CL2012001300A1 - Proceso de preparación de un compuesto de fórmula (i) en forma de sal iónica, que comprende las etapas de i) hidrogenar un compuesto de fórmula (ii) usando un catalizador metálico con hidrógeno y ii) filtrar el catalizador seguido de tratamiento con una solución ácida o gas. - Google Patents
Proceso de preparación de un compuesto de fórmula (i) en forma de sal iónica, que comprende las etapas de i) hidrogenar un compuesto de fórmula (ii) usando un catalizador metálico con hidrógeno y ii) filtrar el catalizador seguido de tratamiento con una solución ácida o gas.Info
- Publication number
- CL2012001300A1 CL2012001300A1 CL2012001300A CL2012001300A CL2012001300A1 CL 2012001300 A1 CL2012001300 A1 CL 2012001300A1 CL 2012001300 A CL2012001300 A CL 2012001300A CL 2012001300 A CL2012001300 A CL 2012001300A CL 2012001300 A1 CL2012001300 A1 CL 2012001300A1
- Authority
- CL
- Chile
- Prior art keywords
- compound
- formula
- catalyst
- hydrogenating
- filtering
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003054 catalyst Substances 0.000 title abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 238000001914 filtration Methods 0.000 title abstract 2
- 239000007789 gas Substances 0.000 title abstract 2
- 239000001257 hydrogen Substances 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003839 salts Chemical group 0.000 title abstract 2
- 239000003863 metallic catalyst Substances 0.000 title 1
- 239000002184 metal Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26753809P | 2009-12-08 | 2009-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012001300A1 true CL2012001300A1 (es) | 2012-09-07 |
Family
ID=43416915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012001300A CL2012001300A1 (es) | 2009-12-08 | 2012-05-18 | Proceso de preparación de un compuesto de fórmula (i) en forma de sal iónica, que comprende las etapas de i) hidrogenar un compuesto de fórmula (ii) usando un catalizador metálico con hidrógeno y ii) filtrar el catalizador seguido de tratamiento con una solución ácida o gas. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20110137042A1 (en:Method) |
| EP (1) | EP2509952A1 (en:Method) |
| JP (1) | JP2013512954A (en:Method) |
| KR (1) | KR20120101667A (en:Method) |
| CN (1) | CN102596908A (en:Method) |
| AR (1) | AR079324A1 (en:Method) |
| AU (1) | AU2010328480A1 (en:Method) |
| BR (1) | BR112012013582A2 (en:Method) |
| CA (1) | CA2782384A1 (en:Method) |
| CL (1) | CL2012001300A1 (en:Method) |
| EA (1) | EA201200820A1 (en:Method) |
| IL (1) | IL219274A0 (en:Method) |
| IN (1) | IN2012DN05081A (en:Method) |
| MX (1) | MX2012006524A (en:Method) |
| PH (1) | PH12012501153A1 (en:Method) |
| TW (1) | TW201144282A (en:Method) |
| WO (1) | WO2011071730A1 (en:Method) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2285783B1 (en) | 2008-04-29 | 2014-05-21 | Boehringer Ingelheim International GmbH | Indazole compounds as ccr1 receptor antagonists |
| CA2722811C (en) * | 2008-05-06 | 2016-07-05 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as ccr1 antagonists |
| MX2011002951A (es) | 2008-09-26 | 2011-04-26 | Boehringer Ingelheim Int | Compuestos de azaindazol como antagonistas del receptor de ccr1. |
| KR20120087923A (ko) | 2009-10-21 | 2012-08-07 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｃｃｒ１ 수용체 길항제로서의 인다졸 및 피라졸로피리딘 화합물 |
| WO2011056440A1 (en) | 2009-10-27 | 2011-05-12 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as ccr1 receptor antagonists |
| EP2563787B1 (en) | 2010-04-30 | 2014-11-26 | Boehringer Ingelheim International GmbH | Azaindazole amide compounds as ccr1 receptor antagonists |
| EP2655371B1 (en) | 2010-12-23 | 2015-02-25 | Boehringer Ingelheim International GmbH | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5242931A (en) * | 1988-06-09 | 1993-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds as TXA2 antagonists |
| US4999363A (en) * | 1988-06-09 | 1991-03-12 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| RU2105005C1 (ru) * | 1992-07-03 | 1998-02-20 | Кумиай Кемикал Индастри Ко., Лтд. | Конденсированное гетероциклическое производное, способ его получения и гербицидное средство |
| GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| ES2122290T3 (es) * | 1993-06-25 | 1998-12-16 | Kumiai Chemical Industry Co | Derivado de indazolsulfonilurea, su utilizacion e intermediario para su produccion. |
| EP0796258A1 (en) * | 1994-12-06 | 1997-09-24 | MERCK SHARP & DOHME LTD. | Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists |
| GB9519563D0 (en) * | 1995-09-26 | 1995-11-29 | Merck Sharp & Dohme | Therapeutic agents |
| GB9523583D0 (en) * | 1995-11-17 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| US5760028A (en) * | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
| GB9615449D0 (en) * | 1996-07-23 | 1996-09-04 | Merck Sharp & Dohme | Therapeutic agents |
| CA2309175A1 (en) * | 1997-11-04 | 1999-05-14 | Pfizer Products Inc. | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
| US6331640B1 (en) * | 1998-10-13 | 2001-12-18 | Hoffmann-La Roche Inc. | Diaminopropionic acid derivatives |
| JP2003502314A (ja) * | 1999-06-14 | 2003-01-21 | イーライ・リリー・アンド・カンパニー | 化合物 |
| WO2001000656A2 (en) * | 1999-06-29 | 2001-01-04 | Ortho-Mcneil Pharmaceutical, Inc. | Novel indazole peptidomimetics as thrombin receptor antagonists |
| GB0030303D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030304D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030306D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030305D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
| US7058826B2 (en) * | 2000-09-27 | 2006-06-06 | Amphus, Inc. | System, architecture, and method for logical server and other network devices in a dynamically configurable multi-server network environment |
| US20020052373A1 (en) * | 2000-10-26 | 2002-05-02 | Zorn Stevin H. | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| ES2338539T3 (es) * | 2001-11-01 | 2010-05-10 | Icagen, Inc. | Pirazolamidas para uso en el tratamiento del dolor. |
| AU2003241925A1 (en) * | 2002-05-31 | 2003-12-19 | Eisai R&D Management Co., Ltd. | Pyrazole compound and medicinal composition containing the same |
| TW200500341A (en) * | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
| SE0203825D0 (sv) * | 2002-12-20 | 2002-12-20 | Astrazeneca Ab | Novel fused heterocycles and uses thereof |
| AU2004220457A1 (en) * | 2003-03-12 | 2004-09-23 | Celgene Corporation | 7-amino- isoindolyl compounds amd their pharmaceutical uses |
| US7129264B2 (en) * | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
| US20040220170A1 (en) * | 2003-05-01 | 2004-11-04 | Atkinson Robert N. | Pyrazole-amides and sulfonamides as sodium channel modulators |
| US7371757B2 (en) * | 2003-08-15 | 2008-05-13 | Astrazeneca Ab | Fused heterocycles as inhibitors of glutamate racemase(MURI) |
| SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| GB0504828D0 (en) * | 2005-03-09 | 2005-04-13 | Merck Sharp & Dohme | Therapeutic agents |
| MX2007011287A (es) * | 2005-03-16 | 2007-11-08 | Basf Ag | Bifenil-n-(4-piridil) metilsulfonamidas. |
| PT2444079T (pt) * | 2005-05-17 | 2017-03-03 | Sarcode Bioscience Inc | Composições e métodos para tratamento de distúrbios dos olhos |
| ES2397400T3 (es) * | 2005-09-01 | 2013-03-06 | Eli Lilly & Company | 6-arilalquilamino-2,3,4,5-tetrahidro-1H-benzo[D]azepinas como agonistas del receptor 5-HT2C |
| US20080262040A1 (en) * | 2005-10-25 | 2008-10-23 | Smithkline Beecham Corporation | Chemical Compounds |
| KR20080104351A (ko) * | 2006-03-31 | 2008-12-02 | 노파르티스 아게 | 유기 화합물 |
| PE20081775A1 (es) * | 2006-12-20 | 2008-12-18 | Bristol Myers Squibb Co | Compuestos macrociclicos como inhibidores del factor viia |
| GB0716292D0 (en) * | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
| AU2008319735A1 (en) * | 2007-10-31 | 2009-05-07 | Nissan Chemical Industries, Ltd. | Pyridazinone derivatives and use thereof as P2X7 receptor inhibitors |
| EP2285783B1 (en) * | 2008-04-29 | 2014-05-21 | Boehringer Ingelheim International GmbH | Indazole compounds as ccr1 receptor antagonists |
| CA2722811C (en) * | 2008-05-06 | 2016-07-05 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as ccr1 antagonists |
| MX2011002951A (es) * | 2008-09-26 | 2011-04-26 | Boehringer Ingelheim Int | Compuestos de azaindazol como antagonistas del receptor de ccr1. |
-
2010
- 2010-12-01 EA EA201200820A patent/EA201200820A1/ru unknown
- 2010-12-01 JP JP2012543154A patent/JP2013512954A/ja active Pending
- 2010-12-01 WO PCT/US2010/058594 patent/WO2011071730A1/en not_active Ceased
- 2010-12-01 CA CA2782384A patent/CA2782384A1/en not_active Abandoned
- 2010-12-01 EP EP10787651A patent/EP2509952A1/en not_active Withdrawn
- 2010-12-01 CN CN2010800504234A patent/CN102596908A/zh active Pending
- 2010-12-01 KR KR1020127014239A patent/KR20120101667A/ko not_active Withdrawn
- 2010-12-01 US US12/957,483 patent/US20110137042A1/en not_active Abandoned
- 2010-12-01 IN IN5081DEN2012 patent/IN2012DN05081A/en unknown
- 2010-12-01 PH PH1/2012/501153A patent/PH12012501153A1/en unknown
- 2010-12-01 AU AU2010328480A patent/AU2010328480A1/en not_active Abandoned
- 2010-12-01 MX MX2012006524A patent/MX2012006524A/es not_active Application Discontinuation
- 2010-12-01 BR BR112012013582A patent/BR112012013582A2/pt not_active IP Right Cessation
- 2010-12-07 AR ARP100104528A patent/AR079324A1/es unknown
- 2010-12-07 TW TW099142648A patent/TW201144282A/zh unknown
-
2012
- 2012-04-19 IL IL219274A patent/IL219274A0/en unknown
- 2012-05-18 CL CL2012001300A patent/CL2012001300A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2509952A1 (en) | 2012-10-17 |
| TW201144282A (en) | 2011-12-16 |
| IL219274A0 (en) | 2012-06-28 |
| KR20120101667A (ko) | 2012-09-14 |
| AR079324A1 (es) | 2012-01-18 |
| IN2012DN05081A (en:Method) | 2015-10-09 |
| WO2011071730A1 (en) | 2011-06-16 |
| US20110137042A1 (en) | 2011-06-09 |
| JP2013512954A (ja) | 2013-04-18 |
| PH12012501153A1 (en) | 2012-10-22 |
| EA201200820A1 (ru) | 2013-01-30 |
| AU2010328480A1 (en) | 2012-05-17 |
| CN102596908A (zh) | 2012-07-18 |
| BR112012013582A2 (pt) | 2016-07-05 |
| MX2012006524A (es) | 2012-07-17 |
| CA2782384A1 (en) | 2011-06-16 |
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