CL2004000676A1 - Compuestos derivados de 17 alpha-cianometilestra-4,9-dieno; procedimiento de preparacion; y composicion farmaceutica que los contiene; utiles como gestagenos. - Google Patents

Compuestos derivados de 17 alpha-cianometilestra-4,9-dieno; procedimiento de preparacion; y composicion farmaceutica que los contiene; utiles como gestagenos.

Info

Publication number
CL2004000676A1
CL2004000676A1 CL200400676A CL2004000676A CL2004000676A1 CL 2004000676 A1 CL2004000676 A1 CL 2004000676A1 CL 200400676 A CL200400676 A CL 200400676A CL 2004000676 A CL2004000676 A CL 2004000676A CL 2004000676 A1 CL2004000676 A1 CL 2004000676A1
Authority
CL
Chile
Prior art keywords
alpha
cyanometilestra
dieno
gestagens
useful
Prior art date
Application number
CL200400676A
Other languages
English (en)
Inventor
Gerhard Teichmueller
Gerd Mueller
Sigfrid Prof-Dr Schwarz
Bernd Dr Undeutsch
Harry Henkel
Ronald Gebuehr
Guenter Dr Kaufmann
Doris Dr Huebler
Michael Prof-Dr Oettel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1995148449 external-priority patent/DE19548449A1/de
Priority claimed from DE1995148450 external-priority patent/DE19548450A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of CL2004000676A1 publication Critical patent/CL2004000676A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Abstract

DERIVADOS 17a-CIANOMETILESTRA-4,9-DIENO DE LA FORMULA GENERAL I EN DONDE R1 ES UN GRUPO ALQUILO CON 1 A 2 ATOMOS DE CARBONO, R2, ES UN RADICAL ACILO CON 1 A 10 ATOMOS DE CARBONO, R3 ES UN ATOMO DE OXIGENO O UNA SAL AGRUPACION R-O-N, DONDE R REPRESENTA U ATOMO DE HIDROGENO, UN RADICAL ACILO CON 1 A 10 ATOMOS DE CARBONO, UN RADICAL ALQUILO CON 1 A 10 ATOMOS DE CARBONO UN RADICAL SULFAMOILO O UN RADICAL TRIALQUILSILILO. METODO PARA OBTENER DICHOS DERIVADOS Y COMPOSICIONES FARMACEUTICAS QUE CONTIENEN POR LO MENOS UN DERIVADO 17a-CIANOMETILESTRA-4,9-DIENO, OPCIONALMENTE CON SUSTANCIAS AUXILIARES Y VEHICULOS FARMACEUTICAMENTE ACEPTABLES.
CL200400676A 1995-12-22 2004-03-30 Compuestos derivados de 17 alpha-cianometilestra-4,9-dieno; procedimiento de preparacion; y composicion farmaceutica que los contiene; utiles como gestagenos. CL2004000676A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995148449 DE19548449A1 (de) 1995-12-22 1995-12-22 17alpha-Cyanomethyl-3-oxyiminoestra-4,9-dien-3-on-17beta-yl-derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE1995148450 DE19548450A1 (de) 1995-12-22 1995-12-22 17alpha-Cyanomethylestra-4,9-dien-3-on-17beta-yl- derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
CL2004000676A1 true CL2004000676A1 (es) 2005-01-14

Family

ID=26021644

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400676A CL2004000676A1 (es) 1995-12-22 2004-03-30 Compuestos derivados de 17 alpha-cianometilestra-4,9-dieno; procedimiento de preparacion; y composicion farmaceutica que los contiene; utiles como gestagenos.

Country Status (10)

Country Link
US (1) US5866559A (es)
EP (1) EP0780397B1 (es)
JP (1) JP2834721B2 (es)
AT (1) ATE167190T1 (es)
CA (1) CA2193610A1 (es)
CL (1) CL2004000676A1 (es)
DE (1) DE59600274D1 (es)
DK (1) DK0780397T3 (es)
ES (1) ES2120267T3 (es)
GR (1) GR3027627T3 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167111A1 (en) * 1998-04-15 2004-08-26 Michael Oettel Pharmaceutical preparations for treating side effects during and/or after GnRHa therapy
US20080214512A1 (en) * 2007-03-01 2008-09-04 Christian Seitz Pharmaceutical preparation containing a gestagen, and kit and method for treating endometriosis using the preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337537A (en) * 1961-03-31 1967-08-22 Merck & Co Inc 17alpha-unsaturated-halohydrocarbon-17beta-hydroxy-19-nor-4, 9-androstadiene-3-one 17-ethers
US3907844A (en) * 1971-06-17 1975-09-23 Sandoz Ag 3-Oximino-17{60 -propadienyl-substituted-4,9-gonadienes
US3904611A (en) * 1972-10-16 1975-09-09 Syntex Corp Preparation of 17' -propadienyl steroids
US3961053A (en) * 1973-05-08 1976-06-01 Sandoz, Inc. Substituted carbinol derivatives
DE2718872A1 (de) 1976-06-14 1977-12-22 Jenapharm Veb Verfahren zur herstellung von neuen gona-4,9(10)-dienen
WO1995004536A1 (en) * 1993-08-04 1995-02-16 Akzo Nobel N.V. Antiglucocorticoid steroids for the treatment of anxiety disorders
CN1072678C (zh) * 1994-05-30 2001-10-10 中国科学院上海有机化学研究所 三氟甲基甾体化合物、制备及其用途

Also Published As

Publication number Publication date
JP2834721B2 (ja) 1998-12-14
CA2193610A1 (en) 1997-06-23
EP0780397A3 (de) 1997-07-23
US5866559A (en) 1999-02-02
DE59600274D1 (de) 1998-07-16
JPH09183793A (ja) 1997-07-15
DK0780397T3 (da) 1999-03-29
GR3027627T3 (en) 1998-11-30
EP0780397B1 (de) 1998-06-10
EP0780397A2 (de) 1997-06-25
ATE167190T1 (de) 1998-06-15
ES2120267T3 (es) 1998-10-16

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