CH625626A5 - Process for the preparation of stable immunological reagents - Google Patents
Process for the preparation of stable immunological reagents Download PDFInfo
- Publication number
- CH625626A5 CH625626A5 CH310277A CH310277A CH625626A5 CH 625626 A5 CH625626 A5 CH 625626A5 CH 310277 A CH310277 A CH 310277A CH 310277 A CH310277 A CH 310277A CH 625626 A5 CH625626 A5 CH 625626A5
- Authority
- CH
- Switzerland
- Prior art keywords
- latex
- serologically
- suspension
- antigen
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title claims description 6
- 230000001900 immune effect Effects 0.000 title description 4
- 239000003153 chemical reaction reagent Substances 0.000 title description 2
- 239000004816 latex Substances 0.000 claims description 59
- 229920000126 latex Polymers 0.000 claims description 59
- 239000000725 suspension Substances 0.000 claims description 29
- 239000000463 material Substances 0.000 claims description 28
- 239000000427 antigen Substances 0.000 claims description 24
- 108091007433 antigens Proteins 0.000 claims description 24
- 102000036639 antigens Human genes 0.000 claims description 24
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 20
- 239000008101 lactose Substances 0.000 claims description 19
- 239000002245 particle Substances 0.000 claims description 17
- 239000002270 dispersing agent Substances 0.000 claims description 9
- 239000007900 aqueous suspension Substances 0.000 claims description 6
- 150000001720 carbohydrates Chemical class 0.000 claims description 6
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims description 3
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 108010074605 gamma-Globulins Proteins 0.000 claims description 3
- 229940099472 immunoglobulin a Drugs 0.000 claims description 3
- 229940027941 immunoglobulin g Drugs 0.000 claims description 3
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 241001505901 Streptococcus sp. 'group A' Species 0.000 claims description 2
- 229940084986 human chorionic gonadotropin Drugs 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000000654 additive Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 230000000996 additive effect Effects 0.000 description 11
- 229920000642 polymer Polymers 0.000 description 7
- 239000012153 distilled water Substances 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 230000004520 agglutination Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000009257 reactivity Effects 0.000 description 5
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- -1 alkali metal salt Chemical class 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000008105 immune reaction Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- HYZDOKBFNBVDPA-UHFFFAOYSA-N 2-(aminomethyl)-2-(hydroxymethyl)propane-1,3-diol;hydrochloride Chemical compound Cl.NCC(CO)(CO)CO HYZDOKBFNBVDPA-UHFFFAOYSA-N 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- WRVRNZNDLRUXSW-UHFFFAOYSA-N acetic acid;prop-2-enoic acid Chemical class CC(O)=O.OC(=O)C=C WRVRNZNDLRUXSW-UHFFFAOYSA-N 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- SQNNHEYXAJPPKH-UHFFFAOYSA-N chloroethene;prop-2-enoic acid Chemical class ClC=C.OC(=O)C=C SQNNHEYXAJPPKH-UHFFFAOYSA-N 0.000 description 1
- 229940015047 chorionic gonadotropin Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000037029 cross reaction Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002717 polyvinylpyridine Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67021276A | 1976-03-25 | 1976-03-25 | |
| US70065276A | 1976-06-28 | 1976-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH625626A5 true CH625626A5 (en) | 1981-09-30 |
Family
ID=27100272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH310277A CH625626A5 (en) | 1976-03-25 | 1977-03-11 | Process for the preparation of stable immunological reagents |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS52117420A (enExample) |
| CH (1) | CH625626A5 (enExample) |
| DE (1) | DE2712044A1 (enExample) |
| FR (1) | FR2345723A1 (enExample) |
| GB (1) | GB1564987A (enExample) |
| IT (1) | IT1085527B (enExample) |
| NL (1) | NL7703150A (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1603406A (en) * | 1977-08-31 | 1981-11-25 | Nat Res Dev | Assay of immune complexes |
| JPS5633550A (en) * | 1979-08-29 | 1981-04-04 | Seikagaku Kogyo Co Ltd | Latex reagent sensitized with hemolytic streptococcal nicotinamide adenine dinucleotidase (nadase), method of producing the same and method of detecting nadase antibody using the same |
| JPS5873866A (ja) * | 1981-10-28 | 1983-05-04 | Toray Ind Inc | 免疫学的検査方法 |
| GB8307156D0 (en) * | 1983-03-15 | 1983-04-20 | Celltech Ltd | Heterogeneous binding assays |
| GB2136565B (en) * | 1983-03-15 | 1986-05-08 | Boots Celltech Diagnostics | Heterogeneous binding assay |
| US4931385A (en) * | 1985-06-24 | 1990-06-05 | Hygeia Sciences, Incorporated | Enzyme immunoassays and immunologic reagents |
| AU609332B2 (en) * | 1988-11-09 | 1991-04-26 | Biotrack, Inc. | Method and composition of stabilizing and solubilizing latex reagents |
| US5102788A (en) * | 1988-11-21 | 1992-04-07 | Hygeia Sciences, Inc. | Immunoassay including lyophilized reactant mixture |
| DE69027560T2 (de) * | 1989-08-23 | 1997-01-09 | Canon K.K., Tokio/Tokyo | Methode zur Messung eines immunologisch aktiven Materials und Vorrichtung, die dazu geeignet ist |
| EP0466170B1 (en) * | 1990-07-13 | 1997-11-05 | Canon Kabushiki Kaisha | Detection reagent |
| WO2007003327A1 (en) | 2005-07-01 | 2007-01-11 | Roche Diagnostics Gmbh | Carboxylated latex particles |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1493772A (fr) * | 1965-07-28 | 1967-09-01 | Organon Nv | Procédé pour le traitement des érythrocytes |
| US3413198A (en) * | 1966-06-30 | 1968-11-26 | Calbiochem | Reagents and method for assaying biological samples |
| CH621561A5 (en) * | 1974-01-14 | 1981-02-13 | Ceskoslovenska Akademie Ved | Process for producing a bromocyan-activated, hydrophilic, polymeric carrier for biologically active compounds in dried form |
-
1977
- 1977-03-11 CH CH310277A patent/CH625626A5/de not_active IP Right Cessation
- 1977-03-18 DE DE19772712044 patent/DE2712044A1/de not_active Ceased
- 1977-03-23 FR FR7708675A patent/FR2345723A1/fr active Granted
- 1977-03-23 JP JP3122077A patent/JPS52117420A/ja active Pending
- 1977-03-23 NL NL7703150A patent/NL7703150A/xx not_active Application Discontinuation
- 1977-03-24 GB GB1244677A patent/GB1564987A/en not_active Expired
- 1977-03-25 IT IT2170977A patent/IT1085527B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| JPS52117420A (en) | 1977-10-01 |
| DE2712044A1 (de) | 1977-09-29 |
| IT1085527B (it) | 1985-05-28 |
| FR2345723A1 (fr) | 1977-10-21 |
| FR2345723B1 (enExample) | 1982-04-09 |
| NL7703150A (nl) | 1977-09-27 |
| GB1564987A (en) | 1980-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |