AR216945A1 - Procedimiento para la preparacion de derivados de benzo(d,e)isoquinolein-1,3-dionas,sus sales con acidos farmacologicamente aceptables,sus n-oxidos y sus sales de amonio cuaternario - Google Patents

Procedimiento para la preparacion de derivados de benzo(d,e)isoquinolein-1,3-dionas,sus sales con acidos farmacologicamente aceptables,sus n-oxidos y sus sales de amonio cuaternario

Info

Publication number
AR216945A1
AR216945A1 AR271557A AR27155778A AR216945A1 AR 216945 A1 AR216945 A1 AR 216945A1 AR 271557 A AR271557 A AR 271557A AR 27155778 A AR27155778 A AR 27155778A AR 216945 A1 AR216945 A1 AR 216945A1
Authority
AR
Argentina
Prior art keywords
salts
isoquinolein
dionas
benzo
oxides
Prior art date
Application number
AR271557A
Other languages
English (en)
Spanish (es)
Original Assignee
Made Labor Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Made Labor Sa filed Critical Made Labor Sa
Application granted granted Critical
Publication of AR216945A1 publication Critical patent/AR216945A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AR271557A 1977-06-04 1978-03-28 Procedimiento para la preparacion de derivados de benzo(d,e)isoquinolein-1,3-dionas,sus sales con acidos farmacologicamente aceptables,sus n-oxidos y sus sales de amonio cuaternario AR216945A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES459497A ES459497A1 (es) 1977-06-04 1977-06-04 Un metodo para la preparacion industrial de naftalimidas y sus derivados.

Publications (1)

Publication Number Publication Date
AR216945A1 true AR216945A1 (es) 1980-02-15

Family

ID=8473948

Family Applications (1)

Application Number Title Priority Date Filing Date
AR271557A AR216945A1 (es) 1977-06-04 1978-03-28 Procedimiento para la preparacion de derivados de benzo(d,e)isoquinolein-1,3-dionas,sus sales con acidos farmacologicamente aceptables,sus n-oxidos y sus sales de amonio cuaternario

Country Status (8)

Country Link
US (1) US4204063A (fr)
JP (2) JPS5439076A (fr)
AR (1) AR216945A1 (fr)
CH (1) CH634483A5 (fr)
DE (1) DE2823987A1 (fr)
ES (1) ES459497A1 (fr)
FR (1) FR2392978A2 (fr)
GB (2) GB1602683A (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614820A (en) * 1983-04-01 1986-09-30 Warner-Lambert Co. 3,6-disubstituted-1,8-naphthalimides
DE3481120D1 (de) * 1983-04-01 1990-03-01 Warner Lambert Co 3,6-disubstituierte-1,8-naphthalimide, verfahren zu ihrer herstellung und ihre verwendung.
US5183821A (en) * 1983-09-19 1993-02-02 Laboratories Knoll, S.A. Method for treating leukemias using N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide for treating leukemias and solid tumors
DE3604827A1 (de) * 1986-02-15 1987-08-20 Bayer Ag Elektrophotographische toner
JPH0228365Y2 (fr) * 1986-04-22 1990-07-30
JPS6344707U (fr) * 1986-09-09 1988-03-25
DE3635711A1 (de) * 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
DE8715181U1 (de) * 1987-10-17 1987-12-03 Ledermann Gmbh + Co, 7240 Horb Spannvorrichtung
DE3922771A1 (de) * 1989-07-11 1991-01-24 Knoll Ag Amonafide-salze
US5420137A (en) * 1989-07-11 1995-05-30 Knoll Ag Amonafide salts
CA2030129A1 (fr) * 1989-11-29 1991-05-30 Thomas Saupe 1,8-napthalenedicarboximides utilises comme antidotes
DE3942280A1 (de) * 1989-12-21 1991-06-27 Knoll Ag N-substituierte naphthalimide, ihre herstellung und verwendung
US5202318A (en) * 1990-05-14 1993-04-13 Syntex (U.S.A.) Inc. Tricyclic compounds acting at serotonin receptor subtypes
ATE162526T1 (de) * 1990-06-26 1998-02-15 Res Corp Technologies Inc 1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel
US5635506A (en) * 1990-06-26 1997-06-03 Research Corporation Technologies, Inc. 1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents
FR2673944B1 (fr) * 1991-03-13 1995-03-10 Sanofi Elf Derives de l'1,8-naphtalimide, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5206250A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amide and thioamide linkers as anticancer agents
AU5127893A (en) * 1992-09-11 1994-04-12 Research Corporation Technologies, Inc. 1,2 dihydro-3-h-dibenz(de,h) isoquinoline 1,3 dione and their use as anticancer agents
JPH07581U (ja) * 1993-05-31 1995-01-06 株式会社遠藤製作所 浴槽用浄水器
DK0930883T3 (da) * 1996-10-21 2006-05-22 Nps Allelix Corp Neurotrofinantagonister til behandling af epilepsi, Alzheimers sygdom og smerte
HUP0104520A3 (en) * 1998-11-25 2002-10-28 Merck Patent Gmbh Substituted benzo[de]isoquinoline-1,3-diones process for their preparation and pharmaceutical compositions containing them
US6492380B1 (en) * 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
US6468990B1 (en) * 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
US6693198B2 (en) * 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts
US20050239816A1 (en) * 2002-04-22 2005-10-27 Xanthus Life Sciences, Inc. Amonafide salts
US20040082788A1 (en) * 2002-07-08 2004-04-29 Chemgenex Therapeutics, Inc. Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
CA2554775A1 (fr) * 2004-01-30 2005-08-18 Chemgenex Pharmaceuticals, Inc. Dosage de naphthalimide par genotypage de n-acetyle transferase
JP2007536283A (ja) * 2004-05-05 2007-12-13 ユニバイオスクリーン エス．アー． ナフタルイミド誘導体、それらの製造方法、およびそれらの医薬組成物
US20050288310A1 (en) * 2004-06-04 2005-12-29 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and PARP-1 inhibitors
EP1931664A4 (fr) 2005-09-15 2010-12-08 Painceptor Pharma Corp Methodes de modulation de l'activite induite par la neurotrophine
EP2887939B1 (fr) * 2012-08-27 2018-04-11 University of Tennessee Research Foundation Dérivés de l'acide benzoïque spécifiques au récepteur lpa2

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3330834A (en) * 1967-07-11 Naphthalimide whitening agents anb method of making same
US1796012A (en) * 1928-04-12 1931-03-10 Gen Aniline Works Inc Amino-naphthalimido-sulphonic acid compounds and process of preparing same
GB309552A (en) 1928-04-12 1930-06-26 Ig Farbenindustrie Ag Manufacture of acid wool dyestuffs
US1886797A (en) * 1928-05-18 1932-11-08 Gen Aniline Works Inc Naphthalimide dyestuffs and process of preparing them
DE530906C (de) * 1929-07-02 1931-08-01 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von sauren Wollfarbstoffen
US3625947A (en) * 1957-01-30 1971-12-07 Nippon Kayaku Kk N heterocyclic ethyl naphthalimides
GB1003083A (en) * 1961-01-21 1965-09-02 Toshiyasu Kasai Novel 4-alkoxynaphthalimides
US3310564A (en) * 1961-01-21 1967-03-21 Kasai Toshiyasu Novel 4-alkoxy naphthalimides
GB962019A (en) * 1961-04-12 1964-06-24 Mitsubishi Chem Ind Naphthalimide optical whitening agents
AT257528B (de) * 1964-08-08 1967-10-10 Bayer Ag Aufhellungsmittel
US3308127A (en) * 1964-08-24 1967-03-07 Mitsubishi Chem Ind Process for the production of naphthalic acid derivatives
FR1557945A (fr) * 1967-01-30 1969-02-21
US3798224A (en) * 1969-12-30 1974-03-19 Sumitomo Chemical Co Naphthalimide hydrazinamides
DE2423548C2 (de) * 1974-05-15 1984-08-23 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung von 4-Amino1,8-naphthalimid-Verbindungen
DE2423547A1 (de) * 1974-05-15 1975-12-04 Hoechst Ag Basische farbstoffe, verfahren zu ihrer herstellung und ihre verwendung
GB1435238A (en) * 1974-07-24 1976-05-12 Made Labor Sa Substituted naphthalimides and processes for their preparation
FR2279396A1 (fr) * 1974-07-25 1976-02-20 Made Labor Sa Naphtalimides substitues
JPS5116674A (en) * 1974-08-01 1976-02-10 Made Labor Sa Nafutaruimidoruino seizoho
JPS5851024B2 (ja) * 1975-05-26 1983-11-14 帝人株式会社 ユウシヨクカゴウブツノセイゾウホウ
GB1520944A (en) * 1975-06-12 1978-08-09 Teijin Ltd Quinoline derivatives for use als colouring agents

Also Published As

Publication number Publication date
GB1602683A (en) 1981-11-11
FR2392978B2 (fr) 1982-07-02
JPS5439076A (en) 1979-03-24
ES459497A1 (es) 1978-04-16
CH634483A5 (fr) 1983-02-15
JPS56103166A (en) 1981-08-18
DE2823987C2 (fr) 1990-08-02
DE2823987A1 (de) 1978-12-07
US4204063A (en) 1980-05-20
JPS5835995B2 (ja) 1983-08-05
FR2392978A2 (fr) 1978-12-29
GB1602684A (en) 1981-11-11

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