CL2012000551A1 - Molecula de union a antigeno (abm) porque dicho dominio de union a antigeno se une especificamente a antigeno carcinoembrionario humano (cea) unido a membrana; polipep que comprende dominio de union a antigeno que se une a cea; anticuerpo que se une a cea; composicion que comprende moleculas que se unen a cea. - Google Patents
Molecula de union a antigeno (abm) porque dicho dominio de union a antigeno se une especificamente a antigeno carcinoembrionario humano (cea) unido a membrana; polipep que comprende dominio de union a antigeno que se une a cea; anticuerpo que se une a cea; composicion que comprende moleculas que se unen a cea.Info
- Publication number
- CL2012000551A1 CL2012000551A1 CL2012000551A CL2012000551A CL2012000551A1 CL 2012000551 A1 CL2012000551 A1 CL 2012000551A1 CL 2012000551 A CL2012000551 A CL 2012000551A CL 2012000551 A CL2012000551 A CL 2012000551A CL 2012000551 A1 CL2012000551 A1 CL 2012000551A1
- Authority
- CL
- Chile
- Prior art keywords
- cea
- antigen
- binds
- binding domain
- polypep
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23850509P | 2009-08-31 | 2009-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012000551A1 true CL2012000551A1 (es) | 2012-10-12 |
Family
ID=42985489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012000551A CL2012000551A1 (es) | 2009-08-31 | 2012-02-29 | Molecula de union a antigeno (abm) porque dicho dominio de union a antigeno se une especificamente a antigeno carcinoembrionario humano (cea) unido a membrana; polipep que comprende dominio de union a antigeno que se une a cea; anticuerpo que se une a cea; composicion que comprende moleculas que se unen a cea. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9068008B2 (https=) |
| EP (1) | EP2473532B1 (https=) |
| JP (1) | JP5744872B2 (https=) |
| KR (1) | KR101528013B1 (https=) |
| CN (1) | CN102741293B (https=) |
| AR (1) | AR078111A1 (https=) |
| AU (1) | AU2010288469A1 (https=) |
| BR (1) | BR112012003983A2 (https=) |
| CA (1) | CA2770174A1 (https=) |
| CL (1) | CL2012000551A1 (https=) |
| CO (1) | CO6491105A2 (https=) |
| CR (1) | CR20120087A (https=) |
| EC (1) | ECSP12011698A (https=) |
| IL (1) | IL218038A0 (https=) |
| MA (1) | MA33536B1 (https=) |
| MX (1) | MX339608B (https=) |
| PE (1) | PE20121552A1 (https=) |
| RU (1) | RU2570554C2 (https=) |
| SG (1) | SG178567A1 (https=) |
| TW (1) | TW201121994A (https=) |
| WO (1) | WO2011023787A1 (https=) |
| ZA (1) | ZA201200954B (https=) |
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| JPS5992710A (ja) * | 1982-11-16 | 1984-05-29 | 関西電力株式会社 | 直接水冷線路の立坑部の布設方法 |
| NZ571596A (en) | 2001-08-03 | 2010-11-26 | Glycart Biotechnology Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| KR20130118941A (ko) | 2011-02-10 | 2013-10-30 | 로슈 글리카트 아게 | 면역치료법 |
| SG192673A1 (en) | 2011-02-10 | 2013-09-30 | Roche Glycart Ag | Mutant interleukin-2 polypeptides |
| PE20141017A1 (es) * | 2011-03-02 | 2014-08-25 | Roche Glycart Ag | Anticuerpos del cea |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| WO2013026839A1 (en) | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
| EP2748202B1 (en) | 2011-08-23 | 2018-07-04 | Roche Glycart AG | Bispecific antigen binding molecules |
| NO2748201T3 (https=) | 2011-08-23 | 2018-05-12 | ||
| WO2013054320A1 (en) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
| GB201213858D0 (en) | 2012-08-03 | 2012-09-19 | Mab Design Ltd | Method |
| MY175687A (en) | 2012-08-07 | 2020-07-06 | Roche Glycart Ag | Composition comprising two antibodies engineered to have reduced and increased effector function |
| RU2015117393A (ru) | 2012-10-08 | 2016-12-10 | Роше Гликарт Аг | Лишенные fc антитела, содержащие два Fab-фрагмента, и способы их применения |
| EP2961773B1 (en) | 2013-02-26 | 2019-03-20 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
| LT2961771T (lt) | 2013-02-26 | 2020-03-10 | Roche Glycart Ag | Bispecifinės t ląstelę aktyvinančios antigeną surišančios molekulės, specifinės cd3 ir cea antigenams |
| EP2961770A1 (en) * | 2013-02-26 | 2016-01-06 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
| US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
| US10550196B2 (en) | 2014-04-27 | 2020-02-04 | Famewave Ltd. | Humanized antibodies against CEACAM1 |
| EP3177643B1 (en) | 2014-08-04 | 2019-05-08 | F.Hoffmann-La Roche Ag | Bispecific t cell activating antigen binding molecules |
| EP4141032B1 (en) | 2014-11-20 | 2024-05-29 | F. Hoffmann-La Roche AG | Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists |
| PT3221356T (pt) | 2014-11-20 | 2020-10-29 | Hoffmann La Roche | Moléculas de ligação ao antigénio biespecíficas ativadoras das células t contra folr1 e cd3 |
| DK3221357T3 (da) | 2014-11-20 | 2020-08-10 | Hoffmann La Roche | Fælles letkæder og fremgangsmåder til anvendelse |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| PE20180484A1 (es) | 2015-10-02 | 2018-03-07 | Hoffmann La Roche | Moleculas biespecificas de union a antigeno activadoras de celulas t |
| IL313608A (en) | 2015-12-09 | 2024-08-01 | Hoffmann La Roche | Antibody against CD20 type II to reduce the formation of antibodies against drugs |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| JP7015244B2 (ja) | 2016-03-22 | 2022-02-02 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | プロテアーゼ活性化t細胞二重特異性分子 |
| CN107663240B (zh) | 2016-07-29 | 2021-01-12 | 中国人民解放军第四军医大学 | 高度糖基化cea特异性结合的单链抗体及其在检测和治疗上的应用 |
| US10882918B2 (en) | 2016-09-30 | 2021-01-05 | Hoffmann-La Roche Inc. | Bispecific T cell activating antigen binding molecules |
| IL325995A (en) | 2018-02-08 | 2026-03-01 | Genentech Inc | Bispecific antigen binding molecules and methods of use |
| TWI890481B (zh) | 2018-02-09 | 2025-07-11 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
| CN113906053B (zh) * | 2019-06-26 | 2022-10-25 | 江苏恒瑞医药股份有限公司 | 抗cea抗体及其应用 |
| KR20220025848A (ko) | 2019-06-26 | 2022-03-03 | 에프. 호프만-라 로슈 아게 | Cea 및 4-1bbl에 결합하는 항체의 융합 |
| CN110713539B (zh) * | 2019-09-23 | 2021-04-16 | 华道(上海)生物医药有限公司 | 一种抗癌胚抗原的抗体及其制备方法和用途 |
| CN110862456B (zh) * | 2019-09-23 | 2021-04-09 | 华道(上海)生物医药有限公司 | 一种抗癌胚抗原的抗体及其制备方法和用途 |
| WO2021255155A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 and cd19 |
| IL300500A (en) | 2020-08-20 | 2023-04-01 | A2 Biotherapeutics Inc | Preparations and methods for the treatment of mesothelin positive cancer |
| CA3188867A1 (en) | 2020-08-20 | 2022-02-24 | Xueyin Wang | Compositions and methods for treating ceacam positive cancers |
| CA3213632A1 (en) | 2021-04-30 | 2022-11-03 | F. Hoffmann-La Roche Ag | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| JP2024519078A (ja) * | 2021-05-21 | 2024-05-08 | ベイジーン スウィッツァーランド ゲーエムベーハー | 抗cea抗体及びその使用方法 |
| AU2023212292A1 (en) * | 2022-01-27 | 2024-09-12 | Janssen Biotech, Inc. | Enhanced protein compositions |
| KR20250024741A (ko) | 2022-03-23 | 2025-02-19 | 시나픽스 비.브이. | 암배아성 항원을 발현하는 종양을 표적화하기 위한 항체-컨쥬게이트 |
| EP4724490A2 (en) | 2023-06-12 | 2026-04-15 | Amgen Inc. | Lymphotoxin beta receptor agonist binding proteins |
| WO2025257185A1 (en) * | 2024-06-11 | 2025-12-18 | Abcely | Humanized anti-human-carcinoembryonic antigen antibody |
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| EP2248892B1 (en) | 2003-01-22 | 2015-04-22 | Roche Glycart AG | Fusion constructs and use of same to produce antibodies with increased FC receptor binding affinity and effector function |
| US20090005257A1 (en) * | 2003-05-14 | 2009-01-01 | Jespers Laurent S | Process for Recovering Polypeptides that Unfold Reversibly from a Polypeptide Repertoire |
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-
2010
- 2010-08-27 KR KR1020127008265A patent/KR101528013B1/ko not_active Expired - Fee Related
- 2010-08-27 PE PE2012000266A patent/PE20121552A1/es not_active Application Discontinuation
- 2010-08-27 BR BR112012003983-0A patent/BR112012003983A2/pt not_active Application Discontinuation
- 2010-08-27 RU RU2012112340/10A patent/RU2570554C2/ru active
- 2010-08-27 EP EP10745651.9A patent/EP2473532B1/en active Active
- 2010-08-27 SG SG2012013306A patent/SG178567A1/en unknown
- 2010-08-27 CA CA2770174A patent/CA2770174A1/en not_active Abandoned
- 2010-08-27 AU AU2010288469A patent/AU2010288469A1/en not_active Abandoned
- 2010-08-27 JP JP2012526072A patent/JP5744872B2/ja not_active Expired - Fee Related
- 2010-08-27 MX MX2012002461A patent/MX339608B/es active IP Right Grant
- 2010-08-27 CN CN201080048622.1A patent/CN102741293B/zh not_active Expired - Fee Related
- 2010-08-27 WO PCT/EP2010/062527 patent/WO2011023787A1/en not_active Ceased
- 2010-08-30 AR ARP100103166A patent/AR078111A1/es not_active Application Discontinuation
- 2010-08-30 TW TW099129130A patent/TW201121994A/zh unknown
- 2010-08-31 US US12/872,908 patent/US9068008B2/en active Active
-
2012
- 2012-01-30 CO CO12014021A patent/CO6491105A2/es not_active Application Discontinuation
- 2012-02-08 ZA ZA2012/00954A patent/ZA201200954B/en unknown
- 2012-02-09 IL IL218038A patent/IL218038A0/en unknown
- 2012-02-20 CR CR20120087A patent/CR20120087A/es unknown
- 2012-02-27 MA MA34650A patent/MA33536B1/fr unknown
- 2012-02-28 EC ECSP12011698 patent/ECSP12011698A/es unknown
- 2012-02-29 CL CL2012000551A patent/CL2012000551A1/es unknown
-
2015
- 2015-05-26 US US14/721,795 patent/US20160075795A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2770174A1 (en) | 2011-03-03 |
| WO2011023787A1 (en) | 2011-03-03 |
| ECSP12011698A (es) | 2012-03-30 |
| MA33536B1 (fr) | 2012-08-01 |
| RU2570554C2 (ru) | 2015-12-10 |
| IL218038A0 (en) | 2012-04-30 |
| HK1176951A1 (en) | 2013-08-09 |
| EP2473532A1 (en) | 2012-07-11 |
| US20160075795A1 (en) | 2016-03-17 |
| MX339608B (es) | 2016-05-31 |
| US20110104148A1 (en) | 2011-05-05 |
| RU2012112340A (ru) | 2013-10-10 |
| JP2013502913A (ja) | 2013-01-31 |
| US9068008B2 (en) | 2015-06-30 |
| CN102741293A (zh) | 2012-10-17 |
| CO6491105A2 (es) | 2012-07-31 |
| BR112012003983A2 (pt) | 2021-09-14 |
| AU2010288469A1 (en) | 2012-03-01 |
| MX2012002461A (es) | 2012-03-14 |
| SG178567A1 (en) | 2012-04-27 |
| AR078111A1 (es) | 2011-10-12 |
| KR101528013B1 (ko) | 2015-06-16 |
| TW201121994A (en) | 2011-07-01 |
| EP2473532B1 (en) | 2017-06-21 |
| JP5744872B2 (ja) | 2015-07-08 |
| PE20121552A1 (es) | 2012-11-26 |
| KR20120060874A (ko) | 2012-06-12 |
| CR20120087A (es) | 2012-03-22 |
| ZA201200954B (en) | 2014-07-30 |
| CN102741293B (zh) | 2015-04-01 |
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| CL2012000551A1 (es) | Molecula de union a antigeno (abm) porque dicho dominio de union a antigeno se une especificamente a antigeno carcinoembrionario humano (cea) unido a membrana; polipep que comprende dominio de union a antigeno que se une a cea; anticuerpo que se une a cea; composicion que comprende moleculas que se unen a cea. | |
| CY1116376T1 (el) | Τρισθενη, διειδικα αντισωματα | |
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| NI201200052A (es) | Anticuerpos que se unen específicamente al receptor epha2 | |
| CY1119287T1 (el) | Συζευγματα αντισωματων πυρρολοβενζοδιαζεπινης-αντι-her2 | |
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| CU20190109A7 (es) | Moléculas de anticuerpo que se unen a cd73 | |
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