CH626896A5 - - Google Patents

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Publication number
CH626896A5
CH626896A5 CH1140476A CH1140476A CH626896A5 CH 626896 A5 CH626896 A5 CH 626896A5 CH 1140476 A CH1140476 A CH 1140476A CH 1140476 A CH1140476 A CH 1140476A CH 626896 A5 CH626896 A5 CH 626896A5
Authority
CH
Switzerland
Prior art keywords
neamine
acid
acetyl
compound
formula
Prior art date
Application number
CH1140476A
Other languages
German (de)
English (en)
Inventor
Barney John Magerlein
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of CH626896A5 publication Critical patent/CH626896A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CH1140476A 1975-09-08 1976-09-08 CH626896A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/611,349 US3996205A (en) 1975-09-08 1975-09-08 Aminoglycoside antibiotics and intermediates

Publications (1)

Publication Number Publication Date
CH626896A5 true CH626896A5 (fr) 1981-12-15

Family

ID=24448676

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1140476A CH626896A5 (fr) 1975-09-08 1976-09-08

Country Status (14)

Country Link
US (1) US3996205A (fr)
JP (1) JPS5233649A (fr)
AU (1) AU506262B2 (fr)
BE (1) BE845942A (fr)
CA (1) CA1067899A (fr)
CH (1) CH626896A5 (fr)
DE (1) DE2638794A1 (fr)
FR (2) FR2322608A1 (fr)
GB (1) GB1530643A (fr)
HU (1) HU177271B (fr)
NL (1) NL7609874A (fr)
PL (1) PL111474B1 (fr)
SU (1) SU700066A3 (fr)
ZA (1) ZA764726B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182855A (en) * 1977-05-05 1980-01-08 The Upjohn Company Nitrosugar
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
JP5345928B2 (ja) 2006-04-03 2013-11-20 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド 新規なアミノグリコシド類および遺伝子疾患の治療におけるその使用
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US10786520B2 (en) 2015-09-02 2020-09-29 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
EP3344641A4 (fr) 2015-09-02 2019-09-18 Eloxx Pharmaceuticals Ltd. Dérivés d'aminoglycosides et leurs utilisations dans le traitement de troubles génétiques
WO2017037717A1 (fr) 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Dérivés d'aminoglycoside et leurs utilisations dans le traitement de troubles génétiques
AU2018235441B2 (en) 2017-03-15 2022-07-21 Eloxx Pharmaceuticals Ltd. Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof
WO2020105054A1 (fr) 2018-11-22 2020-05-28 Technion Research & Development Foundation Limited Composés aminoglycosides modifiés et leurs utilisations dans la désactivation de ribosomes bactériens

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH84A (fr) * 1889-01-10 Fontainemelon Horlogerie Perfectionnement apporté dans la construction des mécanismes de remontoir des montres de tous calibres
JPS507595B1 (fr) * 1970-07-29 1975-03-27
US3792037A (en) * 1971-11-04 1974-02-12 Bristol Myers Co Process for preparing ambutyrosin
CA992535A (en) * 1972-03-08 1976-07-06 Bristol-Myers Squibb Company Antibiotic derivatives
US3897412A (en) * 1972-05-04 1975-07-29 Bristol Myers Co Paromomycin antibiotic derivatives
US3860574A (en) * 1972-12-06 1975-01-14 Bristol Myers Co Derivatives of neomycin b and neomycin c
US3886139A (en) * 1973-02-23 1975-05-27 Bristol Myers Co Derivatives of kanamycin
US3893997A (en) * 1974-07-01 1975-07-08 Smithkline Corp Pseudodisaccharide intermediates

Also Published As

Publication number Publication date
PL192253A1 (pl) 1979-02-26
NL7609874A (nl) 1977-03-10
FR2322608A1 (fr) 1977-04-01
AU1662676A (en) 1978-02-09
ZA764726B (en) 1977-07-27
FR2355852A1 (fr) 1978-01-20
AU506262B2 (en) 1979-12-20
DE2638794A1 (de) 1977-03-10
PL111474B1 (en) 1980-08-30
JPS5233649A (en) 1977-03-14
FR2355852B1 (fr) 1980-04-04
CA1067899A (fr) 1979-12-11
HU177271B (en) 1981-08-28
GB1530643A (en) 1978-11-01
US3996205A (en) 1976-12-07
BE845942A (fr) 1977-03-08
SU700066A3 (ru) 1979-11-25
FR2322608B1 (fr) 1979-09-07

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PL Patent ceased