FR2392978A2 - Naphtalimides substitues utilisables comme medicaments - Google Patents
Naphtalimides substitues utilisables comme medicamentsInfo
- Publication number
- FR2392978A2 FR2392978A2 FR7815612A FR7815612A FR2392978A2 FR 2392978 A2 FR2392978 A2 FR 2392978A2 FR 7815612 A FR7815612 A FR 7815612A FR 7815612 A FR7815612 A FR 7815612A FR 2392978 A2 FR2392978 A2 FR 2392978A2
- Authority
- FR
- France
- Prior art keywords
- naphthalimides
- substitute
- medicinal products
- medicinal
- products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Naphtalimides de synthèse répondant à la formule générale :
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES459497A ES459497A1 (es) | 1977-06-04 | 1977-06-04 | Un metodo para la preparacion industrial de naftalimidas y sus derivados. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2392978A2 true FR2392978A2 (fr) | 1978-12-29 |
FR2392978B2 FR2392978B2 (fr) | 1982-07-02 |
Family
ID=8473948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7815612A Granted FR2392978A2 (fr) | 1977-06-04 | 1978-05-25 | Naphtalimides substitues utilisables comme medicaments |
Country Status (8)
Country | Link |
---|---|
US (1) | US4204063A (fr) |
JP (2) | JPS5439076A (fr) |
AR (1) | AR216945A1 (fr) |
CH (1) | CH634483A5 (fr) |
DE (1) | DE2823987A1 (fr) |
ES (1) | ES459497A1 (fr) |
FR (1) | FR2392978A2 (fr) |
GB (2) | GB1602683A (fr) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0125439A2 (fr) * | 1983-04-01 | 1984-11-21 | Warner-Lambert Company | 1,8-Naphtalimides 3,6-disubstituées, leurs procédés de préparation et leur application |
WO1991009850A1 (fr) * | 1989-12-21 | 1991-07-11 | Knoll Aktiengesellschaft | Naphtalimides n-substitues, leur fabrication et utilisation |
WO1992017454A1 (fr) * | 1991-03-27 | 1992-10-15 | The Du Pont Merck Pharmaceutical Company | Bis-naphtalimides contenant des linkers amide et thioamide et utilises comme agents anticancereux |
WO1992021673A1 (fr) * | 1991-05-28 | 1992-12-10 | Syntex (U.S.A.) Inc. | Nouvelles azabicyclobenzisoquinoleines |
EP0536208A1 (fr) * | 1990-06-26 | 1993-04-14 | Research Corporation Technologies, Inc. | Agents anticancereux a base de 1,2-dihydro-3h-dibenzisoquinoline-1,3-diones |
WO1994006771A1 (fr) * | 1992-09-11 | 1994-03-31 | Research Corporation Technologies, Inc. | 1,2 DYHYDRO-3-H-DIBENZ(de,h) ISOQUINOLINE 1,3-DIONES ET LEUR UTILISATION EN TANT QU'AGENTS ANTICANCEREUX |
US5635506A (en) * | 1990-06-26 | 1997-06-03 | Research Corporation Technologies, Inc. | 1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents |
WO2000032577A2 (fr) * | 1998-11-25 | 2000-06-08 | Merck Patent Gmbh | Benzo[de]isoquinoline-1,3-diones substituees |
EP1539150A1 (fr) * | 2002-07-08 | 2005-06-15 | Chemgenex Pharmaceuticals Limited | Synthese de naphtalimides, y compris d'amonafides, et preparations pharmaceutiques les contenant |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4614820A (en) * | 1983-04-01 | 1986-09-30 | Warner-Lambert Co. | 3,6-disubstituted-1,8-naphthalimides |
US5183821A (en) * | 1983-09-19 | 1993-02-02 | Laboratories Knoll, S.A. | Method for treating leukemias using N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide for treating leukemias and solid tumors |
DE3604827A1 (de) * | 1986-02-15 | 1987-08-20 | Bayer Ag | Elektrophotographische toner |
JPH0228365Y2 (fr) * | 1986-04-22 | 1990-07-30 | ||
JPS6344707U (fr) * | 1986-09-09 | 1988-03-25 | ||
DE3635711A1 (de) * | 1986-10-21 | 1988-04-28 | Knoll Ag | 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung |
DE3707651A1 (de) * | 1987-03-10 | 1988-09-22 | Knoll Ag | Bis-naphthalimide, ihre herstellung und verwendung |
DE8715181U1 (fr) * | 1987-10-17 | 1987-12-03 | Ledermann Gmbh + Co, 7240 Horb, De | |
US5420137A (en) * | 1989-07-11 | 1995-05-30 | Knoll Ag | Amonafide salts |
DE3922771A1 (de) * | 1989-07-11 | 1991-01-24 | Knoll Ag | Amonafide-salze |
CA2030129A1 (fr) * | 1989-11-29 | 1991-05-30 | Thomas Saupe | 1,8-napthalenedicarboximides utilises comme antidotes |
FR2673944B1 (fr) * | 1991-03-13 | 1995-03-10 | Sanofi Elf | Derives de l'1,8-naphtalimide, leur procede de preparation et les compositions pharmaceutiques les contenant. |
JPH07581U (ja) * | 1993-05-31 | 1995-01-06 | 株式会社遠藤製作所 | 浴槽用浄水器 |
ATE315397T1 (de) * | 1996-10-21 | 2006-02-15 | Allelix Biopharma | Neurotrophin antagoniste zur behandlung von der epilepsie, alzheimer'schen krankheit und schmerzen |
US6468990B1 (en) | 1999-05-17 | 2002-10-22 | Queen's University At Kingston | Method of inhibiting binding of nerve growth factor to p75 NTR receptor |
US6492380B1 (en) * | 1999-05-17 | 2002-12-10 | Queen's University At Kingston | Method of inhibiting neurotrophin-receptor binding |
US20050239816A1 (en) * | 2002-04-22 | 2005-10-27 | Xanthus Life Sciences, Inc. | Amonafide salts |
US6693198B2 (en) * | 2002-04-22 | 2004-02-17 | Xanthus Life Sciences, Inc. | Amonafide salts |
AU2005209845A1 (en) * | 2004-01-30 | 2005-08-18 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide dosing by N-acetyl transferase genotyping |
BRPI0510719A (pt) * | 2004-05-05 | 2007-11-20 | Unibioscreen Sa | derivados de naftalimida, composição farmacêutica, uso e método de preparação dos mesmos |
AU2005249593A1 (en) * | 2004-06-04 | 2005-12-15 | Chemgenex Pharmaceuticals Inc. | Methods of treating cellular proliferative disease using naphthalimide and PARP-1 inhibitors |
CA2622571A1 (fr) | 2005-09-15 | 2007-03-22 | Painceptor Pharma Corporation | Methodes permettant de moduler l'activite induite par la neurotrophine |
JP6132915B2 (ja) * | 2012-08-27 | 2017-05-24 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | Lpa2受容体特異的安息香酸誘導体 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1557945A (fr) * | 1967-01-30 | 1969-02-21 | ||
DE2423547A1 (de) * | 1974-05-15 | 1975-12-04 | Hoechst Ag | Basische farbstoffe, verfahren zu ihrer herstellung und ihre verwendung |
FR2279396A1 (fr) * | 1974-07-25 | 1976-02-20 | Made Labor Sa | Naphtalimides substitues |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3330834A (en) * | 1967-07-11 | Naphthalimide whitening agents anb method of making same | ||
US1796012A (en) * | 1928-04-12 | 1931-03-10 | Gen Aniline Works Inc | Amino-naphthalimido-sulphonic acid compounds and process of preparing same |
GB309552A (en) | 1928-04-12 | 1930-06-26 | Ig Farbenindustrie Ag | Manufacture of acid wool dyestuffs |
US1886797A (en) * | 1928-05-18 | 1932-11-08 | Gen Aniline Works Inc | Naphthalimide dyestuffs and process of preparing them |
DE530906C (de) * | 1929-07-02 | 1931-08-01 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von sauren Wollfarbstoffen |
US3625947A (en) * | 1957-01-30 | 1971-12-07 | Nippon Kayaku Kk | N heterocyclic ethyl naphthalimides |
GB1003083A (en) * | 1961-01-21 | 1965-09-02 | Toshiyasu Kasai | Novel 4-alkoxynaphthalimides |
US3310564A (en) * | 1961-01-21 | 1967-03-21 | Kasai Toshiyasu | Novel 4-alkoxy naphthalimides |
GB962019A (en) * | 1961-04-12 | 1964-06-24 | Mitsubishi Chem Ind | Naphthalimide optical whitening agents |
AT257528B (de) * | 1964-08-08 | 1967-10-10 | Bayer Ag | Aufhellungsmittel |
US3308127A (en) * | 1964-08-24 | 1967-03-07 | Mitsubishi Chem Ind | Process for the production of naphthalic acid derivatives |
GB1342350A (en) * | 1969-12-30 | 1974-01-03 | Sumitomo Chemical Co | Naphthalimide derivatives |
DE2423548C2 (de) * | 1974-05-15 | 1984-08-23 | Hoechst Ag, 6230 Frankfurt | Verfahren zur Herstellung von 4-Amino1,8-naphthalimid-Verbindungen |
GB1435238A (en) * | 1974-07-24 | 1976-05-12 | Made Labor Sa | Substituted naphthalimides and processes for their preparation |
JPS5116674A (en) * | 1974-08-01 | 1976-02-10 | Made Labor Sa | Nafutaruimidoruino seizoho |
JPS5851024B2 (ja) * | 1975-05-26 | 1983-11-14 | 帝人株式会社 | ユウシヨクカゴウブツノセイゾウホウ |
GB1520944A (en) * | 1975-06-12 | 1978-08-09 | Teijin Ltd | Quinoline derivatives for use als colouring agents |
-
1977
- 1977-06-04 ES ES459497A patent/ES459497A1/es not_active Expired
-
1978
- 1978-03-28 AR AR271557A patent/AR216945A1/es active
- 1978-05-25 FR FR7815612A patent/FR2392978A2/fr active Granted
- 1978-05-26 GB GB23468/78A patent/GB1602683A/en not_active Expired
- 1978-05-26 GB GB37253/80A patent/GB1602684A/en not_active Expired
- 1978-05-30 CH CH587678A patent/CH634483A5/fr not_active IP Right Cessation
- 1978-06-01 DE DE19782823987 patent/DE2823987A1/de active Granted
- 1978-06-02 US US05/911,801 patent/US4204063A/en not_active Expired - Lifetime
- 1978-06-02 JP JP6588978A patent/JPS5439076A/ja active Pending
-
1980
- 1980-10-22 JP JP55147009A patent/JPS5835995B2/ja not_active Expired
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1557945A (fr) * | 1967-01-30 | 1969-02-21 | ||
DE2423547A1 (de) * | 1974-05-15 | 1975-12-04 | Hoechst Ag | Basische farbstoffe, verfahren zu ihrer herstellung und ihre verwendung |
FR2279396A1 (fr) * | 1974-07-25 | 1976-02-20 | Made Labor Sa | Naphtalimides substitues |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0125439A3 (en) * | 1983-04-01 | 1985-12-04 | Warner-Lambert Company | 3,6-disubstituted-1,8-naphthalimides and methods for their production and use |
EP0125439A2 (fr) * | 1983-04-01 | 1984-11-21 | Warner-Lambert Company | 1,8-Naphtalimides 3,6-disubstituées, leurs procédés de préparation et leur application |
WO1991009850A1 (fr) * | 1989-12-21 | 1991-07-11 | Knoll Aktiengesellschaft | Naphtalimides n-substitues, leur fabrication et utilisation |
EP0536208A4 (en) * | 1990-06-26 | 1993-05-05 | Research Corporation Technologies, Inc. | 1,2-dihydro-3h-dibenzisoquinoline-1,3-dione anticancer agents |
US5635506A (en) * | 1990-06-26 | 1997-06-03 | Research Corporation Technologies, Inc. | 1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents |
EP0536208A1 (fr) * | 1990-06-26 | 1993-04-14 | Research Corporation Technologies, Inc. | Agents anticancereux a base de 1,2-dihydro-3h-dibenzisoquinoline-1,3-diones |
WO1992017454A1 (fr) * | 1991-03-27 | 1992-10-15 | The Du Pont Merck Pharmaceutical Company | Bis-naphtalimides contenant des linkers amide et thioamide et utilises comme agents anticancereux |
WO1992021673A1 (fr) * | 1991-05-28 | 1992-12-10 | Syntex (U.S.A.) Inc. | Nouvelles azabicyclobenzisoquinoleines |
WO1994006771A1 (fr) * | 1992-09-11 | 1994-03-31 | Research Corporation Technologies, Inc. | 1,2 DYHYDRO-3-H-DIBENZ(de,h) ISOQUINOLINE 1,3-DIONES ET LEUR UTILISATION EN TANT QU'AGENTS ANTICANCEREUX |
WO2000032577A2 (fr) * | 1998-11-25 | 2000-06-08 | Merck Patent Gmbh | Benzo[de]isoquinoline-1,3-diones substituees |
WO2000032577A3 (fr) * | 1998-11-25 | 2000-09-21 | Merck Patent Gmbh | Benzo[de]isoquinoline-1,3-diones substituees |
EP1539150A1 (fr) * | 2002-07-08 | 2005-06-15 | Chemgenex Pharmaceuticals Limited | Synthese de naphtalimides, y compris d'amonafides, et preparations pharmaceutiques les contenant |
EP1539150A4 (fr) * | 2002-07-08 | 2006-10-11 | Chemgenex Pharmaceuticals Inc | Synthese de naphtalimides, y compris d'amonafides, et preparations pharmaceutiques les contenant |
EP2305257A1 (fr) * | 2002-07-08 | 2011-04-06 | ChemGenex Pharmaceuticals, Inc. | Sels d'amonafide et compositions les contenant |
Also Published As
Publication number | Publication date |
---|---|
FR2392978B2 (fr) | 1982-07-02 |
GB1602683A (en) | 1981-11-11 |
JPS5439076A (en) | 1979-03-24 |
US4204063A (en) | 1980-05-20 |
DE2823987A1 (de) | 1978-12-07 |
GB1602684A (en) | 1981-11-11 |
CH634483A5 (fr) | 1983-02-15 |
AR216945A1 (es) | 1980-02-15 |
DE2823987C2 (fr) | 1990-08-02 |
JPS5835995B2 (ja) | 1983-08-05 |
ES459497A1 (es) | 1978-04-16 |
JPS56103166A (en) | 1981-08-18 |
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