU2020110517A/ru unknown
- 2018-08-15 JP JP2020508463A patent/JP2020531433A/ja active Pending
- 2018-08-15 SG SG11202001182QA patent/SG11202001182QA/en unknown
- 2018-08-15 MX MX2020001717A patent/MX2020001717A/es unknown
- 2018-08-15 UA UAA202001749A patent/UA126586C2/uk unknown
- 2018-08-15 EP EP18846737.7A patent/EP3652184A1/en not_active Withdrawn
- 2018-08-15 EP EP21197248.4A patent/EP3988555A1/en active Pending
- 2018-08-15 SG SG10202106345VA patent/SG10202106345VA/en unknown
- 2018-08-15 KR KR1020207007568A patent/KR20200041942A/ko not_active Application Discontinuation
- 2018-08-15 BR BR112020003180-1A patent/BR112020003180A2/pt unknown
- 2018-08-15 UY UY0001037843A patent/UY37843A/es not_active Application Discontinuation
-
2020
- 2020-02-12 CL CL2020000363A patent/CL2020000363A1/es unknown
- 2020-02-13 PH PH12020500327A patent/PH12020500327A1/en unknown
- 2020-02-14 IL IL272681A patent/IL272681A/en unknown
- 2020-03-10 CO CONC2020/0002678A patent/CO2020002678A2/es unknown
- 2020-03-13 EC ECSENADI202018703A patent/ECSP20018703A/es unknown
- 2020-05-11 US US16/872,279 patent/US20200325153A1/en not_active Abandoned
- 2020-11-12 CL CL2020002943A patent/CL2020002943A1/es unknown
-
2022
- 2022-02-03 US US17/649,906 patent/US20230183261A1/en not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11414390B2 (en) | 2017-09-07 | 2022-08-16 | Hutchison Medipharma Limited | Cycloolefin substituted heteroaromatic compounds and their use |
US11957673B2 (en) | 2017-09-07 | 2024-04-16 | Augusta University Research Institute, Inc. | Specific AKT3 activator and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2019035911A1 (en) | 2019-02-21 |
KR20200041942A (ko) | 2020-04-22 |
US20190144465A1 (en) | 2019-05-16 |
MX2020001717A (es) | 2020-10-08 |
AU2018316620A1 (en) | 2020-03-12 |
US10676485B2 (en) | 2020-06-09 |
BR112020003180A2 (pt) | 2020-09-15 |
TW201920194A (zh) | 2019-06-01 |
EP3988555A1 (en) | 2022-04-27 |
UY37843A (es) | 2019-03-29 |
US20200325153A1 (en) | 2020-10-15 |
IL272681A (en) | 2020-03-31 |
US20230183261A1 (en) | 2023-06-15 |
JP2020531433A (ja) | 2020-11-05 |
UA126586C2 (uk) | 2022-11-02 |
CN111818917A (zh) | 2020-10-23 |
SG11202001182QA (en) | 2020-03-30 |
CA3073112A1 (en) | 2019-02-21 |
EP3652184A4 (en) | 2020-05-20 |
SG10202106345VA (en) | 2021-07-29 |
RU2020110517A (ru) | 2021-09-16 |
CR20200124A (es) | 2020-09-28 |
CO2020002678A2 (es) | 2020-08-10 |
RU2020110517A3 (es) | 2022-03-23 |
CL2020000363A1 (es) | 2020-06-12 |
ECSP20018703A (es) | 2020-04-22 |
EP3652184A1 (en) | 2020-05-20 |
PH12020500327A1 (en) | 2020-10-12 |
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