CL2018001138A1 - Un método ex vivo para probar la respuesta celular de las poblaciones de células primarias a una droga o combinación de drogas - Google Patents
Un método ex vivo para probar la respuesta celular de las poblaciones de células primarias a una droga o combinación de drogasInfo
- Publication number
- CL2018001138A1 CL2018001138A1 CL2018001138A CL2018001138A CL2018001138A1 CL 2018001138 A1 CL2018001138 A1 CL 2018001138A1 CL 2018001138 A CL2018001138 A CL 2018001138A CL 2018001138 A CL2018001138 A CL 2018001138A CL 2018001138 A1 CL2018001138 A1 CL 2018001138A1
- Authority
- CL
- Chile
- Prior art keywords
- drug
- cell populations
- artificial
- environment
- test
- Prior art date
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0694—Cells of blood, e.g. leukemia cells, myeloma cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/40—Nucleotides, nucleosides, bases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2304—Interleukin-4 (IL-4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/231—Interleukin-10 (IL-10)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2313—Interleukin-13 (IL-13)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/30—Coculture with; Conditioned medium produced by tumour cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
LA INVENCIÓN SE REFIERE A UN MÉTODO PARA PRODUCIR UN ENTORNO ARTIFICIAL DE POBLACIONES DE CÉLULAS PRIMARIAS, PARTICULARMENTE UN ENTORNO TUMORAL ARTIFICIAL DE POBLACIONES DE CÉLULAS TUMORALES PRIMARIAS Y SU USO EN UN MÉTODO EX VIVO PARA EVALUAR LA RESPUESTA CELULAR DE POBLACIONES DE CÉLULAS TUMORALES PRIMARIAS A UN FÁRMACO O DROGAS. EL MÉTODO DE LA INVENCIÓN COMPRENDE LA INCUBACIÓN DE LAS CÉLULAS TUMORALES PRIMARIAS CON EL ENTORNO DEL TUMOR ARTIFICIAL Y EL FÁRMACO O LOS FÁRMACOS Y ANALIZAR LA RESPUESTA DE LAS POBLACIONES DE CÉLULAS TUMORALES PRIMARIAS. LA INCUBACIÓN DE LAS CÉLULAS TUMORALES PRIMARIAS CON EL ENTORNO TUMORAL ARTIFICIAL, MEJORA LA VIABILIDAD DE DICHAS CÉLULAS TUMORALES Y / O INDUCE MAYORES NIVELES DE PROLIFERACIÓN DE CÉLULAS TUMORALES Y, EN CONSECUENCIA, AUMENTA LA SENSIBILIDAD Y PRECISIÓN DE LA PRUEBA CON RESPECTO A LOS FÁRMACOS ENSAYADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562250687P | 2015-11-04 | 2015-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018001138A1 true CL2018001138A1 (es) | 2018-10-12 |
Family
ID=57421814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018001138A CL2018001138A1 (es) | 2015-11-04 | 2018-04-27 | Un método ex vivo para probar la respuesta celular de las poblaciones de células primarias a una droga o combinación de drogas |
Country Status (14)
Country | Link |
---|---|
US (1) | US20190212325A1 (es) |
EP (1) | EP3371595B1 (es) |
JP (1) | JP6774685B2 (es) |
KR (1) | KR20180070603A (es) |
CN (1) | CN108351345B (es) |
AU (1) | AU2016348722A1 (es) |
BR (1) | BR112018008928A2 (es) |
CA (1) | CA3003347A1 (es) |
CL (1) | CL2018001138A1 (es) |
HK (1) | HK1258451A1 (es) |
IL (1) | IL259013A (es) |
MX (1) | MX2018005228A (es) |
SG (1) | SG11201803461RA (es) |
WO (1) | WO2017077046A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111089977A (zh) * | 2019-12-30 | 2020-05-01 | 浙江科途医学科技有限公司 | 一种利用类器官检测溶瘤病毒有效性的方法 |
CN117192115A (zh) * | 2023-11-03 | 2023-12-08 | 赛德特(北京)生物工程有限公司 | 检测t淋巴细胞免疫活性的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2260097B1 (en) * | 2008-03-12 | 2017-04-26 | Sanofi Pasteur VaxDesign Corporation | Disease model incorporation into an artificial immune system (ais) |
TW201024733A (en) * | 2008-09-26 | 2010-07-01 | Sanofi Aventis | Methods for determining sodium-proton-exchanger ligand efficiency |
WO2010120329A1 (en) * | 2009-04-15 | 2010-10-21 | The University Of Medicine And Dentistry Of New Jersey | Reconstituted tumor microenvironment for anticancer drug development |
RU2636614C2 (ru) * | 2009-05-19 | 2017-11-24 | Вивия Байотек С.Л. | Способы персонализированного медицинского тестирования ex vivo на гематологические новообразования |
WO2014035668A1 (en) * | 2012-08-28 | 2014-03-06 | The Brigham And Women's Hospital, Inc. | Functional assay for cancer recurrence and malignant potential |
US9958432B2 (en) * | 2013-09-20 | 2018-05-01 | Lynx Biosciences, Inc. | Cellular cis-co-culture systems for analysis |
-
2016
- 2016-11-04 US US15/773,400 patent/US20190212325A1/en not_active Abandoned
- 2016-11-04 EP EP16801976.8A patent/EP3371595B1/en active Active
- 2016-11-04 MX MX2018005228A patent/MX2018005228A/es unknown
- 2016-11-04 SG SG11201803461RA patent/SG11201803461RA/en unknown
- 2016-11-04 CN CN201680064332.3A patent/CN108351345B/zh active Active
- 2016-11-04 CA CA3003347A patent/CA3003347A1/en not_active Abandoned
- 2016-11-04 WO PCT/EP2016/076690 patent/WO2017077046A1/en active Application Filing
- 2016-11-04 KR KR1020187012867A patent/KR20180070603A/ko unknown
- 2016-11-04 BR BR112018008928-1A patent/BR112018008928A2/pt not_active Application Discontinuation
- 2016-11-04 JP JP2018518687A patent/JP6774685B2/ja active Active
- 2016-11-04 AU AU2016348722A patent/AU2016348722A1/en not_active Abandoned
-
2018
- 2018-04-27 CL CL2018001138A patent/CL2018001138A1/es unknown
- 2018-04-29 IL IL259013A patent/IL259013A/en unknown
-
2019
- 2019-01-16 HK HK19100756.3A patent/HK1258451A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2018533728A (ja) | 2018-11-15 |
JP6774685B2 (ja) | 2020-10-28 |
MX2018005228A (es) | 2018-08-15 |
CN108351345A (zh) | 2018-07-31 |
AU2016348722A1 (en) | 2018-05-17 |
IL259013A (en) | 2018-06-28 |
US20190212325A1 (en) | 2019-07-11 |
CA3003347A1 (en) | 2017-05-11 |
CN108351345B (zh) | 2021-11-30 |
EP3371595A1 (en) | 2018-09-12 |
BR112018008928A2 (pt) | 2019-04-30 |
SG11201803461RA (en) | 2018-05-30 |
WO2017077046A1 (en) | 2017-05-11 |
KR20180070603A (ko) | 2018-06-26 |
HK1258451A1 (zh) | 2019-11-15 |
EP3371595B1 (en) | 2019-12-25 |
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