CL2017002163A1 - Derivado de imidazopirimidina e imidazotriazina, y composición farmacéutica que lo comprende. - Google Patents

Derivado de imidazopirimidina e imidazotriazina, y composición farmacéutica que lo comprende.

Info

Publication number
CL2017002163A1
CL2017002163A1 CL2017002163A CL2017002163A CL2017002163A1 CL 2017002163 A1 CL2017002163 A1 CL 2017002163A1 CL 2017002163 A CL2017002163 A CL 2017002163A CL 2017002163 A CL2017002163 A CL 2017002163A CL 2017002163 A1 CL2017002163 A1 CL 2017002163A1
Authority
CL
Chile
Prior art keywords
pharmaceutical composition
imidazopyrimidine
imidazotriazine
derivative
imidazotriazine derivative
Prior art date
Application number
CL2017002163A
Other languages
English (en)
Inventor
Chun Eung Park
Young Koo Jang
Yong Je Shin
Ji Yeon Kim
Seung Mo HAM
Yong Gil Kim
Hye Kyung Min
Soo Bong Cha
Hyo Jun Jung
Ju Young Lee
Seung Nam Han
Jin Yong Chung
Eun Ju Choi
Chan Mi Joung
Jong Sil Park
Ji Won Lee
Nahm Ryune Cho
Eun Ju Ryu
Cheol Young Maeng
Original Assignee
Sk Biopharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sk Biopharmaceuticals Co Ltd filed Critical Sk Biopharmaceuticals Co Ltd
Publication of CL2017002163A1 publication Critical patent/CL2017002163A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<p>COMPUESTOS DERIVADOS DE IMIDAZOPIRIMIDINA E IMIDAZOTRIAZINA; COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE, UTIL PARA LA PREVENCIÓN O EL TRATAMIENTO DE UN TRASTORNO MEDIADO POR UNA DISFUNCIÓN DE GLUTAMATO Y DEL RECEPTOR METABOTRÓPICO DE GLUTAMATO SUBTIPO 5 (MGLUR5) TAL COMO ESQUIZOFRENIA.</p>
CL2017002163A 2015-02-26 2017-08-25 Derivado de imidazopirimidina e imidazotriazina, y composición farmacéutica que lo comprende. CL2017002163A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20150027395 2015-02-26

Publications (1)

Publication Number Publication Date
CL2017002163A1 true CL2017002163A1 (es) 2018-06-22

Family

ID=56788906

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017002163A CL2017002163A1 (es) 2015-02-26 2017-08-25 Derivado de imidazopirimidina e imidazotriazina, y composición farmacéutica que lo comprende.

Country Status (22)

Country Link
US (5) US9745310B2 (es)
EP (2) EP3842436B1 (es)
JP (1) JP6692367B2 (es)
KR (1) KR102577178B1 (es)
CN (1) CN107635994B (es)
AR (1) AR103769A1 (es)
AU (1) AU2016224227B2 (es)
BR (1) BR112017018192B1 (es)
CA (1) CA2976422C (es)
CL (1) CL2017002163A1 (es)
DK (2) DK3842436T3 (es)
ES (2) ES2854288T3 (es)
FI (1) FI3842436T3 (es)
HK (1) HK1244275A1 (es)
IL (1) IL254070B (es)
MX (1) MX2017010630A (es)
PL (2) PL3262047T3 (es)
PT (2) PT3842436T (es)
RU (1) RU2710556C2 (es)
TW (1) TWI713497B (es)
WO (1) WO2016137260A1 (es)
ZA (1) ZA201705333B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020370958A1 (en) * 2019-10-21 2022-06-09 Sk Biopharmaceuticals Co., Ltd. Use of imidazopyrimidine or imidazotriazine compounds for prevention, alleviation, or treatment of cognitive disorders, or for improving cognitive function
CA3155013A1 (en) * 2019-10-21 2021-04-29 Ki Ho Lee Use of imidazopyrimidine or imidazotriazine compound for prevention, alleviation, or treatment of developmental disability

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4056589B2 (ja) * 1996-07-19 2008-03-05 武田薬品工業株式会社 複素環化合物、その製造法および用途
US6596731B2 (en) * 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
US7329662B2 (en) * 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine
CN1934094A (zh) * 2004-03-05 2007-03-21 万有制药株式会社 二芳基取代杂环5元环衍生物
ES2340321T3 (es) * 2005-09-27 2010-06-01 F.Hoffmann-La Roche Ag Oxadiazolilpirazolo-pirimidinas, como antagonistas de mglur2.
ES2689444T3 (es) * 2006-11-22 2018-11-14 Incyte Holdings Corporation Imidazotriazinas e imidazopirimidinas como inhibidores de la quinasa
NZ581817A (en) 2007-06-03 2012-05-25 Univ Vanderbilt Benzamide mglur5 positive allosteric modulators and methods of making and using same
CA2758731A1 (en) 2009-04-23 2010-10-28 Merck Sharp & Dohme Corp. 2-alkyl piperidine mglur5 receptor modulators
AR078172A1 (es) 2009-09-15 2011-10-19 Sanofi Aventis Fenoximetil dihidro oxazolopirimidinonas sustituidas y uso de las mismas como moduladores de receptores metabotropicos de mglur
BR112012006330A2 (pt) 2009-09-21 2017-07-04 Janssen Cilag S A análogos de o-benzil nicotinamida como moduladores alostéricos positivos de mglur5
JP5775094B2 (ja) * 2009-12-29 2015-09-09 イーライ リリー アンド カンパニー 統合失調症の処置に有用な選択的ｍＧｌｕ５受容体増強因子としてのテトラヒドロトリアゾロピリジン化合物
US8785481B2 (en) * 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
WO2012078817A1 (en) 2010-12-08 2012-06-14 Vanderbilt University Bicyclic pyrazole compounds as allosteric modulators of mglur5 receptors
CA2821972A1 (en) 2010-12-17 2012-06-21 Vanderbilt University Bicyclic triazole and pyrazole lactams as allosteric modulators of mglur5 receptors
EP2681218A1 (en) * 2011-02-23 2014-01-08 Pfizer Inc IMIDAZO[5,1-f][1,2,4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
WO2012125732A1 (en) * 2011-03-15 2012-09-20 Vanderbilt University Substituted imadazapyrinidin-5(6h)-ones as allosteric modulators of mglur5 receptors
US9012450B2 (en) * 2011-12-28 2015-04-21 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
US9422279B2 (en) * 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
GB201321736D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents

Also Published As

Publication number Publication date
EP3262047A4 (en) 2018-08-01
US20200277298A1 (en) 2020-09-03
IL254070B (en) 2020-07-30
FI3842436T3 (fi) 2024-01-24
JP6692367B2 (ja) 2020-05-13
US11046702B2 (en) 2021-06-29
AU2016224227A1 (en) 2017-08-31
US9745310B2 (en) 2017-08-29
BR112017018192A2 (pt) 2018-04-17
HK1244275A1 (zh) 2018-08-03
EP3842436B1 (en) 2023-11-08
CN107635994B (zh) 2019-11-05
PL3262047T3 (pl) 2021-05-31
US10100057B2 (en) 2018-10-16
JP2018506561A (ja) 2018-03-08
AU2016224227B2 (en) 2020-01-16
EP3262047A1 (en) 2018-01-03
ZA201705333B (en) 2019-07-31
KR102577178B1 (ko) 2023-09-11
PL3842436T3 (pl) 2024-03-04
ES2854288T3 (es) 2021-09-21
EP3842436A1 (en) 2021-06-30
IL254070A0 (en) 2017-10-31
US20160251361A1 (en) 2016-09-01
MX2017010630A (es) 2017-11-16
PT3842436T (pt) 2023-12-28
KR20160104579A (ko) 2016-09-05
WO2016137260A1 (en) 2016-09-01
CN107635994A (zh) 2018-01-26
US20210300933A1 (en) 2021-09-30
CA2976422C (en) 2023-09-26
RU2017131514A (ru) 2019-03-26
US20170349597A1 (en) 2017-12-07
BR112017018192B1 (pt) 2023-11-21
TW201639848A (zh) 2016-11-16
RU2710556C2 (ru) 2019-12-27
US20190031669A1 (en) 2019-01-31
TWI713497B (zh) 2020-12-21
PT3262047T (pt) 2021-02-25
AR103769A1 (es) 2017-05-31
DK3842436T3 (da) 2024-02-05
EP3262047B1 (en) 2021-01-06
ES2964324T3 (es) 2024-04-05
CA2976422A1 (en) 2016-09-01
DK3262047T3 (da) 2021-03-01
RU2017131514A3 (es) 2019-05-31

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