CL2018002023A1 - Uso de moduladores de receptores de gabaa para el tratamiento de picor. - Google Patents
Uso de moduladores de receptores de gabaa para el tratamiento de picor.Info
- Publication number
- CL2018002023A1 CL2018002023A1 CL2018002023A CL2018002023A CL2018002023A1 CL 2018002023 A1 CL2018002023 A1 CL 2018002023A1 CL 2018002023 A CL2018002023 A CL 2018002023A CL 2018002023 A CL2018002023 A CL 2018002023A CL 2018002023 A1 CL2018002023 A1 CL 2018002023A1
- Authority
- CL
- Chile
- Prior art keywords
- treatment
- itching
- receptor modulators
- gabaa receptor
- general formula
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
Abstract
SE PROPORCIONA UN COMPUESTO PARA SU USO EN EL TRATAMIENTO DE PICOR, EN EL QUE EL COMPUESTO COMPRENDE LA FÓRMULA GENERAL (1A), FÓRMULA GENERAL (1B) O FÓRMULA GENERAL (1C). LOS COMPUESTOS DE LA INVENCIÓN SON MODULADORES DE RECEPTORES DE GABAA a2 Y/O a3 ALOSTÉRICOS POSITIVOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16153035 | 2016-01-27 | ||
EP16178824 | 2016-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018002023A1 true CL2018002023A1 (es) | 2019-02-01 |
Family
ID=57890845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018002023A CL2018002023A1 (es) | 2016-01-27 | 2018-07-26 | Uso de moduladores de receptores de gabaa para el tratamiento de picor. |
Country Status (14)
Country | Link |
---|---|
US (2) | US10786513B2 (es) |
EP (1) | EP3407886A1 (es) |
JP (2) | JP7115746B2 (es) |
KR (1) | KR102482200B1 (es) |
CN (1) | CN108697694B (es) |
AU (1) | AU2017213154B2 (es) |
BR (1) | BR112018015386A2 (es) |
CA (2) | CA3222584A1 (es) |
CL (1) | CL2018002023A1 (es) |
IL (1) | IL260775B (es) |
MX (1) | MX2018009252A (es) |
SG (1) | SG11201806393QA (es) |
UA (1) | UA125463C2 (es) |
WO (1) | WO2017129801A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018009252A (es) | 2016-01-27 | 2019-01-21 | Univ Zuerich | Uso de moduladores de receptores de gabaa para el tratamiento de picor. |
JP7449272B2 (ja) * | 2018-04-18 | 2024-03-13 | ニューロサイクル・セラピューティクス・インコーポレイテッド | Gabaa陽性アロステリックモジュレーター化合物、その作製の方法および使用 |
EP3796907A4 (en) * | 2018-05-22 | 2021-11-03 | Neurocycle Therapeutics, Inc. | GABAA POSITIVE ALLOSTERIC MODULATING COMPOUNDS FOR THE TREATMENT OF PRURITUS AND / OR DERMATITIS |
EP3849976B1 (en) | 2018-09-13 | 2022-10-26 | Saniona A/S | A gaba a receptor ligand |
WO2020191047A1 (en) * | 2019-03-18 | 2020-09-24 | Neurocycle Therapeutics, Inc. | Use of gabaa receptor modulators for treatment of pain |
CN110004118B (zh) * | 2019-03-29 | 2023-03-28 | 中国科学院武汉物理与数学研究所 | 用于辅助重组狂犬病毒在神经细胞高效逆向跨单级突触的rAAV病毒的包装方法及其应用 |
JP2022554159A (ja) * | 2019-10-23 | 2022-12-28 | ニューロサイクル・セラピューティクス・インコーポレイテッド | Gabaa受容体モジュレーターによるてんかん状態の治療 |
US20210401849A1 (en) * | 2020-06-30 | 2021-12-30 | University Of Mississippi Medical Center | Methods for treating benzodiazepine misuse/use disorder |
Family Cites Families (31)
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US1024526A (en) | 1911-07-25 | 1912-04-30 | George R Schweikert | Chair. |
SK9399A3 (en) * | 1996-07-25 | 2000-04-10 | Merck Sharp & Dohme | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors |
FR2767692B1 (fr) * | 1997-09-01 | 2000-03-03 | Oreal | Utilisation d'une substance agoniste d'un recepteur associe a un canal chlore ou potassique dans le traitement des peaux sensibles |
GB9813576D0 (en) | 1998-06-24 | 1998-08-19 | Merck Sharp & Dohme | Therapeutic agents |
GB9903119D0 (en) * | 1999-02-11 | 1999-04-07 | Merck Sharp & Dohme | Therapeutic agents |
US6936608B2 (en) | 2000-11-10 | 2005-08-30 | Merck Sharp & Dohme Ltd. | Imidazo-triazine derivatives as ligands for GABA receptors |
GB0117277D0 (en) | 2001-07-16 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
TWI248936B (en) | 2001-03-21 | 2006-02-11 | Merck Sharp & Dohme | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
US8835424B2 (en) | 2002-03-28 | 2014-09-16 | Wisconsin Alumni Research Foundation | Selective agents for pain suppression |
KR100865410B1 (ko) | 2002-03-28 | 2008-10-24 | 위시스 테크놀로지 파운데이션, 인크. | 진정 및 운동실조 효과가 감소된 항불안제 |
GB0210124D0 (en) | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
JP2004170323A (ja) * | 2002-11-22 | 2004-06-17 | Sumitomo Pharmaceut Co Ltd | 皮膚疾患治療剤のスクリーニング方法 |
JPWO2005030773A1 (ja) * | 2003-09-26 | 2006-12-07 | 大日本住友製薬株式会社 | 新規ピラゾロピリミジン誘導体 |
WO2005108401A1 (en) * | 2004-04-29 | 2005-11-17 | Dov Pharmaceutical, Inc. | 2-pyridinyl[7-(substituted-pyridin-4-yl) pyrazolo[1,5-a]pyrimidin-3-yl]methanones |
WO2006061428A2 (en) * | 2004-12-10 | 2006-06-15 | Universität Zürich | Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain |
KR20060087386A (ko) * | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
ATE494289T1 (de) | 2006-08-04 | 2011-01-15 | Merz Pharma Gmbh & Co Kgaa | Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin |
ES2689444T3 (es) | 2006-11-22 | 2018-11-14 | Incyte Holdings Corporation | Imidazotriazinas e imidazopirimidinas como inhibidores de la quinasa |
EP2188284A2 (en) * | 2007-08-14 | 2010-05-26 | Novartis Ag | Tricyclic heterocyclic compounds as gaba a modulators |
SI2300455T1 (sl) | 2008-05-21 | 2017-12-29 | Incyte Holdings Corporation | Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo |
WO2010063487A1 (en) | 2008-12-05 | 2010-06-10 | Merz Pharma Gmbh & Co. Kgaa | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
EP2421848A1 (en) | 2009-04-22 | 2012-02-29 | Janssen Pharmaceutica N.V. | Azetidinyl diamides as monoacylglycerol lipase inhibitors |
WO2011011712A1 (en) | 2009-07-24 | 2011-01-27 | Concert Pharmaceuticals, Inc. | Substituted imidazotriazines |
ES2573148T3 (es) | 2010-08-25 | 2016-06-06 | Neopharm Co., Ltd. | Compuestos y composición de 1H-benzo[d]imidazol-5-ilo para el tratamiento de enfermedades inflamatorias |
US20130331394A1 (en) * | 2012-06-11 | 2013-12-12 | The Mclean Hospital Corporation | Treating schizophrenia |
BR122017003181A2 (pt) * | 2013-02-19 | 2019-09-10 | Ono Pharmaceutical Co | composto inibidor de trk, composição farmacêutica e medicamento compreendendo dito composto e seu uso para profilaxia e/ou terapia de doença relacionada à trk e/ou para inibir trk |
WO2015072853A1 (en) | 2013-11-13 | 2015-05-21 | Rjg Developments B.V. | Treatment of herpes virus infection outbreaks |
GB201321732D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
US9844551B2 (en) | 2015-01-14 | 2017-12-19 | Children's Hospital Medical Center | Compositions and methods for treatment of fragile X syndrome |
US10259815B2 (en) | 2015-03-20 | 2019-04-16 | Uwm Research Foundation, Inc. | Gabaergic ligands and their uses |
MX2018009252A (es) | 2016-01-27 | 2019-01-21 | Univ Zuerich | Uso de moduladores de receptores de gabaa para el tratamiento de picor. |
-
2017
- 2017-01-27 MX MX2018009252A patent/MX2018009252A/es unknown
- 2017-01-27 EP EP17701549.2A patent/EP3407886A1/en active Pending
- 2017-01-27 WO PCT/EP2017/051866 patent/WO2017129801A1/en active Application Filing
- 2017-01-27 JP JP2018539149A patent/JP7115746B2/ja active Active
- 2017-01-27 AU AU2017213154A patent/AU2017213154B2/en not_active Expired - Fee Related
- 2017-01-27 BR BR112018015386-9A patent/BR112018015386A2/pt not_active IP Right Cessation
- 2017-01-27 CA CA3222584A patent/CA3222584A1/en active Pending
- 2017-01-27 KR KR1020187022974A patent/KR102482200B1/ko active IP Right Grant
- 2017-01-27 CN CN201780008490.1A patent/CN108697694B/zh active Active
- 2017-01-27 SG SG11201806393QA patent/SG11201806393QA/en unknown
- 2017-01-27 UA UAA201808382A patent/UA125463C2/uk unknown
- 2017-01-27 CA CA3012791A patent/CA3012791C/en active Active
-
2018
- 2018-07-25 IL IL260775A patent/IL260775B/en unknown
- 2018-07-25 US US16/045,193 patent/US10786513B2/en active Active
- 2018-07-26 CL CL2018002023A patent/CL2018002023A1/es unknown
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2020
- 2020-08-14 US US16/994,146 patent/US11529359B2/en active Active
-
2022
- 2022-04-04 JP JP2022062494A patent/JP2022088620A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3222584A1 (en) | 2017-08-03 |
JP2019507736A (ja) | 2019-03-22 |
US20190134057A1 (en) | 2019-05-09 |
IL260775B (en) | 2021-09-30 |
CA3012791A1 (en) | 2017-08-03 |
EP3407886A1 (en) | 2018-12-05 |
US11529359B2 (en) | 2022-12-20 |
JP7115746B2 (ja) | 2022-08-09 |
UA125463C2 (uk) | 2022-03-16 |
CN108697694B (zh) | 2022-12-09 |
WO2017129801A1 (en) | 2017-08-03 |
US20210100814A1 (en) | 2021-04-08 |
KR102482200B1 (ko) | 2022-12-27 |
US10786513B2 (en) | 2020-09-29 |
CA3012791C (en) | 2024-01-23 |
BR112018015386A2 (pt) | 2019-03-19 |
SG11201806393QA (en) | 2018-08-30 |
AU2017213154B2 (en) | 2023-02-02 |
AU2017213154A1 (en) | 2018-08-16 |
CN108697694A (zh) | 2018-10-23 |
KR20180118623A (ko) | 2018-10-31 |
JP2022088620A (ja) | 2022-06-14 |
RU2018128905A (ru) | 2020-02-27 |
RU2018128905A3 (es) | 2020-03-24 |
MX2018009252A (es) | 2019-01-21 |
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