CL2020001182A1 - Método para la síntesis de depsipéptidos cíclicos - Google Patents
Método para la síntesis de depsipéptidos cíclicosInfo
- Publication number
- CL2020001182A1 CL2020001182A1 CL2020001182A CL2020001182A CL2020001182A1 CL 2020001182 A1 CL2020001182 A1 CL 2020001182A1 CL 2020001182 A CL2020001182 A CL 2020001182A CL 2020001182 A CL2020001182 A CL 2020001182A CL 2020001182 A1 CL2020001182 A1 CL 2020001182A1
- Authority
- CL
- Chile
- Prior art keywords
- synthesis
- cyclic depsipeptides
- depsipeptides
- cyclic
- relates
- Prior art date
Links
- 108010002156 Depsipeptides Proteins 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 108010056417 emodepside Proteins 0.000 abstract 1
- ZMQMTKVVAMWKNY-YSXLEBCMSA-N emodepside Chemical compound C([C@@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@H](C(O[C@H](CC=2C=CC(=CC=2)N2CCOCC2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O1)=O)CC(C)C)C(C=C1)=CC=C1N1CCOCC1 ZMQMTKVVAMWKNY-YSXLEBCMSA-N 0.000 abstract 1
- 229960001575 emodepside Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D325/00—Heterocyclic compounds containing rings having oxygen as the only ring hetero atom according to more than one of groups C07D303/00 - C07D323/00
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B51/00—Introduction of protecting groups or activating groups, not provided for in the preceding groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/02—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of urea, its salts, complexes or addition compounds
- C07C273/08—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of urea, its salts, complexes or addition compounds from ammoniacal liquor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se refiere a un método para la síntesis de depsipéptidos cíclicos, en particular, emodepsida, de la forma abierta.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17200415.2A EP3480195A1 (en) | 2017-11-07 | 2017-11-07 | Method for the synthesis of cyclic depsipeptides |
CN201811254536 | 2018-10-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020001182A1 true CL2020001182A1 (es) | 2021-02-12 |
Family
ID=64267786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020001182A CL2020001182A1 (es) | 2017-11-07 | 2020-05-05 | Método para la síntesis de depsipéptidos cíclicos |
Country Status (16)
Country | Link |
---|---|
US (1) | US20210130315A1 (es) |
EP (1) | EP3676265A1 (es) |
JP (2) | JP2021501769A (es) |
KR (1) | KR20200119230A (es) |
CN (1) | CN111757880A (es) |
AU (1) | AU2018363696B2 (es) |
BR (1) | BR112020008933A2 (es) |
CA (1) | CA3081673A1 (es) |
CL (1) | CL2020001182A1 (es) |
IL (1) | IL274283A (es) |
MX (1) | MX2020004702A (es) |
PH (1) | PH12020550538A1 (es) |
SG (1) | SG11202003272UA (es) |
TW (1) | TWI816708B (es) |
UY (1) | UY37965A (es) |
WO (1) | WO2019091975A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023127331A1 (ja) * | 2021-12-27 | 2023-07-06 | 株式会社トクヤマ | ペプチド製造方法、保護基の除去方法、除去剤、及びベンジル化合物 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2166359T3 (es) * | 1992-03-17 | 2002-04-16 | Fujisawa Pharmaceutical Co | Derivado de depsipeptido, su produccion y uso. |
JPH05320148A (ja) * | 1992-05-22 | 1993-12-03 | Meiji Seika Kaisha Ltd | 環状デプシペプチドpf1022物質の合成法 |
RU95105161A (ru) * | 1992-06-11 | 1996-12-27 | Байер АГ (DE) | Производные циклического депсипептида с 18 кольцевыми атомами, их оптические изомеры и рацематы, их применение в качестве средства для борьбы с эндопаразитами и эндопаразитицидное средство |
EP0685469A4 (en) * | 1993-02-19 | 1996-04-03 | Meiji Seika Kaisha | DERIVATIVE OF PF 1022 USED AS A CYCLIC DEPSIPEPTIDE. |
DE4317457A1 (de) * | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
DE4317432A1 (de) * | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
DE4342907A1 (de) * | 1993-12-16 | 1995-06-22 | Bayer Ag | Neue cyclische Depsipeptide mit 18 Ringatomen und ihre Verwendung zur Bekämpfung von Endoparasiten |
CZ295705B6 (cs) * | 1995-09-22 | 2005-10-12 | Bayer Aktiengesellschaft | Cyklodepsipeptidové deriváty sloučeniny PF1022 a farmaceutický prostředek s jejich obsahem |
JP2000044493A (ja) | 1998-07-27 | 2000-02-15 | Asahi Chem Ind Co Ltd | 化合物ライブラリー合成用保護基 |
DE10358525A1 (de) | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasitizide Mittel zur topischen Applikation |
DE102004055316A1 (de) | 2004-11-16 | 2006-05-18 | Bayer Healthcare Ag | Verhinderung vertikaler Endoparasiten-Infektionen |
DE102005011779A1 (de) | 2005-03-11 | 2006-09-14 | Bayer Healthcare Ag | Endoparasitizide Mittel |
ES2546808T3 (es) | 2006-03-24 | 2015-09-28 | Jitsubo Co., Ltd. | Reactivo para síntesis orgánica y método de reacción de síntesis orgánica con dicho reactivo |
HUE042661T2 (hu) * | 2012-06-13 | 2019-07-29 | Meiji Seika Pharma Co Ltd | Új ciklusos depszipeptid származék és ezt tartalmazó kártevõirtó szer |
WO2015093558A1 (ja) * | 2013-12-18 | 2015-06-25 | Meiji Seikaファルマ株式会社 | 環状デプシペプチド誘導体およびそれを含んでなる有害生物防除剤 |
HUE055535T2 (hu) * | 2015-05-20 | 2021-12-28 | Boehringer Ingelheim Animal Health Usa Inc | Féreghajtó depszipeptid-vegyületek |
KR102427124B1 (ko) | 2015-12-28 | 2022-07-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 뎁시펩티드 화합물 |
CN205510398U (zh) * | 2016-03-31 | 2016-08-24 | 乐视控股(北京)有限公司 | 跑步机 |
WO2018093920A1 (en) * | 2016-11-16 | 2018-05-24 | Merial, Inc. | Anthelmintic depsipeptide compounds |
GB201713633D0 (en) * | 2017-08-24 | 2017-10-11 | Walshe Nigel | Methods for production of emodepside from pf 1022a derivatives |
-
2018
- 2018-11-06 BR BR112020008933-8A patent/BR112020008933A2/pt unknown
- 2018-11-06 EP EP18800085.5A patent/EP3676265A1/en active Pending
- 2018-11-06 US US16/762,068 patent/US20210130315A1/en active Pending
- 2018-11-06 CA CA3081673A patent/CA3081673A1/en active Pending
- 2018-11-06 SG SG11202003272UA patent/SG11202003272UA/en unknown
- 2018-11-06 MX MX2020004702A patent/MX2020004702A/es unknown
- 2018-11-06 KR KR1020207016220A patent/KR20200119230A/ko not_active Application Discontinuation
- 2018-11-06 JP JP2020524568A patent/JP2021501769A/ja active Pending
- 2018-11-06 WO PCT/EP2018/080333 patent/WO2019091975A1/en unknown
- 2018-11-06 CN CN201880070191.5A patent/CN111757880A/zh active Pending
- 2018-11-06 AU AU2018363696A patent/AU2018363696B2/en active Active
- 2018-11-07 TW TW107139125A patent/TWI816708B/zh active
- 2018-11-07 UY UY0001037965A patent/UY37965A/es unknown
-
2020
- 2020-04-27 IL IL274283A patent/IL274283A/en unknown
- 2020-05-01 PH PH12020550538A patent/PH12020550538A1/en unknown
- 2020-05-05 CL CL2020001182A patent/CL2020001182A1/es unknown
-
2023
- 2023-11-06 JP JP2023189261A patent/JP2024009021A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2024009021A (ja) | 2024-01-19 |
AU2018363696B2 (en) | 2023-09-14 |
PH12020550538A1 (en) | 2021-03-22 |
MX2020004702A (es) | 2020-11-06 |
BR112020008933A2 (pt) | 2020-10-20 |
EP3676265A1 (en) | 2020-07-08 |
CA3081673A1 (en) | 2019-05-16 |
CN111757880A (zh) | 2020-10-09 |
JP2021501769A (ja) | 2021-01-21 |
SG11202003272UA (en) | 2020-05-28 |
IL274283A (en) | 2020-06-30 |
TW201932011A (zh) | 2019-08-16 |
TWI816708B (zh) | 2023-10-01 |
WO2019091975A1 (en) | 2019-05-16 |
UY37965A (es) | 2019-05-31 |
AU2018363696A1 (en) | 2020-04-23 |
KR20200119230A (ko) | 2020-10-19 |
US20210130315A1 (en) | 2021-05-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2021000630A1 (es) | Métodos para producir un anticuerpo anti-c5 (divisional de la solicitud no. 201701585) | |
MX2022016566A (es) | Composiciones que comprenden una caseina y metodos para producir las mismas. | |
CO2019007228A2 (es) | Sistemas y métodos para la extracción de productos naturales | |
CL2016002455A1 (es) | Anticuerpos multiespecíficos. | |
EA202092435A3 (ru) | Моноклональные антитела против bcma | |
BR112018006696A2 (pt) | métodos e sistemas para obter óleo a partir de uma composição de vinhoto | |
BR112016017584A2 (pt) | Composições de nanotribologia e métodos relacionados incluindo nanofolhas moleculares | |
TR201910057T4 (tr) | Kauçuk bi̇leşi̇mleri̇ | |
DK3555502T3 (da) | Stempelring til en stempelkompressor såvel som stempelkompressor | |
TR201902611T4 (tr) | Sentetik pentapeptit üretme metodu. | |
MY176465A (en) | Synthetic route to 2?-deoxy-2?,2?-difluorotetrahydrouridines | |
TR201908795T4 (tr) | Bi̇r şeki̇llendi̇ri̇lebi̇li̇r kütleni̇n şeki̇llendi̇ri̇lmesi̇ i̇çi̇n ci̇haz | |
BR112017002139A2 (pt) | ?método para preparar um composto? | |
TR201904143T4 (tr) | Silillenmiş poliüretanlar. | |
MX2016003207A (es) | Composiciones que comprenden colina y derivados de esta, usos de las composiciones y procesos para su preparacion. | |
CL2020001182A1 (es) | Método para la síntesis de depsipéptidos cíclicos | |
EA201692246A1 (ru) | Способ получения 2,6-диметилбензохинона | |
AR101951A1 (es) | Síntesis de ent-progesterona e intermediarios de la misma | |
PH12020550958A1 (en) | Method for producing carbodiimides | |
BR112016007816A2 (pt) | composições peptídicas inovadoras | |
IT201700051764A1 (it) | Fermo per cerniera lampo. | |
CL2016001884A1 (es) | Método para sintetizar florfenicol. | |
UA99992U (ru) | 2-оксо-4-фенил-5-циано-1,2,3,4-тетрагидропиридин-6-тиолат n-метилморфолиния | |
UA107468U (uk) | 25,27-ди-(5-тіо-октилокси)калікс[4]арен-краун-6 | |
TN2014000522A1 (fr) | لوح مدرسي بوجهين |