CL2014000922A1 - Compuestos derivados de dihidroisoquinolinas o sus sales, como inhibidores de la actividad de las proteinas antiapoptoticas bcl-xl; composicion farmaceutica que los comprende, util para el tratamiento de cancer de vejiga, de cerebro, de mama, de medula osea, colorrectal, de esofago, de ovario, leucemia linfocitica cronica, o cancer de bazo, entre otros. - Google Patents
Compuestos derivados de dihidroisoquinolinas o sus sales, como inhibidores de la actividad de las proteinas antiapoptoticas bcl-xl; composicion farmaceutica que los comprende, util para el tratamiento de cancer de vejiga, de cerebro, de mama, de medula osea, colorrectal, de esofago, de ovario, leucemia linfocitica cronica, o cancer de bazo, entre otros.Info
- Publication number
- CL2014000922A1 CL2014000922A1 CL2014000922A CL2014000922A CL2014000922A1 CL 2014000922 A1 CL2014000922 A1 CL 2014000922A1 CL 2014000922 A CL2014000922 A CL 2014000922A CL 2014000922 A CL2014000922 A CL 2014000922A CL 2014000922 A1 CL2014000922 A1 CL 2014000922A1
- Authority
- CL
- Chile
- Prior art keywords
- dihydroisoquinolines
- bcl
- esophagus
- colorectal
- ovarian
- Prior art date
Links
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 title 1
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 title 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 title 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 title 1
- 208000000277 Splenic Neoplasms Diseases 0.000 title 1
- 210000001185 bone marrow Anatomy 0.000 title 1
- 210000004556 brain Anatomy 0.000 title 1
- 210000000481 breast Anatomy 0.000 title 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 210000003238 esophagus Anatomy 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002611 ovarian Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 201000002471 spleen cancer Diseases 0.000 title 1
- 210000003932 urinary bladder Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547165P | 2011-10-14 | 2011-10-14 | |
| CN2012078372 | 2012-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014000922A1 true CL2014000922A1 (es) | 2014-08-18 |
Family
ID=47073545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014000922A CL2014000922A1 (es) | 2011-10-14 | 2014-04-11 | Compuestos derivados de dihidroisoquinolinas o sus sales, como inhibidores de la actividad de las proteinas antiapoptoticas bcl-xl; composicion farmaceutica que los comprende, util para el tratamiento de cancer de vejiga, de cerebro, de mama, de medula osea, colorrectal, de esofago, de ovario, leucemia linfocitica cronica, o cancer de bazo, entre otros. |
Country Status (23)
| Country | Link |
|---|---|
| EP (2) | EP3266776A1 (https=) |
| JP (2) | JP6049738B2 (https=) |
| KR (1) | KR102056587B1 (https=) |
| CN (1) | CN109535155B (https=) |
| AR (1) | AR088328A1 (https=) |
| AU (2) | AU2012322818A1 (https=) |
| BR (1) | BR112014009052B1 (https=) |
| CA (1) | CA2850976C (https=) |
| CL (1) | CL2014000922A1 (https=) |
| CO (1) | CO6950477A2 (https=) |
| DO (1) | DOP2014000074A (https=) |
| EC (1) | ECSP14000606A (https=) |
| ES (1) | ES2699966T3 (https=) |
| IL (1) | IL231926A (https=) |
| MX (2) | MX364950B (https=) |
| PE (2) | PE20181357A1 (https=) |
| PH (1) | PH12014500815B1 (https=) |
| RU (1) | RU2594282C2 (https=) |
| SG (2) | SG11201401479SA (https=) |
| TW (1) | TWI561521B (https=) |
| UY (1) | UY34381A (https=) |
| WO (1) | WO2013055895A1 (https=) |
| ZA (1) | ZA201402555B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI571466B (zh) * | 2011-10-14 | 2017-02-21 | 艾伯維有限公司 | 用於治療癌症及免疫與自體免疫疾病之細胞凋亡誘發劑 |
| US8889675B2 (en) | 2011-10-14 | 2014-11-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| CN107207553A (zh) * | 2014-12-09 | 2017-09-26 | 艾伯维公司 | Bcl‑xl抑制性化合物和包括其的抗体药物缀合物 |
| WO2016131100A1 (en) * | 2015-02-18 | 2016-08-25 | The Walter And Eliza Hall Institute Of Medical Research | Methods of treating infectious diseases |
| US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
| WO2017107089A1 (en) | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2019000238A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000236A1 (en) * | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2020210831A1 (en) * | 2019-04-12 | 2020-10-15 | TONIX Pharmaceuticals Holding Corp | Inhibitors of cd40-cd154 binding |
| KR102316961B1 (ko) * | 2020-01-29 | 2021-10-26 | 프라비바이오 주식회사 | 면역억제제로서의 벤젠 유도체의 면역억제용 약학적 조성물 |
| AU2021386367A1 (en) | 2020-11-24 | 2023-06-22 | Les Laboratoires Servier | Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
| JP2024505562A (ja) | 2021-02-02 | 2024-02-06 | レス ラボラトイレス セルビエル | 選択的ｂｃｌ－ｘｌ ｐｒｏｔａｃ化合物及び使用の方法 |
| CN119562832A (zh) | 2022-05-20 | 2025-03-04 | 诺华股份有限公司 | Met bcl-xl抑制剂抗体-药物缀合物及其使用方法 |
| AU2023271885A1 (en) | 2022-05-20 | 2024-12-12 | Les Laboratoires Servier | Epha2 bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
| US20250387504A1 (en) | 2022-05-20 | 2025-12-25 | Novartis Ag | Antibody-drug conjugates of antineoplastic compounds and methods of use thereof |
| PY24103486A (es) | 2023-11-22 | 2025-06-06 | Servier Lab | Conjugados de anticuerpo anti-cd74-fármaco y métodos de uso de los mismos |
| AR134424A1 (es) | 2023-11-22 | 2026-01-14 | Novartis Ag | Conjugados de anticuerpo anti-cd7-fármaco y métodos de uso de los mismos |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| DE69631347T2 (de) | 1995-09-15 | 2004-10-07 | Upjohn Co | Aminoaryl oxazolidinone n-oxide |
| US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| GB9918037D0 (en) | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
| WO2005099353A2 (en) | 2004-04-19 | 2005-10-27 | Symed Labs Limited | A novel process for the preparation of linezolid and related compounds |
| NZ552397A (en) * | 2004-07-15 | 2011-04-29 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| WO2006008754A1 (en) | 2004-07-20 | 2006-01-26 | Symed Labs Limited | Novel intermediates for linezolid and related compounds |
| JP2008514702A (ja) | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | 新規シクロスポリン類似体およびそれらの薬学的使用 |
| US7402596B2 (en) * | 2005-03-24 | 2008-07-22 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| TW200716636A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
| US7514068B2 (en) | 2005-09-14 | 2009-04-07 | Concert Pharmaceuticals Inc. | Biphenyl-pyrazolecarboxamide compounds |
| US8796267B2 (en) | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
| KR101222412B1 (ko) | 2007-02-15 | 2013-01-15 | 에프. 호프만-라 로슈 아게 | Ｔａａｒ1 리간드로서의 2-아미노옥사졸린 |
| AU2008242703B2 (en) | 2007-04-19 | 2011-08-18 | Concert Pharmaceuticals Inc. | Deuterated morpholinyl compounds |
| US7531685B2 (en) | 2007-06-01 | 2009-05-12 | Protia, Llc | Deuterium-enriched oxybutynin |
| WO2009035598A1 (en) | 2007-09-10 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
| US20090118238A1 (en) | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
| US20090088416A1 (en) | 2007-09-26 | 2009-04-02 | Protia, Llc | Deuterium-enriched lapaquistat |
| US20090082471A1 (en) | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched fingolimod |
| WO2009045476A1 (en) | 2007-10-02 | 2009-04-09 | Concert Pharmaceuticals, Inc. | Pyrimidinedione derivatives |
| WO2009051782A1 (en) | 2007-10-18 | 2009-04-23 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
| US20090105338A1 (en) | 2007-10-18 | 2009-04-23 | Protia, Llc | Deuterium-enriched gabexate mesylate |
| EP2217548A1 (en) | 2007-10-26 | 2010-08-18 | Concert Pharmaceuticals Inc. | Deuterated darunavir |
| NZ593536A (en) * | 2008-12-19 | 2013-07-26 | Genentech Inc | Quinoline derivatives and methods of use |
| WO2010080503A1 (en) * | 2008-12-19 | 2010-07-15 | Genentech, Inc. | Heterocyclic compounds and methods of use |
| KR20110123657A (ko) * | 2010-05-07 | 2011-11-15 | 에스케이케미칼주식회사 | 피콜린아마이드 및 피리미딘-4-카복사미드 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
| TWI571466B (zh) | 2011-10-14 | 2017-02-21 | 艾伯維有限公司 | 用於治療癌症及免疫與自體免疫疾病之細胞凋亡誘發劑 |
-
2012
- 2012-10-08 TW TW101137132A patent/TWI561521B/zh not_active IP Right Cessation
- 2012-10-10 UY UY0001034381A patent/UY34381A/es unknown
- 2012-10-11 MX MX2017014059A patent/MX364950B/es unknown
- 2012-10-11 SG SG11201401479SA patent/SG11201401479SA/en unknown
- 2012-10-11 RU RU2014119254/04A patent/RU2594282C2/ru active
- 2012-10-11 EP EP17185702.2A patent/EP3266776A1/en not_active Withdrawn
- 2012-10-11 BR BR112014009052-1A patent/BR112014009052B1/pt not_active IP Right Cessation
- 2012-10-11 CA CA2850976A patent/CA2850976C/en active Active
- 2012-10-11 PH PH1/2014/500815A patent/PH12014500815B1/en unknown
- 2012-10-11 ES ES12778012T patent/ES2699966T3/es active Active
- 2012-10-11 MX MX2014004561A patent/MX351970B/es active IP Right Grant
- 2012-10-11 KR KR1020147012847A patent/KR102056587B1/ko not_active Expired - Fee Related
- 2012-10-11 CN CN201910042347.5A patent/CN109535155B/zh not_active Expired - Fee Related
- 2012-10-11 JP JP2014535867A patent/JP6049738B2/ja not_active Expired - Fee Related
- 2012-10-11 SG SG10201606031XA patent/SG10201606031XA/en unknown
- 2012-10-11 EP EP12778012.0A patent/EP2768830B1/en active Active
- 2012-10-11 PE PE2018001273A patent/PE20181357A1/es unknown
- 2012-10-11 PE PE2014000520A patent/PE20141997A1/es active IP Right Grant
- 2012-10-11 AU AU2012322818A patent/AU2012322818A1/en not_active Abandoned
- 2012-10-11 WO PCT/US2012/059717 patent/WO2013055895A1/en not_active Ceased
- 2012-10-12 AR ARP120103812A patent/AR088328A1/es not_active Application Discontinuation
-
2014
- 2014-04-03 IL IL231926A patent/IL231926A/en active IP Right Grant
- 2014-04-08 ZA ZA201402555A patent/ZA201402555B/en unknown
- 2014-04-11 CL CL2014000922A patent/CL2014000922A1/es unknown
- 2014-04-11 DO DO2014000074A patent/DOP2014000074A/es unknown
- 2014-05-07 CO CO14097119A patent/CO6950477A2/es unknown
- 2014-05-13 EC ECIEPI2014606A patent/ECSP14000606A/es unknown
-
2016
- 2016-11-22 JP JP2016226799A patent/JP6337068B2/ja not_active Expired - Fee Related
-
2017
- 2017-07-17 AU AU2017206149A patent/AU2017206149B2/en not_active Ceased
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