CH634483A5 - Naphtalimide substitue utilisable comme medicament. - Google Patents

Naphtalimide substitue utilisable comme medicament. Download PDF

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Publication number
CH634483A5
CH634483A5 CH587678A CH587678A CH634483A5 CH 634483 A5 CH634483 A5 CH 634483A5 CH 587678 A CH587678 A CH 587678A CH 587678 A CH587678 A CH 587678A CH 634483 A5 CH634483 A5 CH 634483A5
Authority
CH
Switzerland
Prior art keywords
naphthalimide
group
naphthalic anhydride
mol
naphthalic
Prior art date
Application number
CH587678A
Other languages
English (en)
French (fr)
Inventor
Miguel Fernandez Brana
Antonio Martinez Sanz
Rafael Perez Alvarez-Ossorio
Cristobal Martinez Roldan
Cristina Roldan Fernand Gamboa
Original Assignee
Made Labor Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Made Labor Sa filed Critical Made Labor Sa
Publication of CH634483A5 publication Critical patent/CH634483A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH587678A 1977-06-04 1978-05-30 Naphtalimide substitue utilisable comme medicament. CH634483A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES459497A ES459497A1 (es) 1977-06-04 1977-06-04 Un metodo para la preparacion industrial de naftalimidas y sus derivados.

Publications (1)

Publication Number Publication Date
CH634483A5 true CH634483A5 (fr) 1983-02-15

Family

ID=8473948

Family Applications (1)

Application Number Title Priority Date Filing Date
CH587678A CH634483A5 (fr) 1977-06-04 1978-05-30 Naphtalimide substitue utilisable comme medicament.

Country Status (8)

Country Link
US (1) US4204063A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPS5439076A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR216945A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH634483A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2823987A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES459497A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2392978A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB1602684A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125439B1 (en) * 1983-04-01 1990-01-24 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
US4614820A (en) * 1983-04-01 1986-09-30 Warner-Lambert Co. 3,6-disubstituted-1,8-naphthalimides
US5183821A (en) * 1983-09-19 1993-02-02 Laboratories Knoll, S.A. Method for treating leukemias using N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide for treating leukemias and solid tumors
DE3604827A1 (de) * 1986-02-15 1987-08-20 Bayer Ag Elektrophotographische toner
JPS6344707U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1986-09-09 1988-03-25
DE3635711A1 (de) * 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
DE8715181U1 (de) * 1987-10-17 1987-12-03 Ledermann Gmbh + Co, 7240 Horb Spannvorrichtung
DE3922771A1 (de) * 1989-07-11 1991-01-24 Knoll Ag Amonafide-salze
US5420137A (en) * 1989-07-11 1995-05-30 Knoll Ag Amonafide salts
CA2030129A1 (en) * 1989-11-29 1991-05-30 Thomas Saupe 1,8-napthalenedicarboximides as antidotes
DE3942280A1 (de) * 1989-12-21 1991-06-27 Knoll Ag N-substituierte naphthalimide, ihre herstellung und verwendung
US5202318A (en) * 1990-05-14 1993-04-13 Syntex (U.S.A.) Inc. Tricyclic compounds acting at serotonin receptor subtypes
WO1994006771A1 (en) * 1992-09-11 1994-03-31 Research Corporation Technologies, Inc. 1,2 DIHYDRO-3-H-DIBENZ(de,h) ISOQUINOLINE 1,3 DIONE AND THEIR USE AS ANTICANCER AGENTS
WO1992000281A1 (en) * 1990-06-26 1992-01-09 Research Corporation Technologies, Inc. 1,2-dihydro-3h-dibenzisoquinoline-1,3-dione anticancer agents
US5635506A (en) * 1990-06-26 1997-06-03 Research Corporation Technologies, Inc. 1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents
FR2673944B1 (fr) * 1991-03-13 1995-03-10 Sanofi Elf Derives de l'1,8-naphtalimide, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5206250A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amide and thioamide linkers as anticancer agents
JPH07581U (ja) * 1993-05-31 1995-01-06 株式会社遠藤製作所 浴槽用浄水器
JP2001503397A (ja) * 1996-10-21 2001-03-13 アレリックス バイオファーマシューティカルズ インコーポレイテッド ニューロトロフィンアンタゴニスト組成物
AU760136B2 (en) * 1998-11-25 2003-05-08 Merck Patent Gmbh Substituted benzo(DE)isoquinoline-1,3-diones
US6492380B1 (en) * 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
US6468990B1 (en) * 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
US6693198B2 (en) * 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts
US20050239816A1 (en) * 2002-04-22 2005-10-27 Xanthus Life Sciences, Inc. Amonafide salts
CA2491673A1 (en) * 2002-07-08 2004-01-15 Chemgenex Pharmaceuticals, Inc. Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
JP2007525214A (ja) * 2004-01-30 2007-09-06 ケムジェネックス・ファーマシューティカルズ・インコーポレイテッド Ｎ−アセチルトランスフェラーゼ遺伝子型解析によって投与するナフタルイミド
WO2005105753A2 (en) * 2004-05-05 2005-11-10 Unibioscreen S.A. Naphthalimide derivatives, methods for their production and pharmaceutical compositions therefrom
EP1765341A4 (en) * 2004-06-04 2010-04-14 Chemgenex Pharmaceuticals Inc PROCESS FOR TREATING PROLIFERATIVE CELL DISEASE USING NAPHTHALIMIDE AND PARP-1 INHIBITORS
WO2007030939A2 (en) 2005-09-15 2007-03-22 Painceptor Pharma Corporation Methods of modulating neurotrophin-mediated activity
EP2887939B1 (en) 2012-08-27 2018-04-11 University of Tennessee Research Foundation Lpa2 receptor-specific benzoic acid derivatives

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3330834A (en) * 1967-07-11 Naphthalimide whitening agents anb method of making same
GB309552A (en) 1928-04-12 1930-06-26 Ig Farbenindustrie Ag Manufacture of acid wool dyestuffs
US1796012A (en) * 1928-04-12 1931-03-10 Gen Aniline Works Inc Amino-naphthalimido-sulphonic acid compounds and process of preparing same
US1886797A (en) * 1928-05-18 1932-11-08 Gen Aniline Works Inc Naphthalimide dyestuffs and process of preparing them
DE530906C (de) * 1929-07-02 1931-08-01 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von sauren Wollfarbstoffen
US3625947A (en) * 1957-01-30 1971-12-07 Nippon Kayaku Kk N heterocyclic ethyl naphthalimides
US3310564A (en) * 1961-01-21 1967-03-21 Kasai Toshiyasu Novel 4-alkoxy naphthalimides
GB1003083A (en) * 1961-01-21 1965-09-02 Toshiyasu Kasai Novel 4-alkoxynaphthalimides
GB962019A (en) * 1961-04-12 1964-06-24 Mitsubishi Chem Ind Naphthalimide optical whitening agents
AT257528B (de) * 1964-08-08 1967-10-10 Bayer Ag Aufhellungsmittel
US3308127A (en) * 1964-08-24 1967-03-07 Mitsubishi Chem Ind Process for the production of naphthalic acid derivatives
FR1557945A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1967-01-30 1969-02-21
GB1342350A (en) * 1969-12-30 1974-01-03 Sumitomo Chemical Co Naphthalimide derivatives
DE2423547A1 (de) * 1974-05-15 1975-12-04 Hoechst Ag Basische farbstoffe, verfahren zu ihrer herstellung und ihre verwendung
DE2423548C2 (de) * 1974-05-15 1984-08-23 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung von 4-Amino1,8-naphthalimid-Verbindungen
GB1435238A (en) * 1974-07-24 1976-05-12 Made Labor Sa Substituted naphthalimides and processes for their preparation
FR2279396A1 (fr) * 1974-07-25 1976-02-20 Made Labor Sa Naphtalimides substitues
JPS5116674A (en) * 1974-08-01 1976-02-10 Made Labor Sa Nafutaruimidoruino seizoho
JPS5851024B2 (ja) * 1975-05-26 1983-11-14 帝人株式会社 ユウシヨクカゴウブツノセイゾウホウ
GB1520944A (en) * 1975-06-12 1978-08-09 Teijin Ltd Quinoline derivatives for use als colouring agents

Also Published As

Publication number Publication date
DE2823987A1 (de) 1978-12-07
JPS5835995B2 (ja) 1983-08-05
JPS5439076A (en) 1979-03-24
GB1602683A (en) 1981-11-11
FR2392978B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1982-07-02
ES459497A1 (es) 1978-04-16
DE2823987C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-08-02
GB1602684A (en) 1981-11-11
JPS56103166A (en) 1981-08-18
US4204063A (en) 1980-05-20
AR216945A1 (es) 1980-02-15
FR2392978A2 (fr) 1978-12-29

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PFA Name/firm changed
PL Patent ceased