CL2014002062A1 - Compuesto de moleculas pequeñas que inhiben cdk8 y cdk19, excluyendo cortistatina a y otros; formulacion farmceutica; un método para tratar a un mamifero que tiene una enfermedad relacionada con cdk1 como e. de alzheimer, otras demencias, amiloidosis, y un metodo para quimioproteger un paciente que padece cancer de ovario o mama, entre otros. - Google Patents
Compuesto de moleculas pequeñas que inhiben cdk8 y cdk19, excluyendo cortistatina a y otros; formulacion farmceutica; un método para tratar a un mamifero que tiene una enfermedad relacionada con cdk1 como e. de alzheimer, otras demencias, amiloidosis, y un metodo para quimioproteger un paciente que padece cancer de ovario o mama, entre otros.Info
- Publication number
- CL2014002062A1 CL2014002062A1 CL2014002062A CL2014002062A CL2014002062A1 CL 2014002062 A1 CL2014002062 A1 CL 2014002062A1 CL 2014002062 A CL2014002062 A CL 2014002062A CL 2014002062 A CL2014002062 A CL 2014002062A CL 2014002062 A1 CL2014002062 A1 CL 2014002062A1
- Authority
- CL
- Chile
- Prior art keywords
- chemoprotect
- cdk19
- cortistatin
- cdk1
- dementias
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 206010006187 Breast cancer Diseases 0.000 title 1
- 208000026310 Breast neoplasm Diseases 0.000 title 1
- 101150012716 CDK1 gene Proteins 0.000 title 1
- 101150090188 Cdk8 gene Proteins 0.000 title 1
- KSGZCKSNTAJOJS-UHFFFAOYSA-N Cortistatin A Natural products C1=CN=CC2=CC(C3CCC4C56CCC7(O6)CC(C(C(O)C7=CC5=CCC43C)O)N(C)C)=CC=C21 KSGZCKSNTAJOJS-UHFFFAOYSA-N 0.000 title 1
- 206010012289 Dementia Diseases 0.000 title 1
- 101100059559 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) nimX gene Proteins 0.000 title 1
- 241000124008 Mammalia Species 0.000 title 1
- 206010033128 Ovarian cancer Diseases 0.000 title 1
- 206010061535 Ovarian neoplasm Diseases 0.000 title 1
- 101150112625 SSN3 gene Proteins 0.000 title 1
- 101100150415 Schizosaccharomyces pombe (strain 972 / ATCC 24843) srb10 gene Proteins 0.000 title 1
- 206010002022 amyloidosis Diseases 0.000 title 1
- KSGZCKSNTAJOJS-DZBMUNJRSA-N cortistatin A Chemical compound C1=CN=CC2=CC([C@H]3CC[C@H]4[C@@]56CC[C@@]7(O6)C[C@@H]([C@H]([C@H](O)C7=CC5=CC[C@@]43C)O)N(C)C)=CC=C21 KSGZCKSNTAJOJS-DZBMUNJRSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002611 ovarian Effects 0.000 title 1
- 150000003384 small molecules Chemical class 0.000 title 1
- 229940126074 CDK kinase inhibitor Drugs 0.000 abstract 4
- 102100034770 Cyclin-dependent kinase inhibitor 3 Human genes 0.000 abstract 4
- 101000945639 Homo sapiens Cyclin-dependent kinase inhibitor 3 Proteins 0.000 abstract 4
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 abstract 4
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000037361 pathway Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 abstract 1
- 230000009758 senescence Effects 0.000 abstract 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4739—Cyclin; Prad 1
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- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261594023P | 2012-02-02 | 2012-02-02 | |
| US201261673419P | 2012-07-19 | 2012-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014002062A1 true CL2014002062A1 (es) | 2015-03-20 |
Family
ID=47716178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014002062A CL2014002062A1 (es) | 2012-02-02 | 2014-08-01 | Compuesto de moleculas pequeñas que inhiben cdk8 y cdk19, excluyendo cortistatina a y otros; formulacion farmceutica; un método para tratar a un mamifero que tiene una enfermedad relacionada con cdk1 como e. de alzheimer, otras demencias, amiloidosis, y un metodo para quimioproteger un paciente que padece cancer de ovario o mama, entre otros. |
Country Status (16)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX362346B (es) * | 2012-07-27 | 2019-01-11 | Biogen Ma Inc | Compuestos que son agentes moduladores de s1p y/o agentes moduladores de autotaxina. |
| WO2014029726A1 (en) * | 2012-08-23 | 2014-02-27 | F. Hoffmann-La Roche Ag | Novel phenyl-pyridine/pyrazine amides for the treatment of cancer |
| JP6310470B2 (ja) | 2012-11-01 | 2018-04-11 | ユニバーシティ オブ サウス カロライナ | 前立腺がんを処置するための方法 |
| US20160000787A1 (en) * | 2013-02-26 | 2016-01-07 | Senex Biotechnology, Inc. | Inhibitors of cdk8/19 for use in treating estrogen receptor positive breast cancer |
| KR20160101162A (ko) | 2013-12-24 | 2016-08-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 코르티스타틴 유사체 및 그의 합성 및 용도 |
| EP3205645B1 (en) * | 2014-04-18 | 2019-10-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2016018511A2 (en) * | 2014-06-10 | 2016-02-04 | University Of South Carolina | Methods and compositions for treatment of her-positive cancers |
| US20210322651A1 (en) | 2014-12-18 | 2021-10-21 | Senex Biotechnology, Inc. | Suppression of neointimal formation following vascular surgeru using cdk8 inhibitors |
| MX2017014338A (es) * | 2015-05-08 | 2018-04-11 | Harvard College | Seleccion dirigida de pacientes para el tratamiento con derivados de cortistatina. |
| EP3294298A4 (en) | 2015-05-08 | 2018-10-17 | President and Fellows of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
| EP3316889A4 (en) | 2015-07-01 | 2018-11-14 | President and Fellows of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| CN108348509A (zh) * | 2015-11-03 | 2018-07-31 | Lu许可公司 | 用于治疗增殖减少性病症的化合物 |
| WO2017091836A1 (en) * | 2015-11-25 | 2017-06-01 | University Of South Carolina | Enhancement of cytarabine activity by inhibiting cdk8/19 |
| WO2017164230A1 (ja) * | 2016-03-23 | 2017-09-28 | 国立大学法人 岡山大学 | リン酸化ｓａｒｍ１、抗体、ｓａｒｍ１リン酸化阻害剤、神経変性疾患の予防又は治療薬、スクリーニング方法、ｓａｒｍ１改変体及び使用 |
| US11285144B2 (en) | 2016-08-03 | 2022-03-29 | The Broad Institute, Inc. | Use of CDK8 inhibitors to treat diseases of inflammation and autoimmunity |
| ES3004107T3 (en) | 2017-01-30 | 2025-03-11 | Univ Kyoto | Novel compound, and method for producing regulatory t cells |
| WO2018151633A1 (ru) * | 2017-02-20 | 2018-08-23 | Закрытое Акционерное Общество "Биокад" | Способы получения производных 4-(((нафталин-2-ил)алкил)амино)хинозалин-6-карбонитрилов |
| WO2018156858A1 (en) * | 2017-02-23 | 2018-08-30 | University Of South Carolina | Use of cdk8/19 inhibitors for treatment of established colon cancer hepatic metastasis |
| JPWO2018159805A1 (ja) * | 2017-03-03 | 2020-01-09 | 国立大学法人京都大学 | 膵前駆細胞の製造方法 |
| CA3058880A1 (en) * | 2017-04-03 | 2018-10-11 | Kyoto Pharmaceutical Industries, Ltd. | Novel cyclin-dependent kinase 8 and/or 19 inhibitor |
| RU2641001C1 (ru) * | 2017-04-03 | 2018-01-15 | Закрытое Акционерное Общество "Биокад" | Соли 4-((2-(6-(4-метилпиперазин-1-карбонил)нафталин-2-ил)этил)амино)хиназолин-6-карбонитрила и фармацевтическая композиция |
| JP7392954B2 (ja) * | 2017-09-18 | 2023-12-06 | シーゼット・バイオハブ・エスエフ・リミテッド・ライアビリティ・カンパニー | トリプルネガティブ乳癌の治療方法 |
| US11261184B2 (en) | 2017-10-02 | 2022-03-01 | Boehringer Ingelheim International Gmbh | [1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors |
| RU2763347C2 (ru) * | 2018-03-01 | 2021-12-28 | Закрытое Акционерное Общество "Биокад" | Новые ингибиторы cdk8/19 |
| US12281080B2 (en) | 2018-08-21 | 2025-04-22 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| US11014906B2 (en) | 2018-08-21 | 2021-05-25 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| EP3917523B1 (en) | 2019-02-01 | 2024-09-11 | University of South Carolina | Bicyclic pyridine compounds for use in treating cancer |
| JPWO2022107877A1 (cg-RX-API-DMAC7.html) | 2020-11-20 | 2022-05-27 | ||
| AU2022219794A1 (en) | 2021-02-09 | 2023-08-17 | Orizuru Therapeutics, Inc. | Maturation agent |
| WO2022204534A1 (en) * | 2021-03-25 | 2022-09-29 | University Of South Carolina | Cdk8/19 inhibitors for the treatment of cytokine storm |
| US20240400993A1 (en) | 2021-09-27 | 2024-12-05 | Kyoto University | Method for producing t cell |
| TW202334397A (zh) | 2021-11-24 | 2023-09-01 | 日商雷格細胞股份有限公司 | 用於治療或預防t細胞相關疾病之醫藥組合物 |
| JP7572755B2 (ja) | 2021-11-24 | 2024-10-24 | レグセル株式会社 | ヒト誘導性制御性ｔ細胞およびその作製方法 |
| CN119256076A (zh) | 2022-03-23 | 2025-01-03 | 国立大学法人京都大学 | 用于产生调节性t细胞的方法 |
| AU2023262842A1 (en) | 2022-04-25 | 2024-09-12 | Orizuru Therapeutics, Inc. | Maturing agent having both of alk5 inhibitory activity and cdk8/19 inhibitory activity |
| KR20250036837A (ko) | 2022-07-14 | 2025-03-14 | 오리즈루 세라퓨틱스 가부시키가이샤 | 세포 이식용의 피브린 겔 시트 |
| AU2023353929A1 (en) | 2022-09-26 | 2025-05-01 | Kyoto University | T cell production method |
| WO2024071039A1 (ja) | 2022-09-26 | 2024-04-04 | レグセル株式会社 | キメラ抗原受容体（ｃａｒ）を含む誘導性制御性ｔ細胞 |
| EP4663195A1 (en) | 2023-02-08 | 2025-12-17 | Regcell Co., Ltd. | Pharmaceutical composition for treating or preventing pemphigus |
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| US6046206A (en) * | 1995-06-07 | 2000-04-04 | Cell Pathways, Inc. | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives |
| EE200000289A (et) * | 1997-10-27 | 2001-06-15 | Agouron Pharmaceuticals, Inc. | Asendatud 4-amino-tiasool-2-üüli ühendid kui tsükliinisõltuvusega kinaaside inhibiitorid |
| US6440959B1 (en) * | 1999-04-21 | 2002-08-27 | Hoffman-La Roche Inc. | Pyrazolobenzodiazepines |
| US20040180844A1 (en) | 2003-03-10 | 2004-09-16 | Fesik Stephen W. | Method of killing cancer cells |
| US20040180848A1 (en) | 2003-03-10 | 2004-09-16 | Fesik Stephen W. | Method of killing cancer cells |
| JP2006522794A (ja) * | 2003-04-10 | 2006-10-05 | ファイザー株式会社 | Ｎｒ２ｂ受容体拮抗物質としての二環系化合物 |
| WO2007133773A2 (en) * | 2006-05-15 | 2007-11-22 | Senex Biotechnology, Inc | Identification of cdki pathway inhibitors |
| US8598344B2 (en) | 2009-11-30 | 2013-12-03 | Senex Biotechnology | CDKI pathway inhibitors and uses thereof |
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| CN104363913B (zh) | 2018-08-21 |
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| US20170071942A1 (en) | 2017-03-16 |
| EA028595B1 (ru) | 2017-12-29 |
| EA201791284A1 (ru) | 2017-10-31 |
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| MY165446A (en) | 2018-03-22 |
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| CO7151516A2 (es) | 2014-12-29 |
| BR112014019052A8 (pt) | 2017-07-11 |
| PH12014501862A1 (en) | 2014-11-24 |
| CN104363913A (zh) | 2015-02-18 |
| JP2015506376A (ja) | 2015-03-02 |
| JP6193268B2 (ja) | 2017-09-06 |
| US10993945B2 (en) | 2021-05-04 |
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| SG11201404596UA (en) | 2014-10-30 |
| EP2809324B1 (en) | 2018-08-01 |
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| AU2013214783A1 (en) | 2014-08-28 |
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