SG11202003272UA - Method for the synthesis of cyclic depsipeptides - Google Patents

Method for the synthesis of cyclic depsipeptides

Info

Publication number
SG11202003272UA
SG11202003272UA SG11202003272UA SG11202003272UA SG11202003272UA SG 11202003272U A SG11202003272U A SG 11202003272UA SG 11202003272U A SG11202003272U A SG 11202003272UA SG 11202003272U A SG11202003272U A SG 11202003272UA SG 11202003272U A SG11202003272U A SG 11202003272UA
Authority
SG
Singapore
Prior art keywords
synthesis
cyclic depsipeptides
depsipeptides
cyclic
Prior art date
Application number
SG11202003272UA
Other languages
English (en)
Inventor
Dirk Heimbach
Satoshi Omura
Toshiaki Sunazuka
Tomoyasu Hirose
Yoshihiko Noguchi
Johannes Köbberling
Zhijie Wu
Shuibiao Fu
Wei Wu
Jinfeng Qiu
Liu He
Xudong Wei
Original Assignee
Bayer Animal Health Gmbh
The Kitasato Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP17200415.2A external-priority patent/EP3480195A1/en
Application filed by Bayer Animal Health Gmbh, The Kitasato Inst filed Critical Bayer Animal Health Gmbh
Publication of SG11202003272UA publication Critical patent/SG11202003272UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D325/00Heterocyclic compounds containing rings having oxygen as the only ring hetero atom according to more than one of groups C07D303/00 - C07D323/00
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15Depsipeptides; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B51/00Introduction of protecting groups or activating groups, not provided for in the preceding groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/12Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/02Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of urea, its salts, complexes or addition compounds
    • C07C273/08Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of urea, its salts, complexes or addition compounds from ammoniacal liquor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D273/00Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K11/00Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SG11202003272UA 2017-11-07 2018-11-06 Method for the synthesis of cyclic depsipeptides SG11202003272UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17200415.2A EP3480195A1 (en) 2017-11-07 2017-11-07 Method for the synthesis of cyclic depsipeptides
CN201811254536 2018-10-25
PCT/EP2018/080333 WO2019091975A1 (en) 2017-11-07 2018-11-06 Method for the synthesis of cyclic depsipeptides

Publications (1)

Publication Number Publication Date
SG11202003272UA true SG11202003272UA (en) 2020-05-28

Family

ID=64267786

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202003272UA SG11202003272UA (en) 2017-11-07 2018-11-06 Method for the synthesis of cyclic depsipeptides

Country Status (16)

Country Link
US (1) US20210130315A1 (es)
EP (1) EP3676265A1 (es)
JP (2) JP2021501769A (es)
KR (1) KR20200119230A (es)
CN (1) CN111757880A (es)
AU (1) AU2018363696B2 (es)
BR (1) BR112020008933A2 (es)
CA (1) CA3081673A1 (es)
CL (1) CL2020001182A1 (es)
IL (1) IL274283A (es)
MX (1) MX2020004702A (es)
PH (1) PH12020550538A1 (es)
SG (1) SG11202003272UA (es)
TW (1) TWI816708B (es)
UY (1) UY37965A (es)
WO (1) WO2019091975A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023127331A1 (ja) * 2021-12-27 2023-07-06 株式会社トクヤマ ペプチド製造方法、保護基の除去方法、除去剤、及びベンジル化合物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2166359T3 (es) * 1992-03-17 2002-04-16 Fujisawa Pharmaceutical Co Derivado de depsipeptido, su produccion y uso.
JPH05320148A (ja) * 1992-05-22 1993-12-03 Meiji Seika Kaisha Ltd 環状デプシペプチドpf1022物質の合成法
RU95105161A (ru) * 1992-06-11 1996-12-27 Байер АГ (DE) Производные циклического депсипептида с 18 кольцевыми атомами, их оптические изомеры и рацематы, их применение в качестве средства для борьбы с эндопаразитами и эндопаразитицидное средство
EP0685469A4 (en) * 1993-02-19 1996-04-03 Meiji Seika Kaisha DERIVATIVE OF PF 1022 USED AS A CYCLIC DEPSIPEPTIDE.
DE4317457A1 (de) * 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
DE4317432A1 (de) * 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
DE4342907A1 (de) * 1993-12-16 1995-06-22 Bayer Ag Neue cyclische Depsipeptide mit 18 Ringatomen und ihre Verwendung zur Bekämpfung von Endoparasiten
CZ295705B6 (cs) * 1995-09-22 2005-10-12 Bayer Aktiengesellschaft Cyklodepsipeptidové deriváty sloučeniny PF1022 a farmaceutický prostředek s jejich obsahem
JP2000044493A (ja) 1998-07-27 2000-02-15 Asahi Chem Ind Co Ltd 化合物ライブラリー合成用保護基
DE10358525A1 (de) 2003-12-13 2005-07-07 Bayer Healthcare Ag Endoparasitizide Mittel zur topischen Applikation
DE102004055316A1 (de) 2004-11-16 2006-05-18 Bayer Healthcare Ag Verhinderung vertikaler Endoparasiten-Infektionen
DE102005011779A1 (de) 2005-03-11 2006-09-14 Bayer Healthcare Ag Endoparasitizide Mittel
ES2546808T3 (es) 2006-03-24 2015-09-28 Jitsubo Co., Ltd. Reactivo para síntesis orgánica y método de reacción de síntesis orgánica con dicho reactivo
HUE042661T2 (hu) * 2012-06-13 2019-07-29 Meiji Seika Pharma Co Ltd Új ciklusos depszipeptid származék és ezt tartalmazó kártevõirtó szer
WO2015093558A1 (ja) * 2013-12-18 2015-06-25 Meiji Seikaファルマ株式会社 環状デプシペプチド誘導体およびそれを含んでなる有害生物防除剤
HUE055535T2 (hu) * 2015-05-20 2021-12-28 Boehringer Ingelheim Animal Health Usa Inc Féreghajtó depszipeptid-vegyületek
KR102427124B1 (ko) 2015-12-28 2022-07-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 뎁시펩티드 화합물
CN205510398U (zh) * 2016-03-31 2016-08-24 乐视控股(北京)有限公司 跑步机
WO2018093920A1 (en) * 2016-11-16 2018-05-24 Merial, Inc. Anthelmintic depsipeptide compounds
GB201713633D0 (en) * 2017-08-24 2017-10-11 Walshe Nigel Methods for production of emodepside from pf 1022a derivatives

Also Published As

Publication number Publication date
JP2024009021A (ja) 2024-01-19
AU2018363696B2 (en) 2023-09-14
PH12020550538A1 (en) 2021-03-22
MX2020004702A (es) 2020-11-06
BR112020008933A2 (pt) 2020-10-20
EP3676265A1 (en) 2020-07-08
CA3081673A1 (en) 2019-05-16
CN111757880A (zh) 2020-10-09
JP2021501769A (ja) 2021-01-21
IL274283A (en) 2020-06-30
TW201932011A (zh) 2019-08-16
TWI816708B (zh) 2023-10-01
WO2019091975A1 (en) 2019-05-16
UY37965A (es) 2019-05-31
CL2020001182A1 (es) 2021-02-12
AU2018363696A1 (en) 2020-04-23
KR20200119230A (ko) 2020-10-19
US20210130315A1 (en) 2021-05-06

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