GB1479156A - 11,12-secoprostaglandins - Google Patents

11,12-secoprostaglandins

Info

Publication number
GB1479156A
GB1479156A GB53119/74A GB5311974A GB1479156A GB 1479156 A GB1479156 A GB 1479156A GB 53119/74 A GB53119/74 A GB 53119/74A GB 5311974 A GB5311974 A GB 5311974A GB 1479156 A GB1479156 A GB 1479156A
Authority
GB
United Kingdom
Prior art keywords
compounds
secoprostaglandins
formula
antithrombotics
antihypertensives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB53119/74A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1479156A publication Critical patent/GB1479156A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C49/217—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/215—Saturated compounds having only one carboxyl group and containing keto groups containing singly bound oxygen containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB53119/74A 1973-12-13 1974-12-09 11,12-secoprostaglandins Expired GB1479156A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42450173A 1973-12-13 1973-12-13

Publications (1)

Publication Number Publication Date
GB1479156A true GB1479156A (en) 1977-07-06

Family

ID=23682856

Family Applications (1)

Application Number Title Priority Date Filing Date
GB53119/74A Expired GB1479156A (en) 1973-12-13 1974-12-09 11,12-secoprostaglandins

Country Status (8)

Country Link
JP (1) JPS5089322A (tr)
CH (1) CH615659A5 (tr)
DE (1) DE2458911A1 (tr)
DK (1) DK615574A (tr)
FR (1) FR2254326B1 (tr)
GB (1) GB1479156A (tr)
NL (1) NL7415415A (tr)
SE (1) SE7414770L (tr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492412B2 (en) 1996-12-20 2002-12-10 Pfizer, Inc. Prevention of loss and restoration of bone mass by certain prostaglandin agonists
US6498172B1 (en) 1997-10-10 2002-12-24 Pfizer Inc. Prostaglandin agonists and their use to treat bone disorders
US6610719B2 (en) 2000-01-31 2003-08-26 Pfizer Inc. Use of prostaglandin (PGE2) receptor a (EP4) selective agonists for the treatment of acute and chronic renal failure
US6642266B2 (en) 1999-12-22 2003-11-04 Pfizer Inc. EP4 receptor selective agonists in the treatment of osteoporosis

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150235A (en) * 1976-12-17 1979-04-17 Merck & Co., Inc. Interphenylene 11,12-secoprostaglandins

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492412B2 (en) 1996-12-20 2002-12-10 Pfizer, Inc. Prevention of loss and restoration of bone mass by certain prostaglandin agonists
US6649657B2 (en) 1996-12-20 2003-11-18 Pfizer Inc. Prevention of loss and restoration of bone mass by certain prostaglandin agonists
US6998423B2 (en) 1996-12-20 2006-02-14 Pfizer Inc. Prevention of loss and restoration of bone mass by certain prostaglandin agonists
BG64893B1 (bg) * 1996-12-20 2006-08-31 Pfizer Inc. Простагландинови агонисти, фармацевтични състави и китове, съдържащи такива агонисти, и използването им за предотвратяване на загуба и възстановяванена костна маса
US6498172B1 (en) 1997-10-10 2002-12-24 Pfizer Inc. Prostaglandin agonists and their use to treat bone disorders
BG65238B1 (bg) * 1997-10-10 2007-09-28 Pfizer Inc. Простагландинови агонисти и тяхното използване запроизводство на медикаменти за лечение на заболявания на костите
US7442702B2 (en) 1997-10-10 2008-10-28 Pfizer Inc. Prostaglandin agonists
US6642266B2 (en) 1999-12-22 2003-11-04 Pfizer Inc. EP4 receptor selective agonists in the treatment of osteoporosis
US6737437B2 (en) 1999-12-22 2004-05-18 Pfizer Inc. EP4 receptor selective agonists in the treatment of osteoporosis
US6610719B2 (en) 2000-01-31 2003-08-26 Pfizer Inc. Use of prostaglandin (PGE2) receptor a (EP4) selective agonists for the treatment of acute and chronic renal failure

Also Published As

Publication number Publication date
JPS5089322A (tr) 1975-07-17
CH615659A5 (en) 1980-02-15
NL7415415A (nl) 1975-06-17
SE7414770L (tr) 1975-06-16
FR2254326B1 (tr) 1978-06-30
DK615574A (tr) 1975-08-11
FR2254326A1 (tr) 1975-07-11
DE2458911A1 (de) 1975-06-26

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee