CH629492A5 - Derives d'acide epoxysuccinique et leur utilisation notamment pour leur activite anti-inflammatoire. - Google Patents
Derives d'acide epoxysuccinique et leur utilisation notamment pour leur activite anti-inflammatoire. Download PDFInfo
- Publication number
- CH629492A5 CH629492A5 CH229778A CH229778A CH629492A5 CH 629492 A5 CH629492 A5 CH 629492A5 CH 229778 A CH229778 A CH 229778A CH 229778 A CH229778 A CH 229778A CH 629492 A5 CH629492 A5 CH 629492A5
- Authority
- CH
- Switzerland
- Prior art keywords
- group
- carbon atoms
- substituted
- epoxysuccinate
- hydroxy
- Prior art date
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- 230000003110 anti-inflammatory effect Effects 0.000 title claims description 5
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
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- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 229940072033 potash Drugs 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000012257 stirred material Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- ZPHGMBGIFODUMF-UHFFFAOYSA-N thiophen-2-ylmethanol Chemical compound OCC1=CC=CS1 ZPHGMBGIFODUMF-UHFFFAOYSA-N 0.000 description 1
- 229960002898 threonine Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP52023092A JPS6059232B2 (ja) | 1977-03-03 | 1977-03-03 | エポキシサクシニルアミノ酸誘導体 |
| JP52023536A JPS6037104B2 (ja) | 1977-03-04 | 1977-03-04 | エポキシコハク酸モノエステル誘導体 |
| JP2353777A JPS6037105B2 (ja) | 1977-03-04 | 1977-03-04 | エポキシコハク酸モノエステル化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH629492A5 true CH629492A5 (fr) | 1982-04-30 |
Family
ID=27284115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH229778A CH629492A5 (fr) | 1977-03-03 | 1978-03-03 | Derives d'acide epoxysuccinique et leur utilisation notamment pour leur activite anti-inflammatoire. |
Country Status (5)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5547668A (en) | 1978-09-30 | 1980-04-04 | Taisho Pharmaceut Co Ltd | Epoxysuccinamic acid |
| JPS55115878A (en) * | 1979-02-27 | 1980-09-06 | Taisho Pharmaceut Co Ltd | Epoxysuccinic acid derivative |
| JPS55153778A (en) | 1979-05-17 | 1980-11-29 | Taisho Pharmaceut Co Ltd | Epoxysuccinylamino acid derivative |
| JPS56104816A (en) * | 1980-01-25 | 1981-08-20 | Nippon Chemiphar Co Ltd | Preventive and remedy for caridac infarction |
| US4474800A (en) * | 1980-05-13 | 1984-10-02 | Taisho Pharmaceutical Co., Ltd. | Epoxysuccinyl amino acid derivatives |
| JPS57169478A (en) * | 1981-04-10 | 1982-10-19 | Nippon Chemiphar Co Ltd | Piperazine derivative |
| JPS6276A (ja) * | 1985-03-26 | 1987-01-06 | Toyo Jozo Co Ltd | 酵素阻害性新規物質 |
| WO2001032906A2 (en) * | 1999-10-29 | 2001-05-10 | Novus International, Inc. | Oligomers and oligomeric segments of alpha-hydroxy carboxylic acids and alpha-amino acids |
| US6939693B2 (en) * | 1999-10-29 | 2005-09-06 | Novus International, Inc. | Enantioselective oligomerization of α-hydroxy carboxylic acids and α-amino acids |
| CN107151236B (zh) * | 2016-03-03 | 2021-04-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种2,3-环氧丁二酰衍生物及其制备方法和用途 |
| EP4140542A1 (en) * | 2021-08-24 | 2023-03-01 | Centre National De La Recherche Scientifique (Cnrs) | New vashs inhibitors, conjugates thereof and their uses as drugs or as research tools |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS548759B2 (US20030186963A1-20031002-C00026.png) * | 1973-03-06 | 1979-04-18 | ||
| GB1469797A (en) * | 1974-11-07 | 1977-04-06 | Pfizer Ltd | Antibacterial cephalosporin derivatives |
-
1978
- 1978-02-06 GB GB4717/78A patent/GB1595168A/en not_active Expired
- 1978-02-21 FR FR7804933A patent/FR2382447A1/fr active Granted
- 1978-02-22 US US05/880,180 patent/US4393228A/en not_active Expired - Lifetime
- 1978-03-02 DE DE19782809036 patent/DE2809036A1/de active Granted
- 1978-03-03 CH CH229778A patent/CH629492A5/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US4393228A (en) | 1983-07-12 |
| DE2809036C2 (US20030186963A1-20031002-C00026.png) | 1987-01-08 |
| DE2809036A1 (de) | 1978-09-07 |
| FR2382447A1 (fr) | 1978-09-29 |
| FR2382447B1 (US20030186963A1-20031002-C00026.png) | 1981-07-31 |
| GB1595168A (en) | 1981-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |