CL2018001796A1 - Agrupación de genes biosintéticos de carrimicina - Google Patents

Agrupación de genes biosintéticos de carrimicina

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Publication number
CL2018001796A1
CL2018001796A1 CL2018001796A CL2018001796A CL2018001796A1 CL 2018001796 A1 CL2018001796 A1 CL 2018001796A1 CL 2018001796 A CL2018001796 A CL 2018001796A CL 2018001796 A CL2018001796 A CL 2018001796A CL 2018001796 A1 CL2018001796 A1 CL 2018001796A1
Authority
CL
Chile
Prior art keywords
orf
biosynthetic genes
carrimycin
grouping
synthesis
Prior art date
Application number
CL2018001796A
Other languages
English (en)
Inventor
Yiguang Wang
Yang Jiang
Xiaofeng Zhao
Weiqing He
Jianlu Dai
Original Assignee
Shenyang Fuyang Pharmaceutical Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenyang Fuyang Pharmaceutical Tech Co Ltd filed Critical Shenyang Fuyang Pharmaceutical Tech Co Ltd
Publication of CL2018001796A1 publication Critical patent/CL2018001796A1/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01064—Testosterone 17-beta-dehydrogenase (NADP+) (1.1.1.64)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01188—Prostaglandin-F synthase (1.1.1.188)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01008—Acyl-CoA dehydrogenase (NADP+) (1.3.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01013—Glycine N-acyltransferase (2.3.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02007—Glutathione thiolesterase (3.1.2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02003—Dihydroorotase (3.5.2.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE DESCRIPCIÓN PROPORCIONA UNA AGRUPACIÓN DE GENES BIOSINTÉTICOS DE CARRIMICINA. LA AGRUPACIÓN DE GENES BIOSINTÉTICOS COMPRENDE 44 MARCOS ABIERTOS DE LECTURA DE GENES (ORF), ES DECIR, 5 ORFS (ORF10-14) QUE CODIFICAN LA POLICÉTIDO SINTASA, 9 ORF (ORF1, 4-6, 15 Y 36-39) RELACIONADOS CON LA UNIDAD DE EXTENSIÓN DE LA SÍNTESIS DE POLICETONAS Y CON LA MODIFICACIÓN, 16 ORF (ORF9, 16-22, 24, 26, 28, 29, 33-35 Y 41) RELACIONADOS CON LA SÍNTESIS DE GLICÓSILOS, 6 ORF (ORF7, 8, 30-32 Y 40) RELACIONADOS CON LA TRANSFERENCIA DE GLICOSILO, 2 ORF (ORF3 Y 25) RELACIONADOS CON LA RESISTENCIA, 4 ORF (ORF2, 23, 27 Y 42) POSIBLEMENTE RELACIONADOS CON LA REGULACIÓN, UN ORF DE GEN MARCADOR DE RESISTENCIA TSR (ORF43) Y UN ORF DE GEN DE 4''-MICAROSA GLUCÓSIDO ISOVALERIL TRANSFERASA (ORF44).
CL2018001796A 2015-12-31 2018-06-29 Agrupación de genes biosintéticos de carrimicina CL2018001796A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201511028754.9A CN105505954B (zh) 2015-12-31 2015-12-31 可利霉素生物合成基因簇

Publications (1)

Publication Number Publication Date
CL2018001796A1 true CL2018001796A1 (es) 2018-09-28

Family

ID=55714247

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CL2018001796A CL2018001796A1 (es) 2015-12-31 2018-06-29 Agrupación de genes biosintéticos de carrimicina

Country Status (20)

Country Link
US (1) US10858659B2 (es)
EP (1) EP3385386B3 (es)
JP (1) JP6882330B2 (es)
KR (1) KR20180093083A (es)
CN (2) CN105505954B (es)
AU (1) AU2016383270A1 (es)
BR (1) BR112018013309A2 (es)
CA (1) CA3009706A1 (es)
CL (1) CL2018001796A1 (es)
CO (1) CO2018007130A2 (es)
DK (1) DK3385386T6 (es)
ES (1) ES2812256T7 (es)
MY (1) MY193028A (es)
PE (1) PE20190221A1 (es)
PH (1) PH12018501393A1 (es)
PL (1) PL3385386T6 (es)
RU (1) RU2719189C2 (es)
UA (1) UA124058C2 (es)
WO (1) WO2017114034A1 (es)
ZA (1) ZA201804397B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106916835B (zh) * 2015-12-24 2022-08-12 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN105505954B (zh) * 2015-12-31 2019-01-22 沈阳福洋医药科技有限公司 可利霉素生物合成基因簇
RU2746047C1 (ru) 2017-04-06 2021-04-06 Шенянг Фуянг Фармасьютекал Технолоджи Ко., Лтд. Применение карримицина и его фармацевтически приемлемой соли для производства медикаментов для лечения и/или профилактики опухоли
CN111349595A (zh) * 2018-12-20 2020-06-30 沈阳福洋医药科技有限公司 一种螺旋霉素产生菌、可利霉素产生菌、构建方法、应用及提高产物产量的方法
CN111197019B (zh) * 2020-01-10 2022-04-15 安徽大学 一种通过糖多孢红霉菌sace_1906基因途径提高红霉素产量的方法
CN114517175B (zh) * 2020-11-20 2024-04-09 上海医药工业研究院 基因工程菌及其应用

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CN1058295C (zh) * 1997-06-03 2000-11-08 中国医学科学院医药生物技术研究所 一种利用基因工程技术制造生技霉素的方法
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Publication number Publication date
CN105505954B (zh) 2019-01-22
PL3385386T6 (pl) 2021-04-19
JP6882330B2 (ja) 2021-06-02
ZA201804397B (en) 2019-09-25
PH12018501393A1 (en) 2019-02-27
US10858659B2 (en) 2020-12-08
RU2018125487A3 (es) 2020-02-14
MY193028A (en) 2022-09-23
PL3385386T3 (pl) 2020-11-30
RU2719189C2 (ru) 2020-04-17
WO2017114034A1 (zh) 2017-07-06
EP3385386A4 (en) 2018-10-10
CN105505954A (zh) 2016-04-20
ES2812256T3 (es) 2021-03-16
PE20190221A1 (es) 2019-02-13
CN107868789A (zh) 2018-04-03
CN107868789B (zh) 2020-11-17
DK3385386T3 (da) 2020-08-31
KR20180093083A (ko) 2018-08-20
EP3385386B1 (en) 2020-05-27
ES2812256T7 (es) 2021-09-22
DK3385386T6 (da) 2021-02-08
AU2016383270A1 (en) 2018-07-26
RU2018125487A (ru) 2020-01-31
BR112018013309A2 (pt) 2018-12-11
UA124058C2 (uk) 2021-07-14
EP3385386B3 (en) 2020-11-18
EP3385386A1 (en) 2018-10-10
JP2019500903A (ja) 2019-01-17
US20190093112A1 (en) 2019-03-28
CA3009706A1 (en) 2017-07-06
CO2018007130A2 (es) 2018-07-19

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