CH626229A5 - - Google Patents
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- Publication number
- CH626229A5 CH626229A5 CH673677A CH673677A CH626229A5 CH 626229 A5 CH626229 A5 CH 626229A5 CH 673677 A CH673677 A CH 673677A CH 673677 A CH673677 A CH 673677A CH 626229 A5 CH626229 A5 CH 626229A5
- Authority
- CH
- Switzerland
- Prior art keywords
- active ingredient
- composition according
- fungicidal composition
- methyl
- alkyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 57
- 239000004480 active ingredient Substances 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 42
- -1 3-phenyl-5- (substituted-methyl) isoxazole Chemical group 0.000 claims description 26
- 230000000855 fungicidal effect Effects 0.000 claims description 17
- 239000000460 chlorine Substances 0.000 claims description 13
- 229910052801 chlorine Inorganic materials 0.000 claims description 13
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 11
- 229910052794 bromium Inorganic materials 0.000 claims description 11
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 9
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 7
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 239000011737 fluorine Chemical group 0.000 claims description 5
- 229910052731 fluorine Inorganic materials 0.000 claims description 5
- 230000002538 fungal effect Effects 0.000 claims description 5
- TWDAWKIAUQCSLF-UHFFFAOYSA-N [3-(4-chlorophenyl)-1,2-oxazol-5-yl]methanamine Chemical compound O1C(CN)=CC(C=2C=CC(Cl)=CC=2)=N1 TWDAWKIAUQCSLF-UHFFFAOYSA-N 0.000 claims description 4
- 230000002411 adverse Effects 0.000 claims description 4
- 239000004495 emulsifiable concentrate Substances 0.000 claims description 4
- 239000001257 hydrogen Chemical group 0.000 claims description 4
- 229910052739 hydrogen Chemical group 0.000 claims description 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
- ANRMBFFXQKJEIS-UHFFFAOYSA-N 5-(bromomethyl)-3-phenyl-1,2-oxazole Chemical compound O1C(CBr)=CC(C=2C=CC=CC=2)=N1 ANRMBFFXQKJEIS-UHFFFAOYSA-N 0.000 claims description 2
- VBMSVYFNXLNXCL-UHFFFAOYSA-N Br[N+]12CN3CN(CN(C3)C1)C2 Chemical compound Br[N+]12CN3CN(CN(C3)C1)C2 VBMSVYFNXLNXCL-UHFFFAOYSA-N 0.000 claims description 2
- FQHPYWLMGXNZPT-UHFFFAOYSA-N C1N(C2)CN3CN2C[N+]1(Cl)C3 Chemical compound C1N(C2)CN3CN2C[N+]1(Cl)C3 FQHPYWLMGXNZPT-UHFFFAOYSA-N 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 239000004563 wettable powder Substances 0.000 claims description 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- NKAGEEBNULDAAU-UHFFFAOYSA-N 4-(bromomethyl)-3-(4-chlorophenyl)-1,2-oxazole Chemical compound C1=CC(Cl)=CC=C1C1=NOC=C1CBr NKAGEEBNULDAAU-UHFFFAOYSA-N 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 description 35
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 29
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 26
- 238000000034 method Methods 0.000 description 24
- 239000000047 product Substances 0.000 description 22
- 239000006185 dispersion Substances 0.000 description 21
- 238000004458 analytical method Methods 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 239000000155 melt Substances 0.000 description 14
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- 239000002904 solvent Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 238000009472 formulation Methods 0.000 description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 238000010992 reflux Methods 0.000 description 9
- 238000010998 test method Methods 0.000 description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 8
- 239000003208 petroleum Substances 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 238000011835 investigation Methods 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- 239000013543 active substance Substances 0.000 description 6
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- 241000233679 Peronosporaceae Species 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- 235000021028 berry Nutrition 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 241001465180 Botrytis Species 0.000 description 4
- LGDSHSYDSCRFAB-UHFFFAOYSA-N Methyl isothiocyanate Chemical compound CN=C=S LGDSHSYDSCRFAB-UHFFFAOYSA-N 0.000 description 4
- 244000046052 Phaseolus vulgaris Species 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 235000021186 dishes Nutrition 0.000 description 4
- 239000000417 fungicide Substances 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 3
- 244000070406 Malus silvestris Species 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 235000021536 Sugar beet Nutrition 0.000 description 3
- 241000209140 Triticum Species 0.000 description 3
- 235000021307 Triticum Nutrition 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 description 3
- 239000007900 aqueous suspension Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000428 dust Substances 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 3
- 239000004312 hexamethylene tetramine Substances 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229960004011 methenamine Drugs 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000012044 organic layer Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- YORCIIVHUBAYBQ-UHFFFAOYSA-N propargyl bromide Chemical compound BrCC#C YORCIIVHUBAYBQ-UHFFFAOYSA-N 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 3
- AQZLTCXQTOKUAA-UHFFFAOYSA-N (3-phenyl-1,2-oxazol-5-yl)methanamine Chemical compound O1C(CN)=CC(C=2C=CC=CC=2)=N1 AQZLTCXQTOKUAA-UHFFFAOYSA-N 0.000 description 2
- SBVZWCJQNGBAQG-UHFFFAOYSA-N (3-phenyl-1,2-oxazol-5-yl)methanamine;hydrochloride Chemical compound Cl.O1C(CN)=CC(C=2C=CC=CC=2)=N1 SBVZWCJQNGBAQG-UHFFFAOYSA-N 0.000 description 2
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 description 2
- BTNNNJHRJAQJIU-UHFFFAOYSA-N 5-(isothiocyanatomethyl)-3-phenyl-1,2-oxazole Chemical compound O1C(CN=C=S)=CC(C=2C=CC=CC=2)=N1 BTNNNJHRJAQJIU-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 240000008067 Cucumis sativus Species 0.000 description 2
- 241000221785 Erysiphales Species 0.000 description 2
- 244000052355 Hydrilla verticillata Species 0.000 description 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 241000606856 Pasteurella multocida Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- 241001281803 Plasmopara viticola Species 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 240000003768 Solanum lycopersicum Species 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000004703 alkoxides Chemical class 0.000 description 2
- 125000001246 bromo group Chemical group Br* 0.000 description 2
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- 125000001810 isothiocyanato group Chemical group *N=C=S 0.000 description 2
- 125000000842 isoxazolyl group Chemical group 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052901 montmorillonite Inorganic materials 0.000 description 2
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 2
- 150000002923 oximes Chemical class 0.000 description 2
- 229940051027 pasteurella multocida Drugs 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000001965 potato dextrose agar Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 238000006798 ring closing metathesis reaction Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 2
- 150000003585 thioureas Chemical class 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- DLJJLIJTPGZEQV-UHFFFAOYSA-N (3-phenyl-1,2-oxazol-5-yl)methylcarbamic acid Chemical compound O1C(CNC(=O)O)=CC(C=2C=CC=CC=2)=N1 DLJJLIJTPGZEQV-UHFFFAOYSA-N 0.000 description 1
- VTWKXBJHBHYJBI-SOFGYWHQSA-N (ne)-n-benzylidenehydroxylamine Chemical compound O\N=C\C1=CC=CC=C1 VTWKXBJHBHYJBI-SOFGYWHQSA-N 0.000 description 1
- QKWBTCRVPQHOMT-UITAMQMPSA-N (nz)-n-[(4-chlorophenyl)methylidene]hydroxylamine Chemical compound O\N=C/C1=CC=C(Cl)C=C1 QKWBTCRVPQHOMT-UITAMQMPSA-N 0.000 description 1
- HJVKQVTXROGXGE-UHFFFAOYSA-N 1,2,3-triazatricyclo[3.3.1.13,7]decane Chemical compound C1N(N2)CC3CC1CN2C3 HJVKQVTXROGXGE-UHFFFAOYSA-N 0.000 description 1
- XXBVYCPXESQMIL-UHFFFAOYSA-N 1,2-oxazol-3-ylcarbamic acid Chemical class OC(=O)NC=1C=CON=1 XXBVYCPXESQMIL-UHFFFAOYSA-N 0.000 description 1
- HABKYZJFXJPMHF-UHFFFAOYSA-N 1,2-oxazolidine-2-carbothioamide Chemical class NC(=S)N1CCCO1 HABKYZJFXJPMHF-UHFFFAOYSA-N 0.000 description 1
- WNAISYJJJYNOED-UHFFFAOYSA-M 1-[(3-phenyl-5-isoxazolyl)methyl]-3,5,7-triaza-1-azoniaadamantane bromide Chemical compound [Br-].C1N(C2)CN(C3)CN2C[N+]13CC(ON=1)=CC=1C1=CC=CC=C1 WNAISYJJJYNOED-UHFFFAOYSA-M 0.000 description 1
- XGIXXVYNEZVQHP-UHFFFAOYSA-N 1-[[3-(4-chlorophenyl)-1,2-oxazol-5-yl]methyl]-3-methylthiourea Chemical compound O1C(CNC(=S)NC)=CC(C=2C=CC(Cl)=CC=2)=N1 XGIXXVYNEZVQHP-UHFFFAOYSA-N 0.000 description 1
- JGSRFOJWVCKIDC-UHFFFAOYSA-M 1-[[3-(4-chlorophenyl)-5-isoxazolyl]methyl]-3,5,7-triaza-1-azoniaadamantane bromide Chemical compound [Br-].C1=CC(Cl)=CC=C1C1=NOC(C[N+]23CN4CN(CN(C4)C2)C3)=C1 JGSRFOJWVCKIDC-UHFFFAOYSA-M 0.000 description 1
- FCCZDDSQSPCVOA-UHFFFAOYSA-N 1-methyl-3-[(3-phenyl-1,2-oxazol-5-yl)methyl]thiourea Chemical compound O1C(CNC(=S)NC)=CC(C=2C=CC=CC=2)=N1 FCCZDDSQSPCVOA-UHFFFAOYSA-N 0.000 description 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
- 229940093475 2-ethoxyethanol Drugs 0.000 description 1
- IMSYISZEBROLPV-UHFFFAOYSA-N 3-(4-chlorophenyl)-5-(isothiocyanatomethyl)-1,2-oxazole Chemical compound C1=CC(Cl)=CC=C1C1=NOC(CN=C=S)=C1 IMSYISZEBROLPV-UHFFFAOYSA-N 0.000 description 1
- UPLZAOAJYQUAER-UHFFFAOYSA-N 3-(4-fluorophenyl)-5-(isothiocyanatomethyl)-1,2-oxazole Chemical compound C1=CC(F)=CC=C1C1=NOC(CN=C=S)=C1 UPLZAOAJYQUAER-UHFFFAOYSA-N 0.000 description 1
- JXMPZLAZFWCPMI-UHFFFAOYSA-N 3-(furan-2-yl)-4-nitro-4,5-dihydro-1,2-oxazole Chemical class [O-][N+](=O)C1CON=C1C1=CC=CO1 JXMPZLAZFWCPMI-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- YGCXXYLQISERCR-UHFFFAOYSA-N 5-(bromomethyl)-3-(4-chlorophenyl)-1,2-oxazole Chemical compound C1=CC(Cl)=CC=C1C1=NOC(CBr)=C1 YGCXXYLQISERCR-UHFFFAOYSA-N 0.000 description 1
- KTDCTRAYVOBOLV-UHFFFAOYSA-N 5-(bromomethyl)-3-(4-fluorophenyl)-1,2-oxazole Chemical compound C1=CC(F)=CC=C1C1=NOC(CBr)=C1 KTDCTRAYVOBOLV-UHFFFAOYSA-N 0.000 description 1
- MWWCXSRHXJUYLZ-UHFFFAOYSA-N 5-(bromomethyl)-3-[4-(trifluoromethyl)phenyl]-1,2-oxazole Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=NOC(CBr)=C1 MWWCXSRHXJUYLZ-UHFFFAOYSA-N 0.000 description 1
- SLKGLAFNLGTRGT-UHFFFAOYSA-N 5-(chloromethyl)-3-[4-(trifluoromethyl)phenyl]-1,2-oxazole Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=NOC(CCl)=C1 SLKGLAFNLGTRGT-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000607528 Aeromonas hydrophila Species 0.000 description 1
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 241000190150 Bipolaris sorokiniana Species 0.000 description 1
- 241000588779 Bordetella bronchiseptica Species 0.000 description 1
- 241000123650 Botrytis cinerea Species 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 244000045232 Canavalia ensiformis Species 0.000 description 1
- 241000222178 Candida tropicalis Species 0.000 description 1
- 241000209443 Ceratophyllum demersum Species 0.000 description 1
- 241001157813 Cercospora Species 0.000 description 1
- 241000530549 Cercospora beticola Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000588919 Citrobacter freundii Species 0.000 description 1
- 241000222235 Colletotrichum orbiculare Species 0.000 description 1
- 235000009849 Cucumis sativus Nutrition 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 241000371644 Curvularia ravenelii Species 0.000 description 1
- 241000375722 Cyperus eriocauloides Species 0.000 description 1
- 241001113556 Elodea Species 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000588694 Erwinia amylovora Species 0.000 description 1
- 241000896222 Erysiphe polygoni Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000588915 Klebsiella aerogenes Species 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 244000207740 Lemna minor Species 0.000 description 1
- 235000006439 Lemna minor Nutrition 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 241000204045 Mycoplasma hyopneumoniae Species 0.000 description 1
- 241000202938 Mycoplasma hyorhinis Species 0.000 description 1
- 241000221671 Ophiostoma ulmi Species 0.000 description 1
- 235000010617 Phaseolus lunatus Nutrition 0.000 description 1
- 241000233622 Phytophthora infestans Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000589774 Pseudomonas sp. Species 0.000 description 1
- 241000589771 Ralstonia solanacearum Species 0.000 description 1
- 235000003963 Rubus phoenicolasius Nutrition 0.000 description 1
- 244000111447 Rubus phoenicolasius Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000392514 Salmonella enterica subsp. enterica serovar Dublin Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 244000062793 Sorghum vulgare Species 0.000 description 1
- 241000592344 Spermatophyta Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
- 241000228452 Venturia inaequalis Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- MHQHMMLKXGSJCH-UHFFFAOYSA-N [3-(4-bromophenyl)-1,2-oxazol-5-yl]methanamine Chemical compound O1C(CN)=CC(C=2C=CC(Br)=CC=2)=N1 MHQHMMLKXGSJCH-UHFFFAOYSA-N 0.000 description 1
- MOFLNZGDBYVUPF-UHFFFAOYSA-N [3-[4-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methanamine Chemical compound O1C(CN)=CC(C=2C=CC(=CC=2)C(F)(F)F)=N1 MOFLNZGDBYVUPF-UHFFFAOYSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 229940092782 bentonite Drugs 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 150000003935 benzaldehydes Chemical class 0.000 description 1
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzenecarboxaldehyde Natural products O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000013532 brandy Nutrition 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 229940112021 centrally acting muscle relaxants carbamic acid ester Drugs 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- CRPOUZQWHJYTMS-UHFFFAOYSA-N dialuminum;magnesium;disilicate Chemical compound [Mg+2].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] CRPOUZQWHJYTMS-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229940092559 enterobacter aerogenes Drugs 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- MDXBVNYOXKYAOA-UHFFFAOYSA-N ethyl n-[(3-phenyl-1,2-oxazol-5-yl)methyl]carbamate Chemical compound O1C(CNC(=O)OCC)=CC(C=2C=CC=CC=2)=N1 MDXBVNYOXKYAOA-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 239000011872 intimate mixture Substances 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000003854 isothiazoles Chemical class 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 235000019357 lignosulphonate Nutrition 0.000 description 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 description 1
- 229910052808 lithium carbonate Inorganic materials 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- NGDSBQHTMKGUQU-UHFFFAOYSA-N methenamine hydrochloride Chemical compound Cl.C([N@@](C1)C2)[N@]3C[N@@]2C[N@@]1C3 NGDSBQHTMKGUQU-UHFFFAOYSA-N 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- MNDYDYTXPOFXLS-UHFFFAOYSA-N n-[[4-(trifluoromethyl)phenyl]methylidene]hydroxylamine Chemical compound ON=CC1=CC=C(C(F)(F)F)C=C1 MNDYDYTXPOFXLS-UHFFFAOYSA-N 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 230000003032 phytopathogenic effect Effects 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011814 protection agent Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- 229910052903 pyrophyllite Inorganic materials 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- AGGKEGLBGGJEBZ-UHFFFAOYSA-N tetramethylenedisulfotetramine Chemical compound C1N(S2(=O)=O)CN3S(=O)(=O)N1CN2C3 AGGKEGLBGGJEBZ-UHFFFAOYSA-N 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/695,669 US4109002A (en) | 1976-06-14 | 1976-06-14 | Fungicidal 3-phenyl-5-(substituted methyl) isoxaxoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH626229A5 true CH626229A5 (it) | 1981-11-13 |
Family
ID=24793998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH673677A CH626229A5 (it) | 1976-06-14 | 1977-06-01 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4109002A (it) |
| JP (1) | JPS52154525A (it) |
| BE (1) | BE855603A (it) |
| CA (1) | CA1081120A (it) |
| CH (1) | CH626229A5 (it) |
| DE (1) | DE2723688A1 (it) |
| FR (1) | FR2354708A1 (it) |
| GB (1) | GB1580462A (it) |
| IE (1) | IE44869B1 (it) |
| IL (1) | IL51779A (it) |
| IT (1) | IT1075840B (it) |
| NL (1) | NL7706559A (it) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247322A (en) * | 1979-10-01 | 1981-01-27 | Monsanto Company | 3-(m-Trifluoromethylphenyl)-5-halomethyl isoxazoles as safening agents |
| WO1992018908A1 (en) * | 1991-04-11 | 1992-10-29 | Agfa-Gevaert N.V. | Electrophotographic developer composition |
| US6576633B1 (en) | 1996-02-22 | 2003-06-10 | The Dow Chemical Company | Stable liquid antimicrobial suspension compositions containing quarternaries prepared from hexamethylenetetramine and certain halohydrocarbons |
| EP1491535A4 (en) * | 2002-03-07 | 2009-09-23 | Sds Biotech Corp | SUBSTITUTED ISOXAZOLALKYLAMINE DERIVATIVE AND FUNGICIDE FOR AGRICULTURE AND GARDENING |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2946720A (en) * | 1957-05-13 | 1960-07-26 | Monsanto Chemicals | Method of treating nematodes by treating with a heterocyclic methyl isothiocyanate |
| GB1164510A (en) | 1967-06-15 | 1969-09-17 | Ici Ltd | Novel Isoxazole Derivatives, the preparation thereof, and Compositions containing the same |
| NL137326C (it) * | 1967-08-26 | |||
| GB1245238A (en) * | 1967-12-04 | 1971-09-08 | Imp Chemicals Ltd | New isoxazolyl derivatives and compositions containing them |
| US3781438A (en) * | 1972-03-27 | 1973-12-25 | Fmc Corp | Arylisoxazoles as nematicides |
| FR2215219A1 (en) | 1973-01-26 | 1974-08-23 | Roussel Uclaf | Thiocarbamoylthioamides - with bactericidal and fungicidal activity for use in medicine and in agriculture |
| US3869466A (en) * | 1973-07-30 | 1975-03-04 | Dow Chemical Co | 4-cyano-3,5-isothiazolediylbis(thiomethylene)dithiocyanate |
-
1976
- 1976-06-14 US US05/695,669 patent/US4109002A/en not_active Expired - Lifetime
-
1977
- 1977-03-28 IE IE643/77A patent/IE44869B1/en unknown
- 1977-03-29 IL IL51779A patent/IL51779A/xx unknown
- 1977-03-30 CA CA275,149A patent/CA1081120A/en not_active Expired
- 1977-04-27 IT IT22889/77A patent/IT1075840B/it active
- 1977-05-25 DE DE19772723688 patent/DE2723688A1/de not_active Withdrawn
- 1977-06-01 CH CH673677A patent/CH626229A5/de not_active IP Right Cessation
- 1977-06-09 GB GB24260/77A patent/GB1580462A/en not_active Expired
- 1977-06-10 BE BE1008186A patent/BE855603A/xx unknown
- 1977-06-13 FR FR7718051A patent/FR2354708A1/fr active Granted
- 1977-06-13 JP JP7043377A patent/JPS52154525A/ja active Pending
- 1977-06-14 NL NL7706559A patent/NL7706559A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1081120A (en) | 1980-07-08 |
| IL51779A (en) | 1980-06-30 |
| NL7706559A (nl) | 1977-12-16 |
| IT1075840B (it) | 1985-04-22 |
| IE44869B1 (en) | 1982-04-21 |
| FR2354708B1 (it) | 1979-10-12 |
| US4109002A (en) | 1978-08-22 |
| IE44869L (en) | 1977-12-14 |
| FR2354708A1 (fr) | 1978-01-13 |
| JPS52154525A (en) | 1977-12-22 |
| DE2723688A1 (de) | 1977-12-22 |
| IL51779A0 (en) | 1977-05-31 |
| BE855603A (fr) | 1977-12-12 |
| GB1580462A (en) | 1980-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |