CL2014001392A1 - Compuestos derivados de 2h-indazoles, antagonistas del receptor ep2; metodo para prepararlos; farmaco que los contiene en combinacion con un inhibidor de cox; y uso para el control de la fertilidad/anticoncepcion y para prevenir y tratar enfermedades tales como endometriosis, cancer de pulmon, alzheimer y artritis, entre otras. - Google Patents

Compuestos derivados de 2h-indazoles, antagonistas del receptor ep2; metodo para prepararlos; farmaco que los contiene en combinacion con un inhibidor de cox; y uso para el control de la fertilidad/anticoncepcion y para prevenir y tratar enfermedades tales como endometriosis, cancer de pulmon, alzheimer y artritis, entre otras.

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Publication number
CL2014001392A1
CL2014001392A1 CL2014001392A CL2014001392A CL2014001392A1 CL 2014001392 A1 CL2014001392 A1 CL 2014001392A1 CL 2014001392 A CL2014001392 A CL 2014001392A CL 2014001392 A CL2014001392 A CL 2014001392A CL 2014001392 A1 CL2014001392 A1 CL 2014001392A1
Authority
CL
Chile
Prior art keywords
indazoles
contraception
endometriosis
fertility
alzheimer
Prior art date
Application number
CL2014001392A
Other languages
English (en)
Spanish (es)
Inventor
Anne Mengel
Nico Brauer
Ulrike Rohn
Andrea Rotgeri
Bernd Buchmann
Bernhard Lindenthal
Laak Antonius Ter
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47278803&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014001392(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CL2014001392A1 publication Critical patent/CL2014001392A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Transplantation (AREA)
CL2014001392A 2011-11-28 2014-05-27 Compuestos derivados de 2h-indazoles, antagonistas del receptor ep2; metodo para prepararlos; farmaco que los contiene en combinacion con un inhibidor de cox; y uso para el control de la fertilidad/anticoncepcion y para prevenir y tratar enfermedades tales como endometriosis, cancer de pulmon, alzheimer y artritis, entre otras. CL2014001392A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011087170 2011-11-28
DE102012206715 2012-04-24

Publications (1)

Publication Number Publication Date
CL2014001392A1 true CL2014001392A1 (es) 2014-10-03

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ID=47278803

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CL2014001392A CL2014001392A1 (es) 2011-11-28 2014-05-27 Compuestos derivados de 2h-indazoles, antagonistas del receptor ep2; metodo para prepararlos; farmaco que los contiene en combinacion con un inhibidor de cox; y uso para el control de la fertilidad/anticoncepcion y para prevenir y tratar enfermedades tales como endometriosis, cancer de pulmon, alzheimer y artritis, entre otras.

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Country Link
US (1) US9062041B2 (enExample)
EP (1) EP2785707B1 (enExample)
JP (1) JP6192654B2 (enExample)
KR (1) KR20140103984A (enExample)
CN (1) CN104144922B (enExample)
AR (1) AR089011A1 (enExample)
AU (1) AU2012344015A1 (enExample)
BR (1) BR112014012459A2 (enExample)
CA (1) CA2856769A1 (enExample)
CL (1) CL2014001392A1 (enExample)
CO (1) CO6970595A2 (enExample)
CR (1) CR20140257A (enExample)
DO (1) DOP2014000114A (enExample)
EA (1) EA201400623A1 (enExample)
EC (1) ECSP14002542A (enExample)
ES (1) ES2665510T3 (enExample)
IL (1) IL232503A (enExample)
IN (1) IN2014CN03854A (enExample)
MX (1) MX2014006433A (enExample)
PE (1) PE20141579A1 (enExample)
PH (1) PH12014501195A1 (enExample)
SG (1) SG11201402269RA (enExample)
TW (1) TW201326154A (enExample)
WO (1) WO2013079425A1 (enExample)

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TW201326154A (zh) 2011-11-28 2013-07-01 拜耳知識產權公司 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑
CA2913085A1 (en) * 2013-05-23 2014-11-27 Bernhard Lindenthal Pharmaceutical composition and the use thereof, and application regime of said pharmaceutical composition for on-demand contraception
WO2014187793A1 (de) * 2013-05-23 2014-11-27 Bayer Pharma Aktiengesellschaft Verwendung einer pharmazeutischen zusammensetzung zur notfallkontrazeption
CA2951259A1 (en) 2014-06-06 2015-12-10 Flexus Biosciences, Inc. Immunoregulatory agents
UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
WO2016073738A2 (en) * 2014-11-05 2016-05-12 Flexus Biosciences, Inc. Immunoregulatory agents
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
WO2020095215A1 (en) 2018-11-08 2020-05-14 Glaxosmithkline Intellectual Property Development Limited Chemical compounds
WO2022138792A1 (ja) * 2020-12-24 2022-06-30 小野薬品工業株式会社 Ｅｐ２拮抗活性を有する化合物の塩、溶媒和物および結晶

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NZ624722A (en) 2016-08-26
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US9062041B2 (en) 2015-06-23
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JP6192654B2 (ja) 2017-09-06
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