CL2012002536A1 - Composición farmacéutica que comprende un anticuerpo anti-factor de crecimiento nervioso (ngf) o un fragmento de unión al antígeno de éste, un amortiguador histidina 5 a 60mm, polisorbato 80 0,01% a 0,1%, y un ph entre 5,0 y 6,0; composición liofilizada; dispositivo; artículo de manufactura; y su uso en enfermedades mediadas por ngf, tales como trastornos del dolor. - Google Patents

Composición farmacéutica que comprende un anticuerpo anti-factor de crecimiento nervioso (ngf) o un fragmento de unión al antígeno de éste, un amortiguador histidina 5 a 60mm, polisorbato 80 0,01% a 0,1%, y un ph entre 5,0 y 6,0; composición liofilizada; dispositivo; artículo de manufactura; y su uso en enfermedades mediadas por ngf, tales como trastornos del dolor.

Info

Publication number
CL2012002536A1
CL2012002536A1 CL2012002536A CL2012002536A CL2012002536A1 CL 2012002536 A1 CL2012002536 A1 CL 2012002536A1 CL 2012002536 A CL2012002536 A CL 2012002536A CL 2012002536 A CL2012002536 A CL 2012002536A CL 2012002536 A1 CL2012002536 A1 CL 2012002536A1
Authority
CL
Chile
Prior art keywords
ngf
polysorbate
antigen
article
manufacture
Prior art date
Application number
CL2012002536A
Other languages
English (en)
Spanish (es)
Inventor
Wolfgang Fraunhofer
Ravi Chari
Vineet Kumar
Rainer Saedler
Michael Siedler
William B Stine
Carsten Weber
Original Assignee
Abbott Res Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44114427&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012002536(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Res Bv filed Critical Abbott Res Bv
Publication of CL2012002536A1 publication Critical patent/CL2012002536A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CL2012002536A 2010-03-17 2012-09-13 Composición farmacéutica que comprende un anticuerpo anti-factor de crecimiento nervioso (ngf) o un fragmento de unión al antígeno de éste, un amortiguador histidina 5 a 60mm, polisorbato 80 0,01% a 0,1%, y un ph entre 5,0 y 6,0; composición liofilizada; dispositivo; artículo de manufactura; y su uso en enfermedades mediadas por ngf, tales como trastornos del dolor. CL2012002536A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31498410P 2010-03-17 2010-03-17

Publications (1)

Publication Number Publication Date
CL2012002536A1 true CL2012002536A1 (es) 2012-12-07

Family

ID=44114427

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012002536A CL2012002536A1 (es) 2010-03-17 2012-09-13 Composición farmacéutica que comprende un anticuerpo anti-factor de crecimiento nervioso (ngf) o un fragmento de unión al antígeno de éste, un amortiguador histidina 5 a 60mm, polisorbato 80 0,01% a 0,1%, y un ph entre 5,0 y 6,0; composición liofilizada; dispositivo; artículo de manufactura; y su uso en enfermedades mediadas por ngf, tales como trastornos del dolor.

Country Status (25)

Country Link
US (1) US20110256135A1 (cg-RX-API-DMAC7.html)
EP (1) EP2547365A1 (cg-RX-API-DMAC7.html)
JP (1) JP2013522313A (cg-RX-API-DMAC7.html)
KR (1) KR20130031247A (cg-RX-API-DMAC7.html)
CN (1) CN102892430A (cg-RX-API-DMAC7.html)
AR (1) AR080685A1 (cg-RX-API-DMAC7.html)
AU (1) AU2011227335B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012023895A2 (cg-RX-API-DMAC7.html)
CA (1) CA2790699A1 (cg-RX-API-DMAC7.html)
CL (1) CL2012002536A1 (cg-RX-API-DMAC7.html)
CO (1) CO6640289A2 (cg-RX-API-DMAC7.html)
CR (1) CR20120490A (cg-RX-API-DMAC7.html)
DO (1) DOP2012000246A (cg-RX-API-DMAC7.html)
EC (1) ECSP12012211A (cg-RX-API-DMAC7.html)
GT (1) GT201200258A (cg-RX-API-DMAC7.html)
MX (1) MX2012010728A (cg-RX-API-DMAC7.html)
NZ (1) NZ602054A (cg-RX-API-DMAC7.html)
PE (1) PE20130203A1 (cg-RX-API-DMAC7.html)
PH (1) PH12012501761A1 (cg-RX-API-DMAC7.html)
RU (1) RU2012144017A (cg-RX-API-DMAC7.html)
SG (2) SG183983A1 (cg-RX-API-DMAC7.html)
TW (1) TW201201835A (cg-RX-API-DMAC7.html)
UY (1) UY33280A (cg-RX-API-DMAC7.html)
WO (1) WO2011116090A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201206761B (cg-RX-API-DMAC7.html)

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UY33280A (es) 2011-10-31
BR112012023895A2 (pt) 2016-11-29
JP2013522313A (ja) 2013-06-13
US20110256135A1 (en) 2011-10-20
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