CL2015002060A1 - Compuestos. - Google Patents

Compuestos.

Info

Publication number
CL2015002060A1
CL2015002060A1 CL2015002060A CL2015002060A CL2015002060A1 CL 2015002060 A1 CL2015002060 A1 CL 2015002060A1 CL 2015002060 A CL2015002060 A CL 2015002060A CL 2015002060 A CL2015002060 A CL 2015002060A CL 2015002060 A1 CL2015002060 A1 CL 2015002060A1
Authority
CL
Chile
Prior art keywords
compounds
aterosclerosis
pla2
pyrimidinone
imidazo
Prior art date
Application number
CL2015002060A
Other languages
English (en)
Spanish (es)
Inventor
Zehong Wan
Qing Zhang
Yingxia Sang
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50002724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015002060(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of CL2015002060A1 publication Critical patent/CL2015002060A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CL2015002060A 2013-01-25 2015-07-23 Compuestos. CL2015002060A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2013070976 2013-01-25
CN2013001556 2013-12-12

Publications (1)

Publication Number Publication Date
CL2015002060A1 true CL2015002060A1 (es) 2015-11-27

Family

ID=50002724

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002060A CL2015002060A1 (es) 2013-01-25 2015-07-23 Compuestos.

Country Status (23)

Country Link
US (1) US9708330B2 (enExample)
EP (1) EP2948452B1 (enExample)
JP (1) JP6306053B2 (enExample)
KR (1) KR20150108897A (enExample)
CN (1) CN105008368B (enExample)
AU (1) AU2014209949B2 (enExample)
BR (1) BR112015017759B1 (enExample)
CA (1) CA2899091A1 (enExample)
CL (1) CL2015002060A1 (enExample)
CR (1) CR20150390A (enExample)
EA (1) EA025885B1 (enExample)
ES (1) ES2642762T3 (enExample)
HK (1) HK1216425A1 (enExample)
IL (1) IL240046A0 (enExample)
MA (1) MA38284B1 (enExample)
MX (1) MX2015009633A (enExample)
PE (1) PE20151251A1 (enExample)
PH (1) PH12015501586A1 (enExample)
SG (1) SG11201505520WA (enExample)
TW (1) TW201443054A (enExample)
UY (1) UY35276A (enExample)
WO (1) WO2014114694A1 (enExample)
ZA (1) ZA201505025B (enExample)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
WO2014114694A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors
WO2016012917A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
EP3172211B1 (en) 2014-07-22 2019-07-03 GlaxoSmithKline Intellectual Property Development Limited Tricyclic imidazo-pyrimidinone derivatives for the treatment of diseases mediated by lp-pla2
CN104892459A (zh) * 2015-06-16 2015-09-09 苏州明锐医药科技有限公司 利奥西呱中间体及其制备方法
CN112574221B (zh) * 2019-09-30 2022-03-04 上海纽思克生物科技有限公司 四环嘧啶酮类化合物、其制备方法、其组合物和用途
CN114805389B (zh) * 2019-11-09 2023-08-29 上海赛默罗生物科技有限公司 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途
CN111533699B (zh) * 2020-05-27 2023-12-01 龙曦宁（上海）医药科技有限公司 一种2-（三氟甲基）嘧啶-5-醇的合成方法
CN113861220B (zh) * 2020-06-30 2023-06-16 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN113912622B (zh) 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途
CN114057740B (zh) * 2021-12-15 2024-04-02 上海赛默罗生物科技有限公司 螺环嘧啶酮衍生物、其制备方法、药物组合物和用途
JP2025527291A (ja) * 2022-08-04 2025-08-20 ４ビー テクノロジーズ （ベイジン） カンパニー リミテッド Ｌｐ－ＰＬＡ２阻害剤としてのジヒドロイミダゾピリミジノン化合物およびその使用
CN118221687B (zh) 2023-07-17 2024-12-31 上海枢境生物科技有限公司 双环[5,6]咪唑嘧啶酮类衍生物、其制备方法和应用
CN116925023B (zh) * 2023-07-18 2025-11-21 江苏桐孚高新材料有限公司 2-全氟烷基-4h-吡喃-4-酮衍生物的改进合成方法

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WO2014114694A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors

Also Published As

Publication number Publication date
EP2948452A1 (en) 2015-12-02
CR20150390A (es) 2015-10-19
CN105008368B (zh) 2017-02-01
US9708330B2 (en) 2017-07-18
WO2014114694A1 (en) 2014-07-31
CA2899091A1 (en) 2014-07-31
PE20151251A1 (es) 2015-09-10
PH12015501586A1 (en) 2015-10-05
IL240046A0 (en) 2015-08-31
EP2948452B1 (en) 2017-08-09
CN105008368A (zh) 2015-10-28
EA201591379A1 (ru) 2016-01-29
US20150361082A1 (en) 2015-12-17
ZA201505025B (en) 2017-08-30
ES2642762T3 (es) 2017-11-20
HK1216425A1 (zh) 2016-11-11
MX2015009633A (es) 2015-11-30
SG11201505520WA (en) 2015-08-28
JP6306053B2 (ja) 2018-04-04
JP2016505058A (ja) 2016-02-18
KR20150108897A (ko) 2015-09-30
AU2014209949B2 (en) 2016-09-08
EA025885B1 (ru) 2017-02-28
TW201443054A (zh) 2014-11-16
UY35276A (es) 2014-08-29
AU2014209949A1 (en) 2015-07-30
MA38284B1 (fr) 2018-05-31
BR112015017759A2 (pt) 2017-07-11
MA38284A1 (fr) 2017-12-29
BR112015017759B1 (pt) 2022-05-24

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