CH615659A5 - Process for the preparation of novel 11,12-secoprostaglandins - Google Patents

Process for the preparation of novel 11,12-secoprostaglandins Download PDF

Info

Publication number
CH615659A5
CH615659A5 CH1610674A CH1610674A CH615659A5 CH 615659 A5 CH615659 A5 CH 615659A5 CH 1610674 A CH1610674 A CH 1610674A CH 1610674 A CH1610674 A CH 1610674A CH 615659 A5 CH615659 A5 CH 615659A5
Authority
CH
Switzerland
Prior art keywords
acetyl
compounds
group
acid
formula
Prior art date
Application number
CH1610674A
Other languages
German (de)
English (en)
Inventor
Edward Jethro Cragoe Jr
John Beeh Bicking
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH615659A5 publication Critical patent/CH615659A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C49/217—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/215—Saturated compounds having only one carboxyl group and containing keto groups containing singly bound oxygen containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH1610674A 1973-12-13 1974-12-04 Process for the preparation of novel 11,12-secoprostaglandins CH615659A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42450173A 1973-12-13 1973-12-13

Publications (1)

Publication Number Publication Date
CH615659A5 true CH615659A5 (en) 1980-02-15

Family

ID=23682856

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1610674A CH615659A5 (en) 1973-12-13 1974-12-04 Process for the preparation of novel 11,12-secoprostaglandins

Country Status (8)

Country Link
JP (1) JPS5089322A (tr)
CH (1) CH615659A5 (tr)
DE (1) DE2458911A1 (tr)
DK (1) DK615574A (tr)
FR (1) FR2254326B1 (tr)
GB (1) GB1479156A (tr)
NL (1) NL7415415A (tr)
SE (1) SE7414770L (tr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150235A (en) * 1976-12-17 1979-04-17 Merck & Co., Inc. Interphenylene 11,12-secoprostaglandins
UA59384C2 (uk) * 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
UA67754C2 (uk) 1997-10-10 2004-07-15 Пфайзер, Інк. Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти)
OA12117A (en) 1999-12-22 2006-05-04 Pfizer Prod Inc EP4 receptor selective agonists in the treatment of osteoporosis.
ATE327751T1 (de) 2000-01-31 2006-06-15 Pfizer Prod Inc Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienz

Also Published As

Publication number Publication date
JPS5089322A (tr) 1975-07-17
NL7415415A (nl) 1975-06-17
SE7414770L (tr) 1975-06-16
FR2254326B1 (tr) 1978-06-30
DK615574A (tr) 1975-08-11
FR2254326A1 (tr) 1975-07-11
GB1479156A (en) 1977-07-06
DE2458911A1 (de) 1975-06-26

Similar Documents

Publication Publication Date Title
DE3219244C2 (de) Sulfonatderivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende Arzneimittel
DE2154309C3 (de) 17-Phenyl-18,19,20-trinor-PGE↓2↓ und - PGF↓2↓ α und dieselben enthaltende Arzneimittel
US4033996A (en) 8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins
EP0025192B1 (de) Substituierte Oxirancarbonsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel
US4066692A (en) 11,12-secoprostaglandins
DE2755759A1 (de) 4-(4-acyl-3-hydroxy-8-methyltridecyl)- benzoesaeuren
US4092356A (en) 11,12-Secoprostaglandins
CH615659A5 (en) Process for the preparation of novel 11,12-secoprostaglandins
EP0306649B1 (de) Neue 3,5-Dihydroxycarbonsäuren und deren Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, pharmazeutische Präparate und Zwischenprodukte
EP0009776B1 (de) N-Monohydroxypropylamide, N-Dihydroxypropylamide und deren Acetonoide der all-E- und 13-Z-Retinsäure, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE2843811A1 (de) Retinsaeure- und 7,8-dehydro-retinsaeure-n-(carboxy)-phenylamide
DE2743283A1 (de) Neue prostacyclin-analoga
CH622020A5 (tr)
US3644502A (en) Prostaglandin synthesis
DE2419860A1 (de) Secoprostaglandine
DE2256537A1 (de) Neue sulfide
DE2331081A1 (de) Neue cyclopentanderivate und verfahren zu ihrer herstellung
AT336556B (de) Verfahren zur herstellung von neuen, gegebenenfalls fluorierten n-alkylsulfonyl- (oder -sulfinyl-) -hydroxyazacarbonsauren
US3799967A (en) Synthetic prostaglandins
DE2449272A1 (de) 8,10-diaza-9-oxo-(und-thioxo)-11,12secoprostaglandine und verfahren zu deren herstellung
DE3818570A1 (de) Neue 6-substituierte-4-hydroxy-tetrahydro-pyran -2-on-derivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen
DE3028776A1 (de) Neue 1,3-diphenoxypropan-2-on-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE1593644C3 (tr)
DE2834248A1 (de) Neue prostaglandinderivate in der delta 2-pgf tief 2 und delta 2-pge tief 2 -reihe
US3769316A (en) Prostaglandin intermediates

Legal Events

Date Code Title Description
PL Patent ceased