MX2013004092A - Proceso de preparacion de clorhidrato de (6r) -tetrahidrobiopterina. - Google Patents

Proceso de preparacion de clorhidrato de (6r) -tetrahidrobiopterina.

Info

Publication number
MX2013004092A
MX2013004092A MX2013004092A MX2013004092A MX2013004092A MX 2013004092 A MX2013004092 A MX 2013004092A MX 2013004092 A MX2013004092 A MX 2013004092A MX 2013004092 A MX2013004092 A MX 2013004092A MX 2013004092 A MX2013004092 A MX 2013004092A
Authority
MX
Mexico
Prior art keywords
preparation process
tetrahydrobiopterin hydrochloride
tetrahydrobiopterin
hydrochloride
dihydrogen phosphate
Prior art date
Application number
MX2013004092A
Other languages
English (en)
Inventor
Zhen Wang
Dongbing Zhao
Weida Wang
Jingbo Lan
Jingsong You
Original Assignee
Innopharmax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innopharmax Inc filed Critical Innopharmax Inc
Publication of MX2013004092A publication Critical patent/MX2013004092A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/42—Platinum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
    • B01J37/02—Impregnation, coating or precipitation
    • B01J37/0215—Coating
    • B01J37/0221—Coating of particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Se proporciona un proceso de preparación del clorhidrato de (6R)-tetrahidrobiopterina, que comprende hidrogenar la L5 biopterina en presencia de un catalizador de metal del grupo Pt en el sustrato básico que contiene el solvente, el hidróxido de potasio y el potasio dihidrógeno fosfato para obtener el clorhidrato de (6R)-tetrahidrobiopterina, donde el valor de pH del sustrato básico es controlado por el hidróxido de potasio y el potasio dihidrógeno fosfato de aproximadamente 10 a aproximadamente 13.
MX2013004092A 2010-10-13 2010-11-15 Proceso de preparacion de clorhidrato de (6r) -tetrahidrobiopterina. MX2013004092A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201010505386.3A CN102443006B (zh) 2010-10-13 2010-10-13 (6r)-四氢生物喋呤盐酸盐的制备方法
PCT/CN2010/001836 WO2012048451A1 (zh) 2010-10-13 2010-11-15 (6r)-四氢生物喋呤盐酸盐的制备方法

Publications (1)

Publication Number Publication Date
MX2013004092A true MX2013004092A (es) 2013-07-05

Family

ID=45937819

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004092A MX2013004092A (es) 2010-10-13 2010-11-15 Proceso de preparacion de clorhidrato de (6r) -tetrahidrobiopterina.

Country Status (13)

Country Link
US (1) US8895735B2 (es)
EP (1) EP2628740B1 (es)
JP (1) JP2013540768A (es)
KR (1) KR101807904B1 (es)
CN (1) CN102443006B (es)
AU (1) AU2010362498B2 (es)
BR (1) BR112013008720A2 (es)
CA (1) CA2814018C (es)
DK (1) DK2628740T3 (es)
ES (1) ES2550928T3 (es)
MX (1) MX2013004092A (es)
PL (1) PL2628740T3 (es)
WO (1) WO2012048451A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
CN112390800B (zh) * 2019-08-19 2022-03-11 江苏众强药业有限公司 L-赤型生物蝶呤类化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS60199889A (ja) 1984-03-24 1985-10-09 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法
JPS60204786A (ja) * 1984-03-29 1985-10-16 Univ Nagoya （６ｒ）―テトラヒドロビオプテリンの合成法
CA1262347A (en) * 1985-01-28 1989-10-17 Suntory Limited Preparation process of (6r)-tetrahydro-l-biopterin
JP2007536210A (ja) 2003-11-17 2007-12-13 メルック・エプロバ・アクチエンゲゼルシヤフト （６ｒ）−ｌ−エリスロ−テトラヒドロビオプテリンジヒドロクロライドの結晶形
US7361759B2 (en) 2004-12-27 2008-04-22 Shiratori Pharmaceutical Co., Ltd Method for producing L-biopterin
CN101959891A (zh) * 2008-01-07 2011-01-26 生物马林药物股份有限公司 合成四氢生物蝶呤的方法

Also Published As

Publication number Publication date
CA2814018C (en) 2018-11-20
WO2012048451A1 (zh) 2012-04-19
JP2013540768A (ja) 2013-11-07
US20130197222A1 (en) 2013-08-01
BR112013008720A2 (pt) 2016-06-28
EP2628740A4 (en) 2014-03-19
EP2628740B1 (en) 2015-07-29
KR20130141505A (ko) 2013-12-26
AU2010362498A1 (en) 2013-05-09
ES2550928T3 (es) 2015-11-13
US8895735B2 (en) 2014-11-25
PL2628740T3 (pl) 2015-12-31
EP2628740A1 (en) 2013-08-21
DK2628740T3 (en) 2015-10-26
CN102443006A (zh) 2012-05-09
AU2010362498B2 (en) 2016-04-28
CN102443006B (zh) 2016-02-24
CA2814018A1 (en) 2012-04-19
KR101807904B1 (ko) 2017-12-11

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